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Triazole Compounds As T Type Calcium Channel Blockers

Abstract: 124n5mThe invention relates to compounds of formula (I) wherein X Y R R (R) and (R) are as defined in the description and to pharmaceutically acceptable salts of such compounds. These compounds are useful as calcium T channel blockers.

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Notices, Deadlines & Correspondence

Patent Information

Application #
Filing Date
11 April 2017
Publication Number
16/2017
Publication Type
INA
Invention Field
CHEMICAL
Status
Email
Parent Application

Applicants

ACTELION PHARMACEUTICALS LTD.
Gewerbestrasse 16, CH-4123 Allschwil

Inventors

1. BEZENCON, Olivier
c/o Actelion Pharmaceuticals Ltd, Gewerbestrasse 16, CH-4123 Allschwil
2. GATFIELD, John
c/o Actelion Pharmaceuticals Ltd, Gewerbestrasse 16, CH-4123 Allschwil
3. HEIDMANN, Bibia
c/o Actelion Pharmaceuticals Ltd, Gewerbestrasse 16, 4123 Allschwil
4. SIEGRIST, Romain
c/o Actelion Pharmaceuticals Ltd, Gewerbestrasse 16, CH-4123 Allschwil
5. STAMM, Simon
c/o Actelion Pharmaceuticals Ltd, Gewerbestrasse 16, CH-4123 Allschwil

Specification

Claims

wherein
X represents a ring carbon or a ring nitrogen atom;
• R1 represents
> (Cz-sjalkyl;
> (C2-4)alkyl mono-substituted with cyano, or (Ci.3)alkoxy;
10 > (Ci.4)fluoroalkyi;
> (Ci-3)fiuoroalkoxy;
> pentafluoro-sulfanyl;
> (C3-e)cycloalkyl-L1- wherein
■ said (C3 e)cycloalkyl optionally contains one ring oxygen atom; wherein said
15 (C3-G)cycloaiky! is unsubstituted; or mono-substituted with fluoro, (Ci^alkyl, (Ci-
3)aikoxy, hydroxy, cyano, or (Ci-3)fluoroafkyl; or di-substituted with fluoro, or tri-substituted with two fluoro substituents and a (Chalky! substituent; and
■ the linker L1 represents a direct bond, (Cu)alkylene, oxygen, or (Ci-2)alkylene-oxy;
> 5- or 6-membered heteroaryl, independently optionally mono-substituted with (Chalky!;
20 > -NR11R12, wherein
■ R11 and R'2 independently represent hydrogen, (Ci-3)alkyl, (C^Jfluoroalkyl,
(C3.6)cycloalkyl, (C3-e)cycloalkyl mono- or di-substituted with fluoro, (C^cycloalkyl-
(Ci.3)alkyl,(C,.3)alkoxy-(C2.3)alkyl;
■ or R11 and R12, together with the nitrogen atom to which they are attached to, form a 4-
25 to- 6 membered ring which is optionally mono- or di-substituted with fluoro; a 2-oxo-
pyrrolidinyl group; or a morpholinyl group; and (R4)n represents one or two optional substituents independently selected from (Ci4)alkyl, (C1-4)alkoxy, {Ci-3)fiuoroaikyl, (Ci-3)fiuoroalkoxy, halogen, and cyano;

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• or R1 together with (R4),, forms a non-aromatic 5- or 6-membered ring which is fused to the phenyl /
pyridine ring; wherein said 5- or 6-membered ring optionally contains one or two heteroatoms
independently selected from oxygen and nitrogen; wherein said fused 5- or 6-membered non-aromatic
ring independently is optionally further mono-substituted with oxo; or di-, tri-, or tetra-substituted wherein
5 one substituent is oxo and the remaining are (Ci-3)alkyl;
• or R1 together with (R4)„ forms an aromatic 5- or 6-membered ring which is fused to the phenyl / pyridine
ring; wherein said 5- or 6-membered ring optionally contains one or two nitrogen atoms, wherein said
fused 5- or 6-membered aromatic ring independently is optionally further mono- or di-substituted wherein
the substituents are independently selected from (Ci4)a!kyl, (C3-6)cycloalky!, (Ci)fluoroalkyl, or cyano;
10 Y represents a ring carbon or a ring nitrogen atom; and
R2 represents (Cu)alkyl; fC3-6)cycloalkyl; (C^Jalkoxy; (C3^)cycloalkyl-oxy; (Ci-3)fluoroalkyi; {Ci-3)fluoroa!koxy; (Ci-3)alkoxy-(C2-3)alkoxy; halogen; cyano; or -NR21R22, wherein R2' and R22 independently represent hydrogen, or (Chalky!, or R21 and R22, together with the nitrogen atom to which they are attached to, form a 4- to- 6 membered ring optionally mono- or di-substituted with fluoro, or a morpholinyl group; 15 and
(R5)m represents one or two optional substituents independently selected from (C^)alkyi; (C3 e)cyc!oalkyl; (C^Jalkoxy; halogen; cyano; (Ci-3)fluoroalkyl; and (Ci-3)fluoroalkoxy; or a salt of such a compound.
2. A compound according to claim 1, wherein X represents a ring carbon atom;
20 or a salt of such a compound.
3. A compound according to claim 1 or 2, wherein
• R1 represents
> (C2-6)alkyl;
> (C^jalkyl mono-substituted with cyano, or (d^Jalkoxy;
25 > (Ci-4)fiuoroalkyl;
> (Ci^fluoroalkoxy;
> pentafluoro-sulfanyl;
> (C3-6)cycloalkyl-L1- wherein
■ said (C3-6)cycioalkyl optionally contains one ring oxygen atom; wherein said
30 (C3-6)cycloalkyl is unsubstituted, or mono-substituted with fluoro, (Ci-3)alkyl, (&.
3)alkoxy, hydroxy, cyano, or {Ci-3)fluoroalkyl, or di-substituted with fluoro, or tri— substituted with two fluoro substituents and a fCi.3)a!kyl substituent; and
■ the linker L1 represents a direct bond, (Cujalkylene, oxygen, or (Ci-2)aJky!ene-oxy;

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> -NR11R12, wherein
- R11 and Ri2 independently represent hydrogen, {Ci-3)alkyl, (C2-3)fluoroa!kyi,
(C3.6)cycloalkyl, (Cs-ejcycloalkyl mono- or di-substituted with fluoro, (C^cycioalkyl-
(Ci.3)alkyl;
5 ■ or R11 and R'?, together with the nitrogen atom to which they are attached to, form an
azetidinyl or a pyrrolidinyl ring, both independently optionally mono- or di-substituted
with fluoro;
and (R")n represents one optional substituent selected from (C^Jalkyl, (Ci-4)a!koxy, (Cnjfluoroalkyl, (Ci-
3)fluoroalkoxy, halogen, and cyano;
10 • or R1 together with (R4}„ forms a non-aromatic 5- or 6-membered ring which is fused to the phenyl /
pyridine ring to form a bicyclic ring system; wherein said bicyclic ring system is selected from 2,3-dihydro-
benzooxazolyl, 3,4-dihydro-2H-benzo[1,4]oxazinyi, 2,3-dihydro-1H-indolyl, and 2,3-dihydro-benzofuranyi;
wherein said non-aromatic 5- or 6-membered ring part of said bicyclic ring system independently is
optionally further mono-substituted with oxo; or di-, tri-, or tetra-substituted wherein one substituent is oxo
15 and the remaining are (Chalky!;
• or R1 together with (R4)„ forms an aromatic 5- or 6-membered ring which is fused to the phenyl / pyridine
ring to form a bicyclic aromatic ring system selected from pyrazolo[3,4-b]pyridinyl, pyrrolo[2,3-b]pyridinyi,
indolyl, indazolyi, quinoxalinyl, benzoimidazolyl, and quinolinyl; wherein said fused 5- or 6-membered
aromatic ring part of said aromatic bicyclic ring system independently is optionally further mono- or di-
20 substituted wherein the substituents are independently selected from (Cujalkyl, (C3-6)cycloalkyl,
(Ci)fluoroalkyl, or cyano; or a salt of such a compound.
4. A compound according to claims 1 or 2, wherein
• R1 represents
25 > (C2-6)alkyl;
> (Ci-^)fluoroalkyi;
> (Ci.3)fluoroaikoxy;
> (C3-6)cycloalkyl wherein
■ said (C3-C)cycloalkyl optionally contains one ring oxygen atom; wherein said
30 (C3-e)cycloa!kyl is mono-substituted with fluoro or (Ci^)fluoroaiky!, or di-substituted with
fluoro; or
> (C3-6)cycloalkyi-oxy- wherein
said (C3-e)cycloalkyl optionally contains one ring oxygen atom; wherein said
(Cs-ejcycloalkyl is unsubstituted, or di-substituted with fluoro;
35 and (R4)r> represents one optional substituent selected from (Ci-4)alkyl, or halogen;
or a salt of such a compound.

