Glucose Sensitive Insulin Derivatives

Abstract: The present invention relates to novel insulin derivatives and their use in the treatment or prevention of medical conditions relating to diabetes. The insulin derivatives are glucose sensitive and display glucose-sensitive albumin binding. The insulin derivatives have a long half-life. The invention also relates to novel intermediates. Finally, the invention provides a pharmaceutical composition comprising the insulin derivatives of the invention and the use of such a composition in the treatment or prevention of medical conditions relating to diabetes.

Patent Information

Application #

Filing Date

20 November 2025

Publication Number

50/2025

Publication Type

INA

Invention Field

BIOTECHNOLOGY

Status

Email

Parent Application

Applicants

NOVO NORDISK A/S

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Inventors

1. HOEG-JENSEN, Thomas

Novo Alle 1 2880 Bagsværd

2. BURON, Line Due

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3. KJELDSEN, Thomas Børglum

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4. VALORE, Henrik

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5. MADSEN, Alice Ravn

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6. SAUERBERG, Per

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Specification

Documents

Application Documents

#	Name	Date
1	202547114106-STATEMENT OF UNDERTAKING (FORM 3) [20-11-2025(online)].pdf	2025-11-20
2	202547114106-Sequence Listing in PDF [20-11-2025(online)].pdf	2025-11-20
3	202547114106-PROOF OF RIGHT [20-11-2025(online)].pdf	2025-11-20
4	202547114106-PRIORITY DOCUMENTS [20-11-2025(online)].pdf	2025-11-20
5	202547114106-POWER OF AUTHORITY [20-11-2025(online)].pdf	2025-11-20
6	202547114106-NOTIFICATION OF INT. APPLN. NO. & FILING DATE (PCT-RO-105-PCT Pamphlet) [20-11-2025(online)].pdf	2025-11-20
7	202547114106-FORM 18 [20-11-2025(online)].pdf	2025-11-20
8	202547114106-FORM 1 [20-11-2025(online)].pdf	2025-11-20
9	202547114106-DRAWINGS [20-11-2025(online)].pdf	2025-11-20
10	202547114106-COMPLETE SPECIFICATION [20-11-2025(online)].pdf	2025-11-20