DESC:FIELD OF THE INVENTION
[001] The present invention generally relates to manufacturing pharmaceutical and nutraceutical capsules, more specifically it relates to a user preferred system and a method of dosing the capsules.

BACKGROUND OF THE INVENTION
[002] Oral administration has become one of the most preferred routes for drug administration. It is the most preferred route due to its advantages, such as non-invasiveness, patient compliance and convenience of administration. Active ingredients or medicaments, such as nutritional or therapeutic agents, may be orally administered in a variety of physical states (i.e., solid, liquid or gas). In this regard, tablets and capsules are generally prescribed for the oral delivery of the medicaments. As conventionally known, a tablet is a pill that is entirely composed of medication and is made by compressing powdered medicine into a solid, smooth pill.
[003] Traditional capsular embodiments include a first containment section referred to as a base or a base shell, and a second containment section referred to as a cap. The two containment sections of a capsule are usually formulated and designed in a manner such that medication/ active pharmaceutical ingredient to be encapsulated may be introduced into the base section, whereas open end of the cap section may be correspondingly positioned over open end of the base section. Subsequently, walls of the cap and the base are generally brought in physical contact with one another to form a single internal cavity. The capsules are preferred over tablets where a faster action, high bioavailability or tastelessness are desired.
[004] With increasing need of automation, faster turn-around times; robustness in manufacturing processes, responsibility to produce encapsulated products shifted mainly to industrial manufacturers. Contemporaneous with overall development of the encapsulation industry, those skilled in the art have advanced the state of the encapsulation art. In the past few decades there has been significant improvement in encapsulation technology including development of soft elastic capsules, film-coating techniques, micro-encapsulation, multiple-compartment technology, etc. However, despite exponential growth there is still a lot to be desired from the encapsulation industry.
[005] To begin with, capsule manufacturing is often more onerous to manufacture (in terms of the number of both ingredients and processing steps) and is generally only cost effective to produce on large scale, meaning large manufacturing facilities with sophisticated equipment is usually required. Further, multiple fillings of different materials in a single capsule are a highly time-consuming task which requires skilled labour at different filling stations. Even though multiple fillings of the capsules are achieved, having variable weights of each of the fillings for separate batches is still desired for. These manufacturing limitations have a detrimental impact on consumer choice and/or the customizability of the dosage forms since, it is overall an impractical and non-cost effective to mass produce a wide variety of different dosages for a given medicament via conventional manufacturing techniques. Consumers (e.g. patients) and healthcare professionals (e.g. doctors, pharmacists) must therefore make the best of the limited variety of dosages available, as dictated by the suppliers rather than a consumer's need.
[006] Thus, there is a need in the art for a user preferred capsule dosing system and a method which addresses at least the aforementioned problems.

