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Bridged Six Membered Ring Compounds

Abstract: The invention relates to compounds of formula (I)   wherein R1, R2 ,R1a, R2a, R3, R4, A, B, X, W and n are as defined in the description, and pharmaceutically acceptable salts of such compounds. These compounds are useful as calcium channel blockers.

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Notices, Deadlines & Correspondence

Patent Information

Application #
Filing Date
26 November 2009
Publication Number
10/2010
Publication Type
INA
Invention Field
CHEMICAL
Status
Email
Parent Application
Patent Number
Legal Status
Grant Date
2020-01-17
Renewal Date

Applicants

ACTELION PHARMACEUTICALS LTD
GEWERBESTRASSE 16, CH-4123 ALLSCHWIL

Inventors

1. HILPERT, KURT
IM WYGARTLI 22, 4114 HOFSTETTEN
2. HUBLER, FRANCIS
16A, RUE DE BUSCHWILLER, 68220 HEGENHEIM
3. RENNEBERG, DORTE
BLOTZHEIMERSTRASSE 28A, 4055 BASEL

Specification

Indian Patent Application Number: 6960/CHENP/2009 As Amended on 16 November 2017
We Claim
1. A compound which is:
Isobutyric acid (lR*,2R*,4R*)-2-(2-{[3-(4,7-dimethoxy-lH-benzoimidazol-2-yl)-
propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;
\ or a pharmaceutically acceptable salt of such a compound.
2. The compound as claimed in claim 1 which is:
Isobutyric acid (lR,2R,4R)-2-(2-{ [3-(4,7-dimethoxy- lH-benzoimidazol-2-yl)-
propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester:
or
Isobutyric acid (lS,2S,4S)-2-(2-{[3-(4,7-dimethoxy-lH-benzoimidazol-2-yl)-propyl]-
methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester:
146

Indian Patent Application Number: 6960/CHENP/2009 As Amended on 16 November 2017
or a pharmaceutically acceptable salt of such a compound.
3. The compound as claimed in claim 1, which is:
Isobutyric acid (lR,2R,4R)-2-(2-{[3-(4,7-dimethoxy-lH-benzoimidazol-2-yl)-
propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester:
or a pharmaceutically acceptable salt thereof.
4. A pharmaceutical composition containing, as active principle, a compound as claimed in any one of claims 1 to 3, or a pharmaceutically acceptable salt thereof, and at least one therapeutically inert excipient.

