DESC:FIELD OF THE INVENTION:

The present invention relates to novel synergistic composition of bioactive amounts of Pymetrozine, at least one fungicide and at least one Insecticide wherein fungicide is selected from Azoxystrobin, Trifloxystrobin, Thifluzamide and Insecticide is selected from Clothianidin, Thiamethoxam, Dinotefuran, Imidacloprid, Tolfenpyrad, Flonicamid, and Buprofezin. The present invention also relates to process for preparing the said synergistic composition comprising bioactive amounts of Pymetrozine, at least one fungicide and at least one Insecticide with one or more inactive excipients.

BACKGROUND OF THE INVENTION

Fungicides can either be contact, translaminar or systemic. Contact fungicides are not taken up into the plant tissue, and protect only the plant where the spray is deposited; translaminar fungicides redistribute the fungicide from the upper, sprayed leaf surface to the lower, unsprayed surface; systemic fungicides are taken up and redistributed through the xylem vessels. Few fungicides move to all parts of a plant. Some are locally systemic, and some move upwardly.

Fungicides also can be classified based upon their chemical composition. Chemically, organic molecules are those that contain carbon atoms in their structure whereas inorganic molecules do not. Many of the first fungicides developed were inorganic compounds based on sulfur or metal ions such as copper, tin, cadmium and mercury that are toxic to fungi. Copper and sulfur are still widely used. Most other fungicides used today are organic compounds and thus contain carbon. The term "organic" as used here is based on chemistry terminology and differs from "organic" used to describe a system of agriculture that strives to be holistic and to enhance agro ecosystem health.

Fungicides kill fungi by damaging their cell membranes, inactivating critical enzymes or proteins, or by interfering with key processes such as energy production or respiration. Others impact specific metabolic pathways such as the production of sterols or chitin. In recent developments, the newly developed fungicides are unique in that they do not directly affect the pathogen itself. Many of new fungicides elicit a response from the host plant known as "systemic acquired resistance" (SAR). These SAR inducers basically mimic chemical signals in plants that activate plant defense mechanisms such as the production of thicker cell walls and anti-fungal proteins. The utility of SAR inducers, however, has been limited so far since many pathogens are capable of over-powering such defenses.

Fungicide resistance is a stable, heritable trait that results in a reduction in sensitivity to a fungicide by an individual fungus. This ability is obtained through evolutionary processes. Fungicides with single-site mode of action are at relatively high risk for resistance development compared to those with multi-side mode of action. Most fungicides being developed today have a single-site mode of action because this is associated with lower potential for negative impact on the environment, including non-target organisms.

When fungicide resistance results from modification of a single major gene, pathogen subpopulations are either sensitive or highly resistant to the pesticide. Resistance in this case is seen as complete loss of disease control that cannot be regained by using higher rates or more frequent fungicide applications. This type of resistance is commonly referred to as "qualitative resistance."

The control of phytopathogenic fungi is of great economic importance since fungal growth on plants or on parts of plants inhibits production of foliage, fruit or seed, and the overall quality of a cultivated crop.

Pymetrozine was first disclosed in US4931439 and US4996325.Pymetrozine is chemically known as (E)-4,5-dihydro-6-methyl-4-(3-pyridylmethyleneamino)-1,2,4-triazin-3(2H)-one and having chemical structure as below;

The mode of action of pymetrozine in insects has not been precisely determined biochemically, but it may involve effects on neuroregulation or nerve-muscle interaction. Physiologically, it appears to act by preventing these insects from inserting their stylus in to the plant tissue.

Pymetrozine is selective against Homoptera, causing them to stop feeding. Pymetrozine is used in control of aphids and whitefly in vegetables, potatoes, ornamentals, cotton, deciduous and citrus fruit, tobacco, hops; both juvenile and adult stages are susceptible and also control planthoppers in rice. Pymetrozine application rates vary from 150 g/ha on potatoes to 200-300 g/ha on ornamentals, tobacco and cotton; 10-30 g/hl on vegetables, fruit and hops. Pymetrozine is available in market with DP; GR; WP; WG formulation.

CN 102388906 A relates to a high-efficiency and low-toxicity compound insecticide which consists of clothianidin and pymetrozine and is particularly used for application research on controlling rice plant hopper.

CN 103766379 A relates to a pesticide composition containing the effective components comprise clothianidin and thifluzamide. The pesticide composition is mainly used for preventing and treating rice sheath blight disease and rice stem borer.

CN 101569312 B relates to composition for preventing and treating rice planthopper, relating to biodiesel cream and suspending agent containing pymetrozine and thiamethoxam.

CN 103109843 A relates to insecticidal disease-preventing suspended seed coating containing thiamethoxam, thifluzamide and/or benzene kresoxim-methyl.

EP 2363023 A1 relates to Synergistic fungicidal and insecticidal mixtures containing Pymetrozine and Tolfenpyrad as one of the composition.

CN 103651505 A relates to a pesticide compound, and particularly relates to a compound insecticide comprising imidacloprid and pymetrozine.

CN 102246766 A relates to an insecticidal composition containing flonicamid and pymetrozine. The insecticidal composition formed by the binary mixing of the flonicamid and pymetrozine which serve as active ingredients.

CN 101422154 A relates to a disinsection compound, in particular to a disinsection compound of Pymetrozine and Buprofezin.

CN 103651504 A relates to a pesticide composition, in particular to a compound insecticide containing dinotefuran and pymetrozine.

However still there is a need for a composition of specific pesticide which overcomes some of the existing problems and can be prepared easily without much complex manufacturing process.

However, the biological properties of these mixtures of known compounds are not completely satisfactory in the field of pest control.

In general use, the pesticide actives are used in the form of a dilute aqueous composition because it can attain a good interaction with the target organism, such as plants, fungi and insects. However, most active pesticide compounds that are used as pesticides are only sparingly or even insoluble in water. The low solubility of such compounds present the challenges and difficulties to formulator in formulating pesticide compounds in stable formulations that can be easily stored for a long time and which still have a high stability and effective activity until end use.

For the reasons mentioned above there does a need to provide further formulation of combinations comprising Pymetrozine and at least one fungicide and at least one Insecticide having synergistic pest control properties. This object is achieved according to the invention by providing the present formulation.

Inventors of the present invention have surprisingly found that the novel synergistic composition of Pymetrozine, at least one fungicide selected from Azoxystrobin, Trifloxystrobin, Thifluzamide and at least one Insecticide selected from as Clothianidin, Thiamethoxam, Dinotefuran, Imidacloprid, Tolfenpyrad, Flonicamid, and Buprofezinas described herein in can provide solution to the above mentioned problems.

SUMMARY OF THE INVENTION

Accordingly, in a first aspect of the present invention provides a novel pesticidal composition comprising (A) Pymetrozine (B) at least one fungicide (C) at least one insecticide wherein fungicide is selected from Azoxystrobin, Trifloxystrobin, Thifluzamide and Insecticide is selected from Clothianidin, Thiamethoxam, Dinotefuran, Imidacloprid, Tolfenpyrad, Flonicamid and Buprofezin and one or inactive excipients.

Accordingly, in a second aspect, the present invention provides a method of preparing the mixture which also relates to process for preparing the novel synergistic composition comprising bioactive amounts of Pymetrozine, at least one fungicide and at least one Insecticide with one or more inactive excipients.

Accordingly, in a third aspect, the present invention provides a method of protecting a plant propagation material, a plant, parts of a plant and/or plant organs that grow at a later point in time against pathogenic damage or pest damage by applying to the plant propagation material a composition comprising a formulated mixture defined in the first aspect.

