FIELD OF THE INVENTION
The invention relates to insecticidal compositions. More particularly, the present
invention relates to a synergistic insecticidal composition comprising Fipronil and
Propargite.
BACKGROUND OF THE INVENTION
Crop protection technology which includes all pesticides, herbicides, insecticides,
fungicides, as well as biotechnological products helps control the thousands of
weed species, harmful insects and numerous plant diseases that afflict crops. In
the absence of these important crop protection and pest control technologies, food
production would decline, many fruits and vegetables would be in short supply
and the price of food would rise. Additionally, the production of important fibers
for clothing such as cotton would decrease as farmers would lose their harvest and
livelihoods to crop pests and diseases. Thus, crop protection is very important to
increase the production of agricultural products and at the same time reduce their
cost.
Several insecticidal agents and compositions have been developed to control
insect pests; however, economically efficient and ecologically safe insect control
compositions are still being sought. Insecticidal compositions which allow for
reduced effective dosage rates, increased environmental safety and lower the
incidence of insect resistance are highly desirable. The rotational application of
insect control agents may be adopted as good pest management practice.
However, this does not necessarily provide satisfactory insect control.
The use of insecticidal combinations is a widespread and documented practice in
the agricultural community. Insecticidal combinations offer significant advantages
over individual applications including improved and extended insect control,
reduced insecticide rates and application costs, shorter contact times for improved
results, less stringent use restrictions, improved selectivity, improved spectrum of
weeds controlled, reduced cost and reduced residue problems. However,
1011/PAT APPLN/12
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identifying appropriate insecticidal application rates and combinations is essential
to achieve synergistic insect control.
Numerous insecticide combinations are commercially available for pest control in
different crops. Most of these products target one or at the most two specific
insects. In tea gardens, the pests most likely to cause damage include red spider
mite, Helopeltis, green fly, thrips, looper caterpillar etc. In recent years, looper
caterpillar complex has emerged as the primary cause of crop damage in tea
plantations. Commercially available insecticidal compositions mainly control
either mites, sucking pests or lepidopteran pests, thereby necessitating the use of
more than one insecticidal sprays for effective pest control. Even molecules or
combinations reported in scientific literature only target or control specific pests.
The study by Regev and Cone, entitled "Evidence of Farnesol As a Male Sex
Attractant of the Two-Spotted Spider Mite, Tetranychus urticae Koch (Acarina:
Tetranychidae)", Environmental Entomology, April 1985, Vol. 4, No. 2, pp. 307-
311, indicated that certain isomers of synthetically produced farnesol, at particular
concentrations, were effective in attracting male spider mites.
A further study by Regev and Cone, "Analysis of Pharate Female Two- spotted
Spider Mites for Nerolidol and Geraniol: Evaluation for Sex Attraction of Males",
Environmental Entomology, February 1976, Vol. 5, No. 1, pp. 133-138, also
revealed that the two-spotted spider mite female deutonymph also contains the
sesquiterpene alcohol nerolidol; their study indicated that synthetic nerolidol, at
particular concentrations, served to attract male two-spotted spider mites.
U.S. Patent No. 4,775,534 discloses a miticidal composition adapted to be sprayed
onto foliage to control spider mite populations. U.S. patent no. US 8486995 B2
also discloses an Acaricidal active substance combination to control different
mites.
In view of the above, obtaining an insecticidal combination which demonstrates
broad-spectrum control of insects, no cross-resistance to the existing insecticidal
agents, no toxicity problems and little negative impact on the environment is
1011/PAT APPLN/12
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extremely important. Thus, it is an objective of this invention to provide a
synergistic insecticidal combination which demonstrate a high controlling effect
along with reduced crop protection cost and reduced environmental load.
Fipronil ((±)-5-amino-1-(2,6-dichloro-α,α,α-trifluoro-p-tolyl)-4-
trifluoromethylsulfinylpyrazole-3-carbonitrile, CAS-Number: 120068-37-3) is a
broad-use insecticide that belongs to the phenylpyrazole chemical family. Apart
from its disclosure in the application EP 0295117, the properties of Fipronil have
been published in the report of the 1992 Brighton Crop Protection Conference
(Pests and Diseases, pages 29-34).
