Abstract: The present invention generally relates to a herbal composition. Specifically, the present invention relates to a herbal composition comprising of extract of apricot, champa flower and rosemary flower. The present invention also relates to a process of preparing a cream formulation comprising the herbal composition and use of the composition in the treatment of acne.
The present invention generally relates to a herbal composition. Specifically, the present invention relates to a herbal composition comprising of apricot, champa flower and rosemary flower. The present invention also relates to a process of preparation of the herbal composition and the method of treating acne using the herbal composition.
BACKGROUND OF THE INVENTION
[0002] Background description includes information that may be useful in understanding the present invention. It is not an admission that any of the information provided herein is prior art or relevant to the presently claimed invention, or that any publication specifically or implicitly referenced is prior art.
[0003] Acne vulgaris is an extremely common disorder of skin (pilocebaceous unit) that affects virtually all individuals at least once during life. The incidence of acne peaks at teenage, but substantial numbers of men and women between 20-30 years of age are also affected by the disorder. It is an inflammatory disease of sebaceous follicles of skin marked by comedones, papules and pustules. The presence of bacterias Propionibacterium acne, Staphylococcus epidermidis and Malassezia furfur in follicular canal was also one of the reasons for the acne. Propionibacterium acneis obligatory anaerobic organism residing in human skin as cutaneous flora. The oxidative stress within the pilo sebaceous unit changes the environment from aerobic to anaerobic which is the best suited for this gram positive bacterium. Propionibacterium acne bacteria use sebum, cellular debrisand metabolic by products from the surrounding skin tissue as their primary sources of energy and nutrients. Elevated production of sebum by hyperactive sebaceousglands or blockage of the follicle can cause Propionibacterium acne bacteria to grow and multiply.
[0004] Acne may be classified according to predominance of specific skin lesions: Comedonal (non-inflammatory), mild Papular (inflammatory), mild-to-moderate Pustular (inflammatory), moderate nodulocystic and severe acne. This order also follows increasing severity, with cutaneous scarring as the ultimate result. All forms of acne involve one or more of these pathophysiologic factors hyperkeratinization of the follicular epithelium with comedone formation, increased sebum production, bacterial proliferation of Propionibacterium acne and local immune hypersensitivity causing inflammation. Multiple
factors can lead to acne such as sebum, abnormal follicular differentiation, hormones,
Propionibacterium acne, inflammation and nutrition.
[0005] Various products are available in the market for the treatment of acne. However,
due to increased instances of resistance of acne inducing bacteria's towards the antibiotics,
the alternate system of medicine for the treatment of acne have been investigated and
adopted. Among the alternate systems of medicine the topical therapeutic agents are more
convenient for application.
[0006] World Health Organization (WHO) suggests that 4 billion people, who make
nearly 70% of the world's population, are users of herbal medicine for some purpose of
primary health care. Medicinal herbs have always been in usage in some form or the other in
indigenous systems of medicines including ayurveda, sidha and unani in India.
[0007] Many herbal origin components are available in nature with good anti acne
property. These components can be incorporated in formulation and can be used as a good
alternate for allopathic treatment without having side effects on the skin. For the anti-acne
purpose a formulation should contain various components such as antioxidants, exfoliators,
antiseptics.
[0008] There is, therefore, a need to develop a herbal composition comprising of
medicinal herbs which is safe, stable, economical and effective against acne.
OBJECTS OF THE INVENTION
[0009] An object of the present invention is to provide a herbal composition comprising
of medicinal herbs for the treatment of acne.
[0010] Another object of the present invention is to provide a herbal composition which
is stable, safe and economical for acne treatment.
[0011] Another object of the present invention is to provide a herbal composition which
is multifunctional in the acne treatment.
SUMMARY OF THE INVENTION
[0012] The present invention relates to a herbal composition comprising of extracts of apricot, champa flower and rosemary flower. The present invention also relates to a process of preparation of the herbal composition and the method of treating acne using the herbal composition.
[0013] In one aspect, the present invention relates to a herbal composition in the form of topical administration comprising of:
(a) extract of Apricot,
(b) extract of champa flower;
(c) extract of rosemary flower;
(d) aqueous soluble components; and
(e) oil soluble components.