Documents

Orders

Section Controller Decision Date

Application Documents

# Name Date
1 6960-CHENP-2009-RELEVANT DOCUMENTS [25-09-2022(online)].pdf 2022-09-25
1 abstract 6960-chenp-2009 abstract 26-11-2009.jpg 2009-11-26
2 6960-chenp-2009 description(complete) 26-11-2009.pdf 2009-11-26
2 6960-CHENP-2009-IntimationOfGrant17-01-2020.pdf 2020-01-17
3 6960-CHENP-2009-PatentCertificate17-01-2020.pdf 2020-01-17
3 6960-chenp-2009 form-2 26-11-2009.pdf 2009-11-26
4 6960-CHENP-2009_Abstract_Granted 329627_17-01-2020.pdf 2020-01-17
4 6960-chenp-2009 claims 26-11-2009.pdf 2009-11-26
5 6960-CHENP-2009_Claims_Granted 329627_17-01-2020.pdf 2020-01-17
5 6960-chenp-2009 abstract 26-11-2009.pdf 2009-11-26
6 6960-CHENP-2009_Description_Granted 329627_17-01-2020.pdf 2020-01-17
6 6960-chenp-2009 power of attorney 26-11-2009.pdf 2009-11-26
7 6960-CHENP-2009_Marked up Claims _Granted 329627_17-01-2020.pdf 2020-01-17
7 6960-chenp-2009 pct 26-11-2009.pdf 2009-11-26
8 6960-CHENP-2009-FORM 3 [22-08-2019(online)].pdf 2019-08-22
8 6960-chenp-2009 form-5 26-11-2009.pdf 2009-11-26
9 6960-chenp-2009 form-3 26-11-2009.pdf 2009-11-26
9 6960-CHENP-2009-FORM 3 [19-02-2019(online)].pdf 2019-02-19
10 6960-chenp-2009 form-1 26-11-2009.pdf 2009-11-26
10 6960-CHENP-2009-FORM 3 [31-08-2018(online)].pdf 2018-08-31
11 6960-chenp-2009 correspondence others 26-11-2009.pdf 2009-11-26
11 6960-CHENP-2009-FORM 3 [17-03-2018(online)].pdf 2018-03-17
12 6960-chenp-2009 form-3 17-05-2010.pdf 2010-05-17
12 6960-CHENP-2009-2. Marked Copy under Rule 14(2) (MANDATORY) [30-01-2018(online)].pdf 2018-01-30
13 6960-chenp-2009 correspondence others 06-04-2011.pdf 2011-04-06
13 6960-CHENP-2009-FORM-26 [30-01-2018(online)].pdf 2018-01-30
14 6960-chenp-2009 form-18 06-04-2011.pdf 2011-04-06
14 6960-CHENP-2009-Retyped Pages under Rule 14(1) (MANDATORY) [30-01-2018(online)].pdf 2018-01-30
15 6960-CHENP-2009 FORM-3 17-10-2014.pdf 2014-10-17
15 6960-CHENP-2009-Written submissions and relevant documents (MANDATORY) [30-01-2018(online)].pdf 2018-01-30
16 6960-CHENP-2009 FORM-3 07-05-2015.pdf 2015-05-07
16 6960-CHENP-2009-Correspondence to notify the Controller (Mandatory) [15-01-2018(online)].pdf 2018-01-15
17 6960-CHENP-2009-HearingNoticeLetter.pdf 2017-12-21
17 6960-CHENP-2009 CORRESPONDENCE OTHERS 07-05-2015.pdf 2015-05-07
18 6960-CHENP-2009-Form 3-220915.pdf 2015-11-30
18 Correspondence by Agent_Form 1_21-11-2017.pdf 2017-11-21
19 6960-CHENP-2009-8(i)-Substitution-Change Of Applicant - Form 6 [18-11-2017(online)].pdf 2017-11-18
19 6960-CHENP-2009-Correspondence-220915.pdf 2015-11-30
20 6960-CHENP-2009-ASSIGNMENT DOCUMENTS [18-11-2017(online)].pdf 2017-11-18
20 6960-CHENP-2009-Form 3-080316.pdf 2016-03-15
21 6960-CHENP-2009-Correspondence-080316.pdf 2016-03-15
21 6960-CHENP-2009-PA [18-11-2017(online)].pdf 2017-11-18
22 6960-CHENP-2009-ABSTRACT [16-11-2017(online)].pdf 2017-11-16
