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Tetrahydroisoquinolin 1 One Derivative Or Salt Thereof
Abstract: [Problems] To provide a pharmaceutical, in particular a compound which can be used as a therapeutic agent for irritable bowel syndrome (IBS). [Means for Solving Problems] It was found that a tetrahydroisoquinolin-l-one derivative having an amide group at the 4-position or a pharmaceutically acceptable salt thereof has an excellent bombesin 2 (BB2) receptor antagonistic action. It is also found that the tetrahydroisoquinolin-l-one derivative is highly effective on bowel movement disorders. From the above, the tetrahydroisoquinolin-l-one derivative of the present invention is useful as a therapeutic agent for diseases associated with a BB2 receptor, in particular IBS.
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Notices, Deadlines & Correspondence
Notices, Deadlines & Correspondence
Patent Information
Application #
Filing Date
26 November 2009
Publication Number
01/2015
Publication Type
INA
Invention Field
CHEMICAL
Status
Email
Parent Application
Applicants
ASTELLAS PHARMA INC.
3-11, NIHONBASHI-HONCHO 2-CHOME, CHUO-KU,
TOKYO 103-8411
Inventors
1. HISAMICHI, HIROYUKI
C/O ASTELLAS PHARMA INC.,
3-11, NIHONBASHI-HONCHO 2-CHOME, CHUO-KU,
TOKYO 103-8411
2. SHIMADA, ITSURO
C/O ASTELLAS PHARMA INC.,
3-11, NIHONBASHI-HONCHO 2-CHOME, CHUO-KU,
TOKYO 103-8411
3. ISHIHARA, TSUKASA
C/O ASTELLAS PHARMA INC.,
3-11, NIHONBASHI-HONCHO 2-CHOME, CHUO-KU,
TOKYO 103-8411
4. TAKUWA, TOMOFUMI
C/O ASTELLAS PHARMA INC.,
3-11, NIHONBASHI-HONCHO 2-CHOME, CHUO-KU,
TOKYO 103-8411
5. SHIMIZU, TAKAFUMI
C/O ASTELLAS PHARMA INC.,
3-11, NIHONBASHI-HONCHO 2-CHOME, CHUO-KU,
TOKYO 103-8411
6. ISHIKAWA, NORIKO
C/O ASTELLAS PHARMA INC.,
3-11, NIHONBASHI-HONCHO 2-CHOME, CHUO-KU,
TOKYO 103-8411
7. MAENO, KYOICHI
C/O ASTELLAS PHARMA INC.,
3-11, NIHONBASHI-HONCHO 2-CHOME, CHUO-KU,
TOKYO 103-8411
8. SEKI, NORIO
C/O ASTELLAS PHARMA INC.,
3-11, NIHONBASHI-HONCHO 2-CHOME, CHUO-KU,
TOKYO 103-8411
Specification
More Than 100 Pages Hence Not Pasted
Documents
Orders
| Section | Controller | Decision Date |
|---|---|---|
Application Documents
| # | Name | Date |
|---|---|---|
| 1 | 6958-chenp-2009 power of attorney 26-11-2009.pdf | 2009-11-26 |
| 1 | 6958-CHENP-2009-Correspondence to notify the Controller (Mandatory) [22-04-2019(online)].pdf | 2019-04-22 |
| 2 | 6958-chenp-2009 pct 26-11-2009.pdf | 2009-11-26 |
| 2 | 6958-CHENP-2009-ExtendedHearingNoticeLetter_22Apr2019.pdf | 2019-04-09 |
| 3 | 6958-CHENP-2009-REQUEST FOR ADJOURNMENT OF HEARING UNDER RULE 129A [27-11-2017(online)].pdf | 2017-11-27 |