[0014] In another embodiment of the present invention, the aqueous soluble components
of the herbal composition is selected from the group consisting of one or more moisturizing
agents, sodium metabisulphite, EDTA, triethanolamine, methyl paraben, propyl paraben,
water and mixtures thereof.
[0015] In another embodiment of the present invention, the one or more moisturizing
agent is selected from the group consisting of propylene glycol, glycerine, sorbitol and
mixtures thereof.
[0016] In another embodiment of the present invention, the oil soluble components are
selected from stearic acid, cetyl alcohol, mineral oil, almond oil and mixtures thereof.
[0017] In another aspect, the present invention relates to a herbal composition comprising
of:
(a) about 0.5% to about 5% of extract of Apricot by weight of the composition;
(b) about 0.5% to about 6%> of extract of champa flower by weight of the composition;
(c) about 0.5%) to about 6%> of extract of rosemary flower by weight of the composition;
(d) about 50%o to about 80%> of aqueous soluble components by weight of the composition; and
(e) about 15% to about 50% of oil soluble components by weight of the composition.
[0018] In an embodiment of the present invention, the extract of Apricot is present in an amount ranges from about 0.5% to about 5 % by weight of the composition. [0019] In another embodiment of the present invention, the extract of champa flower is present in an amount ranges from about 0.5% to about 6 % by weight of the composition. [0020] In another embodiment of the present invention, the extract of rosemary flower is present in an amount ranges from about 0.5% to about 6 % by weight of the composition.
[0021] In another embodiment of the present invention, the aqueous soluble component
is present in an amount of about 85% by weight of the composition.
[0022] In yet another aspect, the composition of the present invention is a cosmetic herbal
composition or a pharmaceutical herbal composition.
[0023] In an embodiment of the present invention, the composition is in the form of
cream, gel, solution, lotion or foam.
[0024] In another aspect, the present invention relates to a process of preparing a cream
formulation comprising the steps of:
(a) mixing extracts of Apricot, champa flower, rosemary flower and oil soluble components to obtain oil phase;
(b) mixing the aqueous soluble components to obtain aqueous phase;
(c) heating the oil phase and aqueous phase separately in the water bath at a temperature range of 70°C to 80°C to obtain oil phase mixture and aqueous phase mixture separately; and
(d) adding the aqueous phase mixture to the oil phase mixture under uniform stirring until the mixture attains the room temperature to obtain a cream formulation.
[0025] Various objects, features, aspects and advantages of the inventive subject matter will become more apparent from the following detailed description of preferred embodiments.
DETAILED DESCRIPTION OF THE INVENTION
[0026] The following is a detailed description of embodiments of the disclosure. The embodiments are in such detail as to clearly communicate the disclosure. However, the amount of detail offered is not intended to limit the anticipated variations of embodiments; on the contrary, the intention is to cover all modifications, equivalents, and alternatives falling within the spirit and scope of the present disclosure as defined by the appended claims. [0027] Unless the context requires otherwise, throughout the specification which follow, the word "comprise" and variations thereof, such as, "comprises" and "comprising" are to be construed in an open, inclusive sense that is as "including, but not limited to." [0028] Reference throughout this specification to "one embodiment" or "an embodiment" means that a particular feature, structure or characteristic described in connection with the embodiment is included in at least one embodiment. Thus, the appearances of the phrases "in
one embodiment" or "in an embodiment" in various places throughout this specification are not necessarily all referring to the same embodiment. Furthermore, the particular features, structures, or characteristics may be combined in any suitable manner in one or more embodiments.
[0029] As used in this specification and the appended claims, the singular forms "a," "an," and "the" include plural referents unless the content clearly dictates otherwise. It should also be noted that the term "or" is generally employed in its sense including "and/or" unless the content clearly dictates otherwise.
[0030] In some embodiments, the numbers expressing quantities of ingredients, properties such as concentration, reaction conditions, and so forth, used to describe and claim certain embodiments of the invention are to be understood as being modified in some instances by the term "about." Accordingly, in some embodiments, the numerical parameters set forth in the written description are approximations that can vary depending upon the desired properties sought to be obtained by a particular embodiment. In some embodiments, the numerical parameters should be construed in light of the number of reported significant digits and by applying ordinary rounding techniques. Notwithstanding that the numerical ranges and parameters setting forth the broad scope of some embodiments of the invention are approximations, the numerical values set forth in the specific examples are reported as precisely as practicable.