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5. A compound according to claims 1 or 2, wherein the fragment
(R4)n
rx
represents 4-isopropy!-phenyl, 4-dimethylamino-phenyl, 4-trifluoromethyl-phenyl, 4-terf.-butyi-phenyl, 4-(1-methoxy-ethyl)-pheny1, 4-(cyclopropyl-oxy)-phenyl, 4-(oxetan-3-yl)-phenyl, 4-(3-fluoro-oxetan-3-yl)-phenyl, 4-5 (cyclobutyl-oxy)-phenyl, 4- (3-methy I -oxeta n-3-y I )-ph en y 1. 4-(1-cyano-cyc!opropy!)-phenyl, 4-(1-cyano-1-methyl-ethyl)-phenyl, 4-(pentafluoro-sulfenyl)-phenyl, 3-methyl-4-(2,2,2-trifluoroethoxy)-phenyl, 4-(3-methoxy-oxetan-3-yl)-phenyl, 4-(oxetan-3-yi-methoxy)-phenyl, 4-(2-trifluoromethyl-cyclopropyl)-phenyl, 4-(1-trifluoromethyl-cyclopropylj-phenyl, - 4-((3-fluoro-oxetan-3-yl)-methoxy)-phenyl, 4-((3-methyl-oxetan-3-yl)-methoxy)-phenyl, 4-(3,3-difluoro-cyclobutyl-oxy)-phenyl, 4-(2,2,2-trifluoro-1,1-dimethyl-ethyl)-phenyl, 4-((3,3-
10 difluoro-cyciobutyl)-methoxy)-phenyi, 4-((3,3-difluoro-1 -methyl-cyclobutyl)-methoxy)-phenyi; 2-fpyrrolidin-1 -yl)-pyridin-5-yl, 2-(cyclopropyl(methyl)amino)-pyridin-5-yl, 2-fdiethylamino)-pyridin-5-yl, 3-fluoro-2-(pyrrolidin-1-yl)-pyridin-5-y!, 2-f(cyclopropylmethyl)-methyl-amino)-pyridin-5-yl, 2-(3,3>difluoro-pyrrolidin-1-y!)-pyridin-5-yl; 3,3-dimethyl-2-oxo-2,3-dihydro-1H-indof-5-yl, 1,3,3-trimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl, 1-meihyl-1H-pyrazolo[3,4-b]pyridin-5-yl, 1H-indo!-5-yl, 1H-indol-6-yl, 1-methyl-1H-indazol-5-yl, 1-methyi-1H-indazoi-6-yi, 1-
15 ethyl-1 H-indazol-5-y!, 1,3-dimethyl-1 H-indazoi-5-yl, 1-propyl-1H-indazol-5-yl, 1 -isopropyl-1 H-indazol-5-yl, 1-butyl-1 H-indazol-5-yi, 3-buty!-1 H-indazol-5-yl, 3-trifluoromethyl-1 H-indazol-5-yl, 3-cyclopropyl-1 H-indazol-5-yl, 3-cyc!opropyi-1-methyl-1H-indazol-5-yl, 1-methyl-1 H-indol-5-yl, 2-methyl-1 H-Sndol-5-yl, 1,3-dimethyl-1H-indol-5-yl, or 1,3-dimethy!-1H-indol-6-yl; or a salt of such a compound.
20 6. A compound according to any one of claims 1 to 5, wherein
• Y represents a ring carbon or a nitrogen atom;
• R2 represents (Ci.4)alkyl; (Ci-^alkoxy; (Ci.3)fluoroalkyl; (Ci-3)fluoroalkoxy; (Ci-3)alkoxy-(C2-3)alkoxy; halogen; or cyano; and
• (R5)m represents one or two optional substituents independently selected from (Cn)alkyl;
25 (Cn)alkoxy; halogen; cyano; (Ci-3)fluoroalkyl; and (Ci-3)fluoroalkoxy;
or a salt of such a compound.
7. A compound according to any one of claims 1 to 5, wherein
• Y represents a ring nitrogen atom; and
> R2 represents cyano; and
30 > (R5)m is absent; or
• Y represents a ring carbon atom; and

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> Rz represents (Cujalkyl; (Cn)aikoxy; (Ci-3)fluoroalkoxy; {Cu)alkoxy-(C2j)alkoxy; halogen; or cyano; and
> (R5)m represents one or two optional substituents independently selected from (CuJaJkyl; (CM)alkoxy; halogen; and cyano;
5 or a salt of such a compound.
8. A compound according to any one of claims 1 to 5, wherein the fragment
R2
V^(R5)m
represents 4-fluorophenyl, 4-methylphenyl, 4-fluoro-3-cyano-phenyl, 3,4-difluorophenyl, 3,5-difluoro-4-methoxy-phenyl, 3-fluoro-4-methoxy-phenyl, 4-cyano-3-fluoro-phenyl, 4-cyano-3-methyl-phenyl, 3-cyano-4-10 methyl-phenyi, 4-methoxyphenyl, 4-ethoxyphenyl, 3,4-dimethoxyphenyl, 4-fluoro-3-methoxy-phenyl; 3,4-difluoro-5-methoxy-phenyl, 3-cyano-4-methoxy-phenyl, 4-cyano-3-methoxy-phenyl, 4-cyano-3-fluoro-5-methoxy-phenyl, 4-cya no phenyl, 4-(2-methoxy-ethoxy)-phenyl, 4-difluoromethoxy-phenyl, 4-trifluoromethoxy-phenyl, 3-fluoro-4-difluoromethoxy-phenyl; 3-fluoro-4-trif!uoromethoxy-phenyl; or 5-cyano-pyridin-2-yi; or a salt of such a compound.
15 9. A compound according to claim 1 selected from the group consisting of
N-[2-(4-Fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(4-isopropyl-pheny!)-acetamide;
2-(4-Dimethylamino-phenyl)-N-[2-(4-fluoro-benzyi)-2H-[1,2,3]triazol-4-yl]-acetamide;
N-[2-(3,4-Difluoro-benzyl)-2H-[1,2,3]triazoi-4-yl]-2-(4-isopropyl-phenyl)-acetamide;
N-[2-(3,4-Dif]uoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-{1-methyl-1H-indazol-5-yl)-acetamide; 20 N-[2-(3,4-Difluoro-benzyi)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indol-5-y!)-acetamide;
N-[2-(3,4-Difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-f1H-indol-6-yl)-acetamide;
2-(4-Cyc[obutoxy-phenyl)-N-[2-(3,4-difluoro-benzyl)-2H-[1,2,33triazol-4-yl]-acetamide;
2-(4-Cyc!opropoxy-phenyl)-N-[2-(3,4-difluoro-benzyl)-2H-[1,2,3]triazol-4-yi3-acetamide;
2-[6-(Cyclopropylfmethyi)amino}-pyridin-3-yl]-N-[2-(3,4-difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide; 25 2-[6-(Cyclopropylmethyl-rnethyl-amino)-pyridin-3-yl]-N-j2-(3,4-difluoro-benzyl)-2H-[1]2,3]triazol-4-yl]-
acetamide;
N-[2-(3,4-DifluorO"benzyl)-2H-[1,2,3]triazol4-yl]-2-{4-(1-methoxy-ethyl)-phenyl]-acetamide;
N-[2-(3,4-Difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-fluoro-oxetan-3-yl)-phenyl]-acetamide;
N-[2-(3,4-Difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1H-indo]-5-yl)-acetamide; 30 2-t6-Diethylamino-pyridin-3-yf)-N-[2-f3,4-difluoro-benzyl)-2H-[1,2,3jtriazol-4-yl]-acetamide;
N-[2-f3,4-Difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[6-(3,3-d!f]uoro-pyrrolidin-1-yl)-pyridin-3-yi]-acetamide;
N-[2-{3,4-Difluoro-benzyl)-2H-[1,2,3]triazoi-4-yl]-2-(6-pyrrol!din-1-yl-pyridin-3-yl)-acetamide;

