The present invention relates to a drug delivery solid dosage formulation of Sirolimus having improved in-vitro dissolution and in-vivo bioavailability, wherein Sirolimus is surface treated with a complexing agent and wetting agent in dissolved state, and to its method for preparation.

A mouth dissolvable and meltable, and water dispersable delivery system for oral administration consisting of an antipileptic drug, one or more swelling agents, one or more of fillers, one or more of disintegrating agents, and one or more of binders is disclosed. The swelling agent is powdered cellulose, filler is s...

A mouth dissolvable and meltable, and water dispersable delivery system for oral administration consisting of an antiepileptic drug, one or more swelling agent, one or more of disintegrating agents, and one or more of binders is disclosed. The swelling agent is powdered cellulose, filler is spray dried mannitol, dis...

A selfemulsifiable formulation comprising of lipophilic system consisting of medium chain triglyceride of caprylic acid and capric acid, and of labrasol, wherein labrasol also serves as surfactant, which is combined with other selected surfactants, like cremophore RH 40 and/or polysorbate 80 is disclosed, wherein sa...

Present invention provides a high yielding, safe and industrially feasible process for the preparation of benzazepine derivative. The dehalogenated side product 5-hydroxy-l-[2-methyi-4-(2-methylbenzoylamino) benzoyl]-2,3,4,5-tetrahydro-lH-1-benzazipine generation in this process is less than 0.1% by weight. ...

Amouth dissolvable and meltable, and water dispersable delivery system for oral administration consisting of an antiepileptic drug, one or more swelling agents one or more of fillers one or more of disintegrating agents and one or more of binders is disclosed. The swelling agent is powdered cellulose filler is spray...

The present invention relates to the process of pantoprazole sodium sesquihydrate Form I having following Formula –I. from pantoprazole sodium comprising formation of a suspension of pantoprazole sodium in a solvent mixture and directly recovering the pantoprazole sodium sesquihydrate Form-I by filtration. ...

A process for preparation of methyl-(+)-(S)-alpha-(2-chlorophenyl) –6,7-dihydrothieno [3,2-c] pyridine-5 (4H)-acetic acid methyl ester or salts thereof [clopidogrel or salts thereof of Formula –I] having higher chiral purity and products thereof is provided. A process for purification of the compound prepared is al...

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The present invention relates to process for preparation of crystalline Form I of clopidogrel bisulfate comprising steps of preparing clear solution of clopidogrel free base in ethyl acetate, which is cooled to a temperature varying from about -7 to about -10°C and reacted with concentrated sulphuric acid white main...

The present invention relates to a pharmaceutical formulation having increased in-vitro dissolution, and reduced and controlled degradation under moisture and heat conditions comprising alpha ketoanalogue of amino acids and additional amino acids as active ingredients, and disintegrant, filler and binder, and coated...

Present invention provides a novel process for the preparation of 7 -Chloro-5-oxo-l-(2-methyl-4-Amino benzoyl) -2,3,4,5-tetrahydro-lH-benzazepine. This process is industrially feasible and scalable. The process does not make use of expensive, hazardous reagents and special equipment"s making it industrially feasible...

A process for the preparation of anti-psychotic 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1 -piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[l,2,-a]pyrimidin-4-one, commonly known as risperidone of the formula I:Formula I comprising condensation of 3-substituted ethyl-6,7,8,9-tetrahydro-2-me...

The present invention rebates to antidiabetic compounds, and more particularly to derivatives of antidiabetic compounds belonging to the class of thiazolidinediones (TZDs), its bioisosieres i.e. a-substituted carboxylic acids and isoxazolidine-3, 5-diones, processes Vor their preparation, and their use as po...

Disclosed is an improved process for the preparation of cinacalcet hydrochloride of formula using key intermediate, sodium {1- hydroxy - 3-(3-trifluoromethyl phenyl) propyl} sulfonate (Bisulphite adduct) (IIIa).

A process for the preparation of 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine of the formula I:c r Formula I commonly known as lamotrigine which comprises :a) reduction of 2,3'dichloronitrobenzene of the formula IX Formula IX in Ci -Ce aliphatic alkanol with hydr...

Disclosed is a process for the preparation of Solifenacin succinate of formula (I) by reacting of racemic (RS)-ethyl 1-phenyl-1, 2, 3, 4-tetrahydro-2-isoquinoline carboxylate with racemic (RS)-3-quinuclidinol followed by separation of (1S, 3R)-isomer from a mixture of four stereoisomers.