Fipronil acts as a blocker of the GABA-Regulated chloride channel. Insects
resistant to pyrethroid, cyclodiene, organophosphorous and/or carbamate
insecticides are susceptible to Fipronil. It is also a broad spectrum insecticide, and
exhibits toxicity by contact and ingestion.
Propargite, 2-(4-tert-butylphenoxy) cyclohexyl prop-2-ynyl sulfite, CAS-Number:
2312-35-8, disclosed in U.S. Pat. No. 3,272,854, a well-known insecticide sold
under the trademark OMITE (Uniroyal Chemical Company), is a pesticide used to
kill mites (an acaricide).
The standard composition of Propargite available in the art is 57 percent
emulsifiable concentrate (EC).
Hitherto, there have been no studies to determine the most-efficacious and
synergistic ratios of the combination of Fipronil and Propargite that are effective
at lower concentrations compared to that observed with individual components.
Consequently, there is a need for preparing a synergistic insecticidal composition
1011/PAT APPLN/12
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comprising Fipronil and Propargite that is not only storage stable but also non
phyto-toxic to crops.
SUMMARY OF THE INVENTION
The present invention relates to synergistic insecticidal composition for wide
spectrum control of insect pests, delaying the appearance of the resistant strains of
the insect-pests, minimizing the risk of development of resistance, and achieving
effective and economical control of undesired insect-pests.
In accordance with an embodiment of the invention, there is provided a
synergistic insecticidal composition, comprising Fipronil and Propargite.
In accordance with another embodiment of the invention, the mass ratio of
Fipronil to Propargite is in the range from 1:7 to 1:13.
In accordance with still another embodiment of the invention, the composition
comprises Fipronil and Propargite in amounts ranging from 4 to 6% and 40 to
50% respectively.
In accordance with yet another embodiment of the invention, the composition
further comprises excipients, wherein the excipients are selected from the group
consisting of a solvent, an emulsifier, an anti-oxidant, an anti-freezing agent, a
dispersing cum wetting agent, a defoamer, a biocide, a thickener and water, and
wherein the composition is in the form of a suspo-emulsion.
In accordance with a further embodiment of the invention, the solvent is present in
an amount of 0 to 10%, the emulsifier is present in an amount of 0 to 5%, the antioxidant
is present in an amount of 0 to 5%, the anti-freezing agent is present in an
amount of 0 to 8%, the dispersing cum wetting agent is present in an amount of 2
to 10%, the defoamer is present in an amount of 0.01 to 0.50%, the biocide is
present in an amount of 0.01 to 0.50%, and the thickener is present in an amount
of 0.10 to 0.50%.
In accordance with still another embodiment of the invention, there is provided a
method for controlling insects and acarids, comprising contacting crops or their
1011/PAT APPLN/12
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environment with an agrochemically effective amount of the synergistic
insecticidal composition.
The synergistic insecticidal combination of the present invention is found to be
useful in protecting a wide range of crops like tea, fruit and vegetables etc. against
mites, major tissue-chewing, cutting, and boring insects of plants. The
composition achieves improved biological activity by enhancing overall control of
insects over a shorter period of time. Additional benefits of using the insecticidal
combination of the present invention includes reduced risk of occupational hazard,
lower cost of application, better cost:benefit ratio to the end user, reduced fuel and
labour cost, saving in applicator’s time and loss caused by mechanical damage to
the crop and soil.
BRIEF DESCRIPTION OF DRAWINGS
Figure 1. is a flowchart for preparing a synergistic insecticidal composition in the
form of a suspo-emulsion (SE).
DETAILED DESCRIPTION OF INVENTION
Discussed below are some representative embodiments of the present invention.
The invention in its broader aspects is not limited to the specific details and
representative methods. The illustrative examples are described in this section in
connection with the embodiments and methods provided. The invention according
to its various aspects is particularly pointed out and distinctly claimed in the
appended claims read in view of this specification and appropriate equivalents.
It is to be noted that, as used in the specification and the appended claims, the
singular forms "a", "an" and "the" include plural referents unless the context
clearly dictates otherwise. Thus, for example, reference to a composition
containing “a compound” includes a mixture of two or more compounds. It should
also be noted that the term “or” is generally employed in its sense including
“and/or” unless the content clearly dictates otherwise.