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N-[2-(3,4-Difluoro-benzyl}-2H-[1,2,3]triazoJ-4-yl]-2-(1l3l3-trimethyl-2-o^o-2,3-dihydro-1H-Jndol-5-yl)-acetamide;
N-{2-(3,4-Difluoro-benzyl)-2H-[1,2,3]triazoi4-yl]-2-[4-(3-methoxy-oxetan-3-yl)-phenyl]-acetamide;
N-(2-(3,4-Difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-f3>3-dimethyl-2-oxo-2l3-dihydro-1H-indol-5-yl)-acetamide;
N-[2-(3l4-Difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-|4-(3-methyl-oxetan-3-yl)-pheny!]-acetamide; 5 N-[2-(3,4-Difluoro-benzyl)-2H-f1,2,3]triazol-4-yl]-2-(4-oxetan-3-yl-pheny|)-acetamide;
2-(4-lsopropyl-phenyl)-N-[2-(4-methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;
2-(4-lsopropyl-phenyl)-N-[2-(4-methoxy-benzyl)-2H-[1,2,3]iriazo!4-yl]-acel:amJde;
N-[2-(4-Cyano-benzyi)-2H-[1,2,3]triazo!-4-yl]-2-(4-isopropy!-phenyl)-acefamide;
N-[2-(3,4-Difiuoro-benzy!)-2H-[1,2,3]triazol-4-yl]-2-(1 -ethyl-1 H-indazol-5-yl)-acetamide; 10 N-[2-(3,4-Difluoro-benzyi)-2H-[1,2,3]triazol-4-yl]-2-f1,3-dimethyi-1HHndazo!-5-yl)-acetamide;
2-(3-Cyclopropyl-1H-indazol-5-yl)-N-[2-(3,4-difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-acelamide;
2-(1-Butyl-1H-indazoi-5-yl)-N-[2-(3,4-difluoro-benzyl)-2H-[1,2,3]triazoi-4-yl]-acetamide;
N-[2-(3,4-Difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-f2-methyl-1HHndoi-5-yl)-acetamide;
2-(3-Butyl-1H-indazol-5-y!)-N-[2-(3,4-difluoro-benzyl)-2H-[1,2,3]triazoi-4-yl]-acetamide; 15 N-[2-(3,4-Difluoro-benzyl)-2H-[1,2,3]triazol-4-yf]-2-(1 -isopropy!-1 H-indazoi-5-yl)-acetamide;
N-[2-(3,4-Difiuoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-propyl-1H-indazo|-5-yl)-acetamide;
2-(3-Cyclopropyl-1-methyl-1H-indazol-5-yl)-N-[2-(3,4-difluoro-benzyl)-2H-|1,2,3]triazo!-4-yl]-acetamide;
N-[2-(3,4-Difiuoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methy]-1H-pyrazolo[3,4-b]pyridin-5-yl)-acetamide;
N-[2-(3,4-Difluoro-benzyi)-2H-[1,2,3]triazol-4-yl]-2-(3-trifluoromethyl-1H-iridazol-5-yl)-acetamide; 20 N-[2-f4-Ethoxy-benzyl)-2H-[1,2,3]triazoi-4-yS]-2-(1-methyi-1H-!ndol-5-y|}-acetamide;
2-[6-(3,3-Difiuoro-pyrrolidin-1-yl)-pyrJdin-3-yt3-N-[2-(4-ethoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;
N-[2-(4-Ethoxy-benzyi)-2H-[1,2,3]Eriazol-4-y!]-2-[4-(3-methyl-oxetan-3-y!)-phenyl]-acetamide;
2-(4-tert-Butyl-phenyl)-N-[2-(4-ethoxy-benzyl)-2H-[1l2,3]triazol-4-yl]-acetamide;
N-[2-(4-Ethoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-f4-isopropyI-phenyl)-acetamide; 25 N-[2-(4-Ethoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(6-pyrrolidin-1-y!-pyridin-3-yl)-acetamide;
N-[2-(4-Ethoxy-benzyJ)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indazol-5-yl)-acetamide;
2-(6-Diethyiamino-pyridin-3-yl)-N-[2-f3,4-dimethoxy-benzyl)-2H-[1,2,3]triazoi-4-yl]-acetamide;
2-[6-(3,3-Dif3uoro-pyrrolidin-1-yl)-pyridin-3-yl]-N-[2-(3,4-dimethoxy-benzyl)"2H-[1,2,3]triazol-4-yl]-acetamide;
2-(4-(erl-Butyl-phenyl)-N-[2-(3,4-dimethoxy-benzyl)-2H-[1,2,3]triazol-4^y|]-acetamide; 30 N-[2-(3,4-Dirne(hoxy-benzyl)-2H-[1>2,3]triazol-4-y!]-2-(4-isopropyl-phenyl)-acetainide;
N-[2-f3,4-Dimethoxy-benzyl)-2H-[1l2l3]triazol-4-yl]-2-(6-pyrrolidin-1-yl-pyridin-3-yl)-acetamide;
N-[2-(4-Fluoro-benzyl)-2H-[1,2,3]tnazol-4-yl]-2-(1-methyl-1H-indol-5-yl)-acetamide;
N-[2-(4-Fluoro-benzyl)-2H-[1,2,33trJazol-4-yl]-2-[4-(3-methyi-oxetan-3-yl)-phenyl]-acetamide;
2-(4-tert-Butyl-pheny!)-N-[2-(4-fluoro-benzy!)-2H-[1,2,3]triazol-4-yl]-acetamide; . 35 N-[2-(4-Ffuoro-benzyl)-2H--[1,2,3]triazo!-4-yl3-2-(6-pyrrol!din-1-yl-pyndin-3-y[)-acetarnide;
N-[2-(4-Fluoro-benzyl)-2H-[1,2,3]triazol~4-yl]-2-(1 -methy!-1 H-indazol-5-yl)-acetamide;

