DESC:
FORM 2
THE PATENTS ACT, 1970
(39 OF 1970)
&
The Patents Rules, 2003
COMPLETE SPECIFICATION
(See section 10; rule 13)

1. TITLE OF THE INVENTION – SYNERGISTIC PESTICIDAL FORMULATION OF ACETAMIPRID AND BIFENTHRIN
2. APPLICANT(S)
1. NAME: MEGHMANI ORGANICS LIMITED
2. NATIONALITY: INDIAN
3. ADDRESS: MEGHMANI HOUSE, BEHIND SAFAL PROFITAIRE, CORPORATE ROAD, PRAHLADNAGAR, AHMEDABAD, GUJARAT, INDIA-380015

3. PREAMBLE TO THE DESCRIPTION

The following specification describes the invention and the manner in which it is to be performed:

SYNERGISTIC PESTICIDAL FORMULATION OF ACETAMIPRID AND BIFENTHRIN

FIELD OF THE INVENTION:
The present invention relates to a synergistic pesticidal formulation comprising Acetamiprid and Bifenthrin. The present invention particularly relates to a synergistic pesticidal formulation comprising Acetamiprid and Bifenthrin and at least one inactive ingredient, wherein the said formulation is Soluble Concentrate (SL) formulation and the process of preparation thereof.

BACKGROUND OF THE INVENTION:

Pesticides are the chemicals which are applied on plants to kill or eliminate fungus, bacteria, insects, snails, slugs, or weeds. Pesticides are broadly used in agriculture and have facilitated a massive increase in yield of crops and productivity.

Acetamiprid (NI-25; (E)-N1-[(6-chloro-3-pyridyl)methyl]-N2-cyano-N1-methylacetamidine) is a carboxamidine that is an acetamidine in which a (6-chloropyridin-3-yl) methyl and a methyl group substitutes the amino hydrogens while cyano group replaces the hydrogen attached to the imino nitrogen.

Acetamiprid is an insecticide that belongs to the class of ‘neonicotinoids’. It is derived from 2-chloropyridine. The specific structure of acetamiprid is that of a chloronicotinyl compound and it is a potent agonist at the nicotinic acetylcholine receptors in insects. The major application of acetamiprid is to control insects such as Hemiptera, Thysanoptera, Lepidoptera and especially aphids.

Acetamiprid is a broad-spectrum and contact insecticide that is extensively used as replacement of other conventional insecticides for controlling sucking-type insects on various crops, especially leafy vegetables, fruits and tea bushes.

Acetamiprid is an agonist of the nicotinic acetylcholine receptor in various insects and affects the synapses in the insect central nervous system. It is highly soluble in water and is volatile. Acetamiprid has moderate toxicological, environmental and eco-toxicological properties.

Acetamiprid was first disclosed in US 5304566 and chemically represented as below structure:

The molecular formula of Acetamiprid is C10H11ClN4 and molecular weight is 222.67 g/ mol and having water solubility of 2950 mg/L at 20oC. Acetamiprid is stable in buffered solutions at pH 4, 5 and 7.

Acetamiprid is the insecticide from IRAC (Insecticide Resistance Action Committee) Group 4A class. Acetamiprid is a systemic insecticide with translaminar activity and with contact and stomach mode of action. The primary mechanism of acetamiprid toxicity against insects is due to its action at nicotinic cholinergic receptors. The unique nature of the neonicotinoids as insecticides is that the negatively charged cyano (or nitro) group will specifically interact with a cationic binding region that is unique to insects. This action will convey selectivity of action against insects and leave mammalian nicotinic receptors relatively unaffected.

Acetamiprid is useful to provide protection in crops like soybean, leafy vegetables, fruiting vegetables, citrus fruits, pome fruits, grapes, cotton and ornamental plants and flowers. Acetamiprid is usually formulated as soluble granules for spray application.

Bifenthrin is a broad spectrum pyrethroid insecticide used in a wide range of crops to control sucking and biting foliar pests like fire ants, blue grass weevil, armyworms, cutworms, centipedes, crickets, earwigs, millipedes, sowbugs, mole crickets, ticks, fleas, grasshoppers. Bifenthrin was first registered for use by the United States Environmental Protection Agency (U.S. EPA) in 1985.

