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A Process For Preparation Of Methyl (+) (S) Alpha (2 Chlorophenyl) 6,7 Dihydrothieno[3,2 C]Pyridine 5(4 H) Acetic Acid Methyl Ester As Free Base
Abstract: A process for preparation of methyl-(+)-(S)-alpha-(2-chlorophenyl) –6,7-dihydrothieno [3,2-c] pyridine-5 (4H)-acetic acid methyl ester or salts thereof [clopidogrel or salts thereof of Formula –I] having higher chiral purity and products thereof is provided. A process for purification of the compound prepared is also provided to enhance its efficacy by enhancing its optical rotation and chiral purity. In Formula –I, R is selected from a group comprising alkyl, alkoxy. hydroxy, amine etc., and R1 is selected from the group comprising C1-4 alkyl, C1-4 alkoxy, hydroxy, nitro & halogen. The particular salt of interest of the present invention is the hydrogen sulfate of compound of the Formula – I, wherein R and R1 are –OCH3 and chloro - group at position 2 respectively.
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Notices, Deadlines & Correspondence
Notices, Deadlines & Correspondence
Patent Information
Application #
Filing Date
12 July 2005
Publication Number
10/2009
Publication Type
INA
Invention Field
PHARMACEUTICALS
Status
Email
Parent Application
Patent Number
Legal Status
Grant Date
2012-06-04
Renewal Date
Applicants
RPG LIFE SCIENCES LIMITED
CEAT MAHAL, 463, DR. ANNIE BESANT ROAD,
WORLI, MUMBAI-400 030,
Inventors
1. SRIVASTAVA ANITA RANJAN
RPG LIFE SCIENCES LIMITED,
25, MIDC LAND, THANE-BELAPUR ROAD,
NAVI MUMBAI 400705,
2. PAWAR PRASHANT PANDURANG
C/O. D.S. SURYAWANSHI,
SAWALI HOUSING SOCIETY,
B-301, PLOT-41, SECTOR-5,
NEAR M.S.E.B. YARD, KHARGHAR,
NAVI MUMBAI 400706
3. POOJARI KRISHNA ANAND
RPG LIFE SCIENCES LIMITED,
25, MIDC LAND, THANE-BELAPUR ROAD,
NAVI MUMBAI 400705.
4. PATIL PRAVIN CHAITRAM
RPG LIFE SCIENCES LIMITED,
25, MIDC LAND, THANE-BELAPUR ROAD,
NAVI MUMBAI 400705.
5. DALVI RAJIV RAMCHANDRA
RPG LIFE SCIENCES LIMITED,
25, MIDC LAND, THANE-BELAPUR ROAD,
NAVI MUMBAI 400705.
Specification
Documents
Orders
| Section | Controller | Decision Date |
|---|---|---|
| 25(1) | DR.RUCHI TIWARI | 2012-05-24 |
| 25(1) | DR.RUCHI TIWARI | 2012-05-24 |
Application Documents
| # | Name | Date |
|---|---|---|
| 1 | 836-mum-2005-form 18(29-11-2007).pdf | 2007-11-29 |
| 1 | 836-MUM-2005-RELEVANT DOCUMENTS [19-03-2020(online)].pdf | 2020-03-19 |
