The present invention relates to pharmaceutical formulations, in particular FVIII formulations. The present invention furthermore relates to methods for producing such compositions.

NOT AVAILABLE

This invention relates to a container (10) for a medication delivery (110) device comprising an optical reader (111), where said container comprises a code information element (20) carrying a set of information readable by said optical reader where the container comprises at least one more code information element (...

The present invention relates to insulin derivatives which are naturally occurring insulins or analogues thereof which have a side chain attached either to the α-amino group of the N-terminal amino acid residue of the B chain or to the ε-amino group of a Lys residue present in the B chain of the parent insulin, the ...

The present invention relates to a handheld medication delivery device comprising first and second mutually displaceable housing parts optionally being operatively connected by a first resilient member thereby allowing the medication delivery device to be in a non-compressed state and in a compressed state. The first ...

A solid phytase composition which comprises (a) an enzyme having phytase activity, and (b) Corn Steep Liquor (CSL), wherein the phytase activity of the composition is above 2 0 units/g.

IL-21 variant are provided wherein amino acids have been deleted and/or substituted in the region consisting of amino acid No. 65-96.

1, A medication delivery device comprising a cartridge assembly (1), a dosing as¬sembly (6) and optionally a needle assembly (16), said cartridge assembly (1) consists of a cartridge 5) and optionally a cartridge housing and has a distal end (22) and a proximal end (21), said distal end (22) being sealed with a pier...

Drug injection device (400) comprising expelling means for expelling an amount of drug from a reservoir the expelling means comprising setting means (411) allowing a user to set a dose to be expelled and actuation means (413) for releasing the drug expelling means to expel the set dose. The actuation means comprises...

This invention relates to a method of producing an enzyme exhibiting isoamylase activity. A host cell comprising the following DNA sequence is cultured (a) an isoamylase encoding part of the DNA sequence cloned into plasmid pUC19 present in Escherichia coli DSM 11971 (b)the DNA sequence shown in positions 1-2178 in se...

N/A

A medical delivery system (100) comprising a dosing assembly (104) and a container (102), wherein the container (102) is adapted to be locked to the dosing assembly (104) through a pure translational movement and unlocked from the dosing assembly (104) through a pure rotational movement. A dosing assembly (104) and ...

This invention relates to a method of assisting a user in a medical self treatment, said self treatment comprising a plurality of actions, said method comprising the steps of collecting in a one or more databases data representing values of parameters relevant for said self treatment, and the step of processing said o...

NOT AVAILABLE

ABSTRACT This invention relates to a starch conversion process for producing syrup. Starch is liquified at a pH between 4.5 and 6.5 at a temperature of 70 to 110°C for 30 to 180 minutes. Liquified starch is saccharified at a temperature of 50 to 80°C in the presence of glucoamylase. The syrup produced is recovered the...

The present invention relates to an electronic injection device wherein an electronic circuit is designed to work in two alternative modes: an air shot mode and a dose injection mode. When working in the air shot mode a small predetermined air shot dose is pressed out from the ampoule when the injection button is ac...

Method for increasing the shelf-life of a pharmaceutical composition comprising a glucagon-like peptide which is prepared from a peptide product that has been dried at a pH above neutral pH.

The present invention relates to novel peptide compounds which have an improved physical stability in solution and improved solubility at neutral pH  to the use of the compounds in therapy  to methods of treatment comprising administration of the compounds to patients in need thereof  and to the use of the compounds...

NOT APPLICABLE

This invention relates to a detergent composition containing a surfactant and alpha-amylase having 25% higher activity than Bacillus licheniformis. The composition may contain other additives used in detergent technology.

Method for increasing the shelf-life of a pharmaceutical composition for parenteral administration comptring a glucagon-like peptide which is prepared from a peptide product that has been subjected to treatment at a pH above neutral pH.

NOT AVAILABLE

Antibodies that are capable of specifically binding and preventing the activation of TREM 1 a protein expressed on monocytes macrophages and neutrophils with both good affinity and low viscosity at clinically relevant concentrations are described. Such antibodies find utility in the treatment of individuals with an ...

The invention relates to PYY compounds with the amino acid modifications 7Lys, 30Trp, and 31Leu, and in addition to these, 22Ile and/or 28Tyr, and derivatives thereof. The compounds of the invention are selective Y2 receptor agonists. The invention also relates to pharmaceutical compositions comprising such PYY comp...

The invention is related to a method for treating or preventing a disorder resulting from the release of bradykinin in said mammal, particularly a mammal which produces an HBP which binds to an HBP antagonist, e.g. a monoclonal antibody that binds to at least one epitope of human HBP, comprising administering to sai...

The invention relates to MIC 1 fusion proteins. More specifically it relates to compounds comprising fusion proteins comprising a MIC 1 protein or an analogue thereof at the C terminus of the fusion protein and a functional variant of human serum albumin at the N terminus of the fusion protein connected via a peptid...

The invention relates to an injection device (100  200  300) which is capable of resisting proximal movements of a piston rod (107  207  307) relative to a housing (102  202  302)  when the piston rod (107  207  307) is subjected to proximally directed forces below a threshold magnitude  and of allowing reversible p...

The present invention relates to novel glucagon peptides to the use of said glucagon peptides in therapy to methods of treatment comprising administration of said glucagon peptides to patients in need thereof and to the use of said glucagon peptides in the manufacture of medicaments. The glucagon peptides of the prese...

The invention provides a fluidic system comprising a permeable membrane, in which one side of the permeable membrane is in contact with a fluid, this lowering the partial pressure of a gas on the other side of the membrane being by raising the pressure of vapour from the fluid by diffusion from the fluidic system th...

NOVEL INSULIN DERIVATIVES AND THE MEDICAL USES HEREOF ABSTRACT The present invention is in the therapeutic fields of drugs for medical conditions relating to diabetes. More specifically the invention relates to novel acylated derivatives of human insulin analogues. The invention also provides pharmaceutical compos...

The present invention relates to an indicating device for use with medical injection devices for administering a drug into the body of a subject user wherein the indicating device is configured for indicating after administration that a dose of the drug actually has been administered and for maintaining this indi...

An assembly comprises a drug delivery device and a monitoring device adapted to detect an action taking place in the drug delivery device. The drug delivery device comprises a main portion having a drug expelling mechanism for expelling drug from a reservoir through an outlet, a housing in which at least a portion o...

The invention provides a device comprising a sealed interior portion with at least one opening covered by a sterilization barrier formed from a non-porous material allowing a sterilization gas to penetrate but prevents germs from penetrating. The size and configuration of the at least one sterilization barrier formed ...

The invention relates to PYY compounds having the amino acid in the position corresponding to position 30 of hPYY(1 36) substituted with tryptophan and derivatives thereof with a modifying group attached to the position corresponding to position 7 of hPYY(1 36). The compounds of the invention are selective Y2 receptor...

A system comprising first and second drug delivery devices based on the same technology platform  each comprising a main portion with a reservoir holding a type of drug  a rug outlet  and drug expelling means for expelling drug from the reservoir through the drug outlet  as well as a cap releasably mountable to the ...

A regular metallic  cylindrical tubular needle cannula (1) is subjected to a metal etching liquid (21) in the inside lumen (4) thereby increasing the inside diameter and enhancing the flow properties while maintaining the outside appearance. The inside diameter is only increased over a controlled length (7) of the ful...

Described is a dipeptide comprising a non proteogenic amino acid methods of making such and methods of using said dipeptide in a process of making a polypeptide or protein comprising one or more non proteogenic amino acids.

The present invention relates to an insulin derivative for the treatment of a condition or disease where administration of insulin will be of benefit, comprising administering, to a patient in need thereof, effective dosages of the insulin derivative, wherein said insulin derivative exhibits a prolonged profile of a...

The present invention provides isolated anti-human NKG2D monoclonal antibodies useful for therapeutic applications in humans. Typically, the antibodies are fully human or humanized to minimize the risk for immune responses against the antibodies when administered to a patient. Preferred antibodies include human mono...

An injection device (1) for delivering a predetermined fixed dose of liquid drug, the device (1) comprising a base member, preferably a housing (2), a first tubular member (7) and a second tubular member (10). The first tubular member (7) and the base member are engaged via a first track (8) and a first protruding par...

The present invention relates to FVIII conjugated to heparosan (HEP) polymers methods for the manufacture thereof and uses of such conjugates. The resultant conjugates may be used in the treatment or prevention of bleeding disorders such as haemophilia.

The present invention relates to methods for stabilizing FVIII in aqueous solutions comprising a relatively high concentration of FVIII. The invention furthermore relates to such aqueous solutions as well as use thereof.

The present invention relates to solid compositions comprising a GLP 1 agonist and a salt of N (8 (2 hydroxybenzoyl)amino)caprylic acid and their use in medicine.

Insulin preparations comprising an insulin compound or a mixture of two or more insulin compounds a nicotinic compound and an amino acid.

The present invention is in the therapeutic fields of drugs for medical conditions relating to diabetes. More specifically the invention relates to novel acylated derivatives of human insulin analogues. The invention also provides pharmaceutical compositions comprising such insulin derivatives and relates to the use...

The invention relates to a derivative of a GLP-1 analogue  which analogue comprises a first K residue at a position corresponding to position 37 of GLP-1(7-37) (SEQ ID NO: 1)  a second K residue at a position corresponding to position 26 of GLP-1(7-37)  and a maximum of ten amino acid modifications as compared to GLP-...

A mechanical injection device (1) for injecting apportioned doses of liquid drug. The injection device (1) comprises a dose setting means, an injection means, a removable cap (15) and a cap receiving part (9) adapted to abut or engage with the cap (15) when the cap (15) is mounted on the injection device (1). The do...