[0031] The recitation of ranges of values herein is merely intended to serve as a shorthand method of referring individually to each separate value falling within the range. Unless otherwise indicated herein, each individual value is incorporated into the specification as if it were individually recited herein.
[0032] All processes described herein can be performed in any suitable order unless otherwise indicated herein or otherwise clearly contradicted by context. The use of any and all examples, or exemplary language (e.g. "such as") provided with respect to certain embodiments herein is intended merely to better illuminate the invention and does not pose a limitation on the scope of the invention otherwise claimed. No language in the specification should be construed as indicating any non-claimed element essential to the practice of the invention.
[0033] The headings and abstract of the invention provided herein are for convenience only and do not interpret the scope or meaning of the embodiments.
[0034] The following discussion provides many example embodiments of the inventive subject matter. Although each embodiment represents a single combination of inventive elements, the inventive subject matter is considered to include all possible combinations of the disclosed elements. Thus if one embodiment comprises elements A, B, and C, and a second embodiment comprises elements B and D, then the inventive subject matter is also considered to include other remaining combinations of A, B, C, or D, even if not explicitly disclosed.
[0035] All publications herein are incorporated by reference to the same extent as if each individual publication or patent application were specifically and individually indicated to be incorporated by reference. Where a definition or use of a term in an incorporated reference is inconsistent or contrary to the definition of that term provided herein, the definition of that term provided herein applies and the definition of that term in the reference does not apply. [0036] Groupings of alternative elements or embodiments of the invention disclosed herein are not to be construed as limitations. Each group member can be referred to and claimed individually or in any combination with other members of the group or other elements found herein. One or more members of a group can be included in, or deleted from, a group for reasons of convenience and/or patentability. When any such inclusion or deletion occurs, the specification is herein deemed to contain the group as modified thus fulfilling the written description that follows, and the embodiments described herein, is provided by way of illustration of an example, or examples, of particular embodiments of the principles and aspects of the present disclosure. These examples are provided for the purposes of explanation, and not of limitation, of those principles and of the disclosure. [0037] It should also be appreciated that the present invention can be implementedin numerous ways, including as a system, a method or a device. In this specification, these implementations, or any other form that the invention may take, may be referred to as processes. In general, the order of the steps of the disclosed processes may be altered within the scope of the invention.
[0038] Various terms as used herein are shown below. To the extent a term used in a claim is not defined below, it should be given the broadest definition persons in the pertinent art have given that term as reflected in printed publications and issued patents at the time of filing.
[0039] The term "about" as used herein refers to a defined range of the value by plus or
minus 10 %.For example, about 2 % means 1.8 % to 2.2 %, about 5 % means 4.5 % to 5.5 %,
about 10 % means 9 % to 11 % and about 40 % means 36 % to 44 %.
[0040] In a general embodiment, the present invention generally relates to a herbal
composition. Specifically, the present invention relates to a herbal composition comprising of
extracts of apricot, champa flower and rosemary flower. The present invention also relates to
a process of preparing a cream formulation comprising the herbal composition and use of the
composition in the treatment of acne.
[0041] In an embodiment, the present invention relates to herbal composition herbal
composition comprising of:
(a) extract of Apricot,
(b) extract of champa flower;
(c) extract of rosemary flower;
(d) aqueous soluble components; and
(e) oil soluble components.
[0042] In another embodiment of the present invention, the aqueous soluble components
of the herbal composition is selected from the group consisting of one or more moisturizing
agents, sodium metabisulphite, EDTA, triethanolamine, methyl paraben, propyl paraben,
water and mixtures thereof.
[0043] In another embodiment of the present invention, the one or more moisturizing
agent is selected from the group consisting of propylene glycol, glycerine, sorbitol and
mixtures thereof.
[0044] In another embodiment of the present invention, the oil soluble components
selected from stearic acid, cetyl alcohol, mineral oil, almond oil and mixtures thereof.