| 2 | 252835-Correspondence (Renewal)-180419.pdf | 2019-04-22 |
| 2 | 836-MUM-2005-REPLY TO EXAMINATION REPORT(23-12-2010).pdf | 2010-12-23 |
| 3 | 836-MUM-2005-PETITION UNDER RULE 137(23-12-2010).pdf | 2010-12-23 |
| 3 | 836-mum-2005-abstract(6-7-2006).doc | 2018-08-09 |
| 4 | 836-MUM-2005-OTHER DOCUMENT(23-12-2010).pdf | 2010-12-23 |
| 4 | 836-mum-2005-abstract(6-7-2006).pdf | 2018-08-09 |
| 5 | 836-MUM-2005-OTHER DOCUMENT-(21-01-2011).pdf | 2011-01-21 |
| 5 | 836-MUM-2005-ABSTRACT(GRANTED)-(4-6-2012).pdf | 2018-08-09 |
| 6 | 836-MUM-2005-CORRESPONDENCE-(21-01-2011).pdf | 2011-01-21 |
| 6 | 836-mum-2005-assignment(6-7-2006).pdf | 2018-08-09 |
| 7 | 836-MUM-2005-CORRESPONDENCE(21-10-2011).pdf | 2011-10-21 |
| 7 | 836-mum-2005-claims(6-7-2006).doc | 2018-08-09 |
| 8 | 836-MUM-2005-CLAIMS(MARKED COPY)-(21-10-2011).pdf | 2011-10-21 |
| 8 | 836-mum-2005-claims(6-7-2006).pdf | 2018-08-09 |
| 9 | 836-MUM-2005-CLAIMS(AMENDED)-(21-10-2011).pdf | 2011-10-21 |
| 9 | 836-MUM-2005-CLAIMS(GRANTED)-(4-6-2012).pdf | 2018-08-09 |
| 10 | 836-MUM-2005-CANCELLED PAGES(21-10-2011).pdf | 2011-10-21 |
| 11 | 836-mum-2005-claims(provisional)-(12-7-2005).pdf | 2018-08-09 |
| 11 | 836-MUM-2005-CORRESPONDENCE(RENEWAL PAYMENT LETTER)-(24-06-2013).pdf | 2013-06-24 |
| 12 | 836-MUM-2005-CORRESPONDENCE (RENEWAL)-270618.pdf | 2018-08-09 |
| 12 | 836-MUM-2005-CORRESPONDENCE-(07-07-2014).pdf | 2014-07-07 |
| 13 | 836-mum-2005-correspondence 1(27-1-2009).pdf | 2018-08-09 |
| 13 | 836-MUM-2005-CORRESPONDENCE(RENEWAL PAYMENT LETTER)-(10-07-2015).pdf | 2015-07-10 |
| 14 | 836-mum-2005-correspondence 2(17-4-2009).pdf | 2018-08-09 |
| 14 | 836-MUM-2005-CORRESPONDENCE(RENEWAL PAYMENT LETTER)-(12-07-2016).pdf | 2016-07-12 |
| 15 | 836-mum-2005-correspondence(18-5-2007).pdf | 2018-08-09 |
| 15 | 836-MUMNP-2005-CORRESPONDENCE(RENEWAL PAYMENT LETTER)-11-07-2017.pdf | 2017-07-11 |
| 16 | 836-MUM-2005-CORRESPONDENCE(2-8-2010).pdf | 2018-08-09 |
| 16 | 836-MUM-2005-OTHERS-09-05-2018.pdf | 2018-05-09 |
| 17 | 836-MUM-2005-CORRESPONDENCE(20-4-2009).pdf | 2018-08-09 |
| 17 | 836-MUM-2005-CORRESPONDENCE (UNDER RULE 94 (1)-09-05-2018.pdf | 2018-05-09 |
| 18 | abstract1.jpg | 2018-08-09 |
| 18 | 836-MUM-2005-CORRESPONDENCE(27-9-2012).pdf | 2018-08-09 |
| 19 | 836-MUM-2005-CORRESPONDENCE(3-11-2011).pdf | 2018-08-09 |
| 19 | 836-MUM-2005_EXAMREPORT.pdf | 2018-08-09 |
