Purpose of present work was to fabricate voriconazole transdermal spray for topical fungal infection. Transdermal spray was generated by using film forming polymers like Eudragit RLPO and Ethyl cellulose along with eutectic mixture (camphor: menthol) used as a penetration enhancer. Formulation optimized by 3" factorial designs, regression analysis, overlay plots and response surface methodology. Evaluate various physicochemical parameters, ex-vivo, kinetic model fitting, characterization by FT-IR and DSC, skin irritation, in-vivo pharmacodynamics studies and container related evaluations. Concentration of Eudragit RLPO and EC were showed influence on viscosity and t50. Diffusion study show 75% of drug transport with 65.8μg/cm2/hr fluxes. Penetration enhancers' show increase penetration of drug through the formulation its increase 1.68 fold. Here concluded that fabricated film forming voriconazole transdermal spray formulations penetrate to the deep layer of skin and it is feasible to treat dennatological fungal infection. Unlike conventional formulations it provides wide range of treatment for fungal infections.
Application ID | 3386/MUM/2014 |
Invention Field | MECHANICAL ENGINEERING |
Date of Application | 2014-10-24 |
Publication Number | 19/2016 |
Name | Address | Country | Nationality |
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KALPESH CHHOTALAL ASHARA | "ASHIRWAD", 37, G.H.B., DUDHSAGAR ROAD, NEAR E.C.H. JAY STEEL LTD. OPP. GOVT. SCHOOL NO.78, RAJKOT-360 003, GUJARAT, INDIA. | India | India |
Name | Address | Country | Nationality |
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NITIN MERUBHAI MORI | AT: ZANZARIYA, TA: UNA, DIST: JUNAGADH, POST: BODIDAR-362560, GUJARAT, INDIA | India | India |
KALPESH CHHOTALAL ASHARA | "ASHIRWAD", 37, G.H.B., DUDHSAGAR ROAD, NEAR E.C.H. JAY STEEL LTD. OPP. GOVT. SCHOOL NO.78, RAJKOT-360 003, GUJARAT, INDIA. | India | India |
NAVIN R. SHETH | DEPARTMENT OF PHARMACEUTICAL SCIENCES, SAURASHTRA UNIVERSITY, RAJKOT, GUJARAT. | India | India |
Name | Date |
3386-MUM-2014-FORM 3.pdf | 2018-08-11 |
3386-MUM-2014-PRE-GRANT OPPOSITION-16-10-2017.pdf | 2017-10-16 |
3386-MUM-2014-PRE-GRANT OPPOSITION-20-10-2017.pdf | 2017-10-20 |
3386-MUM-2014-FORM 2.pdf | 2018-08-11 |
3386-MUM-2014-Other Patent Document-190815.pdf | 2018-08-11 |
3386-MUM-2014-FORM 2(TITLE PAGE).pdf | 2018-08-11 |
3386-MUM-2014-Form 2(Title Page)-190815.pdf | 2018-08-11 |
3386-MUM-2014-Form 18-190815.pdf | 2018-08-11 |
3386-MUM-2014-DESCRIPTION(PROVISIONAL).pdf | 2018-08-11 |
3386-MUM-2014-FORM 1.pdf | 2018-08-11 |
3386-MUM-2014-Form 2-190815.pdf | 2018-08-11 |
3386-MUM-2014-CORRESPONDENCE-11-10-2017.pdf | 2017-10-11 |
3386-MUM-2014-CORRESPONDENCE.pdf | 2018-08-11 |
3386-MUM-2014-Claims-190815.pdf | 2018-08-11 |
3386-MUM-2014-AbandonedLetter.pdf | 2020-03-02 |
3386-MUM-2014-FER.pdf | 2019-08-23 |
3386-MUM-2014-Abstract-190815.pdf | 2018-08-11 |
3386-MUM-2014-Correspondence-090516.pdf | 2018-08-11 |
3386-MUM-2014-Description(Complete)-190815.pdf | 2018-08-11 |
Applicant | Section | Controller | Decision Date | URL |