Accordingly, in a fourth aspect the said composition is to be developed in suitable formulations selected from Flowable Slurry (FS) / Flowable Suspension(FS) / Suspension Concentrate (SC), Water dispersible powder for slurry seed treatment (WS),ZC ( A mixed formulation of CS and SC), ZE (A mixed heterogeneous formulation of CS and SE), ZW( A mixed heterogeneous formulation CS and EW) comprising Pymetrozine, at least one fungicide and at least one Insecticide and one or more customary formulation adjuvants such as a) dispersant b) wetting agent c) anti-foaming agent d) biocides e) anti-freezing agent f) suspending agent g) thickener h) coating agent and i) buffering agent.

Accordingly, in a further aspect of the present invention is containing the pesticide composition of (A) Pymetrozine (B) fungicide and (C) Insecticides, wherein fungicide is selected from Azoxystrobin, Trifloxystrobin, Thifluzamide and Insecticide is selected from Clothianidin, Thiamethoxam, Dinotefuran, Imidacloprid, Tolfenpyrad, Flonicamid, and Buprofezin.

According to another aspect of the present invention there is provided a stable aqueous formulation comprising wherein A) Pymetrozine is present in the range from 0.1 to 30%, B) fungicide is present in the range from 0.05 to 40% and (C) Insecticide is in the range 1 to 20% by weight; by weight of active ingredients, optional formulation also contains and one or more customary formulation adjuvants such as a) dispersant b) wetting agent c) anti-foaming agent d) biocides e) anti-freezing agent f) suspending agent g) thickener h) coating agent and i) buffering agent.

According to another aspect of the present invention there is provided a stable aqueous formulation comprising from Pymetrozine, at least one fungicide and at least one Insecticide, by weight of active ingredients, optional formulation also contains at least one Biocide, dispersant and thickener (or agent of suspension).

DETAILED DESCRIPTION OF THE INVENTION

The present invention provides novel composition comprising bioactive amounts of Pymetrozine, at least one fungicide and at least one Insecticide wherein fungicide is selected from Azoxystrobin, Trifloxystrobin, Thifluzamide and Insecticide is selected from Clothianidin, Thiamethoxam, Dinotefuran, Imidacloprid, Tolfenpyrad, Flonicamid, and Buprofezinwith one or more inactive excipients.

"Bioactive amounts” as mentioned herein means that amount which, when applied treatment of crops, is sufficient to effect such treatment.

The insecticidal and/or fungicidal composition can be classified as below:
The formulation can be in various physical forms, for example in the form of a dustable powder (DP), a gel, a wettable powder (WP), a granule (GR) (such as an emulsifiable granule (EG) or more particularly a water-dispersible granule (WG)), a water-dispersible tablet (WT), an emulsifiable concentrate (EC), a micro- emulsifiable concentrate, an oil-in-water emulsion (EW), an oil flowable (e.g. a spreading oil (SO)), an aqueous dispersion (e.g. aqueous suspension concentrate (SC)), an oily dispersion (OD), a suspo-emulsion (SE), a capsule suspension (CS), a soluble liquid, a water-soluble concentrate (with water or a water-miscible organic solvent as carrier) or an impregnated polymer film

Formulations of the present invention can be in any of the form described above, preferably selected from Flowable Slurry (FS) / Flowable Suspension(FS) / Suspension Concentrate (SC), Water dispersible powder for slurry seed treatment (WS),ZC ( A mixed formulation of CS and SC), ZE (A mixed heterogeneous formulation of CS and SE), ZW( A mixed heterogeneous formulation CS and EW)..

ZC is a mixed formulation of CS and SC and is a stable aqueous suspension of microcapsules and solid fine particles, each of which contains one or more active ingredients. The formulation is intended for dilution into water prior to spray application. Formulating the active ingredients together eliminates the need for tank mixing, which can lead to incompatibility, and facilitates control of a wider range of pests with fewer applications. Like other aqueous liquid formulations, ZC formulations are easy to handle and measure, dust free, non-flammable and offer good miscibility with water.

One or more of the active ingredients is encapsulated for various purposes, such as to increase the residual biological activity, or to reduce the acute toxicity, or to obtain a physical or chemically stable water-based formulation. The purpose determines whether the “free” active ingredient and the “release rate” are relevant properties of a specific product.

Advantageous invention relates to a composition of Pymetrozine, at least one fungicide and at least one Insecticide as shown below:

% of components varies from
Active 1 Active 2 Active 3
Pymetrozine Azoxystrobin Clothianidin
Pymetrozine Azoxystrobin Thiamethoxam
Pymetrozine Azoxystrobin Dinotefuran
Pymetrozine Azoxystrobin Imidacloprid
Pymetrozine Azoxystrobin Tolfenapyrad
Pymetrozine Azoxystrobin Flonicamid
Pymetrozine Azoxystrobin Buprofezin
Pymetrozine Trifloxystrobin Clothianidin
Pymetrozine Trifloxystrobin Thiamethoxam
Pymetrozine Trifloxystrobin Dinotefuran
Pymetrozine Trifloxystrobin Imidacloprid
Pymetrozine Trifloxystrobin Tolfenapyrad
Pymetrozine Trifloxystrobin Flonicamid
Pymetrozine Trifloxystrobin Buprofezin
Pymetrozine Thifluzamide Clothianidin
Pymetrozine Thifluzamide Thiamethoxam
Pymetrozine Thifluzamide Dinotefuran
Pymetrozine Thifluzamide Imidacloprid
Pymetrozine Thifluzamide Tolfenapyrad
Pymetrozine Thifluzamide Flonicamid
Pymetrozine Thifluzamide Buprofezin
0.1 to 30% 0.05 to 40% 1 to 20%

The composition of present invention is effective for management of Cotton (Gossypium spp.), Paddy (Oryza sativa), Wheat (Triticum aestavum), Maize (Zea mays), Sugarcane (Saccharum officinarum) , Soybean (Glycin max), Peanut (Arachis hypogaea), Mustard (Brassica juncea), Green gram (Vigna radiate), Black gram (Vigna mungo), Chickpea (Cicer aritinum), Redgram (Cajanus cajan), Brinjal (Solanum melongena), Cabbage (Brassica oleracea var. capitata), Cauliflower (Brassica oleracea var. botrytis), Okra (Abelmoschus esculentus), Onion (Allium cepa L.), Tomato (Solanum lycopersicun) , Potato (Solanum tuberosum) , Chilly (Capsicum annum), Garlic (Allium sativum), Cucumber (Cucumis sativus), Muskmelons (Cucumis melo), Watermelon (Citrullus lanatus), Bottle gourd (Lagenaria siceraria), Apple (Melus domestica), Banana (Musa spp.), Citrus groups (Citrus spp.), Grape (Vitis vinifera), Mango (Mangifera indica), Pomegranate (Punica granatum) , Tea (Camellia sinensis), Cumin (Cuminum cyminum), Fenugreek (Trigonella foenum-graecum), Fennel (Foeniculum vulgare), Coriander (Coriandrum sativum).