22 Form 3 [06-09-2016(online)].pdf 2016-09-06
23 6960-CHENP-2009-Changing Name-Nationality-Address For Service [16-11-2017(online)].pdf 2017-11-16
23 Form 3 [08-03-2017(online)].pdf 2017-03-08
24 6960-CHENP-2009-FER.pdf 2017-05-18
24 6960-CHENP-2009-CLAIMS [16-11-2017(online)].pdf 2017-11-16
25 6960-CHENP-2009-FER_SER_REPLY [16-11-2017(online)].pdf 2017-11-16
25 6960-CHENP-2009-Proof of Right (MANDATORY) [16-11-2017(online)].pdf 2017-11-16
26 6960-CHENP-2009-FORM 13 [16-11-2017(online)].pdf 2017-11-16
26 6960-CHENP-2009-PETITION UNDER RULE 137 [16-11-2017(online)]_7.pdf 2017-11-16
27 6960-CHENP-2009-FORM 3 [16-11-2017(online)].pdf 2017-11-16
27 6960-CHENP-2009-PETITION UNDER RULE 137 [16-11-2017(online)].pdf 2017-11-16
28 6960-CHENP-2009-Information under section 8(2) (MANDATORY) [16-11-2017(online)].pdf 2017-11-16
28 6960-CHENP-2009-OTHERS [16-11-2017(online)].pdf 2017-11-16
29 6960-CHENP-2009-Information under section 8(2) (MANDATORY) [16-11-2017(online)]_10.pdf 2017-11-16
29 6960-CHENP-2009-MARKED COPIES OF AMENDEMENTS [16-11-2017(online)]_76.pdf 2017-11-16
30 6960-CHENP-2009-Information under section 8(2) (MANDATORY) [16-11-2017(online)]_11.pdf 2017-11-16
30 6960-CHENP-2009-MARKED COPIES OF AMENDEMENTS [16-11-2017(online)].pdf 2017-11-16
31 6960-CHENP-2009-Information under section 8(2) (MANDATORY) [16-11-2017(online)]_12.pdf 2017-11-16
31 6960-CHENP-2009-Information under section 8(2) (MANDATORY) [16-11-2017(online)]_13.pdf 2017-11-16
32 6960-CHENP-2009-Information under section 8(2) (MANDATORY) [16-11-2017(online)]_12.pdf 2017-11-16
32 6960-CHENP-2009-Information under section 8(2) (MANDATORY) [16-11-2017(online)]_13.pdf 2017-11-16
33 6960-CHENP-2009-Information under section 8(2) (MANDATORY) [16-11-2017(online)]_11.pdf 2017-11-16
33 6960-CHENP-2009-MARKED COPIES OF AMENDEMENTS [16-11-2017(online)].pdf 2017-11-16
34 6960-CHENP-2009-Information under section 8(2) (MANDATORY) [16-11-2017(online)]_10.pdf 2017-11-16
34 6960-CHENP-2009-MARKED COPIES OF AMENDEMENTS [16-11-2017(online)]_76.pdf 2017-11-16
35 6960-CHENP-2009-Information under section 8(2) (MANDATORY) [16-11-2017(online)].pdf 2017-11-16
35 6960-CHENP-2009-OTHERS [16-11-2017(online)].pdf 2017-11-16
36 6960-CHENP-2009-PETITION UNDER RULE 137 [16-11-2017(online)].pdf 2017-11-16
36 6960-CHENP-2009-FORM 3 [16-11-2017(online)].pdf 2017-11-16
37 6960-CHENP-2009-FORM 13 [16-11-2017(online)].pdf 2017-11-16
37 6960-CHENP-2009-PETITION UNDER RULE 137 [16-11-2017(online)]_7.pdf 2017-11-16
38 6960-CHENP-2009-FER_SER_REPLY [16-11-2017(online)].pdf 2017-11-16
38 6960-CHENP-2009-Proof of Right (MANDATORY) [16-11-2017(online)].pdf 2017-11-16
39 6960-CHENP-2009-CLAIMS [16-11-2017(online)].pdf 2017-11-16
39 6960-CHENP-2009-FER.pdf 2017-05-18
40 6960-CHENP-2009-Changing Name-Nationality-Address For Service [16-11-2017(online)].pdf 2017-11-16
40 Form 3 [08-03-2017(online)].pdf 2017-03-08