1011/PAT APPLN/12
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The expression of various quantities in terms of “% w/w” or “%” means the
percentage by weight, relative to the weight of the total solution or composition
unless otherwise specified.
The term "agrochemically effective amount" is that quantity of active agent,
applied in any amount which will provide the required control of pest and
diseases. The particular amount is dependent upon many factors including, for
example, the crop, pest and disease sought to be controlled and environmental
conditions. The selection of the proper quantity of active agent to be applied,
however, is within the expertise of one skilled in the art. Further, the term “active
ingredient” (A.I.) or “active agent” used herein refers to that component of the
composition responsible for control of insect pests.
Compositions comprising a single insecticidally active component suffer from
numerous drawbacks such as development of resistant insect species, requirement
of high amount and concentration of the active ingredient, environmental damage,
seepage of the active component into ground water, phyto-toxicity and harmful
effects on the health of animals and humans.
Accordingly, the inventors of the present invention have formulated a synergistic
insecticidal composition, comprising Fipronil and Propargite, wherein the mass
ratio of Fipronil to Propargite is in the range from 1:7 to 1:13 and wherein the
composition comprises Fipronil and Propargite in amounts ranging from 4 to 6%
and 40 to 50% respectively.
The synergistic insecticidal composition may be in the form of a suspo-emulsion,
and comprises excipients such as a solvent, an emulsifier, an anti-oxidant, an antifreezing
agent, a dispersing cum wetting agent, a defoamer, a biocide, a thickener
and water. The term “suspo-emulsion” used herein refers to a mixture of waterinsoluble
active ingredients dispersed in an aqueous solution, where one (or more)
of the active ingredients is in suspension form and one (or more) of the active
ingredients is in emulsion form. The formulation is intended for dilution into
water prior to spray application. Mixtures of active ingredients are often used to
provide a broader spectrum of pest control. Formulating the active ingredients
1011/PAT APPLN/12
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together eliminates the need for tank mixing (which can lead to incompatibilities).
Like other aqueous liquid formulations, suspo-emulsions are easy to handle and
measure, dust free, non-flammable and offer good miscibility with water.
Suitable solvents useful in accordance with the invention are C IX,
cyclohexanone, N-methyl pyrollidone, butanol and combinations thereof, and
present in an amount in the range from 0 to 10%. The term “C IX” refers to a
solvent which mainly comprises of hydrocarbons with nine carbon atoms.
It is desirable to have an emulsifier in the synergistic insecticidal composition. An
emulsifier is a substance that stabilizes an emulsion by increasing its kinetic
stability. One class of emulsifiers are known as "surface active agents",
or surfactants. Non-limiting examples of emulsifiers that can be used in the
present invention include nonionic and anionic surfactants. Each of these
surfactants can be used either singly or in combination and present in an amount
in the range from 0 to 5%.
It is also recommended to add an anti-oxidant to the insecticidal composition. An
anti-oxidant prevents the oxidation of the active ingredients present in said
composition due to exposure to atmospheric oxygen and other oxidizing agents,
thereby increasing the storage stability of the components. Accordingly, the
synergistic insecticidal composition of the present invention contains sunflower
oil as the anti-oxidant in an amount in the range from 0 to 5%.
An anti-freezing agent is generally added to insecticidal compositions, to prevent
the aqueous compositions from freezing. Suitable anti-freezing agents useful
herein, but not limited to, include propylene glycol, di-ethylene glycol (DEG),
mono ethylene glycol (MEG) and combinations thereof. Preferably, the antifreezing
agent is present in an amount in the range from 0 to 8%.
A dispersing cum wetting agent is another important component of a suspoemulsion
as it facilitates the suspension of a water insoluble substrate in an
aqueous suspension. Non-limiting examples of dispersing cum wetting agent that
can be used in the present invention include non-ionic surfactants and amine salt
1011/PAT APPLN/12
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of phosphate tristyryl phenol ethylated, acrylic copolymer, ethoxylated
polyarylphenol phosphate ester, each of which can be used individually or in
combination, in an amount in the range from 2 to 10%.