| 3 | 6958-chenp-2009 form-5 26-11-2009.pdf | 2009-11-26 |
| 4 | 6958-CHENP-2009-ExtendedHearingNoticeLetter_30Nov2017.pdf | 2017-11-20 |
| 4 | 6958-chenp-2009 form-3 26-11-2009.pdf | 2009-11-26 |
| 5 | 6958-CHENP-2009-REQUEST FOR ADJOURNMENT OF HEARING UNDER RULE 129A [01-09-2017(online)].pdf | 2017-09-01 |
| 5 | 6958-chenp-2009 form-2 26-11-2009.pdf | 2009-11-26 |
| 6 | 6958-CHENP-2009-HearingNoticeLetter.pdf | 2017-08-02 |
| 6 | 6958-chenp-2009 form-1 26-11-2009.pdf | 2009-11-26 |
| 7 | Correspondence by Agent_Notarized Assignment_11-04-2017.pdf | 2017-04-11 |
| 7 | 6958-CHENP-2009 DESCRIPTION (COMPLETE) 26-11-2009.pdf | 2009-11-26 |
| 8 | Abstract [05-04-2017(online)].pdf | 2017-04-05 |
| 8 | 6958-CHENP-2009 DESCRIPTION (COMPLETE) 2 26-11-2009.pdf | 2009-11-26 |
| 9 | 6958-CHENP-2009 DESCRIPTION (COMPLETE) 1 26-11-2009.pdf | 2009-11-26 |
| 9 | Claims [05-04-2017(online)].pdf | 2017-04-05 |
| 10 | 6958-chenp-2009 correspondence others 26-11-2009.pdf | 2009-11-26 |
| 10 | Description(Complete) [05-04-2017(online)].pdf | 2017-04-05 |
| 11 | 6958-chenp-2009 claims 26-11-2009.pdf | 2009-11-26 |
| 11 | Description(Complete) [05-04-2017(online)].pdf_611.pdf | 2017-04-05 |
| 12 | 6958-chenp-2009 abstract 26-11-2009.pdf | 2009-11-26 |
| 12 | Examination Report Reply Recieved [05-04-2017(online)].pdf | 2017-04-05 |
| 13 | 6958-chenp-2009 form-3 13-05-2010.pdf | 2010-05-13 |
| 13 | Form 3 [05-04-2017(online)].pdf | 2017-04-05 |
| 14 | 6958-CHENP-2009 CORRESPONDENCE OTHERS 29-07-2010.pdf | 2010-07-29 |
| 14 | Other Document [05-04-2017(online)].pdf | 2017-04-05 |
| 15 | 6958-CHENP-2009 FORM-13 21-01-2011.pdf | 2011-01-21 |
| 15 | 6958-CHENP-2009-Form-13-210111.pdf | 2016-10-19 |
| 16 | 6958-CHENP-2009 CORRESPONDENCE OTHERS 21-01-2011.pdf | 2011-01-21 |
| 16 | 6958-CHENP-2009-FER.pdf | 2016-10-05 |
| 17 | 6958-CHENP-2009-Correspondence-Form 3-130516.pdf | 2016-05-18 |
| 17 | 6958-CHENP-2009 AMENDED CLAIMS 21-01-2011.pdf | 2011-01-21 |
| 18 | 6958-chenp-2009 form-18 08-03-2011.pdf | 2011-03-08 |
| 18 | 6958-CHENP-2009-Form 3-130516.pdf | 2016-05-18 |
| 19 | 6958-chenp-2009 correspondence others 08-03-2011.pdf | 2011-03-08 |
| 19 | 6958-CHENP-2009 CORRESPONDENCE OTHERS 13-01-2015.pdf | 2015-01-13 |
| 20 | 6958-CHENP-2009 CORRESPONDENCE OTHERS 13-02-2014.pdf | 2014-02-13 |
| 20 | 6958-CHENP-2009 POWER OF ATTORNEY 13-02-2014.pdf | 2014-02-13 |
| 21 | 6958-CHENP-2009 FORM-6 13-02-2014.pdf | 2014-02-13 |
| 22 | 6958-CHENP-2009 CORRESPONDENCE OTHERS 13-02-2014.pdf | 2014-02-13 |
| 22 | 6958-CHENP-2009 POWER OF ATTORNEY 13-02-2014.pdf | 2014-02-13 |
| 23 | 6958-chenp-2009 correspondence others 08-03-2011.pdf | 2011-03-08 |