A mechanical injection device (1) for injecting apportioned doses of liquid drug. The injection device (1) comprises a dose setting means, an injection means, a removable cap (15) and a cap receiving part (9) adapted to abut or engage with the cap (15) when the cap (15) is mounted on the injection device (1). The dose...

The invention relates to antibodies that specifically bind to tissue factor pathway inhibitor (TFPI) and that reduce the clotting time of blood. Such antibodies have utility in the treatment of subjects with a coagulopathy

An injection device (1) for injecting predetermined doses of liquid drug is disclosed. The injection device (1) comprises a dose setting mechanism and an injection mechanism. A torsion spring (12) is connected to the dose setting mechanism and to the injection mechanism in such a manner that energy is stored in the ...

The present invention relates to an injection device for administering doses of liquid drug. The injection device comprises a user operable dose adjustment structure configured to adjust in a prepared state of the device a dose of liquid drug of a first size to set a dose of a second size. The present injection devi...

The present invention relates to injection devices for injecting a dose of a medicament. The injection device (100) incorporates a housing (101) a needle assembly (150) and a cover (200). The needle assembly (150) comprises an injection needle (152 153) accommodated in a needle container (151) having an opening whic...

A method for reducing deposits on production equipment during production of a GLP-1 agonist formulation, said method comprising replacing the isotonicity agent previously utilized in said formulation with propylene glycol at a concentration of between 1-1 00 mg/ml.

The invention relates to Leptin derivatives compositions and therapeutic use there of.

The present invention relates to Fibroblast Growth Factor 21 (FGF21), more in particular to derivatives of FGF21 compounds having an albumin binder of the formula A-B-C-D-E- covalently attached. The invention also relates to novel FGF21 analogues, as well as to the pharmaceutical use of these FGF21 derivatives and ana...

The present application discloses a chromatographic process for separating protein components of a protein containing solution said solution comprising an insulin peptide and one or more di or polyvalent metal ions said insulin peptide being capable of self association and/or structural change in the presence of di or...

The present invention relates to B-domain truncated Factor VIII molecules with a modified circulatory half life, said molecule being covalently conjugated with a hydrophilic polymer. The invention furthermore relates to methods for obtaining such molecules as well as use of such molecules.

Novel acylated insulin analogues exhibiting resistance towards proteases can, effectively, be administered pulmonary or orally. The insulin analogues contain B25H and A14E or A14H.

A system for optimizing a patient s basal insulin dosage regimen over time adapted to (a) determine from blood glucose values whether and by how much to vary a patient s present recommended amount of the insulin containing drug in order to maintain the patient s future blood glucose level measurements within a predefi...

27T27T2x642y2222k2nThe invention relates to a derivative of a GLP 1 analogue which analogue comprises a first K residue at a position corresponding to position 27 of GLP 1(7 37) (SEQ ID NO: 1 ); a second K residue at a position corresponding to position T of GLP 1(7 37) where T is an integer in the range of 7 37 excep...

The present invention relates to a PYY or PP peptide derivative or analogue thereof derivatised with one or more serum albumin binding side chains comprising a dis-tal tetrazole or carboxylic acid group. Moreover, the invention relates to compositions hereof and methods of treatment of conditions responsive to Y recep...

A system for optimizing a patient s basal insulin dosage regimen over time adapted to determine from blood glucose values whether and by how much to vary a patient s present recommended amount of the insulin containing drug in order to maintain the patient s future blood glucose level measurements within a predefined ...

The present invention relates to medical delivery devices for administering a dose of a drug into the body of a subject user and incorporating a time lapse indicator which is configured for indicating after administration that a dose of the drug actually has been administered and for maintaining this indication until ...

The present invention relates to a medical delivery comprising a) a housing (101) adapted to accommodate a drug in a drug reservoir (110) the housing (101) having an exterior surface defining at least one non circular section b) a drive mechanism for expelling doses of drug from the drug reservoir (110) and c) an oper...

An injection device is disclosed which comprises a housing (10) with a display for showing the size of a set dose. The display is formed from a number of individual ciphers (11 40) which each comprises a plurality of segments (13 14) extending horizontally and vertically. At the end of the injection device a dose se...

The invention concerns a method for the industrial production of antibodies.

The present invention relates to novel glucagon peptides with improved stability and solubility at neutral pH to the use of the compounds in therapy to methods of treatment comprising administration of the compounds to patients in need thereof and to the use of the compounds in the manufacture of medicaments. The gluc...

An automatic injection device adapted to automatically eject a dose of a medicament by automatically inserting a needle into the skin of a user, ejecting a dose of a medicament through the needle, and subsequently retracting the needle into a housing of the device.

The present invention concerns a prefilled injection device having a container and a dose setting mechanism encapsulated inside the housing. The housing is made from two parts which are locked together by a bayonet coupling: In addition to the bayonet coupling, the two parts are also provided with irreversible locking...

A mechanism for preventing setting of a dose, which exceeds the amount of a medicament in a reservoir in an injection device. The device comprises a threaded piston rod, a limiter and a driver. The three elements are arranged such that during dose setting, the limiter is moved towards an end-of-contend position, where...

A medical delivery system (200) having a container (202) and a dosing assembly (204), where the container is fastenable to the dosing assembly by a movement comprising a translatory movement followed by a rotational movement. One of the container and the dosing assembly comprises one or more blocking elements (207) ...

Anti-human IL20 monoclonal antibodies that can reduce IL20 mediated activation of both IL20R1/IL20R2 and IL22R1/IL20R2 receptor complexes in one or more species, including humans, are described, as well as antigen-binding molecules such as, e.g., antigen-binding antibody fragments, antibody derivatives, and multi-spec...

Medical injection advice adapted for operating in a dose setting mode and in a dose administration mode  comprising a dosing actuator (124) reversibly actuatable from a first state for operating the device in the dose setting mode to a second state for operating the device in the dose administration mode  a switch (13...

A mechanical operated injection device which has the size of a credit card. The very compact size is obtained by using a flexible reservoir containing the drug to be delivered and a suction pump for pumping the liquid drug from the flexible reservoir to the body of the user. The pump is driven in cycles by a spring as...

An injection device (1) for injecting a dose of drug, e.g. insulin for diabetes treatment, in which energy is stored in a spring member (9, 24) during dose setting. The stored energy is released and used for driving an injection mechanism during injection of a previously set dose. The injection device (1) further comp...

The invention provides a pharmaceutical formulation and a method for preparing the formulation.

The present invention relates to a contact free arrangement for determining an absolute position of a member adapted for setting an amount of medicament to be injected from a medication delivery device, or adapted for determining an amount of medicament injected from a medication delivery device. The arrangement accor...

The present invention relates to novel insulin analogues exhibiting resistance towards protease, wherein at least two amino acids are substituted and/or deleted relative to the parent insulin molecule. A method for the preparation of such insulin analogues, insulin preparations containing the insulin analogues of the ...

The present invention relates, inter alia, to novel piperazines, to the use of these compounds in the preparation of pharmaceutical compositions, to pharmaceutical compositions comprising the compounds, and to methods of treatment employing these compounds or compositions. The compounds show a high and selective bindi...

The present invention provides a method for acylating one or more amtno groups of a peptide where the acylation reaction is to be performed in an aqueous mixture containing (ess than 10 %w/w aprotic polar solvent.

Stable pharmaceutical composition comprising insulinotropic peptide

A ratchet-free and gear-free one-to-one mechanism for setting a dose In a syringe device comprising a dose setting member adapted to be rotated along a piston rod with a threaded outer surface so as to set a dose to be ejected. During dose setting the piston rod is locked such that rotational movement of the dose...

The invention concerns an injection device for apportioning set doses of a drug from a reservoir to a subject. The injection device comprises a dose setting member (20, 70) which is screwed out from the housing (30) to set a dose and pushed axially back to the housing (30) in order to expel the set dose. A scale dru...

Method for purifying a racemized polypeptide by ion-exchange chromatography.

Insulins to which there is connected an amino acid oligomer have satisfactory properties.

Novel GLP-1 derivatives FIELD OF THE INVENTION The present invention relates to novel derivatives of glucagon-like-peptide-1 (GLP-1) and fragments thereof and analogues of such fragments which have a protracted profile of action and methods of making and using them. The invention furthermore relates to novel derivat...

Novel compounds of the general formula (I), the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present compounds may be useful in the treatment and/or prevention of conditions mediate...

The present invention relates to pharmaceutical formulations comprising insulin, an insulin analog, an insulin derivative, or a combination of any of the foregoing, and a salt of protamine, to methods of preparing such formulations, and to uses of such formulations in the treatment of diseases and conditions for whi...

The present invention relates to novel peptide compounds which are effective in modulating one or more melanocortin receptor types, to the use of the compounds in therapy, to methods of treatment comprising administration of the compounds to patients in need thereof, and to the use of the compounds in the manuf...

The present invention relates to novel peptide compounds which are effective in modulating one or more melanocortin receptor types, to the use of the compounds in therapy, to methods of treatment comprising administration of the compounds to patients in need thereof, and to the use of the compounds in the manufactur...

The present invention relates to novel peptide compounds which are effective in modulating one or more melanocortin receptor types, to the use of the compounds in therapy, to methods of treatment comprising administration of the compounds to patients in need thereof, and to the use of the compounds in the manuf...

The invention concerns an injection device for apportioning set doses of a drug from a reservoir to a subject. The injection device comprises a housing having an interior thread formed as an outwardly pointing thread carried on an upstanding tower centrally located in the pen shaped device. This outwardly pointing t...

