The invention relates to 3-aza-bicyclo[3.3.0]octane derivatives of the formula (I) wherein R1 R2, R3, and A are as described in the description and their use as orexin receptor antagonists.

The invention relates to antibacterial compounds of formula (I) wherein Ris one of the groups represented below (AA) wherein A is a bond CH=CH or C=C; U is N or CH; V is N or CH; W represents N or CH; and R R R R and R are as defined in the claims; and salts thereof.

The invention relates to novel pyridine derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.

The invention relates to the compound of structural formula I and the salts thereof. Said compound is useful as endothelin receptor antagonist. The invention further relates to a process for preparing said compound.

The invention relates to antibacterial compounds of formula I wherein R1 represents alkoxy; each of U and V represents CH and W represents CH or N, or U represents N, V represents CH and W represents N, or each of U and V represents N and W represents CH; R2 represents hydrogen or fluorine when W ...

The present invention relates to a dosing regimen for a selective S1 P1 receptor agonist, whereby the selective SIP1 receptor agonist is administered to a subject in such a way that during the initial treatment phase the selective S1 P1 receptor agonist is administered at a dose which induces desensitization of the ...

124n5mThe invention relates to compounds of formula (I) wherein X Y R R (R) and (R) are as defined in the description and to pharmaceutically acceptable salts of such compounds. These compounds are useful as calcium T channel blockers.

Abstract The invention relates to pyridine derivatives of Formula (I) wtierein A, R\ R^, R^, R*, R^ and R^ are as described in the description, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.

Abstract The invention relates to fluorinated aminotriazole derivatives of formula (I), wherein A, R1 and R2 are as defined in the description, their preparation and their use as pharmaceutically active compounds.

12345The invention relates to oxazolyl methylether derivatives of formula (I) wherein R R R R and R are as defined in the description their preparation and their use as pharmaceutically active compounds.

The invention relates to antibacterial compounds of formula I wherein R1 represents halogen or alkoxy; U and W each represent N, V represents CH and R2 represents H or F, or U and V each represent CH, W represents N and R2 represents H or F, or U represents N, V represents CH, W represents CH or CRa and R2 r...

302 Abstract The present invention relates to 1 phenyl substituted heterocyclyl derivatives of the formula (I) O Y R 5 R 6 N R 2 R 3 R 4 X Z R 1 R 7 R 7 R 10 n (I) 5 wherein X Y Z n R 1 R 2 R 3 R 4 R 5 R 6 R 7 and R 10 are as described in the description and their use as prostaglandin receptor modulators most partic...

123221A2A3A1B1CThe invention relates to antibacterial compounds of formula (I) wherein R is H or halogen; R is alkynyloxy or the group M; R is H or halogen; M is one of the groups (A B C D) wherein A is a bond CH CH CH=CH or C=C and R R R R and R are as defined in claim 1; and salts thereof.

ABSTRACT The invention relates to a product containing the compound of formula (I) below (I) or a pharmaceutically acceptable salt of this compound, in combination with at least one compound having prostacyclin receptor (IP) agonist properties, or a pharmaceutically acceptable salt thereof. ...

1a1b1a1b 1a" "1b213133534413The invention relates to antibacterial compounds of formula I (Fornula I) (I) wherein R represents H or carboxy and R represents H or R and R represent together either the group * C(0) NH S or the group * C(OH)=N S wherein "*" represents the point of attachment of R and represents the poi...

The invention relates to 1,2-diamido-ethylene derivatives of the formula (I) wherein R1 R2, R3 and A are as described in the description and their use as medicaments, especially as orexin receptor antagonists

The present invention relates to phenyl substituted heterocyclyl derivatives of the formula (I) wherein Z n m R R R R R R R and R are as described in the description and their use as prostaglandin receptor modulators most particularly as prostaglandin Dreceptor modulators in the treatment of various prostaglandin me...