| 23 | 6958-CHENP-2009 CORRESPONDENCE OTHERS 13-01-2015.pdf | 2015-01-13 |
| 24 | 6958-CHENP-2009-Form 3-130516.pdf | 2016-05-18 |
| 24 | 6958-chenp-2009 form-18 08-03-2011.pdf | 2011-03-08 |
| 25 | 6958-CHENP-2009-Correspondence-Form 3-130516.pdf | 2016-05-18 |
| 25 | 6958-CHENP-2009 AMENDED CLAIMS 21-01-2011.pdf | 2011-01-21 |
| 26 | 6958-CHENP-2009 CORRESPONDENCE OTHERS 21-01-2011.pdf | 2011-01-21 |
| 26 | 6958-CHENP-2009-FER.pdf | 2016-10-05 |
| 27 | 6958-CHENP-2009 FORM-13 21-01-2011.pdf | 2011-01-21 |
| 27 | 6958-CHENP-2009-Form-13-210111.pdf | 2016-10-19 |
| 28 | 6958-CHENP-2009 CORRESPONDENCE OTHERS 29-07-2010.pdf | 2010-07-29 |
| 28 | Other Document [05-04-2017(online)].pdf | 2017-04-05 |
| 29 | 6958-chenp-2009 form-3 13-05-2010.pdf | 2010-05-13 |
| 29 | Form 3 [05-04-2017(online)].pdf | 2017-04-05 |
| 30 | 6958-chenp-2009 abstract 26-11-2009.pdf | 2009-11-26 |
| 30 | Examination Report Reply Recieved [05-04-2017(online)].pdf | 2017-04-05 |
| 31 | 6958-chenp-2009 claims 26-11-2009.pdf | 2009-11-26 |
| 31 | Description(Complete) [05-04-2017(online)].pdf_611.pdf | 2017-04-05 |
| 32 | 6958-chenp-2009 correspondence others 26-11-2009.pdf | 2009-11-26 |
| 32 | Description(Complete) [05-04-2017(online)].pdf | 2017-04-05 |
| 33 | 6958-CHENP-2009 DESCRIPTION (COMPLETE) 1 26-11-2009.pdf | 2009-11-26 |
| 33 | Claims [05-04-2017(online)].pdf | 2017-04-05 |
| 34 | 6958-CHENP-2009 DESCRIPTION (COMPLETE) 2 26-11-2009.pdf | 2009-11-26 |
| 34 | Abstract [05-04-2017(online)].pdf | 2017-04-05 |
| 35 | 6958-CHENP-2009 DESCRIPTION (COMPLETE) 26-11-2009.pdf | 2009-11-26 |
| 35 | Correspondence by Agent_Notarized Assignment_11-04-2017.pdf | 2017-04-11 |
| 36 | 6958-CHENP-2009-HearingNoticeLetter.pdf | 2017-08-02 |
| 36 | 6958-chenp-2009 form-1 26-11-2009.pdf | 2009-11-26 |
| 37 | 6958-CHENP-2009-REQUEST FOR ADJOURNMENT OF HEARING UNDER RULE 129A [01-09-2017(online)].pdf | 2017-09-01 |
| 37 | 6958-chenp-2009 form-2 26-11-2009.pdf | 2009-11-26 |
| 38 | 6958-CHENP-2009-ExtendedHearingNoticeLetter_30Nov2017.pdf | 2017-11-20 |
| 38 | 6958-chenp-2009 form-3 26-11-2009.pdf | 2009-11-26 |
| 39 | 6958-CHENP-2009-REQUEST FOR ADJOURNMENT OF HEARING UNDER RULE 129A [27-11-2017(online)].pdf | 2017-11-27 |
| 39 | 6958-chenp-2009 form-5 26-11-2009.pdf | 2009-11-26 |
| 40 | 6958-CHENP-2009-ExtendedHearingNoticeLetter_22Apr2019.pdf | 2019-04-09 |
| 40 | 6958-chenp-2009 pct 26-11-2009.pdf | 2009-11-26 |
| 41 | 6958-CHENP-2009-Correspondence to notify the Controller (Mandatory) [22-04-2019(online)].pdf | 2019-04-22 |
| 41 | 6958-chenp-2009 power of attorney 26-11-2009.pdf | 2009-11-26 |
Search Strategy
| 1 | search6958_04-10-2016.pdf |