The invention provides derivatives of IL-21 or variants thereof.

The present invention describes 2,3-di-substituted N-heteroaromatic propi-onamides, wherein the substitution at the 3-position is an optionally substituted phenyl ring and the substitution at the 2-position is an alkyl or cycloalkyl group; pharmaceutical compositions comprising the same; and, methods of using the sa...

A medical device is provided comprising a transcutaneous device unit and a process unit. The transcutaneous device unit is adapted to be mounted to a skin surface of a subject and comprises a first housing, a transcutaneous device, and may comprise a flexible patch por-tion with an upper surface and a lower mou...

A needle mounting system and methods for mounting a needle assembly on a needle mount are disclosed. The needle mounting system includes a needle hub having protrusions extending radially inward. A needle mount has a plurality of slots to receive the protrusions. The slots have a first portion that defines a passage...

The present invention relates to agents and methods that are capable of augmenting NK-mediated killing of target cells by reducing inhibitory KIR signalling without reducing the binding of KIR to HLA-C. As described herein, transduction of negative signaling via KIR, upon binding of KIR to its HLA class I ligand, ca...

Novel salicylic antlidas are chemical uncouplers useful e.g. for the treatment of obesity

ABSTRACT The invention provides a jet expelling assembly comprising a reservoir and an impulse chamber assembly. The impulse chamber assembly comprises a chamber portion defining a cavity having a general axis, a piston received in the cavity along the general axis and comprising a fluid inlet, thereby defining a v...

Novel compounds, pharmaceutical compositions comprising them and use thereof in the treatment and/or prevention of diseases and disorders related to hormone sensitive lipase. More particularly, the compounds are useful for the treatment and/or prevention of diseases and disorders in which modulation of the activity ...

The present invention is related to single-chain insulin having insulin activity comprising a B- and an A-chain or a modified B- and A-chain connected by a connecting peptide of from 6-11 amino acids. The single-chain insulins will have biological insulin activity and an IGF-1 receptor affinity similar to or lower t...

The invention is related to insulin compositions with a high content of zinc atoms per six molecules of acylated insulin. The insulin is an acylated insulin and may be mixed with a fur¬ther insulin analogue such as the rapid acting insulin Asp B28 human insulin.

Protracted GLP-1 compounds and therapeutic uses thereof.

A medical device is provided comprising a cannula having a distal portion adapted to be arranged through the skin of the subject, and an outer needle arranged coaxially with and being axially moveable relative to the cannula, the needle comprising a pointed distal end, wherein the device is adapted for advancing the...

A medical device is provided comprising a first a second units, the first unit comprising a housing with a skin-mountable surface, and a transcutaneous device having a distal portion adapted to be arranged through the skin of the subject in a situation of use in which the housing has been applied on a skin surface. ...

Methods for the selective conjugation of peptides which comprises an enzymatic incorporation of a functional group at the C-terminal end of a peptide followed by reaction with a second compound comprising the moiety to be conjugated to the peptide, wherein said second compound comprises a functional group which sele...

Novel GLP-1 agonists which are protracted by coupling to a protraction protein.

The present invention relates to a handheld mechanical injection device by which set doses of a liquid medicament can be injected from a medical reservoir. The medicament is expelled through an injection needle by release of a power reservoir in the device, the power reservoir being fully or partially released by ac...

The invention disclosed concerns an injection device for apportioning set doses of a drug from a reservoir to a subject. The injection device comprises a rotatable scale drum which is screwed out from the proximal end of the injection device when a dose is set. The rotatable scale drum is coupled to a piston rod dri...

This invention relates to a method of controlling a dosing operation where a piston in a medical device is moved to a desired position, the dosing operation applies a motor to provide a force from the piston to expel a dose of a liquid medicament, said method comprising the steps of: moving the piston, at a first fi...

The present invention relates to a medication delivery device comprising pump means and a reservoir adapted for containing a medicament. The pump means is adapted to transfer the medicament from the reservoir to an outlet arrangement, said outlet arrangement being adapted to be operatively connected to an associa...

Process for regenerating a chromatographic stationary phase

A sealing membrane 20 on a nozzle 10 for a jet injection device is adapted to seal off the nozzle orifice 12 by having a sealing rim 22 surrounding the nozzle orifice 12, which ensures a distinct closure of the nozzle orifice 12 to protect the nozzle geometry against damage and dirt and to protect the drug 30 contai...

The present invention relates to secure paring of electronically controlled devices adapted to communicate with each other. Thus, a medical system is provided comprising a first unit and a second unit, the system comprising first means of communication allowing a first group of data types to be transmitted between t...

The present invention relates to secure paring of electronically controlled devices adapted to communicate with each other. Thus, a medical system is provided comprising a first unit and a second unit, the system comprising first means of communication allowing a first group of data types to be transmitted between t...

An injection device for injection of set doses of medicine from a cartridge has a nut that is screwed up along a threaded piston rod during a dose setting operation. The nut is screwed along the piston rod by rotating a dose setting member. A rotational coupling mechanism includes an axially displaceable coupling me...

The present invention describes administering a GLP-1 agonist to treat obesity caused by the administration of an obesity-inducing drug.

An injection device with a gearing arrangement providing a gearing ratio between axial movement of an injection button and axial movement of a piston rod. The injection device comprises a dose setting member being operable to set a dose by rotating the dose setting member relatively to a housing, about a rotational ...

A refillable injection device having a dose setting mechanism with a dose setting member and a dose rod. The dose setting member and the dose rod engage during normal operation of the injection device, and they do not engage during change of cartridge. The dose setting member and the dose rod need to be moved into e...

The present invention relates to a replaceable cartridge for a medication delivery device, the cartridge being adapted to contain a medicament to be expelled from the medication delivery device, the cartridge comprising a sidewall portion being made of an essentially electrical non-conducting material, a first elect...

The present invention relates to a cartridge adapted to contain a medicament, the cartridge further being adapted to be inserted into an associated medication delivery device. The cartridge according to the present invention comprises a plurality of electrode elements arranged on an exterior surface part of the cart...

The invention relates to a method for the production of a Factor VIII polypeptide, the method comprising the steps of a) culturing a mammalian cell expressing a Factor VIII polypeptide under conditions for expression of said Factor VIII polypeptide, said culturing conditions involving a cell culture medium comprisin...

The invention relates to management, treatment and prevention of allergic reactlorrar, allergic diseases and allergic conditions by administration of IL-21.

The present invention relates to a medication delivery device for expelling set doses of medicament, the medication delivery device comprising a position determining arrangement for detecting absolute positions of a movably mounted member, such as a dose indicator barrel, relative to a housing of the medication deli...

The present invention relates to novel covalent complexes of a Factor VII polypeptide and a Tissue Factor polypeptide, in particular to such complexes which are functionally active and which have an enhanced proteolytic activity towards Factor X compared to the corresponding free Factor VII polypeptide as well as me...

The present invention provides a fluid reservoir comprising a first wall portion formed from a needle-penetratable material, the first wall portion comprising a seal surface. The reservoir further comprises a seal member formed from a needle-penetratable self-sealing material, wherein the seal member has been applie...

The present invention relates to a manual injection pen suitable for injecting a liquid medication via a non-electrical drive mechanism. The injection pen is provided with a plurality of sensors that senses when a user is taking a specific action with the device. Further the injection pen is provided with a sound ge...

The present invention relates to methods and devices for providing a reduced risk of free flow from medical devices such as an infusion pump. A medicament containing reservoir is provided with a piston having a sealing portion formed by a material of a first stiffness. The piston further comprises a frictional enhan...

The present application relates to methods and devices for providing a reduced risk of free flow from medical devices such as an infusion pump. A medicament containing reservoir (100) is provided with a piston having a sealing portion (121) formed by a material of a first stiffness. The piston further comprises a co...

The present invention relates to a new type of cannula for syringes or injection devices. The cannula according to the present invention comprises a substantially hard portion and a ductile portion axially arranged therewith, where the substantially hard portion comprises a tip which is adapted to penetrate the skin...

A jet injection device comprises a medical jet unit (10), a medical drug dispensing unit (20) and an medical drug injection unit (30). The empty medical jet unit (10) is connected to the medical drug dispensing unit (20) and the plunger (11) inside the medical jet unit (10) snaps to the removable drug container (40)...

A syringe device comprising a spring adapted to be strained so as to store energy, the spring cooperating with an injector piston such when the spring is released from its strained state, the injector piston is forced in the distal direction, whereby a medicament is injected. The syringe device comprising a motor ar...

The present invention relates to a medication delivery device for expelling set doses of medicament, the medication delivery device comprising a position determining assembly for detecting absolute positions of a rotatably mounted member arranged within the device, the position determining assembly comprising a plur...

A medical delivery system having a container and a dosing assembly, and wherein one of the container and the dosing assembly comprises a rotatable element adapted to engage the other one of the container and the dosing assembly. A container suitable for use in said medical delivery system, A dosing assembly suitab...

ABSTRACT A medical delivery system comprising a container for accommodation of a medicament and a dosing assembly adapted to be fastened to the container. The medical delivery system comprises a coding mechanism for ensuring that only a predetermined container can be fastened to a predetermined dosing assembly. ...

The present invention relates to a medication delivery device comprising a cartridge compartment adapted to receive and hold a medicament containing cartridge, the cartridge compartment comprising an electromagnetic device adapted to generate a magnetic field having a spatial overlap with at least part of a medicame...

Described herein are anti-NKG2A antibodies suitable for human therapy, including humanized versions of murine anti-NKG2A antibody Z270, as well as related methods and materials for producing and using such antibodies. Exemplary complementarity-determining regions (CDRs) sequences and sites for optional amino acid ba...