SUMMARY OF THE INVENTION
[007] In one aspect, the present invention is directed to a user preferred dosing system for producing capsules having at least two variably weighed materials. The system of the present invention has a holder for holding a plurality of empty base shells of the capsules. The system further has a plurality of capsule filling stations, each of the capsule filling station having a cartridge for containing a predetermined material, whereby the cartridge has a substantially cylindrical outer surface with a sensor-readable tag attached to the cylindrical surface, and a dosing mechanism disposed vertically downwards from the cartridge. The dosing mechanism is configured to receive a set dose of the material from the cartridge and dispensing the set dose of the material in the base shells of each of the capsules. The system further has at least one gravimetric sensing system configured to weigh the base shells of the capsules. Further, the system has at least one conveying mechanism for conveying the holder from the at least one gravimetric sensing system towards one of the capsule filling stations and back; and one or more processors configured to set a predetermined dose based on instructions received from scanning the sensor-readable tags by one or more sensors, such that the dosing mechanisms in each of the capsule filling stations dispense the predetermined set doses of the materials in each of the base shells of the capsules.
[008] In an embodiment of the invention, the system has a memory including instructions that, when executed by the one or more processors, cause the one or more processors to: scan the sensor-readable tags disposed on the cartridges by the one or more sensors; dispense the predetermined dose of the materials from the cartridges into the dosing mechanisms based on the instructions received from the sensor-readable tags; and dispense the predetermined doses of the materials from the dosing mechanisms into the base shells of the capsules.
[009] In yet another embodiment of the invention, the dosing mechanism has a cavity disposed vertically downwards the cartridge to receive a set dose of the material from the cartridge. The dosing mechanism further has a linearly movable plunger disposed vertically inside the cavity, whereby the plunger is coupled with the one or more processors thereby volumetrically creating a desired space inside the cavity by a linear movement. Additionally, the dosing mechanism also has a chute coupled with the cavity and aligned with an opening of the base shell of the capsule in order to dispense the set dose of the material from the cavity in the base shell.
[010] In a further embodiment of the invention, the gravimetric sensing system is a load cell. In another embodiment, the sensor-readable tags consist of a Quick-Response (QR) code or a Radio Frequency Identification (RFID) code. In another embodiment, the predetermined materials in each of the cartridges of the plurality of the capsule filling stations, consists of a nutraceutical compound, a pharmaceutical compound, a pharmaceutical formulation, an active pharmaceutical ingredient, or an excipient.
[011] In another aspect, the present invention relates to a user preferred dosing method, whereby the method has the steps of conveying, a holder to at least one load cell in order to weigh a plurality of empty base shells of the capsules disposed in the holder. In the next step, the method includes transporting the holder to a first capsule filling station. In the further step, the method involves scanning sensor-readable tags disposed on a first cartridge of the first capsule filling station by one or more sensors. In the next step, the method includes dispensing a predetermined dose of the material from the first cartridge into the base shells of the capsules based on readings from the sensor-readable tags. The next step includes conveying the holder to the at least one load cell in order to weigh the plurality of filled base shells of the capsules to verify weights of each of the base shells. The method further includes transporting the holder to a second capsule filling station. The next step includes scanning the sensor-readable tags disposed on a second cartridge of the second capsule filling station by one or more sensors. Further, the next step is dispensing a predetermined dose of the material from the second cartridge into the base shells of the capsules based on readings from the sensor-readable tags. The method then has the step of conveying the holder to the at least one load cell in order to weigh the plurality of the filled base shells of the capsules to verify weights of each of the base shells. The method then includes conveying the filled base shells to capsule packaging station, such that each of the capsules comprises at least two predetermined set doses of the materials.
[012] In an embodiment of the invention, the method includes the steps of transporting, the holder back to the first capsule filling station upon detection of discrepancy in the weights of the base shells; and refilling the predetermined dose of the materials from the first cartridge into the base shells of the capsules.
[013] In a further embodiment of the invention, the method includes transporting, the holder back to the second capsule filling station upon detection of discrepancy in the weights of the filled base shells; and refilling the predetermined dose of the materials from the second cartridge into the base shells of the capsules.
[014] In yet another embodiment, the sensor-readable tags consist of a Quick-Response (QR) code or a Radio Frequency Identification (RFID) code. In an embodiment of the invention the predetermined materials in each of the first cartridge and the second cartridge, consists of a nutraceutical compound, a pharmaceutical compound, a pharmaceutical formulation, an active pharmaceutical ingredient, or an excipient.

BRIEF DESCRIPTION OF THE DRAWINGS
[015] Reference will be made to embodiments of the invention, examples of which may be illustrated in accompanying figures. These figures are intended to be illustrative, not limiting. Although the invention is generally described in context of these embodiments, it should be understood that it is not intended to limit the scope of the invention to these particular embodiments.
Figure 1 shows a user preferred dosing system in accordance with an embodiment of the invention.
Figure 2 shows a gravimetric sensing system in accordance with an embodiment of the invention.
Figure 3a shows a filling station in accordance with an embodiment of the invention.
Figure 3b shows a filling station in accordance with an embodiment of the invention.
Figure 3c shows filling of a base shell of a capsule in the filling station in accordance with an embodiment of the invention.
Figure 4 shows a capsule closing station in accordance with an embodiment of the invention.
Figure 5 shows a user preferred dosing method in accordance with an embodiment of the invention.