The formulation of the present invention can be used to control the insects-pests from the order of the Lepidoptera, for example Chilo partellus, Chilo suppressalis, Cydia pomonella, beetles (Coleoptera), for example Dicladispa armigera, Epila-chna varivestis, Phyllotreta nemorum, Phyllotreta striolata, flies (Diptera), e.g. Atherigona orientalis, Dacus cucurbi-tae, Dacus oleae, Liriomyza sativae, Liriomyza trifolii, Melanagromyza obtuse, Ophiomyia phaseli, thrips (Thysanoptera), e.g. Dichromothrips corbetti, Dichromothrips ssp , Frankliniella fusca, Frankliniella occidentalis, Frankliniella tritici, Scirtothrips citri, Scirtothrips dorsalis, Thrips oryzae, Thrips palmi and Thrips tabaci, true bugs (Hemiptera), e.g. Amrasca biguttula biguttula, Amrasca devastans, Amritodus atkinsoni, Aphis fabae, Aphis pomi, Aphis gossypii, Aphis crassivora, Bemisia argentifolii, Bemisia tabaci, Brevicoryne brassicae, Clavigralla gibbosa, Dysdercus cingulatus, Idioscopus spp., Leptocorisa acuta, Lygus lineolaris, Myzus persicae, Nilaparvata lugens, Nephotettix virescens, Nephotettix nigropictus, Planococcus spp., Pseudococcus spp., Pyrilla perpusilla, Psylla mail, Psylla piri, Rhopalomyzus ascalonicus, Rhopalosiphum maidis, Rhopalosi-phum padi, Rhopalosiphum insertum, Sappaphis mala, Sappaphis mail, Schizaphis graminum, Schizoneura lanuginosa, Sitobion avenae, Sogatella furcifera, Trialeurodes vaporariorum, Toxoptera aurantiia, Psylla spp., Rhopalosiphum spp., Sitobion spp., crickets, grasshoppers, locusts (Orthoptera), e.g. Gryllotalpa gryllo-talpa, Locusta migratoria, Melanoplus bivittatus, Locustana pardalina.

The composition according to the invention can be applied to any and all developmental stages of pests, such as egg, larva, pupa, and adult. The pests may be controlled by contacting the target pest, its food supply, habitat, breeding ground or its locus with a pesticidally effective amount of the inventive mixtures or of compositions comprising the mixtures.

The formulation of the present invention can be used to control fungal diseases in wheat diseases-Common bunt Tilletia tritici, Karnal bunt Neovossia indica, Leaf rust Puccinia triticina, Puccinia recondite, Loose smut Ustilago tritici, Powdery mildew Erysiphe graminis, Blumeria graminis, Scab/head blight Fusarium graminearum, Septoria blotch Septoria tritici, Rice diseases-Blast Pyricularia oryzae, Crown sheath rot Gaeumannomyces graminis, False smut Ustilaginoidea virens, Grain discoloration by Cochliobolus miyabeanus, Curvularia spp., Fusarium spp., Microdochium oryzae, Sarocladium oryzae, Sheath blight Rhizoctonia solani, Sheath rot Sarocladium oryzae, Corn diseases- Anthracnose leaf blight Colletotrichum graminicola, Aspergillus ear and kernel rot, Banded leaf and sheath spot Rhizoctonia solani, Soybean diseases-Alternaria leaf spot, Anthracnose Colletotrichum truncatum, Charcoal rot Macrophomina phaseolina, Frogeye leaf spot Cercospora sojina, Rust Phakopsora pachyrhizi, Peanut diseases- Early leaf spot Cercospora arachidicola, Late leafspot Cercosporidium personatum, Rust Puccinia arachidis, Cotton diseases- Anthracnose Glomerella gossypii, Colletotrichum gossypii, Areolate mildew Ramularia gossypii=Cercosporella gossypii, Cucurbits diseases-Anthracnose (stem, leaf and fruit) Colletotrichum orbiculare, Cercospora leaf spot Cercospora citrullina, Powdery mildew Sphaerotheca fuliginea, Erysiphe cichoracearum, Diseases of Onion and Garlic- Black mold Aspergillus niger, Blue mold Penicillium aurantiogriseum, Botrytis leaf blight Botrytis squamosa, Diplodia stain Botryodiplodia theobromae, Stemphylium leaf blight and stalk rot Stemphylium vesicarium, Diseases of Pepper (Capsicum spp.) : Anthracnose Colletotrichum gloeosporioides, C. capsici, Glomerella cingulata, Cercospora (frogeye) leaf spot Cercospora capsici, Charcoal rot Macrophomina phaseolina, Choanephora blight (wet rot) Choanephora cucurbitarum, Damping-off and root rot Rhizoctonia solani, Phytophthora spp., Fusarium spp., Pythium spp., Downy mildew Peronospora tabacina, Fusarium stem rot Fusarium solani, Fusarium wilt Fusarium oxysporum f. sp. Capsici,Gray leaf spot Stemphylium solani, Gray mold Botrytis cinerea, Phytophthora blight Phytophthora capsici, Powdery mildew Oidiopsis sicula, Leveillula taurica, Southern blight Sclerotium rolfsii, Verticillium wilt erticillium dahliae, White mold Sclerotinia sclerotiorum, Diseases of Potato (Solanum tuberosum L.) : Brown spot and Black pit Alternaria alternate, Cercospora leaf blotch Mycovellosiella concors= Cercospora concors, Cercospora solani, Early blight Alternaria solani, Gray mold Botrytis cinerea, Late blight Phytophthora infestans, Phoma leaf spot Phoma andigena, Powdery mildew Erysiphe cichoracearum, Powdery scab Spongospora subterranean, Rhizoctonia canker and black scurf Rhizoctonia solani, Septoria leaf spot Septoria lycopersici, Silver scurf Helminthosporium solani, Verticillium wilt Verticillium albo-atrum, Tomato Diseases- Early blight Alternaria solani, Late blight Phytophthora infestans, Powdery mildew Leveillula taurica, Diseases of Apple : Alternaria blotch Alternaria mali, Apple scab Venturia inaequalis, Gray mold rot = dry eye rot, blossom-end rot Botrytis cinerea, Diseases of Banana : Black leaf streak (black Sigatoka) Mycosphaerella fijiensis, Brown spot Cercospora hayi, Cigar-end Verticillium theobromae, Sigatoka (yellow Sigatoka) Mycosphaerella musicola.Diseases of Grape (Vitis spp.) : Botrytis bunch rot and blight (Gray mold) Botrytis cinerea (teleomorph: Botryotinia fuckeliana) Downy mildew Plasmopara viticola, Powdery mildew Uncinula necator.Diseases of Mango (Mangifera indica L.) : Anthracnose Colletotrichum gloeosporioides, Black mold rot Aspergillus niger, Powdery mildew Erysiphe cichoracearum.

The novel active ingredient mixtures have very advantageous curative, preventive and systemic fungicidal properties for protecting cultivated plants. As has been mentioned, said active ingredient mixtures can be used to inhibit or destroy the pathogens that occur on plants or parts of plants (fruit, blossoms, leaves, stems, tubers, roots) of different crops or useful plants, while at the same time those parts of plants which grow later are also protected from attack by such pathogens. Active ingredient mixtures have the special advantage of being highly active against diseases in the soil that mostly occur in the early stages of plant development

Composition of the present invention can be in any of the form described above. The novel synergistic combination of Pymetrozine, at least one fungicide and at least one Insecticide is effective for management of mixed infestation of various insects and fungal diseases crops.

The novel composition of the present invention in addition to Pymetrozine, at least one fungicide and at least one Insecticide further comprises inactive excipients including but not limited to dispersant, anti-freezing agent, anti-foam agent, wetting agent, suspension aid, anti-microbial agent, thickener, quick coating agent or sticking agents (also referred to as “stickers” or “binders”) and buffering agent.