The IUPAC name of Bifenthrin is (2-methyl-3-phenylphenyl) methyl 3-[(Z)-2-chloro-3, 3, 3-trifluoroprop-1-enyl]-2, 2-dimethylcyclopropane-1-carboxylate and the molecular formula is C23H22ClF3O2. The relative Molecular mass of Bifenthrin is 422.87 g/ mol.

Bifenthrin is a Type I pyrethroid which is effective by contact or ingestion. It affects the central and peripheral nervous system by interfering with sodium channel gating and delays the closure of the sodium channel. Bifenthrin tend to hold the channel open for shorter times compared to type II pyrethroids.

Bifenthrin is chiral molecule and is a mixture of the Z-isomer (~99.7%) and the E-isomer (~0.3%). Bifenthrin is chemically represented as below structure:

Bifenthrin is having water solubility of 0.001 mg/ L at 20 °C. Bifenthrin is the insecticide from IRAC (Insecticide Resistance Action Committee) Group 3(A) class.

Bifenthrin is effective against a broad range of foliar pests, including Coleoptera, Diptera, Heteroptera, Homoptera, Lepidoptera and Orthoptera and some species of Acarina.

Bifenthrin is useful to provide protection in crops like cereals, citrus, cotton, grapes, ornamentals and vegetables. Bifenthrin is usually formulated as emulsifiable concentrate, granular, suspension concentrate, Ultra-low volume liquid, wettable powder formulation.

In India or anywhere in the world, in agricultural production, using synthetic or chemical agent is the most effective means in order to control plant pest. However, the main disadvantage of such insecticide or pesticide is that on long run, the insects or pets develop the resistance to that insecticide or pesticide and as a result to produce effective result, higher concentration of the insecticide or pesticide is to be used. Here again using higher dose of insecticide or pesticide may result in some detrimental effect to soil as well as environment. Therefore in general practice, usually combination of pesticide with another pesticide or another herbicide or fungicide is used in different concentration as per requirement.

However, when combination of one or more pesticide are used, the main challenge comes is to develop a formulation or composition which is stable, easy to use and effective.

There are few formulations of Acetamiprid and Bifenthrin either reported individually as well in combination with other pesticides.

IN 3894/DELNP/2006 describes an insecticidal composition suitable for use in controlling general household pests comprising a mixture of i) Bifenthrin and ii) Acetamiprid, wherein the amount of bifenthrin is equal to from 0.001% by weight to 0.12% by weight and the amount of acetamiprid is equal to from 0.001% by weight to 0.20% by weight. This prior art does not comprise soluble concentrate formulation of acetamiprid and bifenthrin.

IN 1510/DEL/2015 discloses an insecticidal synergistic composition, comprising Diafenthiuron, Acetamiprid, wetting, dispersing, anticaking agent, stabilizing antifoaming agent and inert carrier silica and lavigated clay. This prior art does not comprise combination of bifenthrin with acetamiprid.

CN110637827 relates to a hygienic insecticidal composition containing acetamiprid and pyrethroid, the hygienic insecticidal composition comprises the following effective components: 1%-15% of the acetamiprid, 1%-15% of the pyrethroid and the balance of an auxiliary agent. The dosage forms comprise missible oil, emulsion in water, microemulsion and soluble liquid, wherein the pyrethroid is tetramethylfluthrin, dimefluthrin, metofluthrin, dextral trans-permethrin chlorpromazine acetylene, transfluthrin, phenothrin, teflumethrin, dextral teflumethrin, bioallethrin, chlorempenthrin, dextral allethrin and rich dextral trans-allethrin. This prior art does describe the combination acetamiprid with pyrethroid but nowhere discloses the combination of bifenthrin and acetamiprid in soluble concentrate formulation.

US2018000072 discloses a composition comprising a) Acetamiprid, b) Bifenthrin and c) a toxicity control agent. The invention also provides a method for preparing the composition as well as a method for controlling insects and acarids using the composition. This prior art does contain the combination of acetamiprid and bifenthrin but in granular formulation. While the present invention differs from the prior art because the present invention provide soluble concentrate formulation of acetamiprid and bifenthrin.

However, there is no formulation or composition available where Acetamiprid and Bifenthrin are combined in a Soluble Concentrate formulation which is stable and yet effective.

In the present invention, inventors have arrived to a pesticidal formulation of Acetamiprid and Bifenthrin in the form of Soluble Concentrate formulation which is stable, effective and overcome all the problems mentioned in prior art as described herein.

