Synthesis Of Teduglutide

Abstract: The present invention provides for novel synthetic approach of solid phase synthesis of peptides with C-terminal Aspartic acid by anchoring the side chain carboxylic group of aspartic acid to the solid support to avoid the formation of various impurities and thus resulting in higher yield and ease the purification process. The present invention further provides the usage of free amino acids and reducing agents as antioxidants in the cleavage cocktail to negate the formation of oxidative impurities formed during the global cleavage and isolation of the peptide from solid support.

Patent Information

Application #

Filing Date

04 July 2023

Publication Number

15/2024

Publication Type

INA

Invention Field

BIO-CHEMISTRY

Status

Email

Parent Application

Applicants

BIOCON LIMITED

20th KM, Hosur Road, Electronic City Post, Karnataka Bangalore 560 100

Inventors

1. GANGA RAMU, Vasanthakumar

#40, G5, Abhinav Poorna Palace, Opp. Kaveri Handlooms, K. R. Road, Karnataka Bengaluru 560 004

2. PATIL, Nitin

B-211 Floriana Estate, 53 Sarjapur Road, Koramangala 3rd Block, Karnataka Bangalore 560034

3. SUVARNA, Deepa Shankar

# 227, 1st Floor, 2nd D-Main, Koramangala 8th Block, Koramangala Adugodi Road, Karnataka, India Bengaluru 560 095

Specification

Documents

Application Documents

#	Name	Date
1	202347044720-STATEMENT OF UNDERTAKING (FORM 3) [04-07-2023(online)].pdf	2023-07-04
2	202347044720-PRIORITY DOCUMENTS [04-07-2023(online)].pdf	2023-07-04
3	202347044720-NOTIFICATION OF INT. APPLN. NO. & FILING DATE (PCT-RO-105-PCT Pamphlet) [04-07-2023(online)].pdf	2023-07-04
4	202347044720-FORM 1 [04-07-2023(online)].pdf	2023-07-04
5	202347044720-DRAWINGS [04-07-2023(online)].pdf	2023-07-04
6	202347044720-DECLARATION OF INVENTORSHIP (FORM 5) [04-07-2023(online)].pdf	2023-07-04
7	202347044720-COMPLETE SPECIFICATION [04-07-2023(online)].pdf	2023-07-04
8	202347044720-Proof of Right [28-07-2023(online)].pdf	2023-07-28
9	202347044720-FORM-26 [21-08-2023(online)].pdf	2023-08-21
10	202347044720-MARKED COPIES OF AMENDEMENTS [27-12-2024(online)].pdf	2024-12-27
11	202347044720-FORM 18 [27-12-2024(online)].pdf	2024-12-27
12	202347044720-FORM 13 [27-12-2024(online)].pdf	2024-12-27
13	202347044720-Annexure [27-12-2024(online)].pdf	2024-12-27
14	202347044720-AMMENDED DOCUMENTS [27-12-2024(online)].pdf	2024-12-27