DETAILED DESCRIPTION OF THE INVENTION
[016] The present invention relates to a user preferred system and a method of dosing capsules.
[017] Referring to Figure 1, in one aspect the present invention relates to a user preferred dosing system 100 for producing capsules 200 (shown in Figure 5), whereby each of the capsules 200 has at least two variably weighted materials 17. According to an embodiment of the invention, empty capsules 200 having a cap 210 and a base shell 220 are brought into a capsule loading and separation station 30. The base shells 220 of the capsules 200 are separated from the caps 210 in the capsule loading and separation station 30 and the base shells 220 are prepared for filling predetermined materials 17. In an embodiment of the invention, the predetermined material 17 is a nutraceutical compound, a pharmaceutical compound, a pharmaceutical formulation, an active pharmaceutical ingredient, or an excipient. According to the invention, the system 100 has at least a holder 60 (shown in Figure 2). In another embodiment of the invention, the system 100 has a plurality of such holders. Pluralities of the separated base shells 220 of the capsules 200 are then loaded in the holder 60 and the holder is conveyed by a conveying mechanism to various stations in the system 100 as explained hereinunder.
[018] As seen in the Figure 1, the system 100 has a plurality of capsule filling stations 10 – a first capsule filling station 10a, a second capsule filling station 10b, a third capsule filling station 10c, a fourth capsule filling station 10d, a fifth capsule filling station 10e, so on and so forth. As seen in Figure 3a, according to the invention, each of the capsule filling stations 10 has at least one cartridge 12. Each of the cartridges 12 has a substantially cylindrical outer surface and is configured to contain a predefined volume of the material 17. Further, each cartridge 12 has a sensor-readable tag (not shown) on the outer surface of the cartridge 12. In various embodiments, the sensor-readable tag is either disposed on, or removably attached to, or etched on the cylindrical outer surface of the cartridge 12. In another embodiment of the invention, the sensor-readable tag is a Quick-Response (QR) code or a Radio Frequency Identification (RFID) code.
[019] According to the invention, the system 100 has one or more processors (not shown) and one or more sensors (not shown). The one or more processors are configured to set a predetermined dose based on instructions received from scanning the sensor-readable tags by the one or more sensors. Accordingly, the predetermined set doses of the materials 17 are made available to be dispensed in each of the base shells 220 of the capsules 200. In an embodiment of the invention, the system 100 further has a memory (not shown) which stores the predefined instructions. According to the embodiment, when the instructions are executed, they cause the one or more processors to scan the sensor-readable tags disposed on the cartridges by the one or more sensors. Further, the one or more processors cause dispensing the predetermined dose of the materials 17 from the cartridges 12 into dosing mechanisms (explained hereinunder) based on the instructions received from the sensor-readable tags. Furthermore, as per the embodiment, the predetermined doses of the materials 17 are then dispensed from the dosing mechanisms into the base shells 220 of the capsules 200.
[020] Referring now to Figures 3a, 3b and 3c, the system 100 has a dosing mechanism. The dosing mechanism is disposed vertically downwards from the cartridge 17 and is configured to receive a set dose of the material 17 from the cartridge 12. As per the invention, the dosing mechanism then dispenses the set dose of the material 17 in the base shells 220 of each of the capsules 200. In an embodiment of the invention, the dosing mechanism has a cavity 14 disposed vertically downwards the cartridge 12. The cavity 14 receives the set dose of the material 17 from the cartridge 12. The set dose of the material 17 is dispensed by the processor as explained hereinabove, i.e. upon receipt of instructions stored on the sensor-readable tags the processor assesses the user preferred dose that is required inside each of the capsules 200. Based on the preferred dose amount, the processor controls the dispensing of the material 17 from the cartridge into the cavity. As seen in Figures 3a and 3b, the cartridge 12 is coupled with a slider/ gate 13. Thus, upon instructions from the processor, the slider 13 slides away in order for the material 17 to be released into the cavity 14. The dosing mechanism further has a linearly movable plunger 16 which is disposed inside the cavity 14. The plunger 16 being coupled to the one or more processors is thus configured to move vertically inside the cavity 14 by an electrical actuator 19. The plunger 16 thereby volumetrically creates a desired space inside the cavity 16 thus receiving set dose of the predetermined material inside the cavity 14. According to the embodiment, as soon as the set dose of the material 17 is dispensed inside the cavity 14, the slider 13 slides back underneath the opening of the cartridge 12 to prevent any spillage of the material 17 stored in the cartridge 12. In the same embodiment, and as seen in the Figures 3a, 3b, and 3c, the dosing mechanism has a chute 18. The chute 18 is coupled with the cavity 14 and is aligned with an opening of the base shell 220 of the capsule 200. Accordingly, the set dose of the material 17 passes from the cavity 14 to the chute 18 due to the vertical moving plunger 16 and the set dose of the material 17 from the cavity 14 is subsequently dispensed into the base shell 220 of the capsule 200.