The present invention provides covalent conjugates between a polypeptide and a modifying group, such as a water-soluble polymer (e.g., PEG). The amino acid sequence of the polypeptide includes one or more O-linked glycosylation sequence, each being a substrate for a GIcNAc transferase. The modifying group is covalen...

Novel compounds of the general formula (I), the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present compounds may be useful in the treatment and/or prevention of conditions mediate...

1. A composition for breaking filtercake deposits in oil wells comprising a viscoelastic surfactant, an enzyme, and a chelating agent, wherein the enzyme is selected from a-amylase and p-amylase and wherein the chelating agent is selected from the group consisiting of 1-hydroxyethylidene-l, 1-diphosphonic acid-1 (HE...

Novel piperazines of formula (I), pharmaceutical compositions comprising them and use thereof in the treatment and/or prevention of diseases and disorders related to hormone sensitive lipase. More particularly, the compounds arc useful for the treatment and/or prevention of diseases and disorders in which modulation...

Novel compounds of the general formula (I), the use of these compounds as pharmaceutical compositions, pharmaceutical compositions -comprising the compounds and methods of treatment employing these compounds and compositions. The present compounds may be useful in the treatment and/or prevention of conditions mediat...

The current invention provides methods (e.g., large-scale processes) for the production of nucleotide sugars, which are modified with a polymeric modifying group, such as poly(alkylene oxide) moieties (e.g., poly(ethylene glycol) or poly(propylene glycol)) moieties. A typical process of the invention includes anion ...

A method for purifying a recombinant protein using a multimodal or mixed mode resin containing ligands which comprise a hydrophobic part and a negatively charged part is described. The invention is advantageous in that it is a single step chromatographic process which does not require adjustment of pH or conductivit...

A device and method for estimating a nutritional parameter of a meal consumed by an individual is disclosed. The apparatus comprises processing means adapted to obtain input values of at least a physiological parameter of the user measured prior to and after intake of a meal by the user, and of at least a dose of me...

Disclosed herein are compositions and systems having a low coefficient of friction. The low friction system comprises a first surface and a second surface, where the first surface comprises (i) a polycarbonate and a first additive, or (ii) a polybutylene terephthalate and a second additive; and the second surface co...

ABSTRACT The present invention relates to compounds of the general formula (III) which are activators of glycosidase (GK), and which may be useful for the management, treatment, control, or adjunct treatment of diseases or conditions, where increasing glycosidase activity is beneficial, for example diseases such...

The invention provides a device for displaying information, comprising storage means for storing data, display means adapted to display data to a user, and user input means. The data is organized as data units, each data unit comprising time data, type data and information data, and the display means is adapted to g...

A reservoir unit is provided comprising a housing in which a reservoir with a transparent portion is arranged, the housing comprising a window allowing a portion of the reservoir to be inspected. The reservoir unit is adapted to be moved from a first "cold" condition to a second "warm" condition with no visible wate...

In a communication device compatible with either SISO or MIMO access point, a set of antennas is configured as either sector-directional or omni-directional, depending upon whether the communication channel is characterized by the communication device as either strongly line of sight, or strongly scattering, respect...

A medical delivery system comprising a container for accommodation of a medicament and a dosing assembly adapted to be fastened to the container. The medical delivery system comprises a coding mechanism (150, 152) for ensuring that only a predetermined container can be fastened to a predetermined dosing assembly. Th...

A medical delivery system (100) comprising a container (102) which is adapted to be fastened to a dosing assembly (104). One of the container and the dosing assembly comprises a rotatable element (106) adapted to cooperate with the other one of the container and the dosing assembly, so as to lock/fasten the containe...

ABSTRACT IL-21 variants are provided wherein amino acids have been deleted in the region consisting of amino acid residues no. 65 to 98.

A medical delivery system wherein one of a container and a dosing assembly comprises a first fastening means and the other one of the container and the dosing assembly comprises a second fastening means; and wherein the second fastening means is adapted to move at least a part of the first fastening means in a radia...

A needle assembly for an injection device comprising a needle cannula which is mounted in a hub connectable to an injection device, and a biasing shield which is telescopically guided relative to the hub between a position in which the needle cannula is covered and a position in which at least the sharp end of the n...

PEGylated, extended insulins are insulins which, compared with human insulin, has one or more extensions extended from the A1, B1, A21 and/or B30 position(s), said extension(s) consist(s) of amino acid residue(s) and wherein a PEG moiety, via a linker, is attached to one or more of the amino acid residues in the ext...

Abstract INTERLEUKIN-21 VARIANTS WITH ALTERED BINDING TO THE IL-21 RECEPTOR The invention is concerned with IL-21 polypeptide variants having an altered binding to the common gamma chain © of the IL-21 receptor and the use thereof in therapy.

This application relates to novel urea glucokinase activators and use of the compounds of the invention for preparation of a medicament for the treatment of various diseases, e.g. for the treatment of type 2 diabetes. Further encompassed is a pharmaceutical composition comprising a compound according to the inventio...

A dosing assembly (204) and/or a container (202) comprising fastening means (206,208) for fastening the container to the dosing assembly, the fastening means of the dosing assembly and/or the container defining an asymmetrical pattern in a plane transverse to an axial direction of the dosing assembly and/or a contai...

ABSTRACT "DISUBSTITUTED PIPERIDINE COMPOUNDS" The present invention relates to novel compounds, in particular 4, 4-disubstituted and 3, 3-disubstituted piperidine compounds, compositions containing them, and their use for treating medical disorders resulting from a deficiency in growth hormone. ...

The invention relates to an injection device for injecting a dose of drug. The injection device comprises a housing, a dose setting mechanism being operable to set a desired dose, an injection mechanism comprising a piston rod adapted to cooperate with a piston positioned in a cartridge containing a drug to be deliv...

The invention provides an assembly comprising a housing having an electrical housing connector and a strip port for a BGM sensor arranged in the vicinity of the electrical connector. The assembly further comprises an external electrical connector adapted for releasable connection to the housing connector, wherein th...

The present invention relates to a dial-down mechanism for an injection device comprising a torsion spring for assisting injection of a dose of medicament from the injection device, the dial-down mechanism comprising dial-up cam arranged to receive and engage with a dial-up key, wherein the dial-up cam and the ...

The present invention relates to an injection device comprising a housing, a resilient member adapted to provide a force in the axial direction of the injection device for ejecting a dose from the injection device. The injection device further comprises a dose setting member operatively connected to a dose indi...

The present invention relates to an injection device comprising a torsion spring operatively connected to a dose setting member being adapted to set a dose to be ejected from the injection device. A rotatably mounted display member adapted to display the dose to be ejected in accordance with a setting of the do...

A skin retention device 10 for a medical jet-injection unit 20 comprises a conttect face pro-vided with adhesive 12 in the area surrounding and close to the injection opening(s) 11 of the nozzle 21 which ensures god contact between the nozzle 21 and the skin 30 of a subject in the area chosen for an injection. Conse...

An injection device with a dose delivering mechanism being adapted to provide a non-visual, e.g. audible and/or tactile, feedback signal when a set dose has been at least substantially injected. A first and a second part of the injection device are adapted to perform a relative rotational movement with respect to ea...

NOT AVAILABLE

The invention relates to an optical system for imaging an object on an image sensor, said system having an optical axis extending through an aperture and through image-forming means the comprise an aspheric light-bcam-rcfracting surface. According to the invention an aspheric image-forming element, such as the lens ...

A container consisting of at least two layers, the inner layer consisting of a PE or PP film and the PCTFE layer consisting of a PCTFE film, and the thickness of the PCTFE layer being about 40-100 µm, which container is equipped with a device where the liquid can be lead out through when desired and which container...

The present invention relates to a medical injection device (1) for use in combination with a medicament filled cartridge (2), the injection device being provided with a spring-assisted injecting mechanism where energy released from the spring moves a plunger (3) of a held cartridge (2). Sensor circuitry is adapted ...

The present invention relates to a method and an apparatus for reversing a piston rod in an injection device, the piston rod being operatively connected to a motor shaft of an electrical motor so that a rotational movement of the motor shaft is transformed to a translational movement of the piston rod, the pist...

Novel GLP-1 conjugated with structurally well defined polymers and their therapeutically use.

Protracted GLP-1 compounds and therapeutic uses thereof.

A mechanical injection device (1) for injecting apportioned doses of liquid drug. The injection device (1) comprises a dose setting means, an injection means, a removable cap (15) and a cap receiving part (9) adapted to abut or engage with the cap (15) when the cap (15) is mounted on the injection device (1). The do...

A mechanical injection device (1) for injecting apportioned doses of liquid drug. The injection device (1) comprises a dose setting means, an injection means, a removable cap (15) and a cap receiving part (9) adapted to abut or engage with the cap (15) when the cap (15) is mounted on the injection device (1). The do...

The present invention concerns a prefilled injection device having a container and a dose setting mechanism encapsulated inside the housing. The injection device incorporates an axial variable connection such that the distance between the distal end of the piston rod means and the plunger is minimized preferably to ...

The present invention relates to a device for storage and administration of a medicament suspension comprising a container for receiving a medicament suspension wherein the container has two mixing elements which differ with respect to their density such that the first mixing element has a density significantly ab...

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NOT AVAILABLE

An injector system for needleless, high pressure delivery of a medicament, the system comprising: an injector having an injector piston movable with in an injector body, a medicament container having a reservoir piston movable in a reservoir, a fluid connection interconnecting the injector body and an outlet of th...

