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Cftr Inhibitor Compounds And Uses Thereof

Abstract: The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Tables 1-6 or encompassed by formulas I-VI) or compositions thereof, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease.

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Notices, Deadlines & Correspondence

Patent Information

Application #
Filing Date
09 October 2009
Publication Number
21/2010
Publication Type
INA
Invention Field
PHARMACEUTICALS
Status
Email
Parent Application

Applicants

INSTITUTE FOR ONEWORLD HEALTH
50 CALIFORNIA STREET, SUITE 500, SAN FRANCISCO, CALIFORNIA 94111 UNITED STATES OF AMERICA

Inventors

1. RUSSELL, MICHAEL GEOFFREY NEIL
C/O BIOFOCUS DPI, CHESTERFORD RESEARCH PARK, SAFFRON WALDEN ESSEX, CB10 1XL UNITED KINGDOM
2. VATER, HUW DAVID
C/O BIOFOCUS DPI, CHESTERFORD RESEARCH PARK, SAFFRON WALDEN ESSEX, CB10 1XL UNITED KINGDOM
3. MACRITCHIE, JACQUELINE ANNE
C/O BIOFOCUS DPI, CHESTERFORD RESEARCH PARK, SAFFRON WALDEN ESSEX, CB10 1XL UNITED KINGDOM
4. DOYLE, KEVIN JAMES
C/O BIOFOCUS DPI, CHESTERFORD RESEARCH PARK, SAFFRON WALDEN ESSEX, CB10 1XL UNITED KINGDOM
5. BROWN, DAVID
C/O INSTITUTE FOR ONEWORLD HEALTH, 50 CALIFORNIA STREET, SUITE 500, SAN FRANCISCO, CA 94111 UNITED STATES OF AMERICA
6. PEACH, JOANNE
C/O BIOFOCUS DPI, CHESTERFORD RESEARCH PARK, SAFFRON WALDEN ESSEX, CB10 1XL UNITED KINGDOM

Specification

The present invention relates to compositions and methods for treating a disease in an animal, which disease is
responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to
a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Tables 1-6 or
encompassed by formulas I-VI) or compositions thereof, thereby treating the disease. The present invention particularly, relates to
a method of treating diarrhea and polycystic kidney disease.

Documents

Application Documents

# Name Date
1 3518-KOLNP-2009-ABANDONED LETTER.pdf 2018-01-03
1 3518-kolnp-2009-specification.pdf 2011-10-07
2 3518-kolnp-2009-pct request form.pdf 2011-10-07
2 3518-KOLNP-2009-FIRST EXAMINATION REPORT.pdf 2018-01-03
3 3518-KOLNP-2009_EXAMREPORT.pdf 2016-06-30
3 3518-kolnp-2009-pct priority document notification.pdf 2011-10-07
4 3518-KOLNP-2009-PA.pdf 2011-10-07
4 3518-kolnp-2009-abstract.pdf 2011-10-07
5 3518-kolnp-2009-international publication.pdf 2011-10-07
5 3518-KOLNP-2009-ASSIGNMENT.pdf 2011-10-07
6 3518-kolnp-2009-form 5.pdf 2011-10-07
6 3518-KOLNP-2009-CLAIMS-1.1.pdf 2011-10-07
7 3518-kolnp-2009-form 3.pdf 2011-10-07
7 3518-kolnp-2009-claims.pdf 2011-10-07
8 3518-KOLNP-2009-FORM 3.1.1.pdf 2011-10-07
8 3518-KOLNP-2009-CORRESPONDENCE 1.2.pdf 2011-10-07
9 3518-KOLNP-2009-FORM 18.pdf 2011-10-07
9 3518-KOLNP-2009-CORRESPONDENCE 1.3.pdf 2011-10-07
10 3518-KOLNP-2009-CORRESPONDENCE-1.1.pdf 2011-10-07
10 3518-KOLNP-2009-FORM 13.pdf 2011-10-07
11 3518-kolnp-2009-correspondence.pdf 2011-10-07
11 3518-kolnp-2009-form 1.pdf 2011-10-07
12 3518-kolnp-2009-description (complete).pdf 2011-10-07
13 3518-kolnp-2009-correspondence.pdf 2011-10-07
13 3518-kolnp-2009-form 1.pdf 2011-10-07
14 3518-KOLNP-2009-CORRESPONDENCE-1.1.pdf 2011-10-07
14 3518-KOLNP-2009-FORM 13.pdf 2011-10-07
15 3518-KOLNP-2009-CORRESPONDENCE 1.3.pdf 2011-10-07
15 3518-KOLNP-2009-FORM 18.pdf 2011-10-07
16 3518-KOLNP-2009-CORRESPONDENCE 1.2.pdf 2011-10-07
16 3518-KOLNP-2009-FORM 3.1.1.pdf 2011-10-07
17 3518-kolnp-2009-claims.pdf 2011-10-07
17 3518-kolnp-2009-form 3.pdf 2011-10-07
18 3518-KOLNP-2009-CLAIMS-1.1.pdf 2011-10-07
18 3518-kolnp-2009-form 5.pdf 2011-10-07
19 3518-KOLNP-2009-ASSIGNMENT.pdf 2011-10-07
19 3518-kolnp-2009-international publication.pdf 2011-10-07
20 3518-KOLNP-2009-PA.pdf 2011-10-07
20 3518-kolnp-2009-abstract.pdf 2011-10-07
21 3518-KOLNP-2009_EXAMREPORT.pdf 2016-06-30
21 3518-kolnp-2009-pct priority document notification.pdf 2011-10-07
22 3518-kolnp-2009-pct request form.pdf 2011-10-07
22 3518-KOLNP-2009-FIRST EXAMINATION REPORT.pdf 2018-01-03
23 3518-kolnp-2009-specification.pdf 2011-10-07
23 3518-KOLNP-2009-ABANDONED LETTER.pdf 2018-01-03