[0045] In another aspect, the present invention relates to a herbal composition comprising
of:
(a) about 0.5% to about 5% of extract of Apricot by weight of the composition;
(b) about 0.5% to about 6%> of extract of champa flower by weight of the composition;
(c) about 0.5%) to about 6%> of extract of rosemary flower by weight of the composition;
(d) about 50%o to about 80%> of aqueous soluble components by weight of the composition; and
(e) about 15% to about 50% of oil soluble components by weight of the
composition. [0046] In another embodiment, the extract of apricot is present in an amount of 0.2%, 0.5%, 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5% and 5% by weight of the composition. Preferably, in an amount of 0.2%, 0.5%, 1%, 1.5%, 2%, 2.5%, 3% and 3.5% by weight of the composition. Most preferably, in an amount of 0.2%, 0.5%, 1%, 1.5%, 2% and 2.5% by weight of the composition.
[0047] In another embodiment, the extract of champa flower is present in an amount of 0.5%, 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, 5%, 5.5% and 6% by weight of the composition. Preferably, in an amount of 0.5%, 1%, 1.5%, 2%, 2.5%, 3%, 3.5% and 4% by weight of the composition. Most preferably, in an amount of 0.5%, 1%, 1.5%, 2%, 2.5% and 3%> by weight of the composition.
[0048] In another embodiment, the extract of rosemary flower is present in an amount of 0.5%, 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, 5%, 5.5% and 6% by weight of the composition. Preferably, in an amount of 0.5%, 1%, 1.5%, 2%, 2.5%, 3%, 3.5% and 4% by weight of the composition. Most preferably, in an amount of 0.5%, 1%, 1.5%, 2%, 2.5% and 3%> by weight of the composition.
[0049] In another embodiment, the aqueous soluble components is present in an amount of 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80% and 85% by weight of the composition. Preferably, in an amount of 50%, 55%, 60%, 65%, 70% and 75% by weight of the composition. Most preferably, in an amount of 55%, 60%, 65% and 70% by weight of the composition.
[0050] In another embodiment, the oil soluble components is present in an amount of 15%, 20%, 25%, 30%, 35%, 40%, 45% and 50% by weight of the composition. Preferably, in an amount of 20%, 25%, 30%, 35%, 40%, 45% and 50% by weight of the composition. Most preferably, in an amount of 25%, 30%, 35%, 40%, and 45% by weight of the composition. [0051] In yet another aspect, the present invention relates to a herbal composition in the form of topical administration. Accordingly, the herbal composition can be prepared in the form of cream, gel, solution and foam. Preferably, in the form of cream. The person having ordinary skill in the art would easily prepare the various forms of the composition using the common general knowledge and routine experimentation based on the composition of the present invention.
[0052] In yet another aspect, the present invention relates to a process of preparing a cream formulation comprising the steps of:
(a) mixing extracts of Apricot, champa flower, rosemary flower and oil soluble
components to obtain oil phase;
(b) mixing the aqueous soluble components to obtain aqueous phase;
(c) heating the oil phase and aqueous phase separately in the water bath at a temperature range of 70°C to 80°C to obtain oil phase mixture and aqueous phase mixture separately;
(d) adding the aqueous phase mixture to the oil phase mixture under uniform stirring until the mixture attains the room temperature to obtain a cream formulation.
[0053] In an embodiment of the present invention, the oil soluble components used in the
process of preparing a cream formulation are selected from stearic acid, cetyl alcohol,
mineral oil, almond oil and mixture thereof.
[0054] In another embodiment of the present invention, the aqueous soluble components
used in the process of preparing a cream formulation are selected from sodium
metabisulphite, EDTA, moisturizing agents, triethanolamine, methyl paraben, propyl
paraben, water and mixtures thereof.
[0055] In another embodiment of the present invention, the moisturizing agents are
propylene glycol, glycerine, sorbitol and mixture thereof. The ratio of mixture of
moisturizing agents, propylene glycol: glycerine: sorbitol is 2:1:1.
[0056] The herbal composition of the present invention possesses multifunctional activity
for example, antimicrobial activity, antioxidant activity and anti- acne effect on skin.
According to the present invention, the herbal composition has demonstrated improved and
synergistic cosmetic properties due to the combination of the extract of Apricot, champa
flower and rosemary flower.
