Claims

1. A compound of formula I

wherein

R1 is the group M, whereby M is one of the groups MA and MB represented below

wherein A represents a bond or C=C;

R1A is H or halogen;

R 2 A is H or halogen; and

R3A is H, (C C3)alkoxy, hydroxy(C2-C4)alkoxy, hydroxy(d-C4)alkyl, dihy droxy(C2-C4)alkyl, 2-hydroxyacetamido, 1 -hydroxymethyl-cycloprop- 1 -yl, /ra«s-2-hydroxymethyl-cycloprop-l-yl, 3-hydroxyoxetan-3-yl, 3-(hydroxy(Ci-C3)alkyl)oxetan-3-yl, 3-aminooxetan-3-yl or 1-aminocycloprop-l-yl;

and wherein R1B is hydroxy(Ci-C4)alkyl, dihydroxy(C2-C4)alkyl, amino(Ci-C4)alkyl, di(Ci-C4)alkylamino(Ci-C3)alkyl, 1-amino-cycloprop-l-yl, 1-hydroxymethyl-cycloprop-1 -yl, /ra«s-2-hydroxymethyl-cycloprop- 1 -yl, tra«5-2-aminomethyl-cycloprop- 1 -yl, /ra«5-2-hydroxymethyl-l-methyl-cycloprop-l-yl, /ra«s-2-hydroxymethyl-2-methyl-cycloprop-l-yl, c/5-l-fluoro-2-(hydroxymethyl)cycloprop-l-yl, cz's-2-fluoro- 2- (hydroxymethyl)cycloprop- 1 -yl, 2-( 1 ,2-dihydroxyethyl)-cycloprop- 1 -yl, 1 -(hydroxymethyl)-cyclobutan- 1 -yl, cis-3 -(hydroxymethyl)- 1 -hydroxy-cyclobutan- 1 -yl, 3-hydroxyoxetan-3-yl, 3-hydroxyoxetan-3-yl-(C1-C3)alkyl, 3-aminooxetan-3-yl,

3- hydroxymethyl-oxetan-3-yl, tra«5-(c/5-3,4-dihydroxy)-cyclopent-l-yl, 3 -hydroxymethylbicyclo[ 1,1, 1 ]pentan- 1 -yl, 4-hydroxytetrahydro-2H-pyran-4-yl, (3R,<5S)-3-aminotetrahydro-2H-pyran-6-yl, piperidin-4-yl, l-(2-hydroxyacetyl)piperidin- 4- yl, 3-hydroxythietan-3-yl, l-(2-hydroxyacetyl)azetidin-3-yl or l-glycylazetidin-3-yl; or a salt thereof.

2. A compound of formula I according to claim 1, wherein R1 is the group MA;

or a salt thereof.

3. A compound of formula I according to claim 2, wherein

A represents a bond or C≡C;

R1A is H or halogen;

R2A is H; and

R3A is (Ci-C3)alkoxy, hydroxy(C1-C4)alkyl, 1-hydroxymethyl-cycloprop-l-yl, 3-hydroxyoxetan-3-yl, or 3-aminooxetan-3-yl;

or a salt thereof.

4. A compound of formula I according to claim 2, wherein A represents a bond;

or a salt thereof.

5. A compound of formula I according to claim 4, wherein

R1A is H or halogen;

R2A is H; and

R3A is (Ci-C3)alkoxy;

or a salt thereof.

6. A compound of formula I according to claim 2, wherein A represents C≡C;

or a salt thereof.

7. A compound of formula I according to claim 6, wherein

R1A and R2A are both H; and

R3A is hydroxy(Ci-C4)alkyl, 1 -hydroxymethyl-cycloprop- 1-yl, 3-hydroxyoxetan-3-yl, or 3 -aminooxetan-3 -yl;

or a salt thereof.

8. A compound of formula I according to claim 1, wherein R1 is the group MB;

or a salt thereof.

9. A compound of formula I according to claim 8, wherein R1B is hydroxy(Ci-C4)alkyl, dihydroxy(C2-C4)alkyl, amino(Ci-C4)alkyl, di(Ci-C4)alkylamino(Ci-C3)alkyl, 1-amino-cycloprop-l-yl, 1 -hydroxymethyl-cycloprop- 1-yl, tra«s-2-hydroxymethyl-cycloprop-l-yl, /ra«5-2-hydroxymethyl- 1 -methyl-cycloprop- 1 -yl, cis- 1 -fluoro- 2- (hydroxymethyl)cycloprop-l-yl, c/5-2-fluoro-2-(hydroxymethyl)cycloprop-l-yl, 1 -(hydroxymethyl)-cyclobutan- 1 -yl, cis-3 -(hydroxymethyl)- 1 -hydroxy-cyclobutan- 1 -yl,