OBJECT OF THE INVENTION

The main objective of the present invention is to provide a synergistic pesticidal formulation comprising Acetamiprid and Bifenthrin, wherein the said formulation is Soluble Concentrate (SL) formulation.

Another objective of the present invention is to provide a synergistic pesticidal formulation comprising Acetamiprid and Bifenthrin which is stable.

Another objective of the present invention is to provide a synergistic pesticidal formulation comprising Acetamiprid and Bifenthrin which reduces the harmful effects to environment.

Another objective of the present invention is to provide a synergistic pesticidal formulation comprising Acetamiprid and Bifenthrin which is effective against crop pests.

Another objective of the present invention is to provide a synergistic pesticidal formulation comprising Acetamiprid and Bifenthrin which is easy to manufacture.

Another objective of the present invention is to provide a synergistic pesticidal formulation comprising Acetamiprid and Bifenthrin which is effective and in use at the field.

SUMMARY OF THE INVENTION

The main aspect of the invention is to provide a synergistic pesticidal formulation comprising Acetamiprid and Bifenthrin.

Another aspect of the present invention is to provide a synergistic pesticidal formulation comprising Acetamiprid and Bifenthrin with one or more inactive ingredients, wherein the said formulation is a Soluble Concentrate (SL) formulation.

Another aspect of the present invention there is provided a synergistic pesticidal formulation comprising Acetamiprid and Bifenthrin, wherein the said formulation is in Soluble Concentrate (SL) formulation comprising: Acetamiprid technical in the range of 10-20% w/w and Bifenthrin technical in the range of 2-15% w/w and other adjuvants.

Yet another aspect of the present invention is to provide a process for the preparation of synergistic pesticidal formulation comprising Acetamiprid and Bifenthrin and at least one inactive ingredient.

DESCRIPTION OF THE INVENTION

The present invention is all about providing a synergistic pesticidal formulation comprising Acetamiprid and Bifenthrin.

The detailed description set forth below is intended as a description of exemplary embodiments and is not intended to represent the only forms in which the exemplary embodiments may be constructed and/or utilized. The description sets forth the functions and the sequence of steps for constructing and/or operating the exemplary embodiments. However, it is to be understood that the same or equivalent functions and sequences which may be accomplished by different exemplary methods are also intended to be encompassed within the spirit and scope of the invention.

As defined herein, all scientific and technical terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which the invention belongs. Although any process and materials similar or equivalent to those described herein can be used in the practice or testing of the present invention, the preferred methods and materials are now described.

As used herein, the terms "pesticidal effect" and "pesticidal activity" mean any direct or indirect action on the target pest that results in reduced feeding damage on the seeds, roots, shoots and foliage of plants as a result of foliar spray.

To facilitate the understanding of this invention, a number of terms are defined below. Terms defined herein have meanings as commonly understood by a person of ordinary skill in the areas relevant to the present invention. Terms such as “a”, “an” and “the” are not intended to refer to only a singular entity, but include the general class of which a specific example may be used for illustration. The terminology herein is used to describe specific embodiments of the invention, but their usage does not delimit the invention, except as outlined in the claims. The main embodiment of the present invention is to provide stable Soluble Concentrate formulation of Acetamiprid and Bifenthrin which is effective against crop pests and is easy to manufacture and is safe and stable.

In various embodiments the present invention provides a synergistic pesticidal formulation of Acetamiprid and Bifenthrin.

As per one embodiment, the present invention is to provide a pesticidal soluble concentrate formulation of Acetamiprid and Bifenthrin with one or more inactive ingredients.

As per one embodiment, the present invention is to provide a pesticidal soluble concentrate formulation comprising Acetamiprid and Bifenthrin as active agent, emulsifier, binder, sticker and spreads, solvent.

As per one embodiment, the present invention provides a synergistic pesticidal formulation comprising Acetamiprid and Bifenthrin with the following mass percentage of the composition:
Sr. No. Raw Material Concentration range (% w/w)
1 Acetamiprid Technical (Purity 98% w/w) 10-20
2 Bifenthrin Technical (Purity 98% w/w) 2-15
3 Emulsifier 15-20
4 Binder 0-4
5 Spreader and sticker 2-6
6 Solvent 20-30

Active ingredient is the actual chemical in the product mixture that controls the pests. Active ingredient plays a key role in the functioning of the product mixture.