[0057] The present invention provides a cream formulation comprising of extract of
Apricot, champa flower and rosemary flower. The formulation is ideal oil in water cream
with good consistency, smooth and shining texture, and good stability. The present invention
provides an anti-acne cream formulation that can be used for retarding the symptoms of acne
and showing skin-renewal activity. The pH and spreadability parameters of the formulations
of present invention were found in the limit for use in the cosmetic applications.
[0058] While the foregoing describes various embodiments of the disclosure, other and
further embodiments of the disclosure may be devised without departing from the basic scope
thereof. The scope of the invention is determined by the claims that follow. The invention is
not limited to the described embodiments, versions or examples, which are included to enable a person having ordinary skill in the art to make and use the invention when combined with information and knowledge available to the person having ordinary skill in the art. [0059] The present invention is further explained in the form of following examples. However, it is to be understood that the following examples are merely illustrative and are not to be taken as limitations upon the scope of the invention. Example 1: Preparation ofCream formulation Essential Ingredients:
Sr. No. Name of Ingredients Weight in %
1. Extract of Apricot 1.5
2. Extract of champa flower 2
3. Extract of rosemary flower 2
4. Mineral oil 3
5. Moisturizer 12
6. Sodium Metabisulphide 0.1
7. EDTA 0.1
8. Methylparaben 0.25
9. Propyl paraben 0.02
10. Triethanolamine 1.50
11. Stearic Acid 8
12. Cetyl Alcohol 1
13. Water QS
[0060] The formulation components listed in the table 1 were used in the preparation of cream formulation. Moisturizing agent was a mixture of propylene glycol: glycerine: sorbitol (2:1:1). All the aqueous soluble components, sodium metabisulphite, EDTA, moisturizer, triethanolamine, methyl paraben, propyl paraben and water were mixed in a beaker. On the other hand the oil soluble components that were stearic acid, cetyl alcohol, mineral oil, almond oil and active ingredients were mixed in another beaker. Both beakers were kept on water bath for maintaining the temperature 75±5°C and when the temperature was maintained then aqueous phase was added to oil phase with continuous stirring until the mixture cools to obtain a cream formulation.
[0061] Examples 2-9: The following examples were prepared by following the experimental procedure of example 1 with minor changes in non-critical steps.
Ingredients Ex-2 Ex-3 Ex-4 Ex-5 Ex-6 Ex-7 Ex-8 Ex-9
Apricot oil 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5
Champa Flower Extract 0.5 1 2 2 2 2 1 1
Rosemerry Extract 0.5 1 2 1 1 2 1 2
Mineral oil 3 3 3 3 3 3 3 3
Moisturizer 12 12 12 12 12 12 12 12
Sodium Metabisulphide 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1
EDTA 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1
Methylparaben 0.25 0.25 0.25 0.25 0.25 0.25 0.25 0.25
Propyl paraben 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02
Triethanolamine 1.35 1.35 1.35 1.50 1.50 1.50 1.50 1.50
Stearic Acid 10 9 9 9 8 9 8 8
Cetyl Alcohol 0.5 1 1.5 1 1 1 1 1
Water, QS=100gm QS QS QS QS QS QS QS QS
Results:
[0062] Ordinary one way ANOVA was applied and all the results were significant of
each other with p value =<0.0001. It was found in the results that total antioxidant capacity of
the example 1 was maximum because of synergistic effect of these three herbal extracts and
oil.
[0063] The example 1 of the present invention results in uniform distribution of extracts
in cream. This was confirmed by visual appearance and by touch. Emolliency, slipperiness
and amount of residue left after the application of fixed amount of cream was found good.
The % drug release was also studied for 1440 min which show good results.
[0064] The two way ANOVA with Dunnett multiple comparisons test showed that the
formulation of example 1 gave significant release (p<0.0001) profile.