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N-[2-(4-Methoxy-benzyl)-2H-[1.2,3]triazol-4-yl]-2-( 1 -methyl-1 H-tndol-5-yl)-acetamide;
2-(6-DieEhylamino-pyridin-3-yl)-N-[2-(4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;
2-[6-(3,3-DJftuoro-pyrrolidin-1-yl)-pyridin-3-yl]-N-[2-(4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamJde;
N-(2-(4-Me[hoxy-benzyl)-2H-[1,2,3]tfiazol-4-yl]-2-[4-f3-methyl-oxetan-3-yi)-phenyfacefamide; 5 2-(4-tert-8uty!-phenyl)-N-[2-(4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;
N-[2-(4-Methoxy-benzyl)-2H-[1,2,33triazol-4-yl]-2-{6-pyrrolidin-1-yl-pyridin-3-yl}-acetamide;
N-[2-(4-Methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indazoi-5-yl)-acetamide;
N-[2-(4-Methyl-benzyl)-2H-[1,2,3]trJazol4-yl]-2-(1-methyl-1H-indol-5-yl)-acetamide;
2-[6-(3,3-Difluoro-pyrrolidin-1-yl)-pyridJn-3-yl]-N-[2-(4-methyl-benzyi)-2H-[1,2,3]triazol-4-yl]-acetamide; 10 2-(4-tert-Butyl-phenyl)-N-[2-(4-methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;
N-[2-(4-Methyl-benzyl)-2H-i1,2l3]triazol-4-yl]-2-[4-(3-methyl-oxetan-3-yl)-phenyl]-acetamide;
N-[2-(4-Methyl-benzyl)-2H-[1]2]3]trJazol4-yl]-2-(6-pyrrolidin-1-yl-pyrJdin-3-yl)-acetamide;
N-[2-(4-Methy!-benzyl)-2H-j1,2,3]triazol4-yi]-2-(1 -methyl-1 H-indazol-5-yl)-acetamide;
N-[2-(4-Cyano-3-fiuoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indol-5-yl)-acetamide; 15 N-[2-(4-Cyano-3-fluoro-benzyl}-2H-[1,2,3]triazol-4-y]]-2-[6-(3,3-difJuoro-pyrrolidJn-1-yl)-pyridin-3-yl]-acetamide;
N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1]2,3]triazol-4-yl]-2-[4-f3-methyl-oxetan-3-yl)-phenySj-acetamide;
2-(4-(ert-Buty!-phenyi)-N-[2-(4-cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;
N-[2-(4-Cyano-3-fluoro-benzyi)-2H-[1,2,3]triazol-4-yl]-2-(4-isopropyl-phenyl)-acetamide;
N-i2-f4-Cyano-3-fluoro-benzyi)-2H-[1,2,3]triazo!-4-yl]-2-(6-pyrrolidin-1-yl-pyridin-3-yl)-acetamide; 20 N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1l2,3]triazol-4-yl]-2-(1-methyl-1H-indazol-5-yl)-acetamide;
N-[2-f3,5-Difiuoro-4-methoxy-benzyl)-2H-[1,2,3]trJazol4-yl]-2-f1-methyl-1H-indol-5-yl)-acetamide;
N-[2-(3,5-Difluoro-4-methoxy-benzyl)-2H-[1l2,33triazol-4-ylj-2-[4-(3-methyl-oxetan-3-yl)-phenyl]-acetamide;
2-(4-tert-Butyi-phenyl)-N-(2-(3,5-difluoro4-methoxy-benzyl}-2H-[1,2,3]triazol-4-yi]-acetamide;
N-[2-(3,5-Difluoro4-methoxy-benzyl)-2H-[1,2,33triazoi-4-yl]-2-(4-isopropyl~phenyl)-acetamide; 25 N-[2-(3,5-Dif!uoro-4-methoxy-benzyl)-2H-[1,2,3]triazol4-yl]-2-(6-pyrrolidin-1-yl-pyridin-3-yl)-acetamide;
N-[2-(3,5-Difluoro-4-methoxy'benzyl)-2H-[1,2,3]triazol4-yl]-2-(1-methyl-1H-indazol-5-y])-acetamide;
2-(4-tert-Butyl-phenyi)-N-{2-[4-(2-methoxy-ethoxy)-benzyl]-2H-[1,2,3]triazol-4-y!}-acetamide;
N-{2-[4-(2-Methoxy-ethoxy)-benzyl]-2H-[1,213]triazol-4-yl}-2-(1-methyl-1H-indol--5-y])-acetamide;
2-(4-tert-Butyl-phenyl)-N-[2-f4-difIuoromethoxy-benzyl)-2H-[1,2,3]triazol-4-yl3-acetamide; 30 N-[2-(4-Difluoromethoxy-benzyl)-2H-|1,2,3]triazol4-yl]-2-(1 -methyl-1 H-indol-5-yl)-acetamide;
2-(4-tert-Butyl-phenyl)-N-[2-f4-trJfiuoromethoxy-benzyl)-2H-[1,2,3]trJazol4-yl|-acetamJde;
2-(1-Methyl-1H-indol-5-yl)-N-[2-(4-trifluoromethoxy-benzyl)-2H-[1,2,3]triazo!-4-yl]-acetamide;
2-(1-Methyl-1H-indazol-5-yl)-N-{2-(4-trif!uoromethoxy-benzyl)-2H-[1,2,3]tnazol-4-yl]-acetamide; 2-[4-(3-Methyl-oxetan-3-yl)-phenyl]-N-[2-(4-trifluoromethoxy-benzyl)-2H-{1,2,3]triazol4-yl]-acetamide; 35 2-|6-(3]3-Diffuoro-pyrro!idin-1-yl)-pyridin-3-y[]-N-[2-(4-fluoro-benzyl)-2H-[1,2,3]tnazol-4-yl]-acetamide; 2-(6-Diethylamino-pyridin-3-yf}-N-[2-f4-fluoro-benzyl)-2H-l1,2,3]triazol4-yl]-acetamide;