The invention relates to antibacterial compounds of formula I wherein "----" is a bond or is absent, V is CH, CR° or N; Ru is II or, if "----" is a bond, may also be alkoxy; R1 is notably H or halogen; U is CH or N when "----" is a bond, or, if "----" is absent, U is CH2, NH or NR9; R2 is H, alkylcnrbonyl or -CH2...

The invention relates to the use of tetrahydroquinoline derivatives of formula I wherein R1 and R2 each independently represent (C1-C4)alkoxy, R3 represents aryl-(C1-C4)alkyl or heteroaryl-(C1-C4)alkyl, and R4 represents hydrogen or (C1-C4)alkyl, or of pharmaceutically acceptable salts thereof, for the prepa...

The invention relates to antibacterial compounds of formula I wherein R1 is alkoxy or halogen; U and V each independently are CH or N; "—" is a bond or is absent; W is CH or N or, when "—" is absent, W is CH2 or NH, with the proviso that U, V and W are not all N; A is a bond or CH2; R2 is H or, provided A is...

The invention relates to novel phenethylamide derivatives and their heterocyclic analogues of formula (I), wherein A, B, R1, R2 and R3 are as described in the application, and to the use of such compounds, or of pharmaceutically acceptable salts of such compounds, as medicaments, especially as orexin receptor an...

123AB221A2A3Atrans1BtranscisThe invention relates to antibacterial compounds of formula (I) wherein X is N or CH; R is H or halogen; R is alkynyloxy or the group M; R is H or halogen; M is one of the groups M and M represented below wherein A is a bond CHCH CH=CH or C=C; R is H or halogen; R is H alkoxy or haloge...

The invention relates to novel pyrimidine derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.

The invention relates to aminotriazole derivatives of formula (I), wherein A, E, R1 and R2 are as defined in the description, their preparation and their use as pharmaceutically active compounds.

The invention relates to novel thiophene derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.

The present invention relates to a process for the preparation of the compound of formula 7 which process comprises the hydrogenation of the compound of formula 4 using bis[chloro-1,5-cyclooctadiene-iridium], (S)-1-dicyclohexylphosphino- 2-[(S)-a-(dimethylamino)-2-(cyclohexylphosphino)(dicyclohexylphosphino)be...

n2a2b3a3b4121The present invention relates to derivatives of formula (I) Formula (I) wherein (R1) R  R  R  R  R  L L X Y and Ar are as described in the description to their preparation to pharmaceutically acceptable salts thereof and to their use as pharmaceuticals to pharmaceutical compositions containing one or mo...

The invention relates to novel aminomethyl benzene derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.

The invention relates to novel 2-aza-bicyclo[2.2.1] heptane derivatives of formula (I), Formula (I) wherein A, B, n and R1 are as described in the description, and to the use of such compounds, an or of pharmaceutically acceptable salts of such compounds, as medicaments, especially as orexin receptor antagonists...

The invention relates to pyridine derivatives of Formula (I) wherein A, R1, R2, R3, R4, R6, R8 and R7 are as described in the description, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.

113134235The invention relates to isoquinolin 3 ylurea derivatives of formula (I) wherein R represents (C C)alkyl (C C)haloalkyl or cyclopropyl R represents H and the substituents R and R and R have the meanings disclosed in the specification; and to the salts of such compounds. These compounds are useful for the pr...

The invention relates to antibacterial compounds of formula I wherein n is 0 or 1; R1 represents H or F; U represents CH2 or, provided n is 1, O or NH; "----- " is a bond or is absent; V represents CH or N when "-----" is a bond, or CH2 or NH when "-----" is absent; W represents CH or N; A represents -(CH2)p-N...

The invention relates to the combination of an endothelin receptor antagonist of formula (I) with paclitaxel, and in particular to this combination for therapeutic use, simultaneously, separately or over a period of time, in the treatment of ovarian cancer.