[021] Referring to Figure 2, the system 100 of the present invention has a gravimetric sensing system 20. In an embodiment, the gravimetric sensing system 20 is a load cell. Further, the system 100 has at least one conveying mechanism (not shown). When the empty base shells 220 of the capsules 200 are loaded in the holder 60, the holder 60 is conveyed to the gravimetric sensing system 20 by the conveying mechanism. The holder 60 is held by a gripper assembly 40, the empty base shells 220 of the capsules 200 are weighed and the gravimetric sensing system 20 is tared accordingly. After weighing the empty base shells 220, the conveying mechanism then conveys the holder 60 from the gravimetric sensing system 20 towards one of the capsule filling stations 10. Once the base shell 220 of the capsule 200 is filled with the predetermined dose of the material 17, the conveying system conveys the holder 60 back to the gravimetric sensing system 20 to verify weights of the each of the base 220 and ensure that all the base shells 220 have the desired, user preferred quantity of the material 17. Upon confirmation that all the base shells 220 weigh equally, the conveying mechanism conveys the holder with the base shells 220 filled with the material 17 to another capsule filing station 10. Once all the base shells 220 are filled, weighed and verified, the holder 60 is conveyed to a capsule closing station 50 in order to close the base shells 220. As seen in Figure 4, in an embodiment of the invention, the capsule closing station 50 receives the holder 60 with open and filled base shells 220. The caps 210 of the capsules 200 are then aligned with each of the base shells 220. Holder of the caps 210 is operatively coupled with a top closing pin 54, while the holder 60 of the base shells 220 is operatively coupled with bottom closing pin 52 which is further coupled with a lever 56. The lever 56 pivots the bottom closing pin 52 towards the top closing pin 54 thereby leading to closure of the capsules 200. The finished capsules 200 are then transported to a packaging station either manually or automatically.
[022] The present invention, in another aspect, relates to a user preferred dosing method 300 for producing capsules 200 (shown in Figure 5), whereby each of the capsules 200 has at least two variably weighted materials 17. Referring to Figure 5 which depicts a method for producing capsules 200 with at least two variably weighted materials 17. As explained hereinbefore, according to an embodiment of the invention, empty capsules 200 having a cap 210 and base shell 220 are brought into a capsule loading and separation station 30. The base shells 220 of the capsules 200 are separated from the caps 210 in the capsule loading and separation station 30. Further, the separated base shells 220 are prepared for filling the predetermined materials 17. In this regard, a plurality of the base shells 220 are loaded in the holder 30 ready to be filled. In an embodiment of the invention, the predetermined material 17 is a nutraceutical compound, a pharmaceutical compound, a pharmaceutical formulation, an active pharmaceutical ingredient, or an excipient.
[023] As seen in Figure 5, at step 310 the holder 30 is conveyed to the at least one load cell 20. Once the empty base shells 220 are placed on the load cell, the load cell 20 is tared. In an embodiment of the invention, there are plurality of such holders 60 having a plurality of the base shells 220 of the capsules. Upon weighing, the holder 60 with the base shells 220 is then transported at step 320, to the first capsule filling station 10a. At the first capsule filling station 10a, the holder 60 is disposed vertically downwards the cartridge 12. As explained hereinbefore, each cartridge 12 in each of the capsule filling stations 10 has a sensor-readable tag (not shown) on the outer surface of the cartridge 12. In various embodiments, the sensor-readable tag is either disposed on, or removably attached to, or etched on the cylindrical outer surface of the cartridge 12. In another embodiment of the invention, the sensor-readable tag is a Quick-Response (QR) code or a Radio Frequency Identification (RFID) code.
[024] At step 330, the sensor-readable tag disposed on a first cartridge (not shown) of the first capsule filling station 10a is scanned by the one or more sensors. Instructions/ recipes stored on the sensor-readable tag is then communicated to the one or more processors. The one or more processors process the recipe and accordingly, communicate commands to the slider 13. As explained hereinabove, the dosing mechanism has a cavity 14 disposed vertically downwards the cartridge 12. The cavity 14 receives the set dose of the material 17 from the cartridge 12. Basis the preferred dose amount, the processors controls the dispensing of the material 17 from the cartridge into the cavity 14. As seen in the Figures 3a, 3b and 3c, the cartridge 12 is coupled with a slider/ gate 13. Thus, upon instructions from the one or more processors, the slider 13 slides away in order for the material 17 to be released into the cavity 14. Further, the plunger 16 being coupled to the one or more processors and being configured to move vertically inside the cavity 14 by an electrical actuator 19, volumetrically creates a desired space inside the cavity 16 thus receiving set dose of the predetermined material 17 inside the cavity 14. According to the embodiment, as soon as the set dose of the material 17 is dispensed inside the cavity 14, the slider 13 slides back to prevent any spillage of the material 17 stored in the cartridge 12. Further, the set dose of the material 17 passes from the cavity 14 to the chute 18 due to the vertical moving plunger 16 and at step 340, the set dose of the material 17 from the cavity 14 is subsequently dispensed into the base shell 220 of the capsule 200.