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2-(4-tert-Butyl-phenyl)-N-[2-(4-cyano-benzy!)-2H-[1,2,3]triazol-4-yl]-acetamide;
N-[2-(4-Cyano-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[6-(3,3-difluoro-pyrrolidin-1-yl)-pyridin-3-yl]-acetamide;
N-(2-(4-Cyano-benzyl)-2H-[1l2,3]triazoi-4-yl]-2-(6-pyrro!idin-1-y!-pyridin-3-yl)-acetamide;
N-[2-(4-Cyano-benzyl)-2H-[1,2,3]triazol-4-yJ]-2-(1-methy]-1H-indol-5-yl)-ace(amide; 5 N-[2-f4-Cyano-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1,3-dimethyM H-indoi-5-yl)-acetamide;
N-[2-(4-Cyano-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indazol-6-yl)-acetamide;
N-[2-(4-Cyanobenzyl)-2H-[t,2,3]triazol-4-yl]-2-(1,3-dimethyM H-indazol-5-yl)-aceiamide;
N-[2-(4-Cyano-benzyl)-2H-|1,2,3]triazoM-yl]-2-(1-ethy!-1H-indazol-5-yl)-acetamide;
N-[2-(4-Cyano-benzyi)-2H-[1,2,3]triazoi-4-yl]-2-(1 -propyl-1 H-indazol-5-yl)-aceiamide; 10 N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1,2,33triazol-4-yl3-2-(1,3-dimethyl-1H-indol-6-yl)-acetamide;
N-[2-(4-Cyano-benzyl)-2H-[1,2,3]iriazol-4-y!]-2-(1,3-dimethyl-1 H-indol-6-yl)-ace!amide;
N-[2-(4-Fluoro-3-methoxy-benzyl)-2H-[1,2,3]triazol-4-y!]-2-[4-foxeian-3-ylme!hoxy)-phenyl]-acetamide;
N-[2-(4-Fluoro-3-methoxy-benzyl)-2H-[1,2,3]triazoM-yl]-2-(1-meihyf-1H-indazol-6-yl)-acelamide;
N-[2-(4-F!uoro-3-metiioxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-f3-methoxy-oxetan-3-y!)-phenyl]-acetamide; 15 2-[4-(3,3-Diftuoro-cyciobuiylmelhoxy)-pheny!]-N-[2-(4-f!uoro-3-methoxy-benzyl)-2H-[1,2,33triazoM-yl]-
acetamide;
N-[2-(4-Fluoro-3-methoxy-benzyl)-2H-[1,2,3]triazoM-yl]-2-[4-(3-methyl-oxetan-3-ylmethoxy)-phenyl]-
acetamide;
N-[2-(4-Fluoro-3-meihoxy-benzyi)-2H-[1,2,3]triazol-4-yi]-2-[4-(1-trif!uoromethyl-cyclopropyl)-phenyJj-20 acetamide;
2-[4-(3,3-Difluoro-cyciobutoxy)-phenyl]-N-[2-(4-fluoro-3-methoxy-benzyl)-2H-[1,2,3]triazo!-4-yl]-acetamide;
2-[6-(3,3-Difluoro-pyrroiidin-1-yl)-pyridin-3-y!]-N-[2-(4-fluoro-3-methoxy-benzyl)-2H-[1,2,3]triazol-4-y!]-
acetamide;
N-[2-(4-Fluoro-3-methoxy-benzyi)-2H-[1,2,3]triazol-4-yI]-2-(4-f3-fluoro-oxetan-3-yl)-phenyl]-acetamide; 25 2-(1-Ethyl-1H-indazoi-5-yi)-N-|2-(4-Ruoro-3-methoxy-benzyl)-2H-[1,2,3]triazol-4-y!]-acetamide;
2-(1,3-Dimethyl-1H-indoi-5-yl)-N-[2-f4-fluoro-3-methoxy-benzyl)-2H-[1,2,33triazol4-y]]-acetamide;
2-(4-tert-Butyt-phenyl)-N-[2-(4-fluoro-3-methoxy-benzyl)-2H-[1,2,3]triazol-4-y!]-acetamide;
N-[2-(3-Fluoro-4-methoxy-benzyi)-2H-[1,2,3]triazoM-yl]-2-[4-(oxetan-3-ytmethoxy)-phenyl]-acetamide;
N-[2-(3-Fluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-ylJ-2-(1 -methyl-1 H-indazol-6-yI)-acetamide; 30 N-[2-(3-Fluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-methoxy-oxefan-3-yl)-phenyl]-acetamide;
N-[2-f3-Fluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yi]-2-[4-(3-methyl-oxetan-3-ylmethoxy)-phenyi]-
acetamide;
N-[2-(3-Fluoro-4-methoxy-benzyi)-2H-[1,2,3]triazoi-4-yl]-2-[4-(1-trifluoromethyl"Cyclopropyi)-phenyl]-
acetamide; 35 2-[4-(3,3-Difluoro-cyclobutoxy)-phenyl]-N-[2-(3-f!uoro4-methoxy-benzyl)-2H-[1,2,3]triazol4-yl]-acetamide;

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2-[6-(3,3-Difluoro-pyrrolidin-1-y!)-pyridin-3-yl]-N-[2-(3-fiuoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-
acetamide;
N-[2-(3-Fluoro-4-methoxy-benzyf)-2H-[1l2,3]triazoi-4-y[3-2-E4-{3-fluoro-oxetan-3-yl)-phenyl]-acetamide;
2-(1-Ethyi-1H-indazoi-5-yl)-N-[2-(3-fluoro4-meihoxy-benzyl)-2H-[1,2,33iriazol-4-yi]-acetamide; 5 2-(1,3-Dimethyl-1 H-indol-5-yl)-N-[2-(3-fluoro-4-methoxy-benzyi)-2H-[1,2,3]triazol-4-y!]-acetamide;
2-(4-tert-Bulyl-phenyl)-N-[2-(3-f!uoro-4-methoxy-benzyi)-2H-[1,2,3]tri3zol-4-yl3-acetamide;
N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-foxetan-3-ylmethoxy)-phenyl]-acetamide;
N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indazol-6-yl)-acetamide;
N-[2-(4-Cyano-3-fluoro-benzy!)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-methoxy-oxetan-3-yl)-phenyl]-acetamide; 10 N-[2-(4-Cyano-3-fluoro-benzy!)-2H-[1,2,3]triazol-4-yl]-2-[4-(3,3-difluoro-cyclobutylmethoxy)-phenyl]-acetamide;
N-[2~(4-Cyano-3-fluoro-benzyl)-2H-[1]2]3]triazol4-yl]-2-[4-(3-methy!-oxetan-3-ylmethoxy)-phenyl]-acetamide;
N-[2-(4-Cyano-3-f!uoro-benzyl)-2H-[1l2,3]triazol4-yl]-2-[4-(1-trifluoromethyl-cydopropyl)-phenyl]-acetamide;
N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1,2,3]triazo!-4-yl]-2-[4-(3,3-difluoro-cyclobutoxy)-phenyl]-acetamide;
N-[2-f4-Cyano-3-fluoro-benzyi)-2H-[1,2,3]triazo!-4-y]]-2-[4-(3-fluoro-oxeEan-3-yl)-phenyl]-acetamide; 15 N-[2-(4-Cyano-3-fluoro-benzyi)-2H-[1,2,33triazol4-yl]-2-(1-ethyl-1H-indazoi-5-yi)-acetamide;
N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol4-yl]-2-(1,3-dimethy]-1H-indo!-5-yi)-acetamide;
N-[2-(3,5-Difluoro4-methoxy-benzy!)-2H-[1,2,3]triazo!4-yl]-2-[4-(oxetan-3-ylme{hoxy)-pheny!]-acetamide;
N-[2-f3,5-Difluoro4-methoxy-benzyJ)-2H-[1,2,3]triazoJ4-yl]-2-(1-methyl-1H-indazol-6-y!)-ace(amJde;
N-[2-(3,5-Difluoro4-methoxy-benzyl)-2H-[1,2,3]triazol4-yl]-2-[4-f3-methoxy-oxetan-3-y!)-phenyl]-acetamide; 20 N-[2-(3,5-Difluoro4-methoxy-benzyl)-2H-[1,2,3]triazol4-yl]-2-[4-f3-methyl-oxetan-3-ylmethoxy)-phenyl]-
acetamide;
N-[2-(3,5-Difiuoro4-me{hoxy-benzyl)-2H-[1,2,33triazo!4-yl]-2-[4-(1-trifluoromethyi-cyclopropyl)-phenyl]-
acefamide;
2-[4-(3,3-Dif!uoro-cyclobutoxy)-phenyi]-N-[2-(3,5-dif3uoro4-methoxy-benzyl)-2H-[1,2,3]triazol4-yl]-acetamide; 25 N-[2-(3,5-DJfluoro4-methoxy-benzyJ)-2H-[1,2,3]triazol4-y!]-2-[6-(3,3-difluoro-pyrrolidin-1-yi)-pyridin-3-yl]-
acetamide;
N-[2-f3,5-Difiuoro-4-methoxy-benzyl)-2H-[1,2,3]triazoi4-yl]-2-[4-(3-fluoro-oxetan-3-yl)-phenyl]-acetamide;
N-[2-(3,5-Difluoro4-methoxy-benzyl)-2H-[1,2,3]triazol4-yi]-2-(1-ethyi-1H-indazol-5-yl)-acetamide;
N-[2-(3,5-Difluoro-4-methoxy-benzyl)-2H-[^^ 30 N-[2-(4-Fluoro-3-methoxy-benzyl)-2H-{1,2,33triazoi4-yl]-2-(1-methyl-1H-indazol-5-yl)-acetamide;
N-[2-(3-F[uoro4-methoxy-benzyl)-2H-[1,2,3]triazol4-yl]-2-(1-methyl-1H-indazol-5-yl)-acetamide;
N-[2-(4-FJuoro-3-methoxy-benzyl)-2H-[1,2,3]triazol4-yl]-2-f4-isopropyl-phenyl)-acetamide;
N-[2-(3-Fluoro4-methoxy-benzyl)-2H-[1,2,3]triazol4-yl]-2-(4-isopropyl-pheny!)-aceiamide;
N-[2-(4-Fiuoro-3-methoxy-benzyl)-2H-[1,2,3]triazol4-yi]-2-(6-pyrrolidin-1-y!-pyridin-3-yl)-acetamide; 35 N-[2-f 3-Fluoro-4-methoxy-benzyl)-2 H-[ 1,2,3]triazol-4-yl]-2-(6-pyrrolidin-1 -yi-pyridin-3-yl )-acetamide;
2-[4-(Cyano-dimethyl-methyl)-phenyl]-N-[2-(4-cyano-3-fluoro-benzyi)-2H-[1,2,3]tri3zoi4-yl]-acetamide;

