The present invention relates to methods for treating a disease in an animal which disease is responsive to blocking of calcium activated chloride echannel (CaCC) by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Tables 1 2 or encomp...

The present invention relates to methods for treating a disease in an animal which disease is responsive to blocking of chloride channel by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Tables 1 3 or encompassed by formula I III) or...

The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein...

This invention relates to an isolated DNA sequence encoding a polypeptide having the biological activity of amorpha-4,ll-diene synthase. This DNA sequence can be used for the transformation of bacteria, yeasts and plants for the production of amorpha-4,n-diene, a specific precursor in the synthesis of artemisinin, i...