The present invention relates to 2-phenyl-4-cyclopropyl-pyrimidine derivatives and their use as P2Y12 receptor antagonists in the treatment and/or prevention of peripheral vascular, of visceral-, hepatic- and renal-vascular, of cardiovascular and of cerebrovascular diseases or conditions associated with platelet agg...

The present invention relates to 6-(3-aza-bicyclo[3.1.0]hex-3-yl)-2-phenyl-pyrimidine derivatives and their use as P2Y12 receptor antagonists in the treatment and/or prevention of peripheral vascular, of visceral-, hepatic- and renal-vascular, of cardiovascular and of cerebrovascular diseases or conditions associate...

The present invention relates to thiazole derivatives of formula I and their use as P2Y12 receptor antagonists in the treatment and/or prevention of peripheral vascular, of visceral-, hepatic- and renal-vascular, of cardiovascular and of cerebrovascular diseases or conditions associated with platelet aggregation, in...

The invention relates to novel thiophene donatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunosuppressive agents.

The invention relates to the compounds of formula I wherein A is N or CH; and n is 0 or 1; or the pharmaceutically acceptable salts thereof, for preventing or treating intestinal diseases which are caused by bacteria selected from Clostridium difficile, Clostridium perfringens or Staphylococcus aureus. ...

The invention relates to novel bicyclononene derivatives of Formula (I); and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or mor...

ABSTRACT The invention relates to a product containing the compound of formula (I) below or a pharmaceutically acceptable salt of this compound, in combination with at least one compound having PDE5-inhibitory properties, or a pharmaceutically acceptable salt thereof, lor therapeutic use, simultaneously, separa...

Abstract PYRIDIN-3-YL DERIVATIVES AS IMMUNOMODULATING AGEhJTS The invention relates to pyridin-S-y! derivatives of Fonnuia (I) and their use as pharmaceutically active compounds. Said compounds particularly act as immunomoduiating agents.

The invention relates to novel phenyl derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.

The invention relates to the guanine derivatives of general formula (I), and to hydrates or solvents thereof, for use as neuropeptide FF receptor antagonists in the treatment of pains and hyperalgesia, of withdrawal symptoms of addiction to alcohol, psychotropic drugs or nicotine and in the prevention of or recovery...

The invention relates to novel pyridine derivatives and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of ...

One embodiment provides a method of using contextual lighting to assist a user of a medical fluid injection system. In this embodiment, the method includes providing a lighted display in proximity to a component of the injection system during setup of the medical fluid injection system. If the user has properly perf...

The invention relates to novel derivatives and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those com...

Abstract Novel Thiophene Derivatives The invention relates to novel thiophene derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunosuppressive agents.

The present invention relates to a new process for the preparation of 2-imino-thiazolidln-4-one compounds of the Formula (I) and (II) and to compounds of Formula (II) as such. The present compounds of Formula (II) can be used as intermediates in the preparation of thiazolidin-4-one derivatives of the General Formula...

The invention relates to novel 3,9-diazabicyclo[3.3.1]nonene derivatives of formula (I), wherein Z is 0 or 1, one of m, n is 0 and the other is 1, and their use as inhibitors of renin.

The invention relates to compounds of formula I wherein R° represents H or OH; R" represents alkoxy; U and W represent N, V represents CH and R1represents H or F, or U and V represent CH, W represents N and R1represents H or F, or U and V represent N, W represents CH and R" represents H, or U represents N, ...

The invention relates to compounds of formula (I) (I) wherein U, V, W, X, R1, R2 ,R3, R4, R5, R6,A, B, D, E, G, m and n are as defined in the description, to pharmaceutically acceptable salts of such compounds for use in the manufacture of a medicament for the prevention or treatment of a bacterial infection. C...

The invention relates to antibacterial compounds of formula I wherein R1 is hydrogen, halogen, hydroxy, alkoxy or cyano; Y1 and Y2 each represent CH, one or two of U, V, W and X represent(s) N and the remaining each represent CH or, in the case of X, may also represent CRa, Ra being halogen, and, in the case of W, m...

