The present invention provides dihydroorotate dehydrogenase inhibitors of formula (I) methods of preparing them pharmaceutical compositions containing them and methods of treatment prevention and/or amelioration of diseases or disorders wherein the inhibition of Dihydroorotate dehydrogenase is known to show benefici...

The present invention provides inter alia compounds of formula ?? ??? and III as protein kinase modulators methods of preparing them pharmaceutical compositions containing them and methods of treatment prevention and/or amelioration of kinase mediated diseases or disorders with them.

Dislcosed are novel calcium release-activated calcium (CRAC) channel inhibitors, methods for preparing them, pharmaceutical compositions containing them, and methods of treatment using them. The present dislcosure also relates to methods for treating non-small cell lung cancer (NSCLC) with CRAC inhibitors, and to me...