In the present invention is to provide an improved process for the preparation of bisphosphonic acid derivatives by, reacting carboxylic acid of structural formula (II),
with phosphonylating agents a mixture of phosphorous acid and halophosphorous compound, wherein halophosphorous compound is selected from the grou...
This invention relates to a novel and superior process of manufacturing Hydroxyethyl starch which is essentially free from pyrogen. It involves few unit operations, some of which are capable of performing in parallel, such as pretreatment of waxy starch, molecular size reduction by acid hydrolysis, attaching hydroxy...
The present invention relates to an improved process for the preparation of (Z)-(6R, 7R)-3-(acetoxymemyl)-7-[2-(2-amino-l,3-thiazol-4-yl)-2-methoxyiminoacetamido]-8-oxo-5-thia-]-
azabicyclo[4,2,0]oct-2-en-2-carboxylic acid is described, and to remove the by-product and to obtain require product with high purity and...
The invention is a sterile pharmaceutical composition for parenteral administration comprised of an oil-in-water emulsion, in which Propofol is dissolved in a water-immiscible lipophilic agents, and surface stabilizing amphiphilic agent, and tonicity modifying water-soluble hydroxy group and preservative preferably,...
The delivery by liposome technology gives us the advantage to deliver toxic drugs to the without causing damage to the normal cells. Also, many drugs with low aqueous solubility and/or combination of both water-soluble and lipid soluble drugs can be formulated in the liposomes, increasing the bioavailability of the ...
An improved process for producing pyrogen free Tetrastarch (130/0.4). This process involves hydrolyzing the waxy starch to achieve molecular weight distribution between 110,000 to 150,000 daltons and molar substitution between 0.35 to 0.45 is achieved by attachment of hydroxyethyl group. Organic solvent used till te...
The present invention relates to an improved process for the preparation of (Z)-(6R, 7R)-3-(acetoxymethyl)-7-[2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetamido]-8-oxo-5-thia-l-azabicyclo[4,2,0]oct-2-en-2-carboxylic acid (Cefotaxime acid) is described, where S-(2-benzothiazolyl-2-(2-aminothiazol-4-yl)-2-methoxyimi...
The present invention relates to modified formulations of recombinant human glycoprotein having an in-vivo biological activity to increase the production of reticulocytes and red blood cells. A stearically stabilized unilamillar vesicles (SSUV) containing the said biopharmaceutical composition and process for prepar...
The invention relates to a new process for the synthesis of Disodium salt of (6R, 7R)-7-[[(2Z)-(2-A mino -4- thiazolyl) (methoxyimino) acetyl] amino ]-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1, 2, 4-triazin-3-yl)thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-carboxylic acid hemiheptahydrate is described, ...
The present invention is provides a cost effective process for the production of Hydroxy ethyl Starch (HES – 130 {Tetra Starch}). Wherein, 130 indicates the molecular weight of Hydroxy Ethyl Starch, which is 1,30,000 daltons. For the manufacturing Hydroxy ethyl starch various steps like hydrolysis of waxy maize star...
The present invention involves the manufacturing process of iron sucrose complexes. Iron sucrose is basically from the haemitinic therapeutic group. It is a complex between polynuclear iron (Fe+3) hydroxide in a sucrose molecule. The molecular weight of the iron sucrose complex is ranging from 34,000 to 60,000 Dalto...
An innovative method of using D.O.C. for generation of power and steam. After an extraction of oil from Caster seeds whatever is left is known as D.O.C. This D.O.C. has a potential to use in high-pressure fuel dized bed combustion boiler because of its good efficiency for burning and it's ash has good fusion point. ...
The delivery by liposome technology gives us the advantage to deliver toxic drugs to the target cells without causing damage to the normal cells. Also, many drugs with low aqueous solubility and/or combination of both water-soluble and lipid soluble drugs can be formulated in the liposomes, increasing the bioavailab...
An improved process of preparing purified waxy starch from such sources as maize, rice, potato and wheat is described so as to reduce the protein content. Waxy starch treated with alkali such as Sodium Hydroxide or Potassium Hydroxide at a specified pH range for a definite period of time. At the end of such period t...
The present invention relates to modified compositions of stericaliy stabilized
unilamellar vesicles for encapsulating recombinant proteins. More particularly,
recombinant human or animal or plant or microbial derived proteins.
glycoproteins, enzymes, peptides and their pharmaceutically acceptable
der...
The present invention relates to the process of purification of 2,6-diisopropyl phenol, the process of purification of 2,6-diisopropyl phenol by treating raw 2,6-diisopropyl phenol with solution of alkali metal soluble in alcohols at 0˚C to 5˚C, charging with solvents, washing with organic non-polar solvents, treati...
The present invention relates to an improved process for the preparation of (Z)-(6R, 7R)-3-(acetoxymethyl)-7-[2-(2-amino-lf3-thiazol-4-yl)-2-methoxyiminoacetamido]-8-oxo-5-tbia-l-azabicyclo[4,2J0]oct-2-en-2-carboxylic acid (Cefotaxime acid) is described, where S~(2-benzothiazolyl-2-(2-aminothiazol-4-yl)-2-methoxyimi...
The process for the preparation of (Z)-(6R, 7R)-3-(acetoxymethyl)-7-[2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetamido]-8-oxo-5-thia-1-azabicyclo[4,2,0]oct-2-en-2carboxylic acid (Cefotaxime acid) in presence of dichloromethane and suitable base to obtain require product with high yield.
In the present invention relates to process for the preparation of cephalosporin derivative- the process comprises condensing of 7-amino cephalosporanic acids with thiol derivatives to 3-thiodiazolyl derivatives of 7-ACA in the presence of condensing agent (boron trifluoride ethyl etherate) and weak acid, and acylat...
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