Tricyclic Oxazolidinone Antibiotic Compounds

Abstract: The invention relates to antibacterial compounds of formula I wherein "----" is a bond or is absent, V is CH, CR° or N; Ru is II or, if "----" is a bond, may also be alkoxy; R1 is notably H or halogen; U is CH or N when "----" is a bond, or, if "----" is absent, U is CH2, NH or NR9; R2 is H, alkylcnrbonyl or -CH2-R3; R3 is H, alkyl or hydroxyalkyl; R4 is H or, if n is not 0 and R5 is H, may also be OH; R5 is H, alkyl, hydroxyalkyl, aminoalkyl, alkoxyalkyl, carboxy or alkoxycarbonyl; R6 is hydroxyalkyl, carboxy, alkoxycarbonyl or -(CH2)q-NR7R8, q being 1, 2 or 3 and each of R7 and R8 independently being H or alkyl or R7 and R8 forming with the N atom bearing them a ring; R9 is alkyl or hydroxyalkyl; A is -(CH2)P-, -CH2CH2CH(OH)- or -COCH2CH(OH)-; G is substituted phenyl or G1 or G2wherein Q is 0 or S and X is CH or N; and Y1, Y2 and Y3 may each be CH or N; and n is 0 when A is -CH2CH2CH(OH)- or -COCH2CH(OH)-, and n is 0, 1 or 2 when A is -(CH2)P-, p being 1, 2, 3 or 4, with the proviso that the sum of n and p is then 2, 3 or 4; and to salts of such compounds.

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