A dispersant is a substance which adsorbs onto the surface of particles and helps to preserve the state of dispersion of the particles and prevents them from re-aggregating. Dispersants are added to agrochemical compositions to facilitate dispersion and suspension during manufacture, and to ensure the particles re-disperse into water in a spray tank. They are widely used in wettable powders, suspension concentrates and water-dispersible granules. Surfactants that are used as dispersants have the ability to adsorb strongly onto a particle surface and provide a charged or steric barrier to re-aggregation of particles. The most commonly used surfactants are anionic, non-ionic, or mixtures of the two types. For wettable powder compositions, the most common dispersants are sodium lignosulphonates. For suspension concentrates, very good adsorption and stabilization are obtained using polyelectrolytes, such as sodium naphthalene sulphonate formaldehyde condensates. Tristyrylphenolethoxylate phosphate esters are also used. Nonionics such as alkylarylethylene oxide condensates and EO-PO block copolymers are sometimes combined with anionics as dispersants for suspension concentrates. In recent years, new types of very high molecular weight polymeric surfactants have been developed as dispersants. These have very long hydrophobic ‘backbones’ and a large number of ethylene oxide chains forming the ‘teeth’ of a ‘comb’ surfactant. These high molecular weight polymers can give very good long-term stability to suspension concentrates because the hydrophobic backbones have many anchoring points onto the particle surfaces. Examples of dispersants used herein include but not limited to sodium lignosulphonates; sodium naphthalene sulphonate formaldehyde condensates; tristyrylphenolethoxylate phosphate esters; aliphatic alcohol ethoxylates; alky ethoxylates; EO-PO block copolymers; and graft copolymers or mixtures thereof.

Anti-freezing agent as used herein can be selected from the group consisting of polyethylene glycols, methoxypolyethylene glycols, polypropylene glycols, polybutylene glycols, glycerin and ethylene glycol.

Water-based compositions often cause foam during mixing operations in production. In order to reduce the tendency to foam, anti-foam agents are often added either during the production stage or before filling into bottles. Generally, there are two types of anti-foam agents, namely silicones and non-silicones. Silicones are usually aqueous emulsions of dimethyl polysiloxane while the non-silicone anti-foam agents are water-insoluble oils, such as octanol and nonanol, or silica. In both cases, the function of the anti-foam agent is to displace the surfactant from the air-water interface.

A wetting agent is a substance that when added to a liquid increases the spreading or penetration power of the liquid by reducing the interfacial tension between the liquid and the surface on which it is spreading. Wetting agents are used for two main functions in agrochemical compositions: during processing and manufacture to increase the rate of wetting of powders in water to make concentrates for soluble liquids or suspension concentrates; and during mixing of a product with water in a spray tank or other vessel to reduce the wetting time of wettable powders and to improve the penetration of water into water-dispersible granules. Examples of wetting agents used in wettable powder, suspension concentrate, and water-dispersible granule compositions include but not limited to sodium lauryl sulphate; sodium dioctylsulphosuccinate; alkyl phenol ethoxylates; and aliphatic alcohol ethoxylates or mixtures thereof.

Suspension aid in the present description denotes a natural or synthetic, organic or inorganic material with which the active substance is combined in order to facilitate its application to the plant, to the seeds or to the soil. This carrier is hence generally inert, and it must be agriculturally acceptable, in particular to the plant being treated. The carrier may be solid (clays, natural or synthetic silicates, silica, resins, waxes, solid fertilizers, and the like or mixtures thereof) or liquid (water, alcohols, ketones, petroleum fractions, aromatic or paraffinic hydrocarbons, chlorinated hydrocarbons, liquefied gases, and the like or mixtures thereof).

Biocides / Microorganisms cause spoilage of formulated products. Therefore anti-microbial agents are used to eliminate or reduce their effect. Examples of such agents include, but are not limited to: propionic acid and its sodium salt; sorbic acid and its sodium or potassium salts; benzoic acid and its sodium salt; p-hydroxy benzoic acid sodium salt; methyl p-hydroxy benzoate; and biocide such as sodium benzoate, 1,2-benzisothiazoline-3-one, 2-methyl-4-isothiazolin-3-one, 5-chloro-2-methyl-4-isothiazolin-3-one, potassium sorbate, parahydroxy benzoates or mixtures thereof.

Thickeners or gelling agents are used mainly in the composition of suspension concentrates, emulsions and suspoemulsions to modify the rheology or flow properties of the liquid and to prevent separation and settling of the dispersed particles or droplets. Thickening, gelling, and anti-settling agents generally fall into two categories, namely water-insoluble particulates and water-soluble polymers. It is possible to produce suspension concentrate compositions using clays and silicas. Examples of these types of materials, include, but are limited to, montmorillonite, e.g. bentonite; magnesium aluminum silicate; and attapulgite. Water-soluble polysaccharides have been used as thickening-gelling agents for many years. The types of polysaccharides most commonly used are natural extracts of seeds and seaweeds are synthetic derivatives of cellulose or mixtures thereof. Examples of these types of materials include, but are not limited to, guar gum; locust bean gum; carrageenam; xanthan gum; alginates; methyl cellulose; sodium carboxymethyl cellulose (SCMC); hydroxyethyl cellulose (HEC) or mixtures thereof. Other types of anti-settling agents are based on modified starches, polyacrylates, polyvinyl alcohol and polyethylene oxide or mixtures.

The quick coating agent can be a conventionally available sticker, for example polyesters, polyamides, poly- carbonates, polyurea and polyurethanes, acrylate polymers and copolymers, styrene copolymers, butadiene copolymers, polysaccharides such as starch and cellulose derivatives, vinylalcohol, vinylacetate and vinylpyrrolidone polymers and copolymers, polyethers, epoxy, phenolic and melamine resins, polyolefins and define copolymersand mixtures thereof. Examples of preferred polymers are acrylate polymers such as poly(methacrylate), poly(ethyl methacrylate), poly(methylmethacrylate), acrylate copoylmers and styrene-acrylic copolymers as defined herein below, poly(styrene-co maleic anhydride), cellulosic polymers such as ethyl cellulose, cellulose acetate, cellulose acetatebutyrate, acetylated mono, di, and triglycerides, poly(vinylpyrrolidone), vinyl acetate polymers and copolymers, poly(alkylene glycol), styrene butadiene copolymers, poly(orthoesters), alkyd resins, and mixtures of two or more of these. Polymers that are biodegradable are also useful in the present invention. As used herein, a polymer is biodegradable if is not water soluble, but is degraded over a period of several weeks when placed in an application environment. Examples of biodegradable polymers that are useful in the present invention include biodegradable polyesters, starch, polylactic acid starch blends, polylactic acid, poly(lactic acid-glycolic acid) copolymers, polydioxanone, cellulose esters, ethyl cellulose, cellulose acetate butyrate, starch esters, starch esteraliphatic polyester blends, modified corn starch, polycaprolactone, poly(namylmethacrylate), wood rosin, polyanhydrides, polyvinylalcohol, polyhydroxybutyratevalerate, biodegradable aliphatic polyesters, and polyhydroxybutyrate or mixtures thereof.

Buffering agent as used herein is selected from group consisting of calcium hydroxyapatite, Potassium Dihydrogen Phosphate, Sodium Hydroxide, carbonated apatite, calcium carbonate, sodium bicarbonate, tricalcium phosphate, calcium phosphates, carbonated calcium phosphates, amine monomers, lactate dehydrogenase and magnesium hydroxide.

The solvent for the composition of the present invention may include water, water-soluble alcohols and dihydroxy alcohol ethers. The water-soluble alcohol which can be used in the present invention may be lower alcohols or water-soluble macromolecular alcohols. The term "lower alcohol", as used herein, represents an alcohol having 1-4 carbon atoms, such as methanol, ethanol, n-propanol, isopropanol, n-butanol, tert-butanol, etc. Macromolecular alcohol is not limited, as long as it may be dissolved in water in a suitable amount range, e.g., polyethylene glycol, sorbitol, glucitol, etc. The examples of suitable dihydroxy alcohol ethers used in the present invention may be dihydroxy alcohol alkyl ethers or dihydroxy alcohol aryl ethers. The examples of dihydroxy alcohol alkyl ether include ethylene glycol methyl ether, diethylene glycol methyl ether, propylene glycol methyl ether, dipropylene glycol methyl ether, ethylene glycol ethyl ether, diethylene glycol ethyl ether, propylene glycol ethyl ether, dipropylene glycol ethyl ether, etc. The examples of dihydroxy alcohol aryl ethers include ethylene glycol phenyl ether, diethylene glycol phenyl ether, propylene glycol phenyl ether, dipropylene glycol phenyl ether, and the like. Any of the above mentioned solvent can be used either alone or in combination thereof.