As per one embodiment, the active ingredient for the present invention is Acetamiprid and Bifenthrin, wherein acetamiprid is in the range of 10-20 %w/w and bifenthrin is in the range of 2-15 %w/w in Soluble Concentrate (SL) formulation.

Emulsifier is a chemical that aids in suspending one liquid into another. Emulsifier is a surface-active agent a surface-active agent promoting the formation and stabilization of the product mixture.

As per one embodiment, the emulsifier for the present invention is Macrogol glycerol Hydroxy stearate in the range of 15-20 %w/w.

An adjuvant is an additive which is added to make the formulations more effective, that improves or enhances application, performance, safety, storage, or handling of an active ingredient. Adjuvants include materials such as binders, stickers, stabilizers, antifreeze, antifoam, etc.

The spreaders allow the pesticidal formulation to form a uniform coating layer over the treated surface. The stickers allow the pesticidal formulation to adhere on the treated surface.

As per one embodiment, the binder for the present invention is Polyvinyl pyrrolidine in the concentration range of 0-4% w/w and the sticker/spreader used in the present invention is Alkoxylated Polyol Ester in the concentration range of 2-6% w/w.

As per one embodiment, the solvent used in the present invention can be selected from N, N-dimethyl formamide, Dimethyl sulfoxide and their combination thereof in the concentration range of 20-30% w/w.

As per one embodiment, the process for manufacturing the Soluble Concentrate pesticidal formulation of Acetamiprid and Bifenthrin comprising the steps:
1. To a clean mixing vessel of SS 316 make, with a capacity of 5000 L; solvent DMSO is weighed and transferred to the mixing vessel.
2. The technical Acetamiprid with continuous stirring for 1 hour in solvent DMSO of step (1).
3. Dissolve the technical Bifenthrin with continuous stirring for 1 hour in solvent after step (2).
4. The emulsifier blend & other ingredients as mentioned in the recipe is weighed and transferred with mixing. The mixing operation is continued for a further period of 2 hr.
5. A sample is drawn to check for the compliance of specifications and if the formulation is OK, it is taken for further processing and packing.
6. The approved material as obtained in step (5) is filtered through pressure filter (packed with absorbent material made of clay to remove fine suspended particles) at room temperature and the clear formulated material is transferred to packing as per customers, requirements.

In yet another embodiment of the present invention, the benefits of the synergistic pesticidal soluble concentrate formulation of Acetamiprid and Bifenthrin and process of preparation are described as follows:
1. Increased bio-efficacy by reduction in particle size as the surface area of product particles is higher.
2. The combination is formulated in SL formulation in order to reduce inhalation toxicity towards human and other mammals than the solo formulations of acetamiprid and bifenthrin.
3. Effective on wide range of pests without harming the desired crop.
4. As it is SL formulation, it is easily gets dispersed in water.
5. Better flowability.
6. Product is adapted to use practices by farmers.
7. Decreased dosage of Acetamiprid and Bifenthrin compared to its solo formulations.
8. Higher control of pests by the application of SL formulation of Acetamiprid and Bifenthrin.

EXAMPLES
Example 1: Acetamiprid 12.5% + Bifenthrin 12.5% Soluble Concentrate (SL) Formulation
Chemical Composition Percent (% w/w)
1 Acetamiprid Technical (Purity-98.00%) 12.04
2 Bifenthrin Technical (Purity-98.00%) 12.04
3 Macrogol glycerol Hydroxy stearate 18.00
4 Polyvinyl pyrrlidone 1.00
5 Alkoxylated Polyol Ester 3.00
6 N,N-dimethylformamide 26.96
7 Dimethyl sulfoxide 26.96
Total 100.00

Example 2: Stability study of Example 1
2.1: Heat stability for 14 days at 54 degrees centigrade & cold stability 7 days at 0 degrees centigrade
Parameters Specification (in house) Initial Heat stability at 54±2 degrees centigrade Cold stability at 0±2 degrees centigrade
Acetamiprid content % by mass 11.75 to 13.75 12.75 12.68 12.73
Bifenthrin content % by mass 11.75 to 13.75 12.80 12.75 12.78
pH range (1% aq Suspension) 5 to 8 5.75 5.8 5.82
Solubility (0.5% aq. solution) Should be soluble in water Complies Complies Complies
Specific gravity 1.05- 1.10 1.066 1.064 1.062
Flash point Above 24.5oC Complies Complies Complies