Abstract Tetrahydroisoquinoline derivatives to enhance memory function The invention relates to the use of tetrahydroisoquinoline derivatives for the preparation of a medicament to enhance, maintain and/or restore all stages and/or types of short-, middle- and/or long-term memory.

The invention relates to compounds of formula (I)   wherein R1, R2 ,R1a, R2a, R3, R4, A, B, X, W and n are as defined in the description, and pharmaceutically acceptable salts of such compounds. These compounds are useful as calcium channel blockers.

Abstract (3-Amino-1,2,3,4-tetrahydro-9H-carbazol-9-yl)-acetic Acid Derivatives The present invention relates to (3-amino-l,2,3,4-tetrahydro-9//-carbazol-9-yl)-acetic acid derivatives of Formula I I wherein R1, R2, R3, R4, R5 and R6 are as described in the description and their use as prostaglandin receptor mo...

Abstract THIOPHENE DERIVATIVES AS S1P1/EDG1 RECEPTOR AGONISTS The invention relates to novel thiophene derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.

Stable pharmaceutical composition comprising a pyrimidine-sulfamide The invention relates to stable pharmaceutical compositions comprising the compound of the below formula, or pharmaceutically acceptable salts, solvates, hydrates or morphological forms thereof

Abstract 2-PHENYL-6-AMINOCARBONVL-PYRIM1DINE DERIVATIVES AND THEIR USE AS P2Y12 RECEPTOR ANTAGONISTS The invention relates to 2-phenyl-6-ai'ninbcarbonyl-pyrimidine derivatives and their use as P2Yi2 receptor antagonists in the treatment and/or prevention and/or treatment of peripheral vascular, or visceral-, hepat...

ABSTRACT The invention relates to novel bicyclic derivatives, and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the Compounds, pharmaceutical compositions containing one ...

The invention relates to novel sulfamic acid amides of General Formula (I) and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of...

The invention relates to aminopyrazole derivatives of formula (I), wherein A, E, R1 and R2 are as defined in the description, their preparation and their use as pharmaceutically active compounds.

The invention relates to novel thiophene derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunosuppressive agents.

The invention relates to antibacterial compounds of formula I wherein one or two of U, V, W, and X represent N, the rest represent CH or, in the case of X, may also represent CRa wherein Ra is fluorine; R1 represents alkoxy, halogen or cyano; R2 represents H, CH2OH, CH2N3, CH2NH2, alkylcarbonylaminomethyl or triazo...

The invention relates to novel pyridine derivatives, their preparation and their use as pharmaceuticaily active compounds. Said compounds particularly act as immunosuppressive agents.

The invention relates to novel thiophene derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunosuppressive agents.

Abstract The invention relates to novel primary amine derivatives and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of t...

Abstract The invention relates to novel amine derivatives and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pbarmaceulical compositions containing one or more of those com...

Abstract Treatment of early stage idiopathic pulmonary fibrosis This present invention relates to the use of an endothelia receptor antagonist for the preparation of a medicament for the treatment of early stage idiopathic pulmonary fibrosis.

The invention relates to dispersible tablets comprising the compound 4-tert-butyl-N-[6-(2-hydroxy-ethoxy)-5-(2-methoxy-phenoxy)-2-(pyrimidin-2-yl)-pyrimidin-4-yl]-benzenesulfonamide.

The invention relates to novel piperidine carboxylic acid amide derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of these novel compounds, pharmaceutical compositions comprising such ...

The invention relates to compounds of formula (I) wherein R1 represents aryl, which is unsubstituted, or mono-, di-, or tri-substituted wherein the substituents are independently selected from the group consisting of (C1-4)alkyl, (C1-4)alkoxy, halogen, and trifluoromethyl; R2 represents hydrogen, or -CO-R21; ...

