Abstract: The invention relates to compounds of formula (I) wherein R1, R2 ,R1a, R2a, R3, R4, A, B, X, W and n are as defined in the description, and pharmaceutically acceptable salts of such compounds. These compounds are useful as calcium channel blockers.
Indian Patent Application Number: 6960/CHENP/2009 As Amended on 16 November 2017
We Claim
1. A compound which is:
Isobutyric acid (lR*,2R*,4R*)-2-(2-{[3-(4,7-dimethoxy-lH-benzoimidazol-2-yl)-
propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester;
\ or a pharmaceutically acceptable salt of such a compound.
2. The compound as claimed in claim 1 which is:
Isobutyric acid (lR,2R,4R)-2-(2-{ [3-(4,7-dimethoxy- lH-benzoimidazol-2-yl)-
propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester:
or
Isobutyric acid (lS,2S,4S)-2-(2-{[3-(4,7-dimethoxy-lH-benzoimidazol-2-yl)-propyl]-
methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester:
146
Indian Patent Application Number: 6960/CHENP/2009 As Amended on 16 November 2017
or a pharmaceutically acceptable salt of such a compound.
3. The compound as claimed in claim 1, which is:
Isobutyric acid (lR,2R,4R)-2-(2-{[3-(4,7-dimethoxy-lH-benzoimidazol-2-yl)-
propyl]-methyl-amino}-ethyl)-5-phenyl-bicyclo[2.2.2]oct-5-en-2-yl ester:
or a pharmaceutically acceptable salt thereof.
4. A pharmaceutical composition containing, as active principle, a compound as claimed in any one of claims 1 to 3, or a pharmaceutically acceptable salt thereof, and at least one therapeutically inert excipient.
| # | Name | Date |
|---|---|---|
| 1 | abstract 6960-chenp-2009 abstract 26-11-2009.jpg | 2009-11-26 |
| 2 | 6960-chenp-2009 description(complete) 26-11-2009.pdf | 2009-11-26 |
| 3 | 6960-chenp-2009 form-2 26-11-2009.pdf | 2009-11-26 |
| 4 | 6960-chenp-2009 claims 26-11-2009.pdf | 2009-11-26 |
| 5 | 6960-chenp-2009 abstract 26-11-2009.pdf | 2009-11-26 |
| 6 | 6960-chenp-2009 power of attorney 26-11-2009.pdf | 2009-11-26 |
| 7 | 6960-chenp-2009 pct 26-11-2009.pdf | 2009-11-26 |
| 8 | 6960-chenp-2009 form-5 26-11-2009.pdf | 2009-11-26 |
| 9 | 6960-chenp-2009 form-3 26-11-2009.pdf | 2009-11-26 |
| 10 | 6960-chenp-2009 form-1 26-11-2009.pdf | 2009-11-26 |
| 11 | 6960-chenp-2009 correspondence others 26-11-2009.pdf | 2009-11-26 |
| 12 | 6960-chenp-2009 form-3 17-05-2010.pdf | 2010-05-17 |
| 13 | 6960-chenp-2009 correspondence others 06-04-2011.pdf | 2011-04-06 |
| 14 | 6960-chenp-2009 form-18 06-04-2011.pdf | 2011-04-06 |
| 15 | 6960-CHENP-2009 FORM-3 17-10-2014.pdf | 2014-10-17 |
| 16 | 6960-CHENP-2009 FORM-3 07-05-2015.pdf | 2015-05-07 |
| 17 | 6960-CHENP-2009 CORRESPONDENCE OTHERS 07-05-2015.pdf | 2015-05-07 |
| 18 | 6960-CHENP-2009-Form 3-220915.pdf | 2015-11-30 |
| 19 | 6960-CHENP-2009-Correspondence-220915.pdf | 2015-11-30 |
| 20 | 6960-CHENP-2009-Form 3-080316.pdf | 2016-03-15 |
| 21 | 6960-CHENP-2009-Correspondence-080316.pdf | 2016-03-15 |
| 22 | Form 3 [06-09-2016(online)].pdf | 2016-09-06 |
| 23 | Form 3 [08-03-2017(online)].pdf | 2017-03-08 |
| 24 | 6960-CHENP-2009-FER.pdf | 2017-05-18 |
| 25 | 6960-CHENP-2009-Proof of Right (MANDATORY) [16-11-2017(online)].pdf | 2017-11-16 |
