A method of identifying biologically active compounds with defined selectivity profile comprises; ( c ) designing a library of compounds of formula (1) to scan molecular diversity; and (d) assaying the library of compounds in at least two different biological assays.

Use of a compound of general formula 1, for the preparation of a medicament for inhibiting or effecting the activity of GPCR, said compound of formula 1 is: wherein the ring may be of any configuration; Z is selected from the group consisting of: sulphur, oxygen, or NRA wherein RA is selected from the set def...

The invention provides a method of identifying biologically active compounds comprising: (a) designing a first library of compounds of formula 1 to scan molecular diversity wherein each compound of the library has at least two pharmacophoric groups R1 to R5 as defined below and wherein compound of the li...

A compound of formula I for inhibiting the activity of GPCR, said compound having the formula:wherein the ring may be of any configuration;Z is selected from the group consisting of: sulphur, oxygen, or NRA wherein RA is selected from the set defined for R1 to R5 or C1 to C15 acyl, C4 to C15 aryl...