The process for preparing the present agrochemical composition can be modified accordingly by any person skilled in the art based on the knowledge of the manufacturing the composition. However all such variation and modification is still covered by the scope of present invention.
EXAMPLES
Example 1: Pymetrozine 20%+Azoxystrobin 25%+Clothianidin 15% WDG (Water Dispersible Granules)
Compositions Percent (w/w)
Pymetrozine (95% purity) 21.26
Azoxystrobin (95% purity) 26.52
Clothianidin (96% purity) 16.00
Alkylated naphtalene sulfonate, sodium salt 7.00
Sodium Polycarboxylate 4.00
Sodium Lauryl Sulfate 3.00
Silicone antifoam 0.50
Lactose anhydrous 10.00
Sodium SulfateAnhydrous 5.00
China Clay 6.72
TOTAL 100.00

Procedure:
Step 1 Charge the required quantity of filler, wetting agent, dispersing agent, and suspending agent, & technical in premixing blender for homogenization for 30 minutes.
Step 2 Pre-blended material is than grinded through Jet mill/ air classifier mills. Finely grinded material is blended in post blender till it becomes homogeneous. (for approx. 1.5 hr)
Step 3 Homogeneous material is analysed. After getting approval from QC dept. material is unloaded into 25 kg. HDPE bag with LDPE liner inside.
Step 4 Finely grinded powder is mixed with required quantity of water to form extrudable dough.
Step 5 Dough is passed through extruder to get granules of required size.
Step 6 Wet granules are passed through Fluidised bed drier and further graded using vibrating screens.
Step 7 Final product is sent for QC approval.
Step 8 After approval material is packed in required pack sizes.

Example 2: Pymetrozine 20%+Trifloxystrobin 25%+Thiamethoxam 15% WDG (Water Dispersible Granules)
Compositions Percent (w/w)
Pymetrozine (95% purity) 21.26
Trifloxystrobin (96% purity) 26.53
Thiamethoxam (96% purity) 16.00
Alkylated naphtalene sulfonate, sodium salt 8.00
Sodium Polycarboxylate 4.00
Sodium Lauryl Sulfate 3.00
Silicone antifoam 0.50
Sodium SulfateAnhydrous 7.00
China Clay 13.71
TOTAL 100.00

Procedure: As per Example 1

Example 3: Pymetrozine 10%+Azoxystrobin 12.5%+Thiamethoxam 7.5% SC (Suspension Concentrate)
Composition Percent (w/w)
Pymetrozine(95%) 10.74
Azoxystrobin (95%) 13.37
Thiamethoxam (96%) 8.02
Ethoxylated Fatty Alcohol 1.50
Nonionic polyalkylene glycol ether 0.50
Acrylic graft copolymer 3.00
Alkylated naphtalene sulfonate, sodium salt 0.50
Silicone antifoam 1.00
Benzisothiazoline 0.20
Glycol 5.00
Polysaccharides 0.20
Water 55.97
TOTAL 100.00

Procedure:
Step 1 Gum Solution should be made 12-18 hour prior to use. Take required quantity of water, biocide, and defoamer and homogenize, then slowly add gum powder to it and stir till complete dissolution.
Step 2 Charge required quantity of DM water need to be taken in designated vessel for Flowable concentrate/ Suspension concentrate/ Flowable slurry production.
Step 3 Add required quantity of Wetting agent, dispersing agent & suspending agents, colourant/deye and homogenize the contents for 45 – 60 minutes using high shear homogenizer.
Step 4 Then add technical and other remaining adjuvants excluding ‘antifreeze & thickeners’ are added to it and homogenized to get uniform slurry ready for grinding.
Step 5 Before grinding half the quantity of antifoam was added and then material was subjected to three cycles of grinding in Dyno mill.
Step 6 Half quantity of the antifoam was added along with antifreeze after grinding process completes and before sampling for in process analysis.
Step 7 Finally add gum solution to this formulation and send to QC for quality check

Example 4: Pymetrozine 10%+Trifloxystrobin 12.5%+Imidacloprid 7.5% SC (Suspension Concentrate)
Composition Percent (w/w)
Pymetrozine(95%) 10.73
Trifloxystrobin (96%) 13.37
Imidacloprid (97%) 8.11
Ethoxylated Fatty Alcohol 2.00
Acrylic graft copolymer 3.00
Alkylated naphtalene sulfonate, sodium salt 0.50
Silicone antifoam 1.00
Benzisothiazoline 0.20
Glycol 5.00
Polysaccharides 0.20
Water 55.89
TOTAL 100.00
Procedure: As per Example 3

Example 5: Pymetrozine 10%+Thifluzamide 10%+Tolfenpyrad 10% SC (Suspension Concentrate)
Composition Percent (w/w)
Pymetrozine(95%) 10.74
Thifluzamide(95%) 10.74
Tolfenpyrad (97%) 10.52
Ethoxylated Fatty Alcohol 1.50
Nonionic polyalkylene glycol ether 1.00
Acrylic graft copolymer 3.00
Alkylated naphtalene sulfonate, sodium salt 0.70
Silicone antifoam 1.00
Benzisothiazoline 0.20
Glycol 5.00
Polysaccharides 0.20
Water 55.40
TOTAL 100.00

Procedure: As per example 3

EXAMPLE 6: STORAGE STABILITY DATA
Comparison of the stability of formulations
The stability of each of the fromulation of Example 1 to Example 5 were tested for 1 month to 24 months stability at room temperature and at elevated temperature study under the following conditions: Heat stability study at 54 + 2 0C for 14 days and Cold storage stability at 0 + 2 0C for 14 days. The required parameters studied are active content, pH, Persistent Foaming, Suspensibility, Pourability and Viscosity was studied Respective amounts were measured using different instruments and parameters. The results are shown in the Table below of Examples 1 to 5. The results were found satisfactory and this formulation is passing in all physicochemical properties.

Storage stability study of formulation of Example 1 to Example 5
Parameters Specification Initial Heat stability at 54+2 0C for 14 days Cold storage stability at 0+2 0C for 14 days
Description Description* Complies Complies Complies
Pymetrozine content 19.0 - 21.0 Complies Complies Complies
Azoxystrobin content 23.75 - 26.25 Complies Complies Complies
Clothianidin content 14.25 - 15.75 Complies Complies Complies
Pymetrozine suspensibility Mini 70% Complies Complies Complies
Azoxystrobin suspensibility Mini 70% Complies Complies Complies
Clothianidin suspensibility Mini 70% Complies Complies Complies
pH 5 to7 Complies Complies Complies
Wettability Max 30 s Complies Complies Complies
Wet Sieve(45 micron) Mini 98.5% Complies Complies Complies
Bulk Density 0.45-0.85 Complies Complies Complies
Moisture Content Max 2.0% 1.5 1.5 1.5

[*The material shall consist of a homogeneous, together with carriers and any other necessary formulants. It shall be in the form of granules for application after disintegration and dispersion in water. The formulation shall be dry, free flowing, essentially non-dusty and free from visible extraneous matter and hard lumps.]

