Process For Manufacturing A Diphenylpyrazine Derivative

Abstract: The present invention relates to a process for the manufacturing of calcium;{4-[(5, 6- diphenylpyrazin-2-yl)(propan-2-yl)amino]butoxy}acetate, or a pharmaceutically acceptable hydrate or solvate thereof. Moreover, it relates to calcium;{4-[(5,6-diphenylpyrazin-2- yl)(propan-2-yl)amino]butoxy}acetate with high purity, as well as to crystalline forms of calcium;{4-[(5,6-diphenylpyrazin-2-yl)(propan-2-yl)amino]butoxy}acetate and hydrates and solvates thereof. Furthermore, the invention relates to the use of calcium;{4-[(5, 6- diphenylpyrazin-2-yl)(propan-2-yl)amino]butoxy}acetate for the treatment or prevention of e.g. pulmonary arterial hypertension (PAH) or chronic thromboembolic pulmonary hypertension (CTEPH).

Patent Information

Application #

Filing Date

25 July 2023

Publication Number

49/2023

Publication Type

INA

Invention Field

CHEMICAL

Status

Email

Parent Application

Applicants

ACTELION PHARMACEUTICALS LTD

Gewerbestrasse 16 4123 Allschwil

Inventors

1. VANIERSCHOT, Ronny

c/o Janssen Pharmaceutica NV Turnhoutseweg 30 2340 Beerse

2. COLLAS, Alain

c/o Janssen Pharmaceutica NV Turnhoutseweg 30 2340 Beerse

3. LEYS, Carina

c/o Janssen Pharmaceutica NV Turnhoutseweg 30 2340 Beerse

4. VAN MECHELEN, Kore

c/o Janssen Pharmaceutica NV Turnhoutseweg 30 2340 Beerse

Specification

Documents

Application Documents

#	Name	Date
1	202317049999-TRANSLATIOIN OF PRIOIRTY DOCUMENTS ETC. [25-07-2023(online)].pdf	2023-07-25
2	202317049999-STATEMENT OF UNDERTAKING (FORM 3) [25-07-2023(online)].pdf	2023-07-25
3	202317049999-PROOF OF RIGHT [25-07-2023(online)].pdf	2023-07-25
4	202317049999-PRIORITY DOCUMENTS [25-07-2023(online)].pdf	2023-07-25
5	202317049999-NOTIFICATION OF INT. APPLN. NO. & FILING DATE (PCT-RO-105-PCT Pamphlet) [25-07-2023(online)].pdf	2023-07-25
6	202317049999-FORM 1 [25-07-2023(online)].pdf	2023-07-25
7	202317049999-DRAWINGS [25-07-2023(online)].pdf	2023-07-25
8	202317049999-DECLARATION OF INVENTORSHIP (FORM 5) [25-07-2023(online)].pdf	2023-07-25
9	202317049999-COMPLETE SPECIFICATION [25-07-2023(online)].pdf	2023-07-25
10	202317049999-FORM-26 [03-08-2023(online)].pdf	2023-08-03
11	202317049999-Proof of Right [18-10-2023(online)].pdf	2023-10-18
12	202317049999-FORM 3 [15-01-2024(online)].pdf	2024-01-15
13	202317049999-Response to office action [26-07-2024(online)].pdf	2024-07-26
14	202317049999-FORM 18 [23-01-2025(online)].pdf	2025-01-23
15	202317049999-RELEVANT DOCUMENTS [01-07-2025(online)].pdf	2025-07-01