NOT AVAILABLE

The present invention relates to novel compounds that act as chemical uncouplers. Com-pounds of the invention are useful in the treatment, including prevention, of obesity, diabetes and a number of diseases or disorders associated therewith.

The present invention relates to novel compounds that act as chemical uncouplers. Compounds of the invention are useful in the treatment, including prevention, of obesity, diabetes and a number of diseases or disorders associated therewith.

ABSTRACT DIETETIC SOY BASED PRODUCT. METHOD FOR PRODUCTION THEREOF AND USE THEREOF The dietetic soy based product exhibits the following composition of fat free dry matter: Proteins (N x 6.25) > 50% Soluble dietary fibres > 5% Phytate < 0.3% Stachyose < 0.4% Raffinose < 0.4% This dietetic soy based product...

The present invention relates to a process of preparing a spread, said spread, and the use of an enzyme in the production of a spread. The process of preparing a spread comprises the following steps: a) the aqueous phase, which comprises the protein, is treated with an enzyme, capable of enhancing the viscosity ...

The present invention relates to fungi, which do not produce proteases. The fungi of the invention are useful as hosts for the production of proteins susceptible of proteolytic degrada¬tion by the proteases usually produced, and the invention consequently encompasses processes for the production of proteins of inter...

The present invention relates to novel human insulin derivatives which are soluble at physiological pH values and have a prolonged profile of action. The invention also relates to methods of providing such derivatives, to pharmaceutical compositions containing them, to methods of treating diabetes and hyperglycaemia...

The invention relates to an improved process for the production of a secondary metabolite comprising i) fermentation of a microorganism capable of producing said secondary metabolite, and ii) recovering said metabolite in substantially pure form. Said microorganism has been modified in a manner whereby the expressio...

The present invention relates to a pharmaceutical formulation comprising a polypeptide and ethylenediamine or salts thereof and an antimicrobial preservative agent.

The present invention relates to novel affinity ligand-matrix conjugates comprising a ligand with the general formula (a) which ligand is attached to a support matrix in position (A), optionally through a spacer arm interposed between the matrix and ligand. The invention furthermore relates to these novel affini...

The present invention relates to compositions, e.g. pharmaceutical compositions comprising IL-21 and sulphate, and to methods of stabilising IL-21, the method comprising adding sulphate to a solution comprising said peptide.

An injection device comprising a housing, a dose setting member being operable to set a desired dose, a piston rod adapted to cooperate with a piston to cause a set dose to be expelled, and mode locking means. The mode locking means is adapted to be in a first extreme position and in a second extreme position. When ...

A pressurised injection device comprises a mechanical loading mechanism comprising a double set of rackets and ball bearings/pins running in a curved track which enables are sii-ient element to be pre-stressed by twisting the two outer house parts of the device rerative to each other back and forth. When twisted in...

The invention provides a user input device for operating a drug delivery system is provided, comprising display means adapted to simultaneously display at least two user controllable settings, and user input means allowing a user to simultaneously and directly set each of the simultaneously displayed user controllab...

By a dose setting device for a delivery system wherein a piston rod (6, 9) successively presses a piston (2) into a cylinder ampoule (1) a dose is set by 5 rotating a second part (9) of the piston rod (6, 9) in relation to a first part (6) which parts are connected by mating threads so that the total length of the...

The present invention provides an assembly comprising a skin-mountable device with a mounting surface, the device being arranged in a packaging releasably attached to the device and having an opening through which the device can be moved when detached from the packaging. The device and the packaging comprises cooper...

ABSTRACT TITLE: A METHOD FOR PRE-FIBRILLATION OF LYOCELL A method for primary fibrillation of lyocell or lyocell blends comprising the step of immersing lyocell fibres in an aqueous solution at a pH in the range of 2-10 and subjecting the fibres to mechanical stress.

This invention relates to a starch conversion process for producing syrup.It consist of liquifying starch in the presence of an alpha-amylase and iso-amylase at a pH of between 4.5 and 6.5 at 70 to 110˚c for 30 to 180 minutes.this liquified starch is saccharified at 50 to 80˚ c at a pH range of 4.5 to 6.5 in the pre...

Title: Method for Reducing Syneresis ABSTRACT A method for reducing the serum separation of an aqueous mass containing pectin, comprising the steps of : a) providing an aqueous mass substantially free from pectin depolymerizing enzymes. b) adding an effective amount of pectinesterase, preferably substantially fr...

The invention relates to a variant of a parent Termamyl-like α-amylase, which exhibition an alteration in at least one of the following properties relative to said parent α-amylase: i) improve pH stability at a pH from 8 to 10.5; and/or ii) improved Ca2+ stability at pH 8 to 10.5, and/or iii) increased specific...

The invention relates to a variant of a parent Termamyl-like α-amylase, comprising mutations in two, three, four, five or six regions/positions. The variants have increased thermostability at acidic pH and/or at low Ca2+ concentrations {relative to the parent). The invention also relates to a DNA construct comprisi...

ABSTRACT This invention relates to a process for producing dextrose from starch. Staroh is liquified first and is then treated with pure carbohydrate binding domain and atleast one amylopectin debranching enzyme. Dextrose is recovered from the reaction mixture in a known perse.

The present invention provides humanized anti-human IFN-α monoclonal antibodies useful for therapeutic applications in humans. Preferred antibodies are humanized versions of murine antibodies ACO-1 and ACO-2, as well as variants thereof.

The invention is related to a method for making human insulin analogues by culturing an fungi cell comprising a DMA vector encoding a precursor for human insulin analogue , wherein the said precursor comprises a connecting peptide flanked with cleavage sites at both junctions with the A- and the B-chain of th...

The invention provides a compound of general formula (I) wherein the substituents are defined futher in the application, as well as further embodiments hereof described in the attached embodiments. The present invention also provides use of the compounds of the invention for preparation of a medicament for the treat...

The present invention relates to novel peptide compounds which are effective in modulating one or more melanocortin receptor types, to the use of the compounds in therapy, to methods of treatment comprising administration of the compounds to patients in need thereof, and to the use of the compounds in the manufactur...

The present invention relates to a derivative of GLP-1 (7-37) or an analogue of GLP-1 (7-37) which derivative is an agonist of the human GLP-1 receptor, characterized in that the derivative has only one lipophilic substituent which is attached to an amino acid residue which is not the N-terminal or C-terminal amino ...

Novel insulin precursors and insulin precursor analogs comprising a connecting peptide (mini C-peptide) of preferably up to 15 amino acid residues and comprising at least one Gly are provided. The precursors can be converted into human insulin or a human insulin analog. The precursors will typically have a distance ...

NOT AVAILABLE

The present application discloses a solid support material having covalently immobilized thercon an affinity ligand, said ligand comprising one of more hydrophobic functional group(s) and one or more cationic functional group(s) or one or more heteroaromatic functional group(s), wherein at least one hydrophobi...

The present invention relates to a method for ensuring a constant target speed of a battery driven electrical motor, the battery driven electrical motor being adapted to move a piston rod in an injection device so as to inject a set dose of medicine from the injection device, the. method comprising the steps of sett...

The present invention relates to novel amylin derivatives having a protracted action profile, to pharmaceutical compositions comprising these derivatives and to the use of the derivatives for the treatment of diseases related to obesity, diabetes and other metabolic disorders.

The present invention relates to methods and devices for providing an effective change in a drug delivery rate. In an exemplary embodiment the invention provides a method for changing a delivery rate for a drug from a first delivery rate to a second higher delivery rate, comprising the steps of: (a) Deliver the drug...

The present invention relates to a metliod for detecting contact between an injection needle of a medication delivery device and a body of a patient. The method comprises the step of generating a contact signal in response to closure of an electrical signal path comprising an exterior surface part of the injection n...

Pharmaceutical composition for parenteral administration comprising a basal insulin peptide and an insulinotropic GLP-1 peptide comprising at least 6 zinc atoms per 6 insulin molecules.

A cannula (100) for an injection device, the cannula defining a tapered end part termination (102) in a distal end for insertion into the tissue of a living being, wherein the hardness of the cannula decreases in the direction of the distal end. A tool (104) for providing a tapered portion of a cannula, the tool def...

The present invention relates to novel compounds that act as chemical uncouplers. Compounds of the invention are useful in the treatment, including prevention, of obesity, diabetes and a number of diseases or conditions associated therewith.

A semi-recombinant method for the production of GLP-1 analogues and derivatives with non-proteogenic amino acids in the N-terminal part combining the use of recombinant expression techniques and chemical peptide synthesis.

An injection device with an End-of-Content mechanism. The End-of-Content mechanism comprises a track and a track follower each coupled directly or indirectly to the housing and the dose setting member. When setting a dose, the housing and the dose setting member is rotated relatively to each other thereby also ro...

The invention provides a user input device for programming a parameter profile for a drug delivery system, comprising display means adapted to graphically display a parameter profile showing a parameter value as a function of time, the display means being adapted to also show an indicator (or cursor) arranged corres...

The present invention provides a user input device for operating a drug delivery system is provided, comprising display means adapted to simultaneously display a plurality of menu items, display means adapted to display at least one user settable drug delivery parameter, and user input means allowing a user to direc...

A syringe device for ejecting a dose of a medicament, the syringe device comprising: a dose limiting mechanism arranged to interact with a dose ejecting mechanism to prevent ejection of a dose exceeding a set dose, and a safety mechanism, which is arranged such with respect to the dose ejecting mechanism that, if th...

NOT AVAILABLE

The present invention relates to a dial-down mechanism for an injection device comprising a torsion spring for assisting injection of a dose of medicament from the injection device, the dial-down mechanism comprising a ratchet arm (21) engaging a ring element (10) and a reset element (30) which acts on a knob locate...