A defoamer, also called as anti-foam, is generally added to an insecticidal
composition as foam formation prevents the efficient filling of a container.
Preferably, the defoamer is dimethyl polysiloxane emulsion and present in an
amount in the range from 0.01 to 0.50%.
The synergistic insecticidal composition comprises a biocide selected from the
group consisting of Proxel GXL, formaldehyde and combinations thereof, and
preferably present in an amount in the range from 0.01-0.50%. Proxel GXL is a
broad spectrum biocide for the preservation of industrial water-based products,
such as the composition of the present invention, against spoilage from bacteria,
yeasts and fungi.
It is necessary to add a thickener to a insecticidal composition to reduce the
tendency of the insecticide composition to disperse when sprayed, and decrease
the likelihood of it being rinsed off of the crops. Preferably, the synergistic
insecticidal composition comprises xanthan gum as thickener in an amount in the
range from 0.10-0.50%.
It has been surprisingly found that the synergistic insecticidal composition of
present invention provides a wide spectrum control of insect pests, delaying the
appearance of the resistant strains of the insect-pests, and achieving effective and
economical control of undesired insect-pests. Accordingly, there is provided a
method for controlling insects and acarids, comprising contacting crops or their
environment with an agrochemically effective amount of the synergistic
insecticidal composition, wherein the crops are tea, fruit and vegetables and the
insects and acarids, are from the family of hemiptera, lepidoptera, and arachnida.
Preferably, the insects and acarids controlled using the above method may
comprise aphid, jassid, thrips, white fly, mosquito bug, leaf minor, caterpillar
complex, borers, polyphagous or phytophagous mites.
1011/PAT APPLN/12
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The present invention is more particularly described in the following examples
that are intended as illustrations only, since numerous modifications and
variations within the scope of the present invention will be apparent to those of
skilled in the art. The following examples illustrate the basic methodology and
versatility of the present invention.
Examples 1-4
The unit of each value below is “% w/w” i. e. the percentage by weight, relative to
the weight of the total solution or composition unless otherwise specified. The
compositions contemplated by each of the Examples 1-4 that are tabulated in
Table 1 are formulated as a Suspo-emulsion (SE) formulation.
Table 1: Synergistic insecticidal compositions
Component Function Examples
1 2 3 4
Fipronil **A.I 4.00 4.00 5.00 5.00
Propargite **A.I 40.00 50.00 40.00 50.00
C-IX Solvent 0.0-10.0 0.0-
10.0
0.0-
10.0
0.0-
10.0
Blend of Anionic &
Nonionic
Emulsifier 0.0-5.0 0.0-5.0 0.0-5.0 0.0-
5.0
Sunflower Oil Anti-oxidant 0.0-5.0 0.0-5.0 0.0-5.0 0.0-
5.0
Diethylene glycol Antifreeze
agent
0.0-8.0 0.0-8.0 0.0-8.0 0.0-
8.0
Mixture of nonionic Dispersing 2.0-10.0 2.0- 2.0- 2.0-
1011/PAT APPLN/12
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surfactants &
Amine salt of phosphate
tristyryl phenol ethylated
cum
Wetting Agent
10.0 10.0 10.0
Dimethyl Polysiloxane
emulsion
Deformer 0.01-
0.50
0.01-
0.50
0.01-
0.50
0.01-
0.50
Formaldehyde Biocide 0.01-
0.50
0.01-
0.50
0.01-
0.50
0.01-
0.50
Xanthan Gum Thickner 0.10-
0.50
0.10-
0.50
0.10-
0.50
0.10-
0.50
Demineralized Water Solvent *q.s. *q.s. *q.s. *q.s.
*q.s. = quantity sufficient
**A.I = Active ingredient
The aforementioned synergistic insecticidal composition can be formulated as
Suspo-emulsion (SE) by the process described below.
Process of preparation of synergistic insecticide composition in the form of a
Suspo-emulsion (SE).