3- hydroxyoxetan-3-yl, 3-hydroxyoxetan-3-yl-(Ci-C3)alkyl, 3 -aminooxetan-3 -yl, 3-hydroxymethyl-oxetan-3-yl, tra«5-(c/5-3,4-dihydroxy)-cyclopent-l-yl,

4- hydroxytetrahydro-2H-pyran-4-yl, (3R,6S)-3-aminotetrahydro-2H-pyran-6-yl, piperidin-4-yl, or l-(2-hydroxyacetyl)piperidin-4-yl;

or a salt thereof.

10. A compound of formula I according to claim 9, wherein R1B is hydroxy(Ci-C4)alkyl, dihydroxy(C2-C4)alkyl, amino(Ci-C4)alkyl, 1-amino-cycloprop-l-yl, 1 -hydroxymethyl-cycloprop- 1 -yl, tra«s-2-hydroxymethyl-cycloprop- 1 -yl, tra«5-2-hydroxymethyl- 1 -methyl-cycloprop- 1-yl, c/5-l-fluoro-2-(hydroxymethyl)cycloprop-l-yl, cz's-2-fluoro-2-(hydroxymethyl)cycloprop- 1-yl, 3 -hydroxy oxetan-3 -yl, 3 -hydroxy oxetan-3 -yl-(Ci-C3)alkyl, 3-hydroxymethyl-oxetan-3-yl, or tra«s-(cz's-3,4-dihydroxy)-cyclopent-l-yl;

or a salt thereof.

11. A compound of formula I according to claim 1, wherein

R1 is the group MA, A represents a bond,

R1A is halogen,

R2A is H, and

R is (Ci-C3)alkoxy;

or R1 is the group MA, A represents C≡C,

R1A and R2A are both H, and

R3A is 1-hydroxymethyl-cycloprop-l-yl;

or R1 is the group MB and R1B is di(Ci-C4)alkylamino(Ci-C3)alkyl, l-(hydroxymethyl)-cyclobutan- 1 -yl, cis-3 -(hydroxymethyl)- 1 -hydroxy-cyclobutan- 1 -yl, 3 -aminooxetan-3 -yl, 4-hydroxytetrahydro-2H-pyran-4-yl, (3R,6S)-3-aminotetrahydro-2H-pyran-6-yl, piperidin-4-yl, or l-(2-hydroxyacetyl)piperidin-4-yl;

or a salt thereof.

12. A compound of formula I according to claim 1, wherein

A represents a bond or C≡C;

R1A is H or halogen;

R2A is H; and

R3A is (Ci-C3)alkoxy, hydroxy(Ci-C4)alkyl, 1-hydroxymethyl-cycloprop-l-yl, 3-hydroxyoxetan-3-yl, or 3 -aminooxetan-3 -yl;

and wherein R1B is hydroxy(Ci-C4)alkyl, dihydroxy(C2-C4)alkyl, amino(Ci-C4)alkyl, di(Ci-C4)alkylamino(Ci-C3)alkyl, 1-amino-cycloprop-l-yl, 1-hydroxymethyl-cycloprop-1 -yl, tra«5-2-hydroxymethyl-cycloprop- 1 -yl, tra«5-2-hydroxymethyl- 1 -methyl-cycloprop-1 -yl, cis- 1 -fluoro-2-(hydroxymethyl)cycloprop- 1 -yl, c/s-2-fluoro-2-(hydroxymethyl)cycloprop- 1 -yl, 1 -(hydroxymethyl)-cyclobutan- 1 -yl, cis-3 -(hydroxymethyl)- 1 -hydroxy-cyclobutan- 1 -yl, 3 -hydroxy oxetan-3 -yl,

3-hydroxyoxetan-3-yl-(Ci-C3)alkyl, 3 -aminooxetan-3 -yl, 3-hydroxymethyl-oxetan-3-yl, trans-{cis-3 ,4-dihydroxy)-cyclopent- 1 -yl, 4-hydroxytetrahydro-2H-pyran-4-yl, (3R,6S)-3-aminotetrahydro-2H-pyran-6-yl, piperidin-4-yl, or l-(2-hydroxyacetyl)piperidin-4-yl;

or a salt thereof.

13. A compound of formula I according to claim 1, which is selected from the group consisting of:

(R)-N-hydroxy-4-(6-((3-hydroxyoxetan-3-yl)buta-l,3-diyn-l-yl)benzo[