Description:The present invention relates antimalarial screening of the compounds, (Z)-N'-(1-(4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)ethylidene)-1,3-diphenyl-1H-pyrazole-4-carbohydrazides and their Cu(II) complexes against plasmodium falciparum (Pf3D7). , Claims:I/We claim

1. The compounds with Formula I & Formula II where Ar is C6H5, p-FC6H4, p-ClC6H4, p-BrC6H4, p-CH3C6H4 & and their Cu(II) complexes as antimalarial agents for Plasmodium falciparum in different concentrations.

2. The compounds as claimed in claim 1, wherein the said compounds with Formula I & Formula II suppress Plasmodium falciparum (Pf3d7) up to 100 % in 72 h.
3. The compound as claimed in claim 1, wherein the said compound with Formula I & Formula II can be used in concentrations up to 100 µg/ml.
4. The compound as claimed in claim 1, wherein the said compounds with Formula I inhibit the growth of Plasmodium falciparum up to 57 % at 12.5 µg/ml & 97% at 100 µg/ml while compounds with Formula II inhibit up to 100 % growth at 12.5 µg/ml after 72 h treatment whereas standard drug Chloroquine inhibit up to 99.5 % growth of parasitemia.
5. These compounds having same basic skeleton as claimed in claim 1.