2.2: Room Temperature storage stability up to 12 months
Parameters Specification (in house) 1 month 6 months 12 months
Acetamiprid content percent by mass 11.75 to 13.75 12.72 12.70 12.68
Bifenthrin content percent by mass 11.75 to 13.75 12.80 12.78 12.75
pH range (1% aqueous suspension) 5 to 8 5.75 5.8 5.82
Solubility (0.5% aqueous solution) Should be soluble in water Complies Complies Complies
Specific gravity 1.05- 1.10 1.066 1.064 1.063
Flash point Above 24.5 degree centigrade Complies Complies Complies

Example 3: Field Trial Studies
Field trial experiments were conducted to evaluate the efficacy of Acetamiprid and Bifenthrin SL formulation in comparison to its solo applications.

The observations were recorded by counting the no. of pests before the treatment, after 7 days of treatment and after 15 days of treatment on the crops. The % percent population reduction/ control of pests was calculated by below formula:
% Population reduction/ Control = (Mean population in Untreated plot) - (Mean population in Treated Plot) X 100
(Mean population in Untreated Plot)

Example 4(a): Efficacy of Acetamiprid 12.5% + Bifenthrin 12.5% SL on Cotton whitefly (Bemisia tabaci) population control.
Location: Raichur, Karnataka, India
Season: Kharif-2021
Crop: Cotton
Date of sowing: 05/07/2021
Date of application: 04/09/2021
Treatment details Dose Pre-Treatment 7 DAT
* 15 DAT % Reduction / Control
T1 Acetamiprid 12.5% + Bifenthrin 12.5% SL 135 ml/ha 16.50 9.75 9.50 42.14
T2 Acetamiprid 12.5% + Bifenthrin 12.5% SL 160 ml/ha 17.00 4.75 1.75 80.45
T3 Acetamiprid 12.5% + Bifenthrin 12.5% SL 185 ml/ha 16.25 4.25 2.50 79.70
T4 Acetamiprid 20% SP 100ml/ha 16.00 9.25 9.25 44.36
T5 Bifenthrin 10% EC 500ml/ha 14.75 9.00 9.25 45.11
T6 Untreated control 15.50 16.25 17.00 0.00
CV** (%) 33.12 36.70 36.67
CD*** 5% 9.22 5.67 5.24
Note: *DAT: Days After Treatment, **CV= Co-efficient of Variation, *** CD= Critical Difference

The results of the above experiment show that the SL formulation of Acetamiprid 12.5% and Bifenthrin 12.5% show synergistic effect in terms of % Population reduction/ Control of whiteflies in cotton. Maximum synergism is obtained at the dosage application rate of 160 ml/ Ha with 80.45% population reduction/ control of whiteflies.

Example 4(b) Efficacy of Acetamiprid 12.5% and Bifenthrin 12.5% SL on Cotton Thrips (Thrips tabaci) population control.
Location: Raichur, Karnataka, India
Season: Kharif-2021
Crop: Cotton
Date of sowing: 05/07/2021
Date of application: 04/08/2021
Treatment details Dose Pre-Treatment 7 DAT
* 15 DAT % Reduction / Control
T1 Acetamiprid 12.5% + Bifenthrin 12.5% SL 135 ml/ ha 10.50 7.75 8.00 36.39
T2 Acetamiprid 12.5% + Bifenthrin 12.5% SL 160 ml/ ha 11.75 4.00 4.25 66.68
T3 Acetamiprid 12.5% + Bifenthrin 12.5% SL 185 ml/ ha 11.00 3.50 4.00 69.71
T4 Acetamiprid 20% SP 100ml/ha 11.75 9.50 8.25 28.31
T5 Bifenthrin 10% EC 500ml/ha 13.50 10.00 10.50 17.21
T6 Untreated control 12.75 12.75 12.00 -
CV** (%) 33.58 29.20 28.93
CD*** 5% 6.94 4.02 3.94
Note: *DAT: Days After Treatment, **CV= Co-efficient of Variation, ***CD= Critical Difference

The results of the above experiment show that the SL formulation of Acetamiprid 12.5% + Bifenthrin 12.5% show synergistic effect in terms of % Population reduction/ Control of Thrips in cotton. Maximum synergism is obtained at the dosage application rate of 185 ml/ Ha with 69.71% population reduction/ control of thrips.