[025] At step 350, the holder 60 carrying the filed base shells 220 of the capsules 200 with the predetermined dose of the material 17 is conveyed from the first capsule filling station 10a to the at least one load cell 20. At the load cell, the plurality of the filled base shells 220 of the capsules 200 are weighed to verify weights of each of the base shells 220. In an embodiment of the invention, and as seen in Figure 5, if the weights of the filled base shells 220 are with a satisfactory range, the holder 60 is transported to the next station. In case the weights are not within the satisfactory range, the base shells 220 of the capsule are emptied. The holder 60 with the empty base shells 220 of the capsules 200 is transported back to the first capsule filling station 10a whereby the set dose of the material 17 is refilled in the base shells 220. Upon refilling the holder 60 is transported to the load cell 20 again to check and verify the weights. Once the weights of the filled base shells 220 are within a satisfactory range, the holder 60 is transported to the next station. Accordingly, at step 360, the holder 60 with the filled base shells 220 is transported to the second capsule filling station 10b.
[026] At step 370 the sensor-readable tag disposed on a second cartridge (not shown) of the second capsule filling station 10b is scanned by the one or more sensors. Instructions/ recipes stored on the sensor-readable tag is then communicated to the one or more processors. The one or more processors process the recipe and accordingly, communicate commands to the slider 13 present at the second cartridge. Similar to the working of the dosing mechanism, basis the preferred dose amount, the second set dose of the material 17 from the cavity 14 is subsequently dispensed, at step 380 into the filled base shell 220 of the capsule 200.
[027] Yet again, at step 390, the holder 60 carrying the filed base shells 220 of the capsules 200 with the predetermined doses of the material 17 is conveyed from the second capsule filling station 10b to the at least one load cell 20. At the load cell 20, the plurality of the filled base shells 220 of the capsules 200 are weighed to verify weights of each of the base shells 220. In an embodiment of the invention, and as seen in Figure 5, if the weights of the filled base shells 220 are with a satisfactory range, the holder 60 is transported to the next station. In case the weights are not within the satisfactory range, the base shells 220 of the capsule are transported back to the second capsule filling station 10b whereby the set dose of the material 17 is refilled in the base shells 220. Upon refilling, the holder 60 is transported to the load cell 20 again to check and verify the weights. Once the weights of the filled base shells 220 are within a satisfactory range, the holder 60 is transported to the next station. It must be noted that basis various embodiments of the invention, and user preference of the doses, the holder is transported to the next capsule filing station until the user preferred recipe in each of the capsule 200 is achieved.
[028] Once user preferred recipe in each of the capsule 200 is achieved, at step 360, the holder 60 with the filled base shells 220 with at least two predetermined set doses of the materials 18 is transported to the capsule packaging station 50. As explained hereinabove, in an embodiment of the invention, the capsule closing station 50 receives the holder 60 with open and filled base shells 220. The caps 210 of the capsules 200 are then aligned with each of the base shells 220. Holder of the caps 210 is operatively coupled with a top closing pin 54, while the holder 60 of the base shells 220 is operatively coupled with bottom closing pin 52 which is further coupled with a lever 56. The lever 56 pivots the bottom closing pin 52 towards the top closing pin 54 thereby leading to closure of the capsules 200. The finished capsules 200 are then transported to a packaging station either manually or automatically.
[029] Advantageously, in view of the present invention, the manufacturing of capsules having more than one ingredient is easy, timesaving and cost effective. The process requires minimum human intervention thereby achieving a desired result within a desired amount of time. Further, not only multiple fillings of the capsules are achieved, but also each capsule manufactured by the system and method envisaged by the present invention, can have variable weights of each of the fillings. Furthermore, multiple batches of such capsules can be easily produced. The system of the present invention thereby uses machine learning to a substantial extent and thus makes the manufacturing of the tablets even more timesaving, cost-saving and resource-saving.
[030] While the present invention has been described with respect to certain embodiments, it will be apparent to those skilled in the art that various changes and modification may be made without departing from the scope of the invention as defined in the following claims.
,CLAIMS:WE CLAIM