The present invention relates to electronically assisted drug delivery devices. The drug delivery device may include a Gray code type detector for sensing dosage data, wherein the detector comprises a code track consisting of a sequence of alternating markings and a plurality of detectors that are mutually spaced in...

A method of manufacturing a bended injection needle assembly comprising the steps of: mounting a straight one-piece metallic needle cannula (20) in a hub (1), securing the straight needle cannula (20) to the hub (1) and bending the needle cannula (20) such that at least a part of the needle cannula deflects away fro...

The invention is related to a water-free liquid or semisolid pharmaceutical composi-tion comprising a derivatized insulin peptide, at least one polar organic solvent and at least one lipophilic component and a method of treatment using such.

A method and an apparatus for sterilizing packaging material for use in packaging for protein containing products, such as food products or medical drugs. The packaging material is sterilized by irradiating it using a beam of ionizing radiation, such as an electron beam or a beam of gamma rays. Afterwards, the packa...

The present invention relates to shelf stable non-aqueous pharmaceutical compositions, and to the use thereof in methods of treating diabetes and hyperglycaemia.

Novel PEGylated insulin analogues exhibiting resistance towards proteases can, effectively, be administered pulmonary or orally. The insulin analogues contain B25H and A14E or A14H. The PEGylation is at B29K.

A needle magazine for holding a plurality of injection needles (55) is described. The needle magazine comprises a first opening adapted to receive the device fluid access portion (120) of a medical delivery device. Each needle (55) is selectively moveable from a respective storage position not aligned with said firs...

Insulin preparations comprising an insulin compound or a mixture of two or more insulin compounds  a nicotinic compound and an amino acid.

An injection device with a travelling clutch which can be shifted between two different positions by the activation of an injection button. In the first position, the injection buttoil driver is allowed to rotate relatively to the piston rod, which is blocked from rotation by the clicker element. In the second posit...

The present invention describes phenoxy-acetic acids and pharmaceutical compositions containing the same and methods of using the same. The phenoxy-acetic acids are activators of PPAR-8 and should be useful for treating conditions mediated by the same.

The invention concerns a process for preparing a pharmaceutical formulation comprising an insulin derivative  wherein the process comprises dissolving an insulin derivative in water  adjusting the pH of the solution to a pH above 7.2  adding a zinc solution while stirring con-tinuously and adjusting the pH to the ta...

Method for increasing half-life of compounds in plasma and novel derivatives of such compounds.

The invention relates to a method of cleaning, disinfecting and preserving contact lenses comprising treating contact lenses in the following order with: 1) at least one enzyme, 2) at least one enzyme inhibitor, 3) at least one disinfecting agent, and 4) optionally rinsing in e.g. physiological saline solution. A ...

The present invention relates to methods for treatment of a condition or disease where administration of insulin will be of benefit comprising administering to a patient in need thereof effective dosages of an insulin insulin analogue or derivative thereof which exhibits a prolonged profile of action wherein said do...

NOT AVAILABLE

A metallic cylindrical tubular needle cannula (1) is subjected to a metal etching liquid inside the lumen (7) thereby increasing the inside diameter and enhancing the flow properties while maintaining the outside appearance. The inside wall (5) is further provided with a collapse zone (10) manufactured by radiating ...

The invention relates to chemically as well as physically stable compositions comprising Factor VII or a Factor Vll-related polypeptide such that these compositions can be stored, handled and used at room temperature.

Novel cyclic and linear peptides of the formula R1-x-x1-x2-x3-x4-x5- x6-x7-x8-x9-X10-X11-R2 are useful in the treatment of obesity are provided.

Novel substituted pyridinyl carbamates, pharmaceutical compositions comprising them and use thereof in the treatment and/or prevention of diseases and disorders related to hormone sensitive lipase. More particularly, the compounds are useful for the treatment and/or prevention of diseases and disorders in which modu...

The present invention relates to novel compositions and methods for regulating an immune response in a subject. More particularly, the invention relates to specific antibodies that regulate the activity of NK cells and allow a potentiation of NK cell cytotoxicity in mammalian subjects. The invention also relates to ...

NOT APPLICABLE

Small cyclic peptides of the formula X1 -X2-X3-X4-X5-X6- X7 R1 comprising 7-12 amino acid residues are pro vided. Said peptides are MC4 receptor agonists, and thus useful in the treatment of obesity and related diseases.

The invention relates to an injection device for injecting a liquid drug. The injection device comprises a housing assembly supporting a non-removable cartridge having an interior chamber containing the liquid drug to be injected and a reusable needle cannula connected to the cartridge. A needle shield assembly prov...

A medical device is provided comprising a transcutaneous device unit and a reservoir unit. The transcutaneous device unit comprises a transcutaneous device for transporting a fluid through a skin portion of a subject, and a mounting surface adapted for application to the skin of the subject. The reservoir unit compr...

The present invention relates to pharmaceutical formulations comprising a peptide and propylene glycol, to methods of preparing such formulations, and to uses of such formulations in the treatment of diseases and conditions for which use of the peptide contained in such formulations is indicated. The present inventi...

The invention relates to a nozzle device adapted for placement against a skin surface of a subject, the nozzle device providing a means for stretching the skin, the nozzle device being suitable for use in jet injection. More specifically, the skin stretching means is arranged circumferentially relative to a nozzle, ...

Novel GLP-1 compounds and their therapeutic use.

Methods for conjugating peptides are provided comprising i) reacting a peptide with a first compound comprising a funcţional group in the presence of a transglutaminase capa-ble of incorporating said compound into the peptide to form a transaminated peptide, and ii) reacting said transaminiated peptide with e.g. a f...

The invention relates to compounds derived from the EGF(A) domain of LDL-R in particular compounds comprising a peptide analogue of the wild-type EGF(A) (LDL-R(293- 332)) sequence and at least one substituent comprising at least one fatty acid group. The invention also relates to a pharmaceutical composition thereof...

The invention provides an actuator system comprising an actuator member having first and second positions. The system further comprises actuating means for moving the actuator member between the first and second positions and detection means for detecting the first respectively the second position and supplying time...

Compositions and methods for regulating an immune response in a subject are described. More particularly, described arc human antibodies that regulate the activity of NK cells and allow a poteniiation of NK cell cytotoxicity in mammalian subjects, and antibodies having antigen-binding properties similar to those of ...

A polymer substrate functionalized with a functionality comprising at least one cyclic, metal ion coordinating ligand group which comprises at least 3 nitrogen donor atoms in the ring of the cyclic group, at least one of the nitrogen atoms having an optionally substituted carboxy(lower alkyl) or optionally substitut...

A method for selectively acylating an amino group in a peptide or protein which has two or more reactive nucleophilic functional groups is described.

The present invention relates to a method for spray-drying of protein solutions and the spray-dried protein product. The invention also relates to pharmaceutical compositions containing such spray-dried protein, to methods of treating diabetes and hyperglycaemia using the spray-dried protein of the invention and to ...

The present invention relates to agents that are non-competitive antagonists of the CD94/NKG2A receptor such as certain anti-NKG2A antibodies, in particular humanized versions of murine anti-NKG2A antibody Z199, as well as methods of producing and using such agents and antibodies.

A needle assembly for a medical device comprising a needle cannula which is mounted in a hub connectable to a medical device, and which needle assembly comprises releasable lock-ing means which co-operates with the connection means of the hub such that the needle cap is locked to the hub when the releasable locking ...

The invention provides a pump assembly comprising an actuator lever, an actuator for moving the actuator lever, a supporting structure, a pump comprising a pump member moveable by actuation of the actuator lever, a first pivoting joint formed between the actuator lever and the supporting structure, and a second pivo...

Method for purifying a glucagon-like peptide by reversed phase high performance liquid chromatography

ABSTRACT The invention relates to a medicament delivery device (1  100) for delivering one or more solid dose pegs (10  110) through the skin. The device (1  100) has a number of exit openings (9  109) corresponding to the number of solid dose pegs (10  110) to be delivered. A detachable portion (3  103) of the dev...

An acylated insulin analogue wherein the insulin analogue comprises a lysine residue connected C-terminally to the A21 amino acid residue or a peptide residue of up to 4 amino acid residues comprising a lysine residue which peptide residue is connected C-terminally to the A21 amino acid residue, characterized in tha...

A needle assembly for an injection device comprising a needle cannula which is mounted in a hub connectable to an injection device, and which needle assembly comprises a back needle. Further the needle assembly is provided with means which, when activated, prevents a user from physically contacting the back needle. ...

A drug injector (1) comprising expelling means for expelling a dose of drug from a reservoir a release member (13) for releasing the drug expelling means and an actuation member (33) adapted to be moved by a user between an initial intermediate and actuated position in which the release member is moved to release th...

Dicycloalkyl urea glucokinase activators compounds are glucokinase inhibitors useful for the treatment of diabetes. (I)

The present invention relates to a medicament reservoir adapted to contain a medicament, the reservoir further being adapted to be received by an associated medical delivery device. The reservoir according to the present invention comprises an identification code comprising a plurality of electrode arrays arranged o...

The present invention relates to a process for re-coating of a silica gel material with a coating, especially re-coating of an already used or spent coated silica gel material, and the re-coated silica gel material obtainable by the process, and uses thereof.

ABSTRACT "ARYL CARBONYL DERIVATIVES AS GLUCOKINASE ACTIVATORS" The present invention relates to a compound of the general formula (lb) wherein the substations are as described in the description.