Room temperature storage data of the formulation of Example 1 to Example 5

Parameters Specification Study Duration
1 month 6 month 12 months 24 months
Description Description* Complies Complies Complies Complies
Pymetrozine content 19.0 - 21.0 Complies Complies Complies Complies
Azoxystrobin content 23.75 - 26.25 Complies Complies Complies Complies
Clothianidin content 14.25 - 15.75 Complies Complies Complies Complies
Pymetrozine suspensibility Mini 70% Complies Complies Complies Complies
Azoxystrobin suspensibility Mini 70% Complies Complies Complies Complies
Clothianidin suspensibility Mini 70% Complies Complies Complies Complies
pH 5 to7 Complies Complies Complies Complies
Wettability Max 30 s Complies Complies Complies Complies
Wet Sieve(45 micron) Mini 98.5% Complies Complies Complies Complies
Bulk Density 0.45-0.85 Complies Complies Complies Complies
Moisture Content Max 2.0% Complies Complies Complies Complies

[* The material shall consist of a homogeneous, together with carriers and any other necessary formulants. It shall be in the form of granules for application after disintegration and dispersion in water. The formulation shall be dry, free flowing, essentially non-dusty and free from visible extraneous matter and hard lumps.]

Example 7: Bio efficacy trial
Bioefficacy studies were carried out in different crops. Various formulations containing mixtures of Pymetrozine, at least one fungicide selected from Azoxystrobin, Trifloxystrobin and Thifluzamide, and one more insecticide selected from the group of Clothianidin, Thiamethoxam, Dinotefuran, Imidacloprid, Tolfenpyrad, Flonicamid and Buprofezin, were developed and evaluated for their efficacy against insect-pest and diseases, effect on growth and vigor of plants, their impact on yield and yield attributing characters.

Example 7a
A pot experiment was conducted on Aphid, Myzus persicae infesting potato crop to study the synergism between Pymetrozine, Azoxystrobin and Clothianidin. The potato plants were raised in pots. The potato aphid culture reared in laboratory were released on potato plant and allowed to multiply and build up. Four potted plants per treatment were taken and sprayed with required concentration of Pymetrozine, Azoxystrobin and Clothianidin. Immediately after spraying, the micro cages were clipped on potato leaf and kept under observations. The number of aphid nymphs and adults were counted per micro cage before spraying and after 72 hrs. The percent control was calculated by considering number of aphids in untreated plot, as below formula.

Number of live insect in treated plot
% Insect Control = 100 - -------------------------------------------------- x 100
Number of live insects in untreated plot

The % insect control data used to calculate the synergism, as per the below formula.
The synergistic pesticide action of the inventive mixtures calculated as follows:
E = [A + B + C] - [{AB} + {BC} + {AC}] / 100 + [{ABC}/10000]
in which, E = Expected percentage of Insecticidal or fungicidal control for the combination of three active ingredient, A is the percentage of insecticidal or fungicidal control observed by active ingredient I at defined dose, B is the percentage of insecticidal or fungicidal control observed by Active Ingredient II at defined dose, C is the percentage of insecticidal or fungicidal control observed by Active Ingredient III at defined dose. When the percentage of insecticidal or fungicidal control observed for the combination is greater than the expected percentage, there is a synergistic effect. (Ratio of O/E > 1, means synergism observed.)

Table 1: Control of Aphid, Myzus persicae on Potato
Compositions % Aphid control
Obs.Value Cal. Value Ratio
Pymetrozine 150+Azoxystrobin 250+Clothianidin 100 ppm 98.84 76.22 1.30
Pymetrozine 150 + Azoxystrobin 250 ppm 46.26 47.47 0.97
Pymetrozine 150 + Clothianidin 100 ppm 72.76 73.91 0.98
Azoxystrobin 250 + Clothianidin 100 ppm 56.36 58.75 0.96
Pymetrozine 150 ppm 42.36
Azoxystrobin 250 ppm 8.86
Clothianidin 100 ppm 54.74

Pymetrozine+Azoxystrobin+Clothiandin shows synergism in terms of their efficacy against potato aphid compared to their two active ingredient mixtures as well as solo application.
Example 7b
In Vitro Chemical screening : The synergistic effect of compositions of Pymetrozine, Azoxystrobin and Clothianidin on growth of the pathogen in vitro was studied by poison food technique. Different concentration of active ingredient were prepared by dissolving the requisite quantity of each active ingredient in warm potato dextrose agar medium before autoclaving. After autoclaving the medium was then dispensed uniformly into 90 mm diameter petriplate and inoculated at the 2 mm mycelial discs of pathogen taken from 7 day old culture. Pathogen inoculated in unamended medium served as control. Each treatment was maintained in four replications. The inoculated plates were incubated at 28 +/- 2 C for 3 days and the diameter of the fungal colony was measured by measuring the two opposite circumference of the colony growth at 3 days interval for 15 days. The growth of fungus was monitored by measuring the radial growth (in mm) every 72 h till the fungus covers the plate completely in control plates. The percent inhibition (PI) of the fungus over the control was calculated using the following formula :
PI = A-B X 100/A
Where A= Colony diameter of fungus in control plates (mm)
B= Colony diameter of fungus in treated plates (mm)
The synergistic pesticidal action of the inventive mixtures calculated as follows :
For mixture of three active ingredients,
E = [A + B + C]- [{AB}+{BC}+{AC}] / 100 + [ {ABC}/10000]
For mixture of two active ingredients,
E = [ A + B] – [AB/ 100]
in which,
E = Expected percentage of Insecticidal or fungicidal control for the combination of three active ingredient,
A is the percentage of insecticidal or fungicidal control observed by active ingredient I at defined dose,
B is the percentage of insecticidal or fungicidal control observed by Active Ingredient II at defined dose,
C is the percentage of insecticidal or fungicidal control observed by Active Ingredient III at defined dose.

When the percentage of insecticidal or fungicidal control observed for the combination is greater than the expected percentage, there is a synergistic effect. (Ratio of O/E > 1, means synergism observed.)
Table 2: Effect of Pymetrozine+Azoxystrobin+Clothianidin mixtures on growth inhibition of Alternaria solani
Concentrations Alternaria solani
Mycelial growth (mm) % Inhibition over control
Pymetrozine 150+Azoxystrobin 250+Clothianidin 100 ppm 1.2 98
Pymetrozine 150 + Azoxystrobin 250 ppm 20.6 72
Pymetrozine 150 + Clothianidin 100 ppm 62.4 14
Azoxystrobin 250 + Clothianidin 100 ppm 23.8 67
Pymetrozine 150 ppm 60.8 16
Azoxystrobin 250 ppm 24.6 66
Clothianidin 100 ppm 57.2 21
Untreated 72.4 0
Table 3 : Synergistic activity on mycelial growth of Alternaria solani
Compositions % Growth Inhibition of Alternaria solani
Obs.Value Cal.Value Ratio
Pymetrozine 150+Azoxystrobin 250+Clothianidin 100 ppm 98 77.46 1.27
Pymetrozine 150 + Azoxystrobin 250 ppm 72 71.47 1.00
Pymetrozine 150 + Clothianidin 100 ppm 14 33.65 0.41
Azoxystrobin 250 + Clothianidin 100 ppm 67 73.16 0.92
Pymetrozine 150 ppm 16
Azoxystrobin 250 ppm 66
Clothianidin 100 ppm 21

In vitro studies indicated the suppressive effect of various active ingredient on the radial growth of the mycelium of Alternaria solani (Table 2). It can be seen that the synergism was observed between Pymetrozine+Azoxystrobin+Clothianidin terms of excellent suppressive effect on radial growth of Alternaria solani (Table3).