The synergistic insecticidal compositions of Examples 1-4 are prepared by the
process depicted in Figure 1. All the raw materials were verified for conformance
to the laid down individual specifications. The raw materials required for
Examples 1, 2, 3 and 4 are illustrated in table 2 under the column headings 1, 2, 3
and 4 respectively. Entries for Fipronil and Propargite in table 2 differ from those
in table 1 as entries in table 1 are for 100% pure compounds, whereas those in
table 2 are for technical ones, i.e. the ones containing a certain percentage of
impurities.
The amounts of active ingredients presented in table 2 may be greater than the
values calculated taking into account the percentage purity of the active
1011/PAT APPLN/12
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ingredients, to compensate for losses of said ingredients during the manufacturing
process. It was observed that following said procedure on industrial scale the final
yield of A.I. will be similar or same as to standardized values. The required
quantities of raw materials as illustrated in Table 2 below, were weighed, and
transferred through the auto-batching system. Propargite Technical is dissolved in
a solvent, emulsifier and water are added, and mixed by high shear mixer to form
a homogeneous emulsion.
The dispersing cum wetting agent is diluted in demineralized (D.M.) water
separately, and solubilized by high shear mixing and then anti freezing
agent, Fipronil technical, deformer, Sunflower oil are added and mixed to make
homogeneous mass. The homogenous mass is ground in a Bead Mill until a mean
particle size of 3-5 (D-90) μ is obtained.
After grinding, the mass is mixed with Propargite homogeneous emulsion and an
aqueous solution of xanthan gum under stirring. After mixing, the quality of inprocess
sample was checked for conformance to the laid out specifications. The
quality approved in-process sample was transferred to the holding tank after
passing through sparkler filter pump for packing as per the requirements.
Table 2: Quantities of the TGAI* and raw materials charged
Component Function Quantities of materials
charged (kg)
1 2 3 4
Fipronil (based on 95% w/w
minimum purity)
TGAI* 4.25 4.25 5.30 5.30
Propargite (based on 90.80% w/w
minimum purity)
TGAI* 44.1
0
55.1
5
44.2
0
55.1
5
C-IX Solvent 5.00 5.00 5.00 5.00
1011/PAT APPLN/12
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Blend of Anionic & Nonionic Emulsifier 3.00 3.00 3.00 3.00
Sunflower Oil Anti-oxidant 3.00 3.00 3.00 3.00
Diethylene glycol Antifreeze
agent
5.00 5.00 5.00 5.00
Mixture of nonionic surfactants
& Amine salt of phosphate tristyryl
phenol ethylated
Dispersing
cum
Wetting Agent
4.00 4.00 4.00 4.00
Dimethyl Polysiloxane emulsion Deformer 0.20 0.20 0.20 0.20
Formaldehyde Biocide 0.20 0.20 0.20 0.20
Xanthan Gum Thickner 0.20 0.20 0.20 0.20
Demineralized Water Solvent *q.s. *q.s
.
*q.s
.
*q.s.
*q.s. = quantity sufficient
* TGAI: Technical Grade Active Ingredient
Evaluation of bio-efficacy of the synergistic insecticidal composition against
insect pests in tea
Field trials were performed to evaluate the biological efficacy of the synergistic
insecticidal composition of present invention against the common and hazardous
sucking pests. This evaluation was performed by comparing the claimed
synergistic insecticidal composition in the present invention against the marketed
reference products, i.e., Fipronil (WILRISE 5% SC) and Propargite (Omite 57%
EC).
15 plants in each treatment were randomly tagged per plot and pre & post
treatment observations were recorded before the spray and 1 DAT (days after
treatment), 3 DAT, 7 DAT and 10 DAT of the spray for different insects. Based
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on various doses, weighed quantity of test products were dissolved in 10 L of
water/treatment and sprayed uniformly.
Details of the experiment
Target pests: Mosquito Bug (Helopeltis theivora); sucking pests (for e.g.
Scirtothrips dorsalis, Empoasca flavescens etc.), mites (polyphagous &
phytophagous), Caterpillar complex (Buzura suppressaria, Hyposidra talaca,
Hyposidra infixaria).
Crop: Tea
Variety: Assam
Plot Size: 60 m2
Spacing: 1.25 m x 0.75 m
Water volume/acre: 200 liters
Spray Equipment: Power operated knapsack sprayers fitted with cone nozzle
Observation: Means of 15 plants/ plot
Application Stage: 45 days after pruning
The treatment details are tabulated in Table 3 below.