The invention relates to derivatives of GLP 1 like peptides which are C terminally extended analogues of native GLP 1. The derivatives comprise two side chains one at a position corresponding to position 42 and one at a position corresponding to position 18 23 27 31 36 or 38 wherein both positions are when compared ...

The present invention relates to multispecific procoagulant antibodies capable of binding to coagulation Factor IX (FIX) and/or the activated form thereof Factor IXa (FIXa), and Factor X (FX) and/or the activated form thereof Factor Xa (FXa) and promoting FX activation by FIXa, antibodies binding their epitopes or p...

The application discloses compounds useful in treatment of diabetes, weight loss and/or reduction of cardiovascular risks. The compounds are bi-functional and therefore suitable as a simple treatment for patients that may benefit from treatment with both a GLP-1 receptor agonist and a PCSK9 inhibitor. ...

Carbamates and related compounds of formula R1 R2NCO-Y or R1 R2NCS-Y wherein R1 and R2 are hydrogen, alkyl, aryl, heteroaryl or may together form a piperidine, piperazine, morpholine or other heterocyclic ring, are inhibitors of hormone sensitive lipase and are useful for the treatment of any disorder where it is de...

This invention relates to compounds that are activators of glucokinase and thus may be useful for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial.

The present invention provides a novel derivative of an analogue of human insulin useful for the treatment of diabetes.

The invention relates to solid pharmaceutical compositions comprising a GLP-1 agonist, an SGLT2 inhibitor and a salt of N-(8-(2-hydroxybenzoyl)amino)caprylic acid. The invention further relates to processes for the preparation of such compositions, and their use in medicine.

The invention relates to pharmaceutical compositions comprising a PCSK9 inhibitor, such as an EGF(A) peptide, and a salt of N-(8-(2-hydroxybenzoyl)amino)caprylic acid. The invention further relates to processes for the preparation of such compositions, and their use in medicine.

The present invention relates to safe and immuno-stealth implantable cells and their use to prevent, treat or cure a disease.

The present invention provides a process for removal of excess dye from newly manufactured printed or dyed fabric or yarn, comprising treatment with a rinse liquor comprising at least one enzyme selected from the group consisting of enzymes exhibiting peroxidase activity or laccase activity, an oxidation age...

ABSTRACTIN/PCT/200Q/00621/CHE "DISUBSTITUTED PIPERIDINE COMPOUNDS"The present invention relates to novel compounds, in particular 4, 4-disubstituted and 3, 3-disubstituted piperidine compounds, compositions containing them, and their use for treating medical disorders resuhing from a deficiency i...

ABSTRACTIN/PCT/2000/666/CHE'COMPOUND WITH GROWTH HORMONE RELEASING PROPERTIES"The present invention relates to a novel diastereomeric compound, pharmaceutically acceptable salts thereof, compositions containing them, and their use for treating medical disorders resulting from a deficiency i...

The present invention relates to an injection needle assembly comprising: a needle cannula with a lumen extending through said needle cannula from a skin piercing distal end to an opposite proximal end along a longitudinal axis of the needle cannula, which longitudinal lumen is cylindrical and has substantia...

The present invention relates to a glass cartridge 1 for a precision insulin delivery system, said cartridge 1 comprising a distal end 10 and a proximal end 11 connected by a cylindrical wall 2 forming a vessel containing liquid insulin, the distal end 10 being" provided with a flange 3 closed by a flexible ...

A cartridge having a distal end provided with a mechanical coding. The coding has the form of a circular protrusion where the circular outer diameter is dedicated a specific concentration of insulin contained in the cartridge. The distal end of the cartridge is fitted in to a circular contour in the housing....

This invention relates to a method of controlling data information between.two portable medical apparatuses. Said portable apparatuses comprising a first apparatus for performing the first operation and a second apparatus for performing the. second operation, where each apparatus has means for one or m...

This invention relates to a portable medical device for communication of medical data information comprising a medical device part comprising a first processor and first storage means, and means for executing one or more medical related functions, a communication device part comprising a second processor, se...

ABSTRACT1089/CHENP/2004"Process for preparing insulin compounds"The present invention relates to a process for preparing an insulin compoundwherein a) in a reaction mixture containing at least about 55 %, preferably at leastabout 60 %, more preferred at least 70 %, water (weight...

ABSTRACT1371/CHENP/2004"A COMPOUND OF FORMULA III AS ACTIVATORS OF GLUCOKINASE (GK)"The present invention relates to compounds of the general formula (III) which are activators of glucokinase (GK), and which may be useful for the management, treatment, control, or adjunct treatm...

A polymer substrate functionalized with a functionality comprising at least one cyclic, metal ion coordinating ligand group, the cyclic ligand group comprising at least 3 metal ion coordinating donor atoms independently selected from the group consisting of N, O and S. The macrocydic ligand is positioned as ...

This invention relates to a safety system for an electrically driven medical delivery device for delivering a dose of medication, wherein the safety system is configured for preventing delivery of an erroneous dose of the medicament and comprising detector means (16) for registering mechanical movement, the ...

Novel ligands for the HisB10 Zn2+ sites of the R-state insulin hexamer that are capable of prolonging the action of insulin preparations are disclosed.

The present invention discloses a cell-free, in vitro method ot forming acovalent conjugate of a precursor peptide having the formula:whereinAA is a terminal or internal amino acid residue of the peptide:X1-X2 is a saccharide covalently linked to the AA. whereinX' is a first gly...

A medical apparatus for use by a patient for medical self treatment of diabetes, the treatment including a first operation and at least a second operation, the apparatus comprising a first apparatus for performing the first operation and a second apparatus for performing the second operation, characterized i...

The present invention relates to a safety needle assembly comprising a cylidrical housing 1, 40 having a top surface 6 and a bottom surface 9,50 said housing 1,40 having means for mounting said housing 1,40 onto a medical injection device; a needle cannula 30 mounted in the bottom surface 9,50 said needle ca...

The present invention relates to a medication delivery device for delivering a set dose of medicament, the medication delivery device comprising pump means having first and second pump chambers. The first pump chamber is adapted to transfer medicament from a first collapsible reservoir to an outlet arrangement, said...

An electronically controlled reminder device is adapted to be set in a programming mode by a user  perform a user-actuated operation  and detect when a user-actuated operation is per-formed. When in programming mode the device is adapted to record and set reminders in accordance with a detected time pattern of opera...

The invention relates to a derivative of a FGF21 protein having a cysteine residue at a position corresponding to position 167 169 170 171 172 173 174 175 and in particular position 180 or position 181 of mature human FGF21 and derivatives thereof having a side chain attached to this cysteine. The FGF21 derivatives ...

PREPARATION COMPRISING INSULIN, NICOTINAMIDE AND AN AMINO ACID Insulin preparations comprising an insulin compound or a mixture of two or more insulin compounds, a nicotinic compound and an amino acid.

The present invention is in the field of pharmaceutical compositions for the treatment of medical conditions relating to diabetes. More specifically the invention provides pharmaceutical compositions comprising a long-acting acylated derivative of a human insulin analogue and to the medical use of such compositions ...

The present invention relates to plasmids encoding insulin antigens and cytokines for use in tolerizing immunization in particular for the prevention and/or delay of e.g. type 1 diabetes.

The present invention relates to improved procoagulant antibodies including bispecific antibodies capable of binding to coagulation Factor IX (FIX) or the activated form thereof Factor IXa (FIXa) and optionally Factor X (FX) and the activated form thereof Factor Xa (FXa) and promoting FX activation by FIXa antibodie...

The present invention relates to solid compositions comprising a GLP-1 agonist and a salt of N-(8-(2-hydroxybenzoyl)amino)caprylic acid and their use in medicine.

The present invention relates to method of enriching NKX6.1 and C-peptide co-expressing cell aggregates derived in vitro from stem cells said method comprising the steps of dissociating the endocrine cell aggregates into single cells, treating the single cells with cryopreservation medium and lowering temperature to...

“COMPOSITIONS OF GLP-1 PEPTIDES AND PREPARATION THEREOF” The invention relates to pharmaceutical compositions comprising a first type of granules and a second type of granules, wherein said first type of granules comprises a salt of N-(8-(2-hydroxybenzoyl)amino)caprylic acid and no GLP-1 peptide, and wherein said s...

The present invention relates to novel insulin analogues and derivatives thereof, such as acylated insulin analogues, and their pharmaceutical use, in particular in the treatment or prevention of medical conditions relating to diabetes, obesity and cardiovascular diseases

A continuous method of producing granules comprising a salt of N-(8-(2- hydroxybenzoyl)amino)caprylic acid or SNAC. The method comprises: (i) providing a powder comprising a salt of N-(8-(2-hydroxybenzoyl)amino)caprylic acid, (ii) dry granulating the powder by using a roller compactor, (iii) continuously during dry ...

The present invention relates to pharmaceutical compositions of the GLP-1 peptide semaglutide comprising a stabilizer such as histidine, their preparation, kits comprising such compositions as well as medical uses thereof.

The present invention relates to a process for producing a tablet comprising a GLP-1 peptide wherein the GLP-1 peptide is obtained by spray-drying of a feed solution comprising the GLP-1 peptide and a feed solution solvent, wherein the pH of the feed solution is higher that the pI of the GLP-1 peptide or wherein the...

The present invention is in the therapeutic field of drugs for medical conditions relating to diabetes. More specifically the invention relates to insulin analogues of human insulin. The invention provides pharmaceutical compositions comprising such insulin analogues and the uses if the such analogues for the treatm...

Disclosed herein are an aqueous pharmaceutical formulation comprising cagrilintide and an aqueous formulation comprising semaglutide. The compositions of these two pharmaceutical formulations allow for their presentation in, and administration using, the dual-chamber medical device disclosed herein. Individuals with...