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2-(4-iert-Butyl-phenyl)-N-[2-(4-cyano-3-f!uoro-5-methoxy-benzyl)-2H-[l,2,3]triazol4-y!]-acetamide;
N-[2-f4-Cyano-3-fluoro-benzy!)-2H-[1,2,3]triazol-4-yl3-2-(4-trJfluoromethyl-phenyl)-acetamide;
N-[2-(4-Cyano-3-fiuoro-benzyl)-2H-[1,2,33trlazol-4-yl]-2-(5-fluoro-6-pyrrolidin-1-yJ-pyrJdin-3-yl)-acetamide;
2-(4-tert-Butyl-phenyl)-N-[2-(4-cyano-3-methyl-benzyl)-2H-[1,2,3]triazol-4-yi]-acetamide; 5 N-[2-(4-Cyano-3-methyi-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyi-1H-indazoi-6-yl)-acetamide;
N-(2-(4-Cyano-3-methy!-benzyl)-2H-[1,2,33triazol-4-y!]-2-(1-methyl-1H-indazol-5-yl)-acetamide;
N-[2-(4-Cyano-3-methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(4-isopropyl-phenyl)-acetamide;
N-[2-(4-Cyano-3-meihyl-benzyl)-2H-[1,2,3]triazol4-yl]-2-[4-(3,3-difluoro-cyclobutoxy)-phenyl]-acetamide;
N-[2-(4-Cyano-3-methyl-benzyl)-2H-[1,2,3]triazol4-yl]-2-[6-(3l3-dJffuoro-pyrro!idin-1-yi)-pyridin-3-yl]-10 acetamide;
N-[2-(4-Cyano-3-methy!-benzyf)-2H-[1,2,3]triazol4-yl]-2-(1-ethyi-1H-indazol-5-y!)-acetamide;
N-[2-(4-Cyano-3-methyl-benzyl)-2H-[1,2,3]triazol4-yl]-2-(1,3-dimethyl-1H-indazol-5-yl)-acetamide;
N-[2-(4-Cyano-3-meihyl-benzyl)-2H-[1,213]inazol4-yl3-2"(6-pyrrolidin-1-y!-pyridin-3-yJ)-acetamide;
N-[2-(4-Cyano-3-methyl-benzyl)-2H-[1,2,3]triazo!4-yl]-2-(1,3-dimethy]-1H-indol-5-yl)-acetamide; 15 2-(4-tert-Butyi-phenyl)-N-[2-(3-cyano4-fluoro-benzyl)-2H-[1,2,33iriazol4-yl]-acelamide;
N-[2-(3-Cyano4-fluoro-benzyi)-2H-[1,2,3]lriazol4-yl]-2-(1-methyl-1H-indazol-5-yl)-acetamide; N-[2-(3-Cyano4-fluoro-benzyl)-2H-[1,2,3]triazol4-yl]-2-(4-isopropyl-phenyi)-acetamide; N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1,2,33trJazoi4-yl]-2-[4-(3-f!uoro-oxetan-3-ylmethoxy)-phenyl]-acetamide; N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1,2,33triazoi-4-yl]-2-[4-(3,3-difSuoro-1-methyl-cyclobutylmethoxy)-pbenyl3-20 acetamide;
N-[2-(4-Cyano-3-fliioro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-{1,3-dimethyl-lH-Jndazol-5-yl)-acetamide; 2-(4-tert-Butyi-phenyl)-N-[2-(4-difluoromethoxy-3-fluoro-benzyi)-2H-[1,2,33triazol4-yl]-3cetamJde; N-[2-(4-Difluoromelhoxy-3-fluoro-benzyi)-2H-[1,2,3]triazoi4-yl3-2-(1-methyl-1H-indazol-5-yl)-acetamide; N-[2-(4-Difluoromethoxy-3-f!uoro-benzyl)-2H-[1,2,33triazol4-yl]-2-(4-Jsopropyl-phenyl)-acetamide; 25 N-[2-(4-Difluoromethoxy-3-f!uoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(1-.trifluoromethyl-cyc!opropyl)-phenyi3-acetamide;
N-[2-(4-Difluoromethoxy-3-fluoro-benzyl)-2H-[1,2,3]trJazol4-yl]-2-[6-f3,3-difluoro-pyrrolidin-1-yl)-pyridin-3-yl]-acetamide;
N-(2-(4-Difluoromethoxy-34!uoro-benzyl)-2H-[1,2,3Jtnazol-4-y!]-2-(6-pyrrolidin-1-yl-pyridm-3-yl)-acetamide; 30 2-(4-tert-Butyl-phenyl)-N-[2-(3-fluoro-44rifiuoromethoxy-benzyl)-2H-[1,2,3]triazol4-yl]-acetamide;
N-[2-(3-Fiuoro4-trifluoromethoxy-benzyl)-2H-[1,2,33triazol4-yl]-2-(1-methyl-1H-indazol-6-yl)-acetamide; N-[2-(3-Fluoro-4-trifJuoromethoxy-benzyl)-2H-[1,2,33triazol4-yl]-2-(1-methyl-1H-indazol-5-yl)-acetamide; N-[2-(3-Fluoro4-trifluoromethoxy-benzyl)-2H-[1,2,33triazol4-yl]-2-(4-isDpropyi-phenyl)-acetamide; N-[2-(3-Fluoro4-trJfluoromethoxy-benzyl)-2H-[1,2,3]trJazol4-yl3-2-[4-f1-trif!uoromethyl-cyclopropyl)-pbenyl]-35 acetamide;