Example 4(c) Efficacy of Acetamiprid 12.5% + Bifenthrin 12.5% SL on Cotton Leaf Hoppers (Amrasca biguttula biguttula) population control.
Location: Raichur, Karnataka, India
Season: Kharif-2021
Crop: Cotton
Date of sowing: 05/07/2021
Date of application: 13/08/2021
Treatment details Dose Pre-Treatment 7 DAT
* 15 DAT % Reduction / Control
T1 Acetamiprid 12.5% + Bifenthrin 12.5% SL 135 ml/ha 13.25 7.50 7.75 34.41
T2 Acetamiprid 12.5% + Bifenthrin 12.5% SL 160 ml/ha 12.25 3.00 2.75 75.27
T3 Acetamiprid 12.5% + Bifenthrin 12.5% SL 185 ml/ha 14.00 2.75 2.00 79.57
T4 Acetamiprid 20% SP 100ml/ha 12.00 7.75 8.75 29.03
T5 Bifenthrin 10% EC 500ml/ha 12.00 7.50 8.00 33.33
T6 Untreated control 13.00 11.25 12.00 -
CV** (%) 16.27 33.30 34.14
CD*** 5% 3.61 3.84 4.08
Note: *DAT: Days After Treatment, **CV= Co-efficient of Variation, ***CD= Critical Difference

The results of the above experiment show that the SL formulation of Acetamiprid 12.5% + Bifenthrin 12.5% show synergistic effect in terms of % Population reduction/ Control of Leaf hoppers in cotton. Maximum synergism is obtained at the dosage application rate of 185 ml/ Ha with 79.57% population reduction/ control of Leaf Hoppers.

Technical advancements:
The present disclosure described herein above has several technical advantages including, but not limited to, the realization of:
• A synergistic pesticidal soluble concentrate formulation comprising Acetamiprid and Bifenthrin;
• A synergistic pesticidal soluble concentrate formulation comprising Acetamiprid and Bifenthrin which is stable and is in a ready to use form;

From the results in Examples 1-4, the pesticidal combination of Acetamiprid and Bifenthrin in SL formulation claimed in the present invention has a synergistic effect on control of pests.

Throughout this specification, the word “comprise”, or variations such as “comprises” or “comprising”, will be understood to imply the inclusion of a stated element, integer or step, or group of elements, integers or steps, but not exclusion of any other element, integer or step, or group of elements, integers or steps.

Although the foregoing invention has been described in some way by way of illustration and example of purposes of clarity of understanding, it will be readily apparent to those of ordinary skill in the art in light of the teachings of this invention that certain changes and modifications may be made thereto.
,CLAIMS:We Claim:
1. A synergistic pesticidal formulation comprising:
a) Acetamiprid Technical (Purity-98.00%) in the concentration range of 10-20% w/w.
b) Bifenthrin Technical (Purity-98.00%) in the concentration range of 2-15% w/w.
c) Emulsifier in the concentration range of 15-20% w/w.
d) Binder in the concentration range of 0-4% w/w.
e) Spreader and sticker in the concentration range of 2-6% w/w
f) Solvent in the concentration range of 0-4% w/w

2. The synergistic pesticidal formulation as claimed in claim 1, wherein the formulation is soluble concentrate (SL) formulation.

3. The synergistic pesticidal formulation as claimed in claim 1, wherein Acetamiprid is in the range of 10-20% w/w.

4. The synergistic pesticidal formulation as claimed in claims 1-2, wherein Bifenthrin is in the range of 2-15% w/w.

5. The synergistic pesticidal formulation as claimed in claims 1-2, wherein the emulsifier is Macrogol glycerol Hydroxy stearate in the range of 15-20% w/w.

6. The synergistic pesticidal formulation as claimed in claims 1-2, wherein binder is Polyvinyl pyrrlidone in the range of 0-4 %w/w.

7. The synergistic pesticidal formulation as claimed in claims 1-2, wherein the stickers or spreaders are Alkoxylated Polyol Ester in the range of 2-6% w/w.

8. The synergistic pesticidal formulation as claimed in claims 1-2, wherein the solvent is selected from the group consisting of N, N-dimethyl formamide, Dimethyl sulfoxide and a combination thereof in the concentration range of 20-30% w/w.

Dated this 23rd day of November, 2022
Signature:
Name: Patel Ankit (CEO)
Meghmani Organics Limited