Example 7c
The field experiment was conducted on potato aphid to evaluate the efficacy of innovative mixtures. The potato crop (variety Kufri Chandramukhi) was raised as per the standard agronomic practices. The crop was sprayed with help of manually operated knap sack sprayer with the water volume of 500 liters per hectare. Each treatment consisting of 4 replications with the each plot of 30 sq.mt. The count on aphid population were taken just before spray and 5, 10 and 15 days after spraying and the percent aphid control was calculated. The data collected and presented in below table.
Table 4 : Bioefficacy against Potato aphid, Myzus persicae
Compositions Rate (g.a.i./h) % Aphid Control
5 DAA 10 DAA 15 DAA
Pymetrozine 20%+Azoxystrobin 25%+Clothianidin 15% WG 100+125+75 98.24 97.72 95.42
Pymetrozine 20%+Azoxystrobin 25%+Tolfenpyrad 20% WG 100+125+100 96.68 95.6 92.56
Pymetrozine 20%+Azoxystrobin 25%+Flonicamid 15% WG 100+125+75 97.64 96.8 94.18
Pymetrozine 20%+Azoxystrobin 25%+Buprofezin 20% WG 100+125+100 94.46 91.82 90.22
Pymetrozine 20% +Azoxystrobin 25% WG 100+125 78.82 75.42 71.68
Azoxystrobin 25% +Clothianidin 15% WG 125+75 75.62 70.28 64.34
Azoxystrobin 25% +Tolfenpyrad 20% WG 125+100 70.26 64.12 60.62
Azoxystrobin 25% +Flonicamid 15% WG 125+75 66.46 61.42 56.82
Azoxystrobin 25% +Buprofezin 20% WG 125+100 62.16 56.42 51.26
Pymetrozine 20% +Clothianidin 15% WG 100+75 89.20 87.26 85.46
Pymetrozine 20% +Tolfenpyrad 20% WG 100+100 88.72 85.62 81.26
Pymetrozine 20% +Flonicamid 15% WG 100+75 84.88 82.46 79.74
Pymetrozine 20% +Buprofezin 20% WG 100+100 83.76 80.54 76.66
Pymetrozine 20% WG 100 84.66 62.74 50.10
Azoxystrobin 25% WG 125 22.62 0.00 0.00
Clothianidin 15% WG 75 80.16 58.24 45.62
Tolfenpyrad 20% WG 100 74.26 50.82 40.62
Flonicamid 15% WG 75 60.54 55.26 42.08
Buprofezin 20% WG 100 55.42 36.80 26.16
Untreated Check (UTC) 0 0.00 0.00 0.00
The field trial observation on potato aphid shows that the innovative mixtures of Pymetrozine + Azoxystrobin with one more insecticide selected from the groups of Clothianidin, Thiamethoxam, Dinotefuran, Imidacloprid, Tolfenpyrad, Flonicamid and Buprofezin provides excellent control along with residual control up to 15 days.
Example 7d
The field trial was conducted to evaluate the efficacy of innovative mixtures of Pymetrozine, Trifloxystrobin and one more insecticide against brown plant hopper, Nilaparvata lugens in paddy field. Trial was conducted with randomized block design with net plot size of 5m x 6m. Paddy crop was raised with all standard agronomic practices. Spraying was done with manual operated back pack sprayer with 500 liter of water spray volume per hectare. The observations was recorded by counting the no. of hoppers (adult and nymph) per hill. 10 hills per plot were observed to record the insect population at before spraying and 5, 10, 15 DAA (Days after application). The percent insect control was worked out by below formula:
Number of insect in treated plot
% Insect Control = 100- ---------------------------------------------- x 100
Number of insects in untreated plot

Table 5 : Field efficacy against paddy brown plant hopper (BPH), Nilaparvata lugens
Compositions Rate (g.a.i./h) % Brwon Plant Hopper Control
5 DAA 10 DAA 15 DAA
Pymetrozine 20%+Trifloxystrobin 25%+Clothianidin 15% WG 100+125+75 96.12 95.26 89.64
Pymetrozine 20%+Trifloxystrobin 25%+Tolfenpyrad 20% WG 100+125+100 96.08 94.78 88.44
Pymetrozine 20%+Trifloxystrobin 25%+Flonicamid 15% WG 100+125+75 93.82 92.16 90.46
Pymetrozine 20%+Trifloxystrobin 25%+Buprofezin 20% WG 100+125+100 92.66 91.8 86.36
Pymetrozine 20% +Trifloxystrobin 25% WG 100+125 86.48 81.38 73.58
Trifloxystrobin 25% +Clothianidin 15% WG 125+75 80.62 71.26 64.52
Trifloxystrobin 25% +Tolfenpyrad 20% WG 125+100 78.58 71.42 63.82
Trifloxystrobin 25% +Flonicamid 15% WG 125+75 82.48 76.40 71.48
Trifloxystrobin 25% +Buprofezin 20% WG 125+100 76.78 70.48 61.62
Pymetrozine 20% +Clothianidin 15% WG 100+75 94.28 91.48 72.58
Pymetrozine 20% +Tolfenpyrad 20% WG 100+100 91.04 89.64 68.36
Pymetrozine 20% +Flonicamid 15% WG 100+75 90.36 90.46 69.60
Pymetrozine 20% +Buprofezin 20% WG 100+100 88.54 82.46 64.52
Pymetrozine 20% WG 100 82.38 70.52 52.48
Trifloxystrobin 25% WG 125 0.00 0.00 0.00
Clothianidin 15% WG 75 68.26 48.12 28.84
Tolfenpyrad 20% WG 100 60.36 38.72 18.40
Flonicamid 15% WG 75 72.46 56.82 36.48
Buprofezin 20% WG 100 56.82 20.48 9.28
Untreated Check (UTC) 0 0.00 0.00 0.00

The innovative mixtures of Pymetrozine+Trifloxystrobin with one more insecticide selected from the group consisting of Clothianidin, Tolfenpyrad, Flonicamid and Buprofezin provides an excellent control of paddy brown plant hopper with long residual control.
,CLAIMS:We claim;

[Claim 1]. A novel pesticidal composition comprising (A) Pymetrozine (B) at least one fungicide (C) at least one insecticide wherein fungicide is selected from Azoxystrobin, Trifloxystrobin, Thifluzamide and Insecticide is selected from Clothianidin, Thiamethoxam, Dinotefuran, Imidacloprid, Tolfenpyrad, Flonicamid and Buprofezin and one or inactive excipients.
[Claim 2]. The novel pesticidal composition according to claim 1, wherein A) Pymetrozine is present in the range from 0.1 to 30%, B) fungicide is present in the range from 0.05 to 40% and (C) Insecticide is in the range 1 to 20% by weight.
[Claim 3]. The novel pesticidal composition according to claim 1 or 2, wherein inactive excipients can be selected from the group consisting of dispersant, anti-freezing agent, anti-foam agent, wetting agent, suspension aid, anti-microbial agent, thickener, quick coating agent or sticking agents and buffering agent.
[Claim 4]. The pesticidal composition according to claims 1-3 wherein formulation is selected from selected from Flowable Slurry (FS) / Flowable Suspension(FS) / Suspension Concentrate (SC), Water dispersible powder for slurry seed treatment (WS),ZC ( A mixed formulation of CS and SC), ZE (A mixed heterogeneous formulation of CS and SE), ZW( A mixed heterogeneous formulation CS and EW).

[Claim 5]. The novel pesticidal composition according to claim 1 or 4 wherein the composition is applied as foliar spray with the help of manual operated knap sack sprayer, battery or power operated or machine or tractor operated sprayer with the spray volume of 250 to 750 liters per hectare.

[Claim 6]. The novel pesticidal composition according to claim 5 wherein the said composition is applied in an amount of from 100 to 3000 g or ml per hectare, preferably from 500 to 1000 g or ml per hectare.