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2-[6-(3>3-Difluoro-pyrrolidin-1-yl)-pyridin-3-yl]-N-[2-(3-fluoro-4-trifluoromethoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-
acetamide;
'2-f1-Ethyl-1H-indazol-5-yl)-N-[2-(3-fluoro-4-trifiuoromethoxy-benzyl)-2H-[1,2,3]triazol4-yl]-ace{arnide;
2-(1,3-Dimethyl-1H-indazol-5-yl)-N-[2-(3-fluoro4-trifluoromethoxy-benzyi}-2H-[1,2,3]triazol-4-yl]-acetamide; 5 N-[2-{3-Fluoro-4-trifluoromethoxy-benzyl)-2H-[1,2,3]trJazol-4-yl]-2-(6-pyrroiidin-1-yl-pyridin-3-yl)-acetamide;
N-[2-(4-Cyano-benzyl)-2H-[1,2,3]triazol-4-yl3-2-[4-(3-methyl-oxetan-3-ylmethoxy)-pheny!]-aceiamide;
N-[2-(4-Cyano-benzyl)-2H-[1,2,3]triazol-4-yJ]-2-[4-(3-fluoro-oxetan-3-ylmethoxy)-phenyi]-acetamide;
N-[2-(4-Cyano-benzyl)-2H-[1,2,3]lriazol-4-yl]-2-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-acetamide;
N-[2-(4-Cyano-benzyl)-2H-[172,3]trJazol-4-yl]-2-[4-(3,3-difluoro-cyclobutoxy)-phenyi]-acetamide; 10 N-[2-(4-Cyano-benzyl)-2H-|1,2,3]triazo!-4-yl]-2-[4-(3,3-difluoro-1-methy|-cyclobutylmethoxy)-phenyl3-
acetamide;
N-[2-(4-Cyano-benzyl)-2H-[1,2,33triazol-4-yl]-2-(4-(3-fiuoro-oxetan-3-yl)-phenyl]-acetamide;
N-[2-(4-Cyano-3-fluoro-benzy!)-2H-[1,2,3]triazo!4-yl]-2-[3-methyl-4-(2,2]2~trifluoro-ethoxy)-pheny!]-acetamide;
N-[2-(3-Cyano-4-methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-fluoro-oxetan-3-y!methoxy)-pheny}]-acetamide; 15 N-[2-(3-Cyano4-methyl-benzyl)-2H-[1l2,3]triazol4-yl]-2-[4-(3-fluoro-oxetan-3-yi)-phenyl]-acetamide; 2-(4-tert-Butyl-phenyl)-N-[2-(3-cyano4-methoxy-benzyl)-2H-[1,2l3]triazol-4-yl]-acetamide; N-[2-(3-Cyano-4-methoxy-benzyl)-2H-[1,2,3]triazoi-4-yl]-2-[4-(1-trif!uoromethyl-cyclopropyl)-phenyl]-acetamide;
N-[2-(3-Cyano4-methyl-benzyl)-2H-[1l2,3]triazol-4-yl3-2-(1-methyl-1H-indazol-5-yl)-acetamide; 20 N-[2-(3-Cyano4-methoxy-benzyl)-2H-[1,2,3](riazol4-yl]-2-(4-isopropyl-phenyl)-ace{amide;
N-[2-f3-Cyano-4-methyl-benzyl)-2H-[1,2,3]triazol4-yJ]-2-[4-(3-meihoxy-oxetan-3-yl)-phenyl]-acetamide; N-[2-f3-Cyano4-meihoxy-benzyl)-2H-[1,2,3]triazol4-yl]-2-[6-(3,3-dif!uoro-pyrrolidin-1-yl)-pyridin-3-yl]-acetamide;
N-[2-(3-Cyano4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indazol-5-yl)-acetamide; 25 N-[2-f3-Cyano-4-methyl-benzy!)-2H-[1,2,3]triazo!4-y[]-2-[4-(3,3-dif]uoro-cyclobutoxy)-phenyl]-acetamide; N-[2-(3,4-Difluoro-5-methoxy-benzyl)-2H-[1]2,3]triazol-4-yl]-2-(1,3-dimethyl-1H-indazo!-5-yl)-acetamide; N-[2-(3-Cyano4-methyl-benzyl)-2H-[1,2,3]triazol4-y!]-2-[6-(3,3-difluoro-pyrrDlidin4-yl)-pyridin-3-y]]-acetamide;
N-[2-f3,4-Difluoro-5-methoxy-benzyl)-2H-(1,2,3]triazol4-yl]-2-(1-methy!-1H-indazol-5-yl)-acetamide; 30 N-[2-f3-Cyano-4-methyl-benzyl)-2H-[1,2,3]triazol4-yl]-2-(6-pyrro!idin-1-y|-pyridin-3-yl)-acetamide;
N-[2-(3-Cyano4-methoxy-benzyl)-2H-[1,2,3]triazo!-4-yl]-2-[4-(3-fluoro-Dxetan-3-yl)-phenyl]-acetatr!ide; N-[2-(3-Cyano4-methy[-benzy!)-2H-[1,2,3]triazo!-4-y]]-2-(1-methyl-1H-indazol-6-y!)-acetamide; N-[2-f3-Cyano-4-methyJ-benzyl)-2H-[1,2,3]triazol4-yl]-2-(4-isopropyl-phenyi)-acetamide; 2-(4-tert-Butyl-phenyl)-N-[2-(3-cyano-4-methy[-benzyl)-2H-[1,2,3]triazol4-yl]-acetamide; 35 2-(4-tert-Butyl-phenyl)-N-[2-(3,4-difluoro-5-methoxy-benzy!)-2H-[1,2,3]triazoi-4-yl]-acetamide;