1. A user preferred dosing system (100) for producing capsules (200) having at least two variably weighed materials (17), the system (100) comprising:
a holder (60) for holding a plurality of empty base shells (220) of the capsules (200);
a plurality of capsule filling stations (10), each of the capsule filling station (10) comprising:
a cartridge (12) for containing a predetermined material (17), the cartridge (12) having a substantially cylindrical outer surface with a sensor-readable tag attached to the cylindrical surface; and
a dosing mechanism disposed vertically downwards from the cartridge (17), the dosing mechanism configured to receive a set dose of the material (17) from the cartridge (12) and dispensing the set dose of the material (17) in the base shells (220) of each of the capsules (200);
at least one gravimetric sensing system (20) configured to weigh the base shells (220) of the capsules (200);
at least one conveying mechanism for conveying the holder (60) from the at least one gravimetric sensing system (20) towards one of the capsule filling stations (10) and back; and
one or more processors configured to set a predetermined dose based on instructions received from scanning the sensor-readable tags by one or more sensors, such that the dosing mechanisms in each of the capsule filling stations (10) dispense the predetermined set doses of the materials (17) in each of the base shells (220) of the capsules (200).

2. The user preferred dosing system (100) as claimed in claim 1, further comprises: a memory including instructions that, when executed by the one or more processors, cause the one or more processors to:
scan the sensor-readable tags disposed on the cartridges by the one or more sensors;
dispense the predetermined dose of the materials (17) from the cartridges (12) into the dosing mechanisms based on the instructions received from the sensor-readable tags; and
dispense the predetermined doses of the materials (17) from the dosing mechanisms into the base shells (220) of the capsules (200).