| 20 | 836-MUM-2005-CORRESPONDENCE(4-7-2011).pdf | 2018-08-09 |
| 20 | 836-MUM-2005-WRITTEN REPLY TO PRE-GRANT OPPOSITION(12-7-2011).pdf | 2018-08-09 |
| 21 | 836-mum-2005-correspondence(ipo)-(2-2-2010).pdf | 2018-08-09 |
| 21 | 836-MUM-2005-US DOCUMENT(1-7-2011).pdf | 2018-08-09 |
| 22 | 836-mum-2005-correspondence(ipo)-(25-5-2009).pdf | 2018-08-09 |
| 22 | 836-MUM-2005-REPLY TO HEARING(2-9-2011).pdf | 2018-08-09 |
| 23 | 836-MUM-2005-CORRESPONDENCE(RENEWAL PAYMENT LETTER)-(3-9-2012).pdf | 2018-08-09 |
| 23 | 836-MUM-2005-REPLY TO EXAMINATION REPORT(1-7-2011).pdf | 2018-08-09 |
| 24 | 836-MUM-2005-REPLY STATEMENT OF PRE GRANT OPPOSITION(21-1-2011).pdf | 2018-08-09 |
| 24 | 836-mum-2005-description(complete)-(6-7-2006).pdf | 2018-08-09 |
| 25 | 836-MUM-2005-DESCRIPTION(GRANTED)-(4-6-2012).pdf | 2018-08-09 |
| 25 | 836-mum-2005-pre-grant oppsition(23-4-2010).pdf | 2018-08-09 |
| 26 | 836-mum-2005-description(provisional)-(12-7-2005).pdf | 2018-08-09 |
| 26 | 836-MUM-2005-PRE GRANT LETTER(9-3-2011).pdf | 2018-08-09 |
| 27 | 836-MUM-2005-FORM 1(10-7-2006).pdf | 2018-08-09 |
| 27 | 836-MUM-2005-OTHER DOCUMENT(2-9-2011).pdf | 2018-08-09 |
| 28 | 836-mum-2005-form 1(12-7-2005).pdf | 2018-08-09 |
| 28 | 836-MUM-2005-OTHER DOCUMENT(2-8-2010).pdf | 2018-08-09 |
| 29 | 836-mum-2005-form 1(6-7-2006).pdf | 2018-08-09 |
| 29 | 836-mum-2005-form pct-ro-102(17-4-2009).pdf | 2018-08-09 |
| 30 | 836-mum-2005-form pct-ib-304(17-4-2009).pdf | 2018-08-09 |
| 31 | 836-mum-2005-form 2(6-7-2006).pdf | 2018-08-09 |
| 31 | 836-mum-2005-form 5(6-7-2006).pdf | 2018-08-09 |
| 32 | 836-MUM-2005-FORM 2(GRANTED)-(4-6-2012).pdf | 2018-08-09 |
| 32 | 836-mum-2005-form 5(12-7-2005).pdf | 2018-08-09 |
| 33 | 836-mum-2005-form 5(10-7-2006).pdf | 2018-08-09 |
| 34 | 836-mum-2005-form 2(provisional)-(12-7-2005).pdf | 2018-08-09 |
| 34 | 836-mum-2005-form 3(6-7-2006).pdf | 2018-08-09 |
| 35 | 836-mum-2005-form 2(title page)-(6-7-2006).pdf | 2018-08-09 |
| 35 | 836-MUM-2005-FORM 3(2-8-2010).pdf | 2018-08-09 |
| 36 | 836-MUM-2005-FORM 2(TITLE PAGE)-(GRANTED)-(4-6-2012).pdf | 2018-08-09 |
| 36 | 836-mum-2005-form 3(12-7-2005).pdf | 2018-08-09 |
| 37 | 836-MUM-2005-FORM 3(1-7-2011).pdf | 2018-08-09 |
| 37 | 836-mum-2005-form 2(title page)-(provisional)-(12-7-2005).pdf | 2018-08-09 |
| 38 | 836-mum-2005-form 26(12-7-2005).pdf | 2018-08-09 |
| 38 | 836-MUM-2005-FORM 26(27-8-2014).pdf | 2018-08-09 |
