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Double Acylated Glp 1 Derivatives
Abstract: 27T27T2x642y2222k2nThe invention relates to a derivative of a GLP 1 analogue which analogue comprises a first K residue at a position corresponding to position 27 of GLP 1(7 37) (SEQ ID NO: 1 ); a second K residue at a position corresponding to position T of GLP 1(7 37) where T is an integer in the range of 7 37 except 18 and 27; and a maximum of ten amino acid changes as compared to GLP 1(7 37); wherein the first K residue is designated K and the second K residue is designated K; which derivative comprises two albumin binding moieties attached to K and K respectively via a linker wherein the albumin binding moiety comprises a protracting moiety selected from HOOC (CH) CO and HOOC CH 0 (CH) CO ; in which x is an integer in the range of 6 16 and y is an integer in the range of 3 17; wherein the linker comprises an element of the formula NH (CH) (O (CH)) O (CH) CO wherein k is an integer in the range of 1 5 and n is an integer in the range of 1 5; or a pharmaceutically acceptable salt amide or ester thereof. The invention also relates to the pharmaceutical use thereof for example in the treatment and/or prevention of all forms of diabetes and related diseases as well as to corresponding novel GLP 1 analogues. The derivatives are suitable for oral administration.
Notices, Deadlines & Correspondence
Patent Information
Applicants
NOVO NORDISK A/S
Inventors
1. WIECZOREK Birgit
2. SPETZLER Jane
3. KRUSE Thomas
4. LINDEROTH Lars
5. KOFOED Jacob
Specification
Documents
Orders
| Section | Controller | Decision Date |
|---|---|---|
Application Documents
| # | Name | Date |
|---|---|---|
| 1 | Squence Listing 8326IN01.pdf | 2013-10-18 |
| 2 | POA 8326IN01.pdf | 2013-10-18 |
| 3 | PCT-