[Claim 7]. The novel pesticidal composition according to any preceding claims, wherein the said composition is be useful in effective for management of Cotton (Gossypium spp.), Paddy (Oryza sativa), Wheat (Triticum aestavum), Maize (Zea mays), Sugarcane (Saccharum officinarum) , Soybean (Glycin max), Peanut (Arachis hypogaea), Mustard (Brassica juncea), Green gram (Vigna radiate), Black gram (Vigna mungo), Chickpea (Cicer aritinum), Redgram (Cajanus cajan), Brinjal (Solanum melongena), Cabbage (Brassica oleracea var. capitata), Cauliflower (Brassica oleracea var. botrytis), Okra (Abelmoschus esculentus) , Onion (Allium cepa L.), Tomato (Solanum lycopersicun) , Potato (Solanum tuberosum) , Chilly (Capsicum annum), Garlic (Allium sativum), Cucumber (Cucumis sativus), Muskmelons (Cucumis melo), Watermelon (Citrullus lanatus), Bottle gourd (Lagenaria siceraria), Apple (Melus domestica), Banana (Musa spp.), Citrus groups (Citrus spp.), Grape (Vitis vinifera), Mango (Mangifera indica), Pomegranate (Punica granatum) , Tea (Camellia sinensis), Cumin (Cuminum cyminum), Fenugreek (Trigonella foenum-graecum), Fennel (Foeniculum vulgare), Coriander (Coriandrum sativum).

[Claim 8]. The novel pesticidal composition according to any preceding claim is to be used to control insects-pests belongs to the order Lepidoptera, for example Chilo partellus, Chilo suppressalis, Cydia pomonella, beetles (Coleoptera), for example Dicladispa armigera, Epila-chna varivestis, Phyllotreta nemorum, Phyllotreta striolata, flies (Diptera), e.g. Atherigona orientalis, Dacus cucurbi-tae, Dacus oleae, Liriomyza sativae, Liriomyza trifolii, Melanagromyza obtuse, Ophiomyia phaseli, thrips (Thysanoptera), e.g. Dichromothrips corbetti, Dichromothrips ssp , Frankliniella fusca, Frankliniella occidentalis, Frankliniella tritici, Scirtothrips citri, Scirtothrips dorsalis, Thrips oryzae, Thrips palmi and Thrips tabaci, true bugs (Hemiptera), e.g. Amrasca biguttula biguttula, Amrasca devastans, Amritodus atkinsoni, Aphis fabae, Aphis pomi, Aphis gossypii, Aphis crassivora, Bemisia argentifolii, Bemisia tabaci, Brevicoryne brassicae, Clavigralla gibbosa, Dysdercus cingulatus, Idioscopus spp., Leptocorisa acuta, Lygus lineolaris, Myzus persicae, Nilaparvata lugens, Nephotettix virescens, Nephotettix nigropictus, Planococcus spp., Pseudococcus spp., Pyrilla perpusilla, Psylla mail, Psylla piri, Rhopalomyzus ascalonicus, Rhopalosiphum maidis, Rhopalosi-phum padi, Rhopalosiphum insertum, Sappaphis mala, Sappaphis mail, Schizaphis graminum, Schizoneura lanuginosa, Sitobion avenae, Sogatella furcifera, Trialeurodes vaporariorum, Toxoptera aurantiia, Psylla spp., Rhopalosiphum spp., Sitobion spp., crickets, grasshoppers, locusts (Orthoptera), e.g. Gryllotalpa gryllo-talpa, Locusta migratoria, Melanoplus bivittatus, Locustana pardalina.

[Claim 9]. The novel pesticidal composition according to any preceding claim is to be used to control Fungal diseases of Wheat diseases-Common bunt Tilletia tritici, Karnal bunt Neovossia indica, Leaf rust Puccinia triticina, Puccinia recondite, Loose smut Ustilago tritici, Powdery mildew Erysiphe graminis, Blumeria graminis, Scab/head blight Fusarium graminearum, Septoria blotch Septoria tritici, Rice diseases-Blast Pyricularia oryzae, Crown sheath rot Gaeumannomyces graminis, False smut Ustilaginoidea virens, Grain discoloration by Cochliobolus miyabeanus, Curvularia spp., Fusarium spp., Microdochium oryzae, Sarocladium oryzae, Sheath blight Rhizoctonia solani, Sheath rot Sarocladium oryzae, Corn diseases- Anthracnose leaf blight Colletotrichum graminicola, Aspergillus ear and kernel rot, Banded leaf and sheath spot Rhizoctonia solani, Soybean diseases-Alternaria leaf spot, Anthracnose Colletotrichum truncatum, Charcoal rot Macrophomina phaseolina, Frogeye leaf spot Cercospora sojina, Rust Phakopsora pachyrhizi, Peanut diseases- Early leaf spot Cercospora arachidicola, Late leafspot Cercosporidium personatum, Rust Puccinia arachidis, Cotton diseases- Anthracnose Glomerella gossypii, Colletotrichum gossypii, Areolate mildew Ramularia gossypii=Cercosporella gossypii, Cucurbits diseases-Anthracnose (stem, leaf and fruit) Colletotrichum orbiculare, Cercospora leaf spot Cercospora citrullina, Powdery mildew Sphaerotheca fuliginea, Erysiphe cichoracearum, Diseases of Onion and Garlic- Black mold Aspergillus niger, Blue mold Penicillium aurantiogriseum, Botrytis leaf blight Botrytis squamosa, Diplodia stain Botryodiplodia theobromae, Stemphylium leaf blight and stalk rot Stemphylium vesicarium, Diseases of Pepper (Capsicum spp.) : Anthracnose Colletotrichum gloeosporioides, C. capsici, Glomerella cingulata, Cercospora (frogeye) leaf spot Cercospora capsici, Charcoal rot Macrophomina phaseolina, Choanephora blight (wet rot) Choanephora cucurbitarum, Damping-off and root rot Rhizoctonia solani, Phytophthora spp., Fusarium spp., Pythium spp., Downy mildew Peronospora tabacina, Fusarium stem rot Fusarium solani, Fusarium wilt Fusarium oxysporum f. sp. Capsici,Gray leaf spot Stemphylium solani, Gray mold Botrytis cinerea, Phytophthora blight Phytophthora capsici, Powdery mildew Oidiopsis sicula, Leveillula taurica, Southern blight Sclerotium rolfsii, Verticillium wilt erticillium dahliae, White mold Sclerotinia sclerotiorum, Diseases of Potato (Solanum tuberosum L.) : Brown spot and Black pit Alternaria alternate, Cercospora leaf blotch Mycovellosiella concors= Cercospora concors, Cercospora solani, Early blight Alternaria solani, Gray mold Botrytis cinerea, Late blight Phytophthora infestans, Phoma leaf spot Phoma andigena, Powdery mildew Erysiphe cichoracearum, Powdery scab Spongospora subterranean, Rhizoctonia canker and black scurf Rhizoctonia solani, Septoria leaf spot Septoria lycopersici, Silver scurf Helminthosporium solani, Verticillium wilt Verticillium albo-atrum, Tomato Diseases- Early blight Alternaria solani, Late blight Phytophthora infestans, Powdery mildew Leveillula taurica, Diseases of Apple : Alternaria blotch Alternaria mali, Apple scab Venturia inaequalis, Gray mold rot = dry eye rot, blossom-end rot Botrytis cinerea, Diseases of Banana : Black leaf streak (black Sigatoka) Mycosphaerella fijiensis, Brown spot Cercospora hayi, Cigar-end Verticillium theobromae, Sigatoka (yellow Sigatoka) Mycosphaerella musicola.Diseases of Grape (Vitis spp.) : Botrytis bunch rot and blight (Gray mold) Botrytis cinerea (teleomorph: Botryotinia fuckeliana) Downy mildew Plasmopara viticola, Powdery mildew Uncinula necator.Diseases of Mango (Mangifera indica L.) : Anthracnose Colletotrichum gloeosporioides, Black mold rot Aspergillus niger, Powdery mildew Erysiphe cichoracearum.

[Claim 10]. The novel pesticidal composition according to any proceeding claims, wherein the use of said composition exhibits improvement in plant health, vigor and yield.