[0065] There was no microbial growth observed and no skin irritation was observed when
the cream of the present invention was applied to the goat skin and no signs of irritation,
inflammation, redness were noticed during the whole period of study that was for 24 hrs. It
was observed during stability studies that the formulation do not showed perceptible signs of
phase separation after centrifugation. Thus, the developed formulation is stable. From the studies discussed, we can conclude that on combining the extracts of Apricot oil, Champa Flower and Rose merry extracts in different ratios give acne effect on skin. The combined extracts of Apricot, champa flower and rosemary flower showed improved and synergistic cosmetic properties when compared to individual extracts. Example 10: Antimicrobial Activity
[0066] Antibiotics are often prescribed in acne treatment; however, Propionibacterium acnes and Staphylococcus epidermidis, the two of the major acne-associated bacteria, developed antibiotic resistance. The potential anti-acne activity of herbal extract of Apricot, Champa Flower and Rose merry flower has been evaluated.
S.No Activity Extracts Minimum inhibitory concentration (MIC) Minimum bactericidal concentration (MBC)
P. acnes S. epidermidis P. acnes S. epidermidis
1 Apricot 0.437 mg/mL 0.722 mg/mL 0.896 mg/mL 1.5 3 mg/mL
2 Champa Flower 0.419 mg/mL 0.782 mg/mL 0.833 mg/mL 1.68mg/mL
3 Rose merry flower 0.401 mg/mL 0.691 mg/mL 0.752 mg/mL 1.47 mg/mL
4 Cream (Example 1) 0.380 mg/mL 0.670 mg/mL 0.710 mg/mL 1.44 mg/mL
Results:
[0067] Antimicrobial activity screening of these extracts in cream exhibit the strongest antimicrobial activity with minimum inhibitory concentration (MIC) of 0.38 mg/mL and minimum bactericidal concentration (MBC) of 0.71 mg/mL against P. acnes; and MIC of 0.67 mg/mL and MBC of 1.44 mg/mL against S. epidermidis. The cream also exhibited the strongest anti-biofilm effect against S. epidermidis with MBC 1.44 mg/mL and killing dynamic time of 11 and 7 h against P. acnes and S. epidermidis, respectively. The formulation of the present invention showed superior healing and antimicrobial effects compared to the available marketed formulation. Collectively, our data suggested that cream with the composition of the present invention is a potential natural and effective alternative for treating acne and overcoming the emerging antibiotic resistance.
[0068] A skilled artisan will appreciate that the quantity and type of each ingredient including the medicinal plant can be used in different combinations or singly. All such variations and combinations would be falling within the scope of present disclosure
[0069] The foregoing examples are merely illustrative and are not to be taken as limitations upon the scope of the invention. Various changes and modifications to the disclosed embodiments will be apparent to those skilled in the art. Such changes and modifications may be made without departing from the scope of the invention.
We Claim:
1. A herbal composition in the form of topical administration comprising of:
(a) extract of Apricot,
(b) extract of champa flower;
(c) extract of rosemary flower;
(d) aqueous soluble components; and
(e) oil soluble components.
2. The herbal composition as claimed in claim 1, wherein the aqueous soluble components is selected from the group consisting of one or more moisturizing agents, sodium metabisulphite, EDTA, triethanolamine, methyl paraben, propyl paraben, water and mixtures thereof.
3. The herbal composition as claimed in claim 2, wherein the one or more moisturizing agent is selected from the group consisting of propylene glycol, glycerine, sorbitol and mixtures thereof.
4. The herbal composition as claimed in claim 1, wherein the oil soluble component is selected from stearic acid, cetyl alcohol, mineral oil, almond oil and mixtures thereof.
5. The herbal composition as claimed in claim 1, wherein the extract of Apricot is present in an amount ranges from about 0.5% to about 5 % by weight of the composition.
6. The herbal composition as claimed in claim 1, wherein the extract of champa flower is present in an amount ranges from about 0.5% to about 6 %> by weight of the composition.
7. The herbal composition as claimed in claim 1, wherein the extract of rosemary flower is present in an amount ranges from about 0.5% to about 6 %> by weight of the composition.
8. The herbal composition as claimed in claim 1, wherein the aqueous soluble components is present in an amount of about 85% by weight of the composition.
9. The herbal composition as claimed in claim 1, wherein the composition comprises
(a) about 0.5% to about 5% of extract of Apricot by weight of the composition;
(b) about 0.5%) to about 6%> of extract of champa flower by weight of the composition;
(c) about 0.5%) to about 6%> of extract of rosemary flower by weight of the composition;
(d) about 50%o to about 80%> of aqueous soluble components by weight of the composition; and
(e) about 15% to about 50% of oil soluble components by weight of the composition.
