A process for the preparation of optically pure R (-) salbutamol of formula (6) and its pharmaceutically acceptable salts by using a (+)4-nitro tartranilic acid as the resolving agent and a binary solvent system comprising alkyl acetate and C1 to C4 branched or normal chain alcohol for dissolution of the racemic mi...

A process for the preparation of benazepril hydrochloride in high yield with high purity. A chiral tert-butyl ester of 3(S)-amino-2,3,4,5-tetrahydro-2-oxo-1H-1-benazazepin-1-acetic acid is prepared by treating ester of 3-amino-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid with chirally active organic acids...

A simple efficient and industrially feasible process for the preapration of crystalline quinapril hydrochloride in high purity an good yield is disclosed a solution of benzyl ester of quinapril hydrochloride is prepared with an alky nitrile and is subjescted to catalytic hydrogenolysis after ph adjustment of the sol...

Process for the preparation of thioether derivative of formula (3): In a three necked round bottom flask, epoxypropanamide of formula (1) (100 Gms), acetone (400 ml), saturated aqeous KOH solution (4ml) and Triton-X-100 (2 ml) is charged under nitrogen atmosphere. The reaction mass is cooled to 0-5°C and p-fluoro t...

The present invention relates to an improved process for the preparation of Ranolazine and the process for the preparation of intermediates useful in the preparation of Ranolazine. More particularly the present invention relates to the process for the preparation of pure Ranolazine of formula (A) and its intermediat...

A simple and cost-effective process for manufacturing the budesonide with purity of about 99.6 % with R,S-isomer in 1:1 ratio without using any purification procedure. The process involves reaction of 11β, 16α, 17α, 21-tetrahydoxypregna-l-diene-3,20-dione of formula (II) with butanal of formula (III) in the presence...

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The present invention relates to the process for the preparation of sodium 2-mercaptoethanesulfonate of formula (I). More particularly the present invention relates to a process for the preparation of pure sodium 2-mercaptoethanesulfonate salt from 2-thiouronium ethanesulfonate of formula (e) using aqueous ammonia a...

The present invention relates to a process for the preparation of cyclohexanol compounds e.g. the compound l-[cyano-l-(p-methoxy phenyl)methyl]cyclohexanol of formula (5) which represents an important preparation of venlafaxine.

Enantio-specfiic synthesis of optically pure (2S)-acetylamino-3 -(2-oxo-cyclopentyl)-propionic acid (I) comprising converting enantiomeric mixture of (1-4C alkyl)-2-acetylamino-3-(2-oxocyc]opentyl) propionoate (II) (+ and -) under the influence of an Alkaline serine endopeptidase is disclosed. The invention farther ...