| 39 | 836-mum-2005-form 26(12-7-2005).pdf | 2018-08-09 |
| 39 | 836-MUM-2005-FORM 26(27-8-2014).pdf | 2018-08-09 |
| 40 | 836-mum-2005-form 2(title page)-(provisional)-(12-7-2005).pdf | 2018-08-09 |
| 40 | 836-MUM-2005-FORM 3(1-7-2011).pdf | 2018-08-09 |
| 41 | 836-MUM-2005-FORM 2(TITLE PAGE)-(GRANTED)-(4-6-2012).pdf | 2018-08-09 |
| 41 | 836-mum-2005-form 3(12-7-2005).pdf | 2018-08-09 |
| 42 | 836-mum-2005-form 2(title page)-(6-7-2006).pdf | 2018-08-09 |
| 42 | 836-MUM-2005-FORM 3(2-8-2010).pdf | 2018-08-09 |
| 43 | 836-mum-2005-form 2(provisional)-(12-7-2005).pdf | 2018-08-09 |
| 43 | 836-mum-2005-form 3(6-7-2006).pdf | 2018-08-09 |
| 44 | 836-mum-2005-form 5(10-7-2006).pdf | 2018-08-09 |
| 45 | 836-MUM-2005-FORM 2(GRANTED)-(4-6-2012).pdf | 2018-08-09 |
| 45 | 836-mum-2005-form 5(12-7-2005).pdf | 2018-08-09 |
| 46 | 836-mum-2005-form 2(6-7-2006).pdf | 2018-08-09 |
| 46 | 836-mum-2005-form 5(6-7-2006).pdf | 2018-08-09 |
| 47 | 836-mum-2005-form pct-ib-304(17-4-2009).pdf | 2018-08-09 |
| 48 | 836-mum-2005-form pct-ro-102(17-4-2009).pdf | 2018-08-09 |
| 48 | 836-mum-2005-form 1(6-7-2006).pdf | 2018-08-09 |
| 49 | 836-mum-2005-form 1(12-7-2005).pdf | 2018-08-09 |
| 49 | 836-MUM-2005-OTHER DOCUMENT(2-8-2010).pdf | 2018-08-09 |
| 50 | 836-MUM-2005-FORM 1(10-7-2006).pdf | 2018-08-09 |
| 50 | 836-MUM-2005-OTHER DOCUMENT(2-9-2011).pdf | 2018-08-09 |
| 51 | 836-mum-2005-description(provisional)-(12-7-2005).pdf | 2018-08-09 |
| 51 | 836-MUM-2005-PRE GRANT LETTER(9-3-2011).pdf | 2018-08-09 |
| 52 | 836-MUM-2005-DESCRIPTION(GRANTED)-(4-6-2012).pdf | 2018-08-09 |
| 52 | 836-mum-2005-pre-grant oppsition(23-4-2010).pdf | 2018-08-09 |
| 53 | 836-mum-2005-description(complete)-(6-7-2006).pdf | 2018-08-09 |
| 53 | 836-MUM-2005-REPLY STATEMENT OF PRE GRANT OPPOSITION(21-1-2011).pdf | 2018-08-09 |
| 54 | 836-MUM-2005-CORRESPONDENCE(RENEWAL PAYMENT LETTER)-(3-9-2012).pdf | 2018-08-09 |
| 54 | 836-MUM-2005-REPLY TO EXAMINATION REPORT(1-7-2011).pdf | 2018-08-09 |
| 55 | 836-mum-2005-correspondence(ipo)-(25-5-2009).pdf | 2018-08-09 |
| 55 | 836-MUM-2005-REPLY TO HEARING(2-9-2011).pdf | 2018-08-09 |
| 56 | 836-MUM-2005-US DOCUMENT(1-7-2011).pdf | 2018-08-09 |
| 56 | 836-mum-2005-correspondence(ipo)-(2-2-2010).pdf | 2018-08-09 |
| 57 | 836-MUM-2005-CORRESPONDENCE(4-7-2011).pdf | 2018-08-09 |
| 57 | 836-MUM-2005-WRITTEN REPLY TO PRE-GRANT OPPOSITION(12-7-2011).pdf | 2018-08-09 |