41 6960-CHENP-2009-ABSTRACT [16-11-2017(online)].pdf 2017-11-16
41 Form 3 [06-09-2016(online)].pdf 2016-09-06
42 6960-CHENP-2009-Correspondence-080316.pdf 2016-03-15
42 6960-CHENP-2009-PA [18-11-2017(online)].pdf 2017-11-18
43 6960-CHENP-2009-ASSIGNMENT DOCUMENTS [18-11-2017(online)].pdf 2017-11-18
43 6960-CHENP-2009-Form 3-080316.pdf 2016-03-15
44 6960-CHENP-2009-8(i)-Substitution-Change Of Applicant - Form 6 [18-11-2017(online)].pdf 2017-11-18
44 6960-CHENP-2009-Correspondence-220915.pdf 2015-11-30
45 6960-CHENP-2009-Form 3-220915.pdf 2015-11-30
45 Correspondence by Agent_Form 1_21-11-2017.pdf 2017-11-21
46 6960-CHENP-2009-HearingNoticeLetter.pdf 2017-12-21
46 6960-CHENP-2009 CORRESPONDENCE OTHERS 07-05-2015.pdf 2015-05-07
47 6960-CHENP-2009 FORM-3 07-05-2015.pdf 2015-05-07
47 6960-CHENP-2009-Correspondence to notify the Controller (Mandatory) [15-01-2018(online)].pdf 2018-01-15
48 6960-CHENP-2009 FORM-3 17-10-2014.pdf 2014-10-17
48 6960-CHENP-2009-Written submissions and relevant documents (MANDATORY) [30-01-2018(online)].pdf 2018-01-30
49 6960-chenp-2009 form-18 06-04-2011.pdf 2011-04-06
49 6960-CHENP-2009-Retyped Pages under Rule 14(1) (MANDATORY) [30-01-2018(online)].pdf 2018-01-30
50 6960-chenp-2009 correspondence others 06-04-2011.pdf 2011-04-06
50 6960-CHENP-2009-FORM-26 [30-01-2018(online)].pdf 2018-01-30
51 6960-chenp-2009 form-3 17-05-2010.pdf 2010-05-17
51 6960-CHENP-2009-2. Marked Copy under Rule 14(2) (MANDATORY) [30-01-2018(online)].pdf 2018-01-30
52 6960-chenp-2009 correspondence others 26-11-2009.pdf 2009-11-26
52 6960-CHENP-2009-FORM 3 [17-03-2018(online)].pdf 2018-03-17
53 6960-chenp-2009 form-1 26-11-2009.pdf 2009-11-26
53 6960-CHENP-2009-FORM 3 [31-08-2018(online)].pdf 2018-08-31
54 6960-chenp-2009 form-3 26-11-2009.pdf 2009-11-26
54 6960-CHENP-2009-FORM 3 [19-02-2019(online)].pdf 2019-02-19
55 6960-CHENP-2009-FORM 3 [22-08-2019(online)].pdf 2019-08-22
55 6960-chenp-2009 form-5 26-11-2009.pdf 2009-11-26
56 6960-CHENP-2009_Marked up Claims _Granted 329627_17-01-2020.pdf 2020-01-17
56 6960-chenp-2009 pct 26-11-2009.pdf 2009-11-26
57 6960-CHENP-2009_Description_Granted 329627_17-01-2020.pdf 2020-01-17
57 6960-chenp-2009 power of attorney 26-11-2009.pdf 2009-11-26
58 6960-CHENP-2009_Claims_Granted 329627_17-01-2020.pdf 2020-01-17
58 6960-chenp-2009 abstract 26-11-2009.pdf 2009-11-26
59 6960-chenp-2009 claims 26-11-2009.pdf 2009-11-26
59 6960-CHENP-2009_Abstract_Granted 329627_17-01-2020.pdf 2020-01-17
60 6960-chenp-2009 form-2 26-11-2009.pdf 2009-11-26
60 6960-CHENP-2009-PatentCertificate17-01-2020.pdf 2020-01-17
61 6960-chenp-2009 description(complete) 26-11-2009.pdf 2009-11-26
61 6960-CHENP-2009-IntimationOfGrant17-01-2020.pdf 2020-01-17
62 6960-CHENP-2009-RELEVANT DOCUMENTS [25-09-2022(online)].pdf 2022-09-25
62 abstract 6960-chenp-2009 abstract 26-11-2009.jpg 2009-11-26

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