10. The herbal composition as claimed in claim 1, wherein the composition is a cosmetic composition or a pharmaceutical composition and is in the form of cream, gel, solution, lotion or foam.
11. A process for preparation of a cream formulation comprising the herbal composition as claimed in claim 1, comprising the steps of:
(a) mixing extracts of Apricot, champa flower, rosemary flower and oil soluble components to obtain oil phase;
(b) mixing the aqueous soluble components to obtain aqueous phase;
(c) heating the oil phase and aqueous phase separately in the water bath at a temperature range of 70°C to 80°C to obtain oil phase mixture and aqueous phase mixture separately;
(d) adding the aqueous phase mixture to the oil phase mixture under uniform stirring until the mixture attains the room temperature to obtain a cream formulation.
| # | Name | Date |
|---|---|---|
| 1 | 202011015296-FORM 18 [11-05-2021(online)].pdf | 2021-05-11 |
| 1 | 202011015296-STATEMENT OF UNDERTAKING (FORM 3) [07-04-2020(online)].pdf | 2020-04-07 |
| 2 | 202011015296-FORM-9 [10-05-2021(online)].pdf | 2021-05-10 |
| 2 | 202011015296-FORM FOR STARTUP [07-04-2020(online)].pdf | 2020-04-07 |
| 3 | 202011015296-Proof of Right [04-08-2020(online)].pdf | 2020-08-04 |
| 3 | 202011015296-FORM FOR SMALL ENTITY(FORM-28) [07-04-2020(online)].pdf | 2020-04-07 |
| 4 | 202011015296-FORM 1 [07-04-2020(online)].pdf | 2020-04-07 |
| 4 | 202011015296-FORM-26 [22-06-2020(online)].pdf | 2020-06-22 |
| 5 | 202011015296-COMPLETE SPECIFICATION [07-04-2020(online)].pdf | 2020-04-07 |
| 5 | 202011015296-EVIDENCE FOR REGISTRATION UNDER SSI(FORM-28) [07-04-2020(online)].pdf | 2020-04-07 |
| 6 | 202011015296-EVIDENCE FOR REGISTRATION UNDER SSI [07-04-2020(online)].pdf | 2020-04-07 |
| 6 | 202011015296-DECLARATION OF INVENTORSHIP (FORM 5) [07-04-2020(online)].pdf | 2020-04-07 |
| 7 | 202011015296-EVIDENCE FOR REGISTRATION UNDER SSI [07-04-2020(online)].pdf | 2020-04-07 |
| 7 | 202011015296-DECLARATION OF INVENTORSHIP (FORM 5) [07-04-2020(online)].pdf | 2020-04-07 |
| 8 | 202011015296-EVIDENCE FOR REGISTRATION UNDER SSI(FORM-28) [07-04-2020(online)].pdf | 2020-04-07 |
| 8 | 202011015296-COMPLETE SPECIFICATION [07-04-2020(online)].pdf | 2020-04-07 |
| 9 | 202011015296-FORM-26 [22-06-2020(online)].pdf | 2020-06-22 |
| 9 | 202011015296-FORM 1 [07-04-2020(online)].pdf | 2020-04-07 |
| 10 | 202011015296-FORM FOR SMALL ENTITY(FORM-28) [07-04-2020(online)].pdf | 2020-04-07 |
| 10 | 202011015296-Proof of Right [04-08-2020(online)].pdf | 2020-08-04 |
| 11 | 202011015296-FORM FOR STARTUP [07-04-2020(online)].pdf | 2020-04-07 |
| 11 | 202011015296-FORM-9 [10-05-2021(online)].pdf | 2021-05-10 |
| 12 | 202011015296-STATEMENT OF UNDERTAKING (FORM 3) [07-04-2020(online)].pdf | 2020-04-07 |
| 12 | 202011015296-FORM 18 [11-05-2021(online)].pdf | 2021-05-11 |
| 13 | 202011015296-FER.pdf | 2025-07-31 |
| 1 | 202011015296_SearchStrategyNew_E_Copyofsearchstrategy_acneE_25-07-2025.pdf |