3. The user preferred dosing system (100) as claimed in claim 1, wherein the dosing mechanism comprises:
a cavity (14) disposed vertically downwards the cartridge (12) to receive a set dose of the material (17) from the cartridge (12);
a linearly movable plunger (16) disposed vertically inside the cavity (14), the plunger (16) coupled with the one or more processors thereby volumetrically creating a desired space inside the cavity (16) by linear movement; and
a chute (18) coupled with the cavity (14) and aligned with an opening of the base shell (220) of the capsule (200) in order to dispense the set dose of the material (17) from the cavity (14) in the base shell (220).

4. The user preferred dosing system (100) as claimed in claim 1, wherein the gravimetric sensing system (20) is a load cell.

5. The user preferred dosing system (100) as claimed in claim 1, wherein the sensor-readable tags consist of a Quick-Response (QR) code or a Radio Frequency Identification (RFID) code.

6. The user preferred dosing system (100) as claimed in claim 1, wherein the predetermined materials (17) in each of the cartridges (12) of the plurality of the capsule filling stations (10), consists of a nutraceutical compound, a pharmaceutical compound, a pharmaceutical formulation, an active pharmaceutical ingredient, or an excipient.

7. A user preferred dosing method (300), comprising the steps of:
conveying (310), a holder (60) to at least one load cell (20) in order to weigh a plurality of empty base shells (220) of the capsules (200) disposed in the holder (60);
transporting (320) the holder (60) to a first capsule filling station (10a);
scanning (330) sensor-readable tags disposed on a first cartridge of the first capsule filling station (10a) by one or more sensors;
dispensing (340) a predetermined dose of the material (17) from the first cartridge into the base shells (220) of the capsules (200) based readings from the sensor-readable tags;
conveying (350) the holder (60) to the at least one load cell (20) in order to weigh the plurality of filled base shells (220) of the capsules (200) to verify weights of each of the base shells (220);
transporting (360) the holder to a second capsule filling station (10b);
scanning (370) the sensor-readable tags disposed on a second cartridge of the second capsule filling station (10b) by the one or more sensors;
dispensing (380) a predetermined dose of the material (17) from the second cartridge into the base shells (220) of the capsules (200) based on readings from the sensor-readable tags;
conveying (390), the holder (60) to the at least one load cell (20) in order to weigh the plurality of the filled base shells (220) of the capsules (200) to verify weights of each of the base shells (220); and
conveying (400) the filled base shells (220) to capsule packaging station (50), such that each of the capsules (200) comprises at least two predetermined set doses of the materials (17).

8. The user preferred dosing method (300) as claimed in claim 7 comprises:
transporting the holder (60) back to the first capsule filling station (10a) upon detection of discrepancy in the weights of the base shells (220); and
refilling the predetermined dose of the materials (17) from the first cartridge into the base shells (220) of the capsules (200).

9. The user preferred dosing method (300) as claimed in claim 7 comprises:
transporting the holder (60) back to the second capsule filling station upon detection of discrepancy in the weights of the filled base shells; and
refilling the predetermined dose of the materials (17) from the second cartridge into the base shells (220) of the capsules (200).

10. The user preferred dosing method (300) as claimed in claim 7, wherein the sensor-readable tags consist of a Quick-Response (QR) code or a Radio Frequency Identification (RFID) code.

11. The user preferred dosing method (300) as claimed in claim 7, wherein the predetermined materials (17) in each of the first cartridge and the second cartridge, consists of a nutraceutical compound, a pharmaceutical compound, a pharmaceutical formulation, an active pharmaceutical ingredient, or an excipient.