"Vla 4 Antagonists"

Abstract: The present invention relates to certain non peptidyl derivatives as very late antigen (VLA-4)inhibitors and to the processes for the synthesis of the same. The compounds of this invention can be useful, for inhibition and prevention of cell adhesion and cell adhesion mediated pathologies including inflammatory adn autoimmunen diseases such as bronchial asthma, rheumatoid arthritis, type I diabetes, multiple sclerosis, allograft rejection or psoriasis. This invention also relates to pharmacological compositions containing the compounds of the present invention and the methods of treating bronchial asthma, rheumatoid arthritis, multiple sclerosis, type I diabetes, psoriais, allograft rejection, and other inflammatory and/or autommune disorders using the compounds.

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