N-f2-(3,4-Difluoro^-methoxy-tenzyl)-2H-[1,2,3]triazol4-yl]-2-[6-(3l3^ifluoro-pyrrolidin-1-y!)-pyridin-3-yl]-
acetamide;
N-[2-(3,4-Difluoro-5-methoxy-benzyl)-2H-(1,2,3]triazol4-yl]-2-(1-ethyl-1H-indazol-5-yl)-acetamide;
N-[2-(3,4-Difluoro-5-methoxy-benzyl)-2H-[1,2,3]triazol4-yl]-2-(6-pyrroiidin-1-y[-pyridin-3-yl)-acetamide;
N-[2-(3l4-Difiuoro-5-methoxy-benzy!)-2H-[1,2,3]triazol-4-y!]-2-(4-isopropyl-phenyl)-ace{amide;
N-[2-(3-Cyano-4-methoxy-benzyl)-2H-l1,2,3]trj'azol-4-y!3-2-[4-{3,3-difluoro-cyclobutoxy)-phenyl]-acetamide;
N-[2-f3,4-Difluoro-5-methoxy-benzy!)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-fluoro-oxetan-3-yl)-phenyl]-acetamide;
N-[2-(3,4-Difluoro-5-methoxy-benzyl)-2H-[1,2,3]triazol4-y!]-2-{1-methy!-1H-indazoi-6-yl)-acetamide;
N42-f3-Cyano4-methyl-benzyl)-2H-[1,2,3]triazol"4-y[J-2-[4"f1-trif!uoromethyl-cyclopropyl)-phenyl]-acetamide;
N-[2-(3,4-DJf!uoro-5-methoxy-benzyl)-2H-[1,2l3]triazol-4-yl]-2-[4-(1-trifluoromethyl-cyc!opropyl)-phenyl]-
acetamide;
N-[2-(3,4-Difluoro-5-methoxy-benzyl}-2H-[1,2,3]triazof4-y!]-2-[4-(3-methoxy-oxetan-3-yl)-pheny!3-acetamide;
N-[2-(3,4-Difluoro-5-methoxy-benzyl)-2H-[1l2,3]triazol-4-yl]-2-[4-f3-fluoro-oxetan-3-ylmethoxy)-phenyl]-
acetamide;
2-[4-(3,3-Dif!uoro-cyclobutoxy)-phenyl]-N-[2-(3,4-difluoro-5-methoxy-benzyl)-2H-[1,2,3]triazoi4-yt]-acetamide;
2-[4-(1-Cyano-cyclopropyl)-phenyO-N-[2-(4-cyano-3-fluoro-benzyi)-2H-[1,2,3]triazol4-yl]-acetamide;
N-(2-(4-cyano-3-fiuorobenzyl)-2H-1,2,3-triazol4-yl)-2-(4-(pentafluorosulfanyl)phenyl)acetamide;
N-[2-(4-Cyano-3-methoxy-benzyl)-2H-[1,2,3]triazol4-y!]-2-[4-f1-trifluoromethyl-cyclopropyl)-phenyi]-
acetamide;
N~[2-(4-Cyano-benzyl)-2H-[1,2,3]tnazoI-4-yi]-2-(1 -methyl-1 H-indazol-5-yl)-acetamide;
N-[2-(4-Cyano-3-methy[-benzy!)-2H-[1,2,3]triazol4-y!]-2-[4-f3-fluoro-oxetan-3-yl)-phenyl]-acetamide;
N-[2-(3-Cyano4-methoxy-benzyl)-2H-[1,2,3]triazo!4-y!]-2-(6-pyrrolidin-1-yl-pyridin-3-y!)-acetairi!de;
N-[2-(4-Cyano-benzyl)-2H-[1,2,3]triazol4-yl]-2-[4-(3-methoxy-oxetan-3-yl)-phenyl]-acetamide;
N-[2-(4-CyanO"benzyl)-2H-[1,2,3]triazol4-yl]-2-[4-f3]3-dif3uoro-cyciobutyJmethoxy}-phenyl]-acetamide;
2-(4-tert-Butyl-phenyi)-N-[2-(4-cyano-3-methoxy-benzyi)-2H-[1,2,3]triazol4-yi]-acetamide;
N-[2-(3,4-Difluoro-5-methoxy-benzyl)-2H-[1,2,3]triazol4-yl]-2-(1,3-dimethy]-1H-indol-5-yl)-acetamide;
N-[2-f4-Cyano-3-methyl-benzyl)-2H-[1,2,3]triazo!4-yl]-2-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-acetamide;
N-[2-(5-Cyano-pyridin-2-ylmethy])-2H-[1,2,33triazol4-yl3-2-[3-methyl4-(2,2,2-trifluoro-ethoxy)-phenyl]-
acetamide;
N-[2-(5-Cyano-pyridin-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-2-(1,3-dimethyl-1H-indo!-5-yl)-acetamide;
2-(4-tert-Butyl-phenyl)-N-[2-f5-cyano-pyndin-2-ylmethyl)-2H-[1]2,3]triazol4-yl]-acetamide;
N-[2-f5-Cyano-pyrid!n-2-ylmethyl)-2H-[1,2,3]triazol4-yl]-2-[4-(1-trifluoromethy[-cyciopropyl)-pheny]]-
acetamide;
N-[2-f5-Cyano-pyridin-2-ylmethyl)-2H-[1,2,3]tri3zol4-yl]-2-[4-(3,3-difluoro-cyclobutoxy)-phenyl]-acetamide;
N42-(5-Cyano-pyridin-2-ylmethyl)-2H--[1,2,3]triazol4-yl]--2-(5"fluorO"6-pyrroiidin-1-yl-pyridin-3-yi)-acetamide;

N-[2-(4-Cyano-3-fluoro-benzyi)-2H-[1,2,3]triazol-4-yl]-2-[4-(2,2,2-trifJuoro-1,1-dimethy!-ethy[)-pheny!]-
acetamide; and
N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol4-yl]-2-[4-((1Si,2S*)-2-trifluoromethyl-cyclopropy!)-phenyl]-
acetamide;
or a salt of such a compound.
10. A pharmaceutical composition containing, as active principle, a compound of formula (I) according to any one of claims 1 to 9, or a pharmaceutical^ acceptable salt thereof, and at least one therapeutically inert excipient
11. A compound of formula (I) according to any one of claims 1 to 9, or a pharmaceutical^ acceptable salt thereof, for use as a medicament.
12. A compound of formula (I) according to any one of claims 1 to 9, or a pharmaceutically acceptable salt thereof, for use in the treatment or prevention of epilepsy; sleep disorders; sleep disturbances; pain; neurological disorders; cardiovascular disorders; cancer; diabetes; diabetic neuropathy; infertility; and sexual dysfunction.
13. Use of a compound of formula fl) according to any one of claims 1 to 9, or a pharmaceutically acceptable salt thereof, for the manufacture of a medicament for the treatment or prevention of epilepsy; sleep disorders; sleep disturbances; pain; neurological disorders; cardiovascular disorders; cancer; diabetes; diabetic neuropathy; infertility; and sexual dysfunction.

Documents

Application Documents

# Name Date
1 201747012841-FORM 3 [17-03-2018(online)].pdf 2018-03-17
1 Translated Copy of Priority Document [11-04-2017(online)].pdf 2017-04-11
2 201747012841-8(i)-Substitution-Change Of Applicant - Form 6 [15-11-2017(online)].pdf 2017-11-15
2 PROOF OF RIGHT [11-04-2017(online)].pdf 2017-04-11
3 Priority Document [11-04-2017(online)].pdf 2017-04-11
3 201747012841-ASSIGNMENT DOCUMENTS [15-11-2017(online)].pdf 2017-11-15
4 Power of Attorney [11-04-2017(online)].pdf 2017-04-11
4 201747012841-PA [15-11-2017(online)].pdf 2017-11-15
5 Form 5 [11-04-2017(online)].pdf 2017-04-11
5 201747012841-FORM 3 [04-10-2017(online)].pdf 2017-10-04
6 Form 3 [11-04-2017(online)].pdf 2017-04-11
6 201747012841-FORM 3 [04-10-2017(online)].pdf_25.pdf 2017-10-04
7 Form 1 [11-04-2017(online)].pdf 2017-04-11
7 Correspondence by Agent_Form1_17-04-2017.pdf 2017-04-17
8 201747012841.pdf 2017-04-12
8 Description(Complete) [11-04-2017(online)].pdf_129.pdf 2017-04-11
9 Description(Complete) [11-04-2017(online)].pdf 2017-04-11
10 Description(Complete) [11-04-2017(online)].pdf_129.pdf 2017-04-11
10 201747012841.pdf 2017-04-12
11 Form 1 [11-04-2017(online)].pdf 2017-04-11
11 Correspondence by Agent_Form1_17-04-2017.pdf 2017-04-17
12 Form 3 [11-04-2017(online)].pdf 2017-04-11
12 201747012841-FORM 3 [04-10-2017(online)].pdf_25.pdf 2017-10-04
13 Form 5 [11-04-2017(online)].pdf 2017-04-11
13 201747012841-FORM 3 [04-10-2017(online)].pdf 2017-10-04
14 Power of Attorney [11-04-2017(online)].pdf 2017-04-11
14 201747012841-PA [15-11-2017(online)].pdf 2017-11-15
15 Priority Document [11-04-2017(online)].pdf 2017-04-11
15 201747012841-ASSIGNMENT DOCUMENTS [15-11-2017(online)].pdf 2017-11-15
16 PROOF OF RIGHT [11-04-2017(online)].pdf 2017-04-11
16 201747012841-8(i)-Substitution-Change Of Applicant - Form 6 [15-11-2017(online)].pdf 2017-11-15
17 Translated Copy of Priority Document [11-04-2017(online)].pdf 2017-04-11
17 201747012841-FORM 3 [17-03-2018(online)].pdf 2018-03-17