| 58 | 836-MUM-2005-CORRESPONDENCE(3-11-2011).pdf | 2018-08-09 |
| 58 | 836-MUM-2005_EXAMREPORT.pdf | 2018-08-09 |
| 59 | 836-MUM-2005-CORRESPONDENCE(27-9-2012).pdf | 2018-08-09 |
| 59 | abstract1.jpg | 2018-08-09 |
| 60 | 836-MUM-2005-CORRESPONDENCE (UNDER RULE 94 (1)-09-05-2018.pdf | 2018-05-09 |
| 60 | 836-MUM-2005-CORRESPONDENCE(20-4-2009).pdf | 2018-08-09 |
| 61 | 836-MUM-2005-CORRESPONDENCE(2-8-2010).pdf | 2018-08-09 |
| 61 | 836-MUM-2005-OTHERS-09-05-2018.pdf | 2018-05-09 |
| 62 | 836-mum-2005-correspondence(18-5-2007).pdf | 2018-08-09 |
| 62 | 836-MUMNP-2005-CORRESPONDENCE(RENEWAL PAYMENT LETTER)-11-07-2017.pdf | 2017-07-11 |
| 63 | 836-mum-2005-correspondence 2(17-4-2009).pdf | 2018-08-09 |
| 63 | 836-MUM-2005-CORRESPONDENCE(RENEWAL PAYMENT LETTER)-(12-07-2016).pdf | 2016-07-12 |
| 64 | 836-mum-2005-correspondence 1(27-1-2009).pdf | 2018-08-09 |
| 64 | 836-MUM-2005-CORRESPONDENCE(RENEWAL PAYMENT LETTER)-(10-07-2015).pdf | 2015-07-10 |
| 65 | 836-MUM-2005-CORRESPONDENCE (RENEWAL)-270618.pdf | 2018-08-09 |
| 65 | 836-MUM-2005-CORRESPONDENCE-(07-07-2014).pdf | 2014-07-07 |
| 66 | 836-mum-2005-claims(provisional)-(12-7-2005).pdf | 2018-08-09 |
| 66 | 836-MUM-2005-CORRESPONDENCE(RENEWAL PAYMENT LETTER)-(24-06-2013).pdf | 2013-06-24 |
| 67 | 836-MUM-2005-CANCELLED PAGES(21-10-2011).pdf | 2011-10-21 |
| 68 | 836-MUM-2005-CLAIMS(GRANTED)-(4-6-2012).pdf | 2018-08-09 |
| 68 | 836-MUM-2005-CLAIMS(AMENDED)-(21-10-2011).pdf | 2011-10-21 |
| 69 | 836-mum-2005-claims(6-7-2006).pdf | 2018-08-09 |
| 69 | 836-MUM-2005-CLAIMS(MARKED COPY)-(21-10-2011).pdf | 2011-10-21 |
| 70 | 836-MUM-2005-CORRESPONDENCE(21-10-2011).pdf | 2011-10-21 |
| 71 | 836-MUM-2005-CORRESPONDENCE-(21-01-2011).pdf | 2011-01-21 |
| 71 | 836-mum-2005-assignment(6-7-2006).pdf | 2018-08-09 |
| 72 | 836-MUM-2005-ABSTRACT(GRANTED)-(4-6-2012).pdf | 2018-08-09 |
| 72 | 836-MUM-2005-OTHER DOCUMENT-(21-01-2011).pdf | 2011-01-21 |
| 73 | 836-mum-2005-abstract(6-7-2006).pdf | 2018-08-09 |
| 73 | 836-MUM-2005-OTHER DOCUMENT(23-12-2010).pdf | 2010-12-23 |
| 74 | 836-MUM-2005-PETITION UNDER RULE 137(23-12-2010).pdf | 2010-12-23 |
| 75 | 252835-Correspondence (Renewal)-180419.pdf | 2019-04-22 |
| 75 | 836-MUM-2005-REPLY TO EXAMINATION REPORT(23-12-2010).pdf | 2010-12-23 |
| 76 | 836-mum-2005-form 18(29-11-2007).pdf | 2007-11-29 |
| 76 | 836-MUM-2005-RELEVANT DOCUMENTS [19-03-2020(online)].pdf | 2020-03-19 |