The invention relates to 2-aza-bicyclo[3.3.0]octane derivatives of Formula (I) wherein A, B, and R1 are as described in the description, and to the use of such compounds, or of pharmaceutically acceptable salts of such compounds, as medicaments, especially as orexin receptor antagonists.

The present invention relates to the compound of formula 7*acetate (see below), a process for its preparation, and its use

The invention relates to compounds of Formula (I) wherein U, V, W, R1, Rl b, A and G are as defined in the description, to pharmaceutical acceptable salts of such compounds and to the use of these compounds in the manufacture of a medicament for the prevention or treatment of a bacterial infection. ...

The present invention relates to compounds of formula I wherein R1, R2, R4, R5 Ra, Rb n, W and Z are as defined in the application, their preparation and their use as P2Y12 receptor antagonists in the treatment and/or prevention of peripheral vascular, of visceral-, hepatic- and renal-vascular, of cardiovascular ...

The invention relates to antibacterial compounds of formula I wherein R1 represents alkoxy or halogen; U, V and W each represent CH, or one of U, V and W represents N and the others each represent CH; A represents CH2 or O; G is CH=CH-E wherein E represents a phenyl group mono- or di-substituted with haloge...

The invention relates to crystalline forms of (R)-5-[3-chloro-4-(2,3-dihydroxy- propoxy)-benz[Z]ylidene]-2-([Z]-propylimino)-3-o-tolyl-thiazolidin-4-one, processes for the preparation thereof, pharmaceutical compositions containing said crystalline forms, and their use as compounds improving vascular function and as...

The invention relates to crystalline salts of isobutyric acid (1R*,2R*,4R*)-2-(2-{[3-(4,7- dimethoxy-1H-benzoimidazol-2-yl)-propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5- en-2-yl ester, processes for the preparation thereof, pharmaceutical compositions containing said crystalline salts, and their use as ...

The invention relates to antibacterial compounds of formula I wherein R1 represents alkoxy (notably methoxy); R2 represents H or F; each of R3, R4, R5 and R6 represents independently H or D; V represents CH and W represents CH or N or V represents N and W represents CH; Y represents CH or N; Z represents O...

The invention relates to novel amino-pyridine derivatives, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.

The invention relates to novel thiazolidine derivatives of the formula (I) wherein A and R1are as described in the description and their use as medicaments, especially as orexin receptor antagonists.

The present invention relates to bridged spiro[2.4]heptane derivatives of fomiula (1), wherein W, Y, Z, R1 and R2 are as defined in the description, their preparation and their use as phamiaceutically active compounds.

The invention relates to pyridine derivatives of Formula (I) Formula (I) wherein A  R1  R2  R3  and R4 are as described in the description  their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.

(EN)The present invention relates to 3-(heteroaryl-amino)-1,2,3,4-tetrahydro-9H-carbazole derivatives of the formula (I), wherein R1, R2 and R3 are as described in the description and their use as prostaglandin receptor modulators, most particularly as prostaglandin D2 receptor modulators, in the treatment of variou...

NOT SCANNED

The invention relates to guanidine derivatives of formula (I) where: A = a chain of 3-c6 carbon atoms, one of which can be replaced by -N(R')- or -O- and R' = H or a substituent, where the ring skeleton only contains both double bonds of the thiazole component, the pharmaceutically-acceptable acid addition salts of ...

The invention relates to novel tetrahydropyridine derivatives and use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those comp...

The invention relates to novel bicyclic derivatives and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of ...

The invention relates to novel 2-aza-bicyclo[3.1.0]hexane derivatives of formula (I), wherein A. B, n and R1are as described in the description, and to the use of such compounds, or of pharmaceutically acceptable salts of such compounds, as medicaments, especially as orexin receptor antagonists. ...

Abstract The invention relates to 5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine derivatives of formula (I) wherein X represents CH2 or O; R 1 represents a phenyl group, which group is independently mono-, di-, or tri-substituted wherein the substituents are independently selected from the group consisting of (C...