Table 3: Insecticidal compositions for evaluation of bio-efficacy against insect
pests in tea
Particulars Treatment Dose/Acre
T1 Fipronil 4% and Propargite 40% SE 440 mL
T2 Fipronil 4% and Propargite 50% SE 440 mL
T3 Fipronil 5% SC 400 mL
T4 Fipronil 5% and Propargite 40% SE 440 mL
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T5 Propargite 57% EC 400 mL
T6 Fipronil 5% and Propargite 50% SE 440 mL
T7 Control Water spray
The bio-efficacy of different insecticidal compositions on tea crop and the
treatment wise yield data of tea leaves are summarized in the Table 4 and Table 5
respectively.
Table 4: The bio-efficacy of insecticidal compositions on Tea crop
Treatments
Mite Mosquito bug Caterpillar Complex
APT count/ plant
No. of mites
Reduction over control
(%)
APT count/ 10 tagged
shoots
No. of mosquito bug
Reduction over control
(%)
APT count / tea plant
No. of looper/ 5 tea
bushes
Reduction over control
(%)
T1 35.62
6.06
(2.56)
87.69 65.95
11.87
(3.52)
84.04 25.36
5.07
(2.36)
86.75
T2 36.31
5.45
(2.44)
88.93 68.70
10.31
(3.29)
86.14 27.69
4.98
(2.34)
86.98
T3 37.45
18.21
(4.33)
63.54 66.99
17.71
(4.27)
76.18 26.85
9.77
(3.20)
74.76
T4 35.15
6.68
(2.68)
86.43 66.23
8.61
(3.02)
88.42 27.30
4.10
(2.14)
89.28
T5 37.36 10.69 78.27 68.17 35.32 52.50 26.96 17.09 55.33
1011/PAT APPLN/12
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(3.35) (5.98) (4.19)
T6 36.12
4.33
(2.20)
91.20 67.21
7.39
(2.81)
90.06 25.85
3.36
(1.96)
91.22
T7 35.17
49.23
(7.05)
- 66.60
74.36
(8.65)
- 27.15
38.26
(6.23)
-
S.E
m±
- 0.06 - - 0.06 - - 0.02 -
CD
at
5%
NS 0.17 - NS 0.18 - NS 0.08 -
*Value in parenthesis are square root transformed value
APT: Average Pre-treatment values
SEm ±: Standard Errors of Means; CD 5%: Critical Difference
Table 5: Treatment Wise Yield Data of Tea leaves
Treatment
Yield
(kg/60 sq. m)
% increase over
control
T1 60.23 74.28
T2 62.31 80.30
T3 53.19 53.91
T4 61.23 77.17
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T5 48.19 39.44
T6 (Fipronil 5% + Propargite 50% SE) 65.23 88.74
T7 34.56 -
SEm ± 0.48 -
CD 5% 1.48
-
*SEm ±: Standard Errors of Means; CD 5%: Critical Difference
The aforementioned trial results indicate that the insecticidal composition (T6)
comprising Fipronil (5%) and Propargite (50%) formulated as SE is most effective
against all the target insects even 10 DAT. Additionally, the use of this
composition results in better crop condition, i.e. fresh green leaves and better
yield. Similar effects were found in the case of SE compositions (T2) comprising
Fipronil (4%) and Propargite (50%), and (T4) Fipronil (5%) and Propargite
(40%). Market reference products failed to show any significant effect.
The phytotoxic effect of different treatment schedules were also observed in ten
randomly selected plants from each plot on 0-10 scale (Table 6) for yellowing,
stunting, necrosis, epinasty hyponasty etc. Observations were recorded on 1, 3, 7,
& 14 days after application and presented in Table 7.