| 26 | 6960-CHENP-2009-PETITION UNDER RULE 137 [16-11-2017(online)]_7.pdf | 2017-11-16 |
| 27 | 6960-CHENP-2009-PETITION UNDER RULE 137 [16-11-2017(online)].pdf | 2017-11-16 |
| 28 | 6960-CHENP-2009-OTHERS [16-11-2017(online)].pdf | 2017-11-16 |
| 29 | 6960-CHENP-2009-MARKED COPIES OF AMENDEMENTS [16-11-2017(online)]_76.pdf | 2017-11-16 |
| 30 | 6960-CHENP-2009-MARKED COPIES OF AMENDEMENTS [16-11-2017(online)].pdf | 2017-11-16 |
| 31 | 6960-CHENP-2009-Information under section 8(2) (MANDATORY) [16-11-2017(online)]_13.pdf | 2017-11-16 |
| 32 | 6960-CHENP-2009-Information under section 8(2) (MANDATORY) [16-11-2017(online)]_12.pdf | 2017-11-16 |
| 33 | 6960-CHENP-2009-Information under section 8(2) (MANDATORY) [16-11-2017(online)]_11.pdf | 2017-11-16 |
| 34 | 6960-CHENP-2009-Information under section 8(2) (MANDATORY) [16-11-2017(online)]_10.pdf | 2017-11-16 |
| 35 | 6960-CHENP-2009-Information under section 8(2) (MANDATORY) [16-11-2017(online)].pdf | 2017-11-16 |
| 36 | 6960-CHENP-2009-FORM 3 [16-11-2017(online)].pdf | 2017-11-16 |
| 37 | 6960-CHENP-2009-FORM 13 [16-11-2017(online)].pdf | 2017-11-16 |
| 38 | 6960-CHENP-2009-FER_SER_REPLY [16-11-2017(online)].pdf | 2017-11-16 |
| 39 | 6960-CHENP-2009-CLAIMS [16-11-2017(online)].pdf | 2017-11-16 |
| 40 | 6960-CHENP-2009-Changing Name-Nationality-Address For Service [16-11-2017(online)].pdf | 2017-11-16 |
| 41 | 6960-CHENP-2009-ABSTRACT [16-11-2017(online)].pdf | 2017-11-16 |
| 42 | 6960-CHENP-2009-PA [18-11-2017(online)].pdf | 2017-11-18 |
| 43 | 6960-CHENP-2009-ASSIGNMENT DOCUMENTS [18-11-2017(online)].pdf | 2017-11-18 |
| 44 | 6960-CHENP-2009-8(i)-Substitution-Change Of Applicant - Form 6 [18-11-2017(online)].pdf | 2017-11-18 |
| 45 | Correspondence by Agent_Form 1_21-11-2017.pdf | 2017-11-21 |
| 46 | 6960-CHENP-2009-HearingNoticeLetter.pdf | 2017-12-21 |
| 47 | 6960-CHENP-2009-Correspondence to notify the Controller (Mandatory) [15-01-2018(online)].pdf | 2018-01-15 |
| 48 | 6960-CHENP-2009-Written submissions and relevant documents (MANDATORY) [30-01-2018(online)].pdf | 2018-01-30 |
| 49 | 6960-CHENP-2009-Retyped Pages under Rule 14(1) (MANDATORY) [30-01-2018(online)].pdf | 2018-01-30 |
| 50 | 6960-CHENP-2009-FORM-26 [30-01-2018(online)].pdf | 2018-01-30 |
| 51 | 6960-CHENP-2009-2. Marked Copy under Rule 14(2) (MANDATORY) [30-01-2018(online)].pdf | 2018-01-30 |
| 52 | 6960-CHENP-2009-FORM 3 [17-03-2018(online)].pdf | 2018-03-17 |
| 53 | 6960-CHENP-2009-FORM 3 [31-08-2018(online)].pdf | 2018-08-31 |
| 54 | 6960-CHENP-2009-FORM 3 [19-02-2019(online)].pdf | 2019-02-19 |
| 55 | 6960-CHENP-2009-FORM 3 [22-08-2019(online)].pdf | 2019-08-22 |
| 56 | 6960-CHENP-2009_Marked up Claims _Granted 329627_17-01-2020.pdf | 2020-01-17 |
| 57 | 6960-CHENP-2009_Description_Granted 329627_17-01-2020.pdf | 2020-01-17 |
| 58 | 6960-CHENP-2009_Claims_Granted 329627_17-01-2020.pdf | 2020-01-17 |
| 59 | 6960-CHENP-2009_Abstract_Granted 329627_17-01-2020.pdf | 2020-01-17 |
| 60 | 6960-CHENP-2009-PatentCertificate17-01-2020.pdf | 2020-01-17 |
| 61 | 6960-CHENP-2009-IntimationOfGrant17-01-2020.pdf | 2020-01-17 |
| 62 | 6960-CHENP-2009-RELEVANT DOCUMENTS [25-09-2022(online)].pdf | 2022-09-25 |
| 1 | SEARCHstrategy_17-05-2017.pdf |