115The present invention relates to 2 (1 2 3 triazol 2 yl)benzamide and 3 (1 2 3 triazol 2 yl)picolinamide derivatives of formula (I) Formula (I) wherein Ar Q and R to R are as described in the description to their preparation to pharmaceutically acceptable salts thereof and to their use as pharmaceuticals to pharma...

ABSTRACT The invention relates to novel ciiimeric antibiotics ot formula 1 n is 0 or 1; ^ and to salts (in particular pharmaceutically acceptable salts) of compounds of formula 1. If These chimeric compounds are useful in the manufacture of medicaments for the

12345The invention relates to compounds of Formula (I) wherein X Y R R R R and R are as described in the description; to pharmaceutically acceptable salts thereof and to the use of such compounds as medicaments especially as modulators of the CXCR3 receptor.

The invention relates to 2 5 disubstituted benzoxazole and benzothiazole derivatives of Formula (I) Formula (I) wherein L X Y and ring (A) are as described in the description their preparation and their use as pharmaceutically active compounds. Said compounds may be useful for the prevention or treatment of diseases...

The invention relates to novel 3,9-diazabicyclo[3.3.1]nonene derivatives of formula (I) and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical com...

The invention relates to pharmaceutical compositions containing at least one 5- (benz- (Z) -ylidene-thiazolidin-4-one derivative (I), to prevent or treat disorders associated with an activated immune system. Furthermore, the invention relates to novel thiazolidin-4-one derivatives notably for use as pharmaceutically...

The present invention relates to a pharmaceutical combination comprising a first active ingredient which is ponesimod and a second active ingredient which is selected from the group consisting of teriflunomide and leflunomide. [Figure 1]

The invention relates to novel secondary amine derivatives and the use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those com...

The invention relates to antibacterial compounds formula (I) wherein R1 is the group M, whereby M is one of the groups MA and MB represented below wherein A is a bond or C≡C; R1A is H or halogen; R2A is H or halogen; R3A is H, alkoxy, hydroxyalkoxy, h...

The present invention relates to a pharmaceutical combination comprising a first active ingredient which is (R) 5 [3 chloro 4 (2 3 dihydroxy propoxy) benz[Z]ylidene] 2 ([Z] propylimino) 3 o tolyl thiazolidin 4 one or a pharmaceutically acceptable salt thereof and a second active ingredient which is selected from the...

The present invention relates to pharmaceutical compositions comprising 2-{4-[N-(5,6- diphenylpyrazin-2-yl)-N-isopropylamino]butyloxy}-N-(methylsulfonyl)acetamide (selexipag, NS-304, ACT-293987) which are suitable for oral administration (p.o.).

The present invention relates to a pharmaceutical combination comprising a first active ingredient which is (R)-5-[3-chloro-4-(2,3-dihydroxy-propoxy)- benz[Z]ylidene]-2-([Z]- propylimino)-3-o-tolyl-thiazolidin-4-one or a pharmaceutically acceptable salt thereof and a second active ingredient which is selected fr...

123AB 1A2A3A1BThe invention relates to antibacterial compounds of formula I wherein R is H or halogen; R is the group M; R is H or halogen; M is M or M wherein A is a bond or C=C; R is H or halogen; R is H alkoxy or halogen; R is H alkoxy hydroxyalkoxy hydroxyalkyl 1 2 dihydroxyethyl dialkylamino 1 hydroxymethyl cyc...

The present invention relates to a process for the manufacturing of calcium;{4-[(5, 6- diphenylpyrazin-2-yl)(propan-2-yl)amino]butoxy}acetate, or a pharmaceutically acceptable hydrate or solvate thereof. Moreover, it relates to calcium;{4-[(5,6-diphenylpyrazin-2- yl)(propan-2-yl)amino]butoxy}acetate with high purity...