Table 6: Phytotoxicity visual scoring 0-10
Description of
crop
Rating Remarks
Description of
crop
Rating Remarks
No injury,
normal
0 Immune Severe injury,
no recovery
possible
6 Moderately
tolerant
Slight injury / 1 Resistant Sever injury, 7 Susceptible
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discoloration stand loss
Some stand
crop, stunning /
discoloration
2 Moderately Almost
destroyed, a few
plants surviving
8 Susceptible
Injury more
pronounced but
not persistent
3 Tolerant Very few plants
alive
9 Highly
susceptible
Moderate
injury, recovery
possible
4 Tolerant Complete
destruction
10 Highly
susceptible
Injury more
persistent,
recovery more
doubtful
5 Moderately
tolerant
Table 7: Phytotoxic Effect of Different compositions on Tea leaves
Treatments
Phytotoxicity ratings*
Leaf injury Wilting Vein clearing
R1 R2 R3 R1 R2 R3 R1 R2 R3
T1 0 0 0 0 0 0 0 0 0
T2 0 0 0 0 0 0 0 0 0
T3 0 0 0 0 0 0 0 0 0
T4 0 0 0 0 0 0 0 0 0
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T5 0 0 0 0 0 0 0 0 0
T6 (Fipronil 5% and
Propargite 50% SE)
0 0 0 0 0 0 0 0 0
T7 0 0 0 0 0 0 0 0 0
*Observed on 1, 3, 7, & 14 days after spraying and mean values were
presented
R: Replication
From the foregoing it will be observed that numerous modifications and variations
can be effectuated without departing from the true spirit and scope of the novel
concepts of the present invention. It is to be understood that no limitations with
respect to the specific embodiments illustrated is intended or should be inferred. It
should be understood that all such modifications and improvements have been
deleted herein for the sake of conciseness and readability but are properly within
the scope of the following claims.

We Claim:
1. A synergistic insecticidal composition, comprising Fipronil and
Propargite.
2. The synergistic insecticidal composition, as claimed in claim 1, wherein
the mass ratio of Fipronil to Propargite is in the range from 1:7 to 1:13.
3. The synergistic insecticidal composition, as claimed in claims 1 and 2,
wherein Fipronil and Propargite are present in amounts ranging from 4 to
6% and 40 to 50% respectively.
4. The synergistic insecticidal composition, as claimed in claims 1 to 3,
further comprising excipients, wherein the excipients are selected from the
group consisting of a solvent, an emulsifier, an anti-oxidant, an antifreezing
agent, a dispersing cum wetting agent, a defoamer, a biocide, a
thickener and water, and wherein the composition is in the form of a
suspo-emulsion (SE).
5. The synergistic insecticidal composition, as claimed in claim 4, wherein
the solvent is selected from the group consisting of C IX, cyclohexanone,
N-methyl pyrollidone, butanol and combinations thereof, and present in an
amount in the range from 0 to 10%.
6. The synergistic insecticidal composition, as claimed in claim 4, wherein
the emulsifier is selected from the group consisting of a nonionic
surfactant, anionic surfactant and combinations thereof, and present in an
amount in the range from 0 to 5%.
7. The synergistic insecticidal composition as claimed in claim 4, wherein the
anti-oxidant is sunflower oil and present in an amount in the range from 0
to 5%.
8. The synergistic insecticidal composition as claimed in claim 4, wherein the
anti-freezing agent is selected from the group consisting of propylene
glycol, DEG, MEG and combinations thereof, and present in an amount in
the range from 0 to 8%.
9. The synergistic insecticidal composition as claimed in claim 4, wherein the
dispersing cum wetting agent is selected from the group consisting of
mixture of nonionic surfactants and amine salt of phosphate tristyryl
phenol ethylated, acrylic copolymer, ethoxylated polyarylphenol
phosphate ester and combinations thereof, and present in an amount in the
range from 2 to 10%.
10. The synergistic insecticidal composition as claimed in claim 4, wherein the
defoamer is dimethyl polysiloxane emulsion and present in an amount in
the range from 0.01 to 0.50%.
11. The synergistic insecticidal composition as claimed in claim 4, wherein the
biocide is selected from the group consisting of Proxel GXL,
formaldehyde and combinations thereof and present in an amount in the
range from 0.01 to 0.50%.
12. The synergistic insecticidal composition as claimed in claim 4, wherein the
thickener is Xanthan gum and present in an amount in the range from 0.10
to 0.50%.
13. The synergistic insecticidal composition as claimed in any of the claims 1
to 12, wherein the composition is non-phytotoxic.