The invention relates to pharmaceutical compositions comprising a PCSK9 inhibitor, such as an EGF(A) peptide, and a salt of N-(8-(2-hydroxybenzoyl)amino)caprylic acid. The invention further relates to processes for the preparation of such compositions, and their use in medicine.

The present invention relates to pharmaceutical compositions of the GLP-1 peptide semaglutide comprising no more than 0.1 %(w/w) phenol and above 6.4 mg/ml sodium chloride, their preparation, kits comprising such compositions as well as uses thereof.

Peptide co-agonists of the human GLP-1 and GIP receptors suitable for oral delivery, including long-acting derivatives, and their medical use in treatment and/or prevention of obesity, diabetes, and/or liver diseases are described.

The invention relates to an injection device wherein the drive element transferring rotation to the piston rod is divided into two elements which are able to move axially in relation to each other such that the drive mechanism can be released to allow the user to reset the piston rod and change the cartridge. ...

A capsule device (100) suitable for insertion into a lumen, such as a gastrointestinal lumen, of a subject. The capsule device (100) comprises: a capsule housing (110, 120), a drug chamber (B) configured to accommodate a drug substance, the drug chamber leading to a drug outlet (190), - an actuation chamber (A), - a...

A capsule device (10) suitable for swallowing into a lumen of an intestinal tract of a patient comprises a housing section (12), a delivery outlet (20) for jet injection by a delivery assembly (22), an expansion assembly (26) and an expansion control mechanism (30). The expansion section (28) is arranged laterally o...

The invention relates to diketopiperazine (DKP) based prodrugs. The invention also relates to the use of DKP-based prodrugs. The prodrugs comprise a pharmacological active compound, such as semaglutide, which is liberated from the prodrug upon conversion of the prodrug.

Peptide co-agonists of the human GLP-1 and GIP receptors, long-acting derivatives thereof and their medical use in treatment and/or prevention of obesity, diabetes, and/or liver diseases are described.

The present invention relates to novel compounds, compositions containing them, and their use for treating medical disorders resulting from a deficiency in growth hormone.

Novel substituted piperidine carbamates, pharmaceutical compositions comprising them and use thereof in the treatment and/or prevention of diseases and disorders related to hormone sensitive lipase. More particularly, the compounds are useful for the treatment and/or prevention of diseases and disorders in which mod...

The invention relates to a derivative of a GLP 1 analogue optionally C terminally extended which derivative comprises a first and a second protracting moiety in the form of a C20 or C22 diacid radical a bis amino branched linker and a first and a second further linker each comprising an OEG like linker element; wher...

The invention relates to derivatives of glucagon analogues comprising the substitutions Imp1 and His3 a substituent having three to ten negatively charged moieties covalently attached to a side chain of a lysine as well as intermediates and compositions thereof and their use in medicine.

The invention relates to MIC-1 compounds. More specifically it relates to compounds comprising a MIC-1 polypeptide with an N-terminal amino acid extension and a protractor wherein the amino acid extension comprises 3 to 36 amino acid residues and where the MIC-1 polypeptide and the N-terminal amino acid extension to...

The present invention relates to solid compositions for oral administration comprising (i) a GLP-1 derivative and the SGLT2 inhibitor dapagliflozin or (ii) a GLP-1 derivative and a salt of NAC in combination with an SGLT2 inhibitor.

The invention relates to pharmaceutical compositions comprising a GLP-1 agonist and a salt of N-(8-(2-hydroxybenzoyl)amino)caprylic acid. The invention further relates to processes for the preparation of such compositions, and their use in medicine.

The present invention relates to novel peptides that are derivatives of glucose- dependent insulinotropic polypeptide (GIP) analogues having improved physical stability in solution and a protracted profile of action. More particular the invention relates to such peptides that are agonists at the GIP receptor and to ...

The invention relates to pharmaceutical compositions comprising a peptide, such a GLP-1 peptide and a salt of N-(8-(2-hydroxybenzoyl)amino)caprylic acid. The invention further relates to processes for the preparation of such compositions, and their use in medicine.

The present invention relates to pharmaceutical compositions of the GLP-1 peptide semaglutide comprising no more than 0.01 %(w/w) phenol, their preparation, kits comprising such compositions as well as uses thereof.

The present invention relates to a process for spray drying of a feed solution comprising semaglutide, said process comprising introducing the feed solution comprising semaglutide in a solvent into a spray dryer and introducing an atomising gas and a drying gas, characterised in that the spray dryer comprises a gas ...

The invention relates to a bispecific antibody comprising a first antigen-binding site capable of binding Factor VII(a) and a second antigen-binding site capable of binding TLT-1, pharmaceutical formulations comprising such bispecific antibodies and uses thereof.

The present invention relates to novel insulin derivatives and their use in the treatment or prevention of medical conditions relating to diabetes. The insulin derivatives are glucose sensitive and display glucose-sensitive albumin binding. The invention also relates to novel intermediates. Finally, the invention pr...

The present document relates to tetrahydropyridazine compounds, pharmaceutical compositions comprising the same and their use in the treatment or prevention of diseases and disorders associated with the cannabinoid CB1 receptor. For example, the tetrahydropyridazine compounds, or a tautomeric form and/or salt thereo...

Disclosed herein is a liquid pharmaceutical formulation comprising an amylin receptor agonist, a GLP-1 receptor agonist and a cyclodextrin comprising hydroxypropyl substitutions. Said co-formulation may be used for the medical treatment of subjects with overweight or obesity, with or without associated co-morbiditie...

HUMAN CD30 LIGAND ANTIGEN BINDING PROTEINS Provided are compositions and methods relating to human CD30L antigen binding proteins. Compositions described herein include: human CD30L antigen binding proteins, polynucleotides encoding human CD30L antigen binding proteins, vectors comprising these polynucleotides, ...

The present invention relates to a method of making sodium N-(8-2-Hydroxybenzoyl)amino caprylate form A, SNAC polymorphic form A having improved stability and the use of said SNAC polymorphic form A in a solid pharmaceutical dosage form-

The invention relates to a tablet comprising a salt of N-(8-(2-hydroxybenzoyl)amino)caprylic acid. The invention further relates to processes for the preparation such a tablet, and its use in medicine.

Oligonucleotides are provided herein that inhibit NR1H3 expression. Also provided are compositions including the same and uses thereof, particularly uses relating to treating diseases, disorders and/or conditions associated with NR1H3 expression.

The present invention relates to a chemical process for the synthesis of the compound 8-[(2-hydroxybenzoyl)amino]octanoic acid or a derivative thereof useful in the process of making sodium 8-[(2-hydroxybenzoyl)amino]octanoate (SNAC), a delivery agent used in solid pharmaceutical compositions. The invention provides...

Antibodies that are capable of specifically binding and preventing the activation of TREM-1, a protein expressed on monocytes, macrophages and neutrophils with both good affinity and low viscosity at clinically relevant concentrations are described. Such antibodies find utility in the treatment of individuals with...

Oligonucleotides are provided herein that inhibit MARC1 expression. Also provided are compositions including the same and uses thereof, particularly uses relating to treating diseases, disorders and/or conditions associated with MARC1 expression.

The invention relates to a compound comprising a GLP-1 receptor agonist and an amylin receptor agonist. The invention also relates to a pharmaceutical formulation, suitable for but not limited to oral administration, which comprises such a compound. The compound and pharmaceutical formulation comprising it may be us...

The present invention relates to novel monovalent anti-ANGPTL3 antibodies for use in medicine and in particular for lowering of plasma triglycerides levels in patients in need thereof, such as patients suffering from or at risk of hypertriglyceridemia and/or cardiovascular disease, such as atherosclerotic cardiovasc...

The present document relates to pyrazolopyrimidine compounds, pharmaceutical compositions comprising the same and their use in the treatment or prevention of diseases and disorders associated with the cannabinoid CB1 receptor. For example, the pyrazolopyrimidine compounds, or a tautomeric form and/or salt thereof, a...

Oligonucleotides are provided herein that inhibit TMPRSS6 expression. Also provided are compositions including the same and uses thereof, particularly uses relating to treating diseases, disorders and/or conditions associated with hepcidin deficiency or suppression. 5

The present invention provides ISVD polypeptide derivatives capable of binding coagulation Factor IX(a) and Factor X(a) which are highly potent and provide a sufficiently long half-life such to allow for effective subcutaneous- as well as peroral administration. The ISVD polypeptides derivatives disclosed herein are...

160031WO03 56 ABSTRACT The invention relates to MIC-1 compounds. More specifically it relates to compounds comprising a MIC-1 polypeptide and an N-terminal amino acid extension wherein said extension consists of 3 to 36 amino acid residues and where the compound has a calculated pI lower than 6.5. The compounds of t...

The subject matter disclosed herein is directed to modulating STAT3 gene expression using siRNA compositions and methods directed to affecting key cell populations supporting the growth and metastasis of cancer to affect the beneficial treatment, remission or removal of the underlying tumor in a patient. ...

This application relates to new C-type natriuretic peptide (CNP) compounds, pharmaceutical compositions comprising these compounds, and these compounds for use as medicaments.

The invention relates to a compound comprising an amylin receptor agonist. The invention also relates to a pharmaceutical composition, suitable for but not limited to oral administration, which comprises such a compound. The compound and pharmaceutical composition comprising it may be used for the medical treatment ...

The present invention relates to novel insulin derivatives and their use in the treatment or prevention of medical conditions relating to diabetes. The insulin derivatives are glucose sensitive and display glucose-sensitive albumin binding. The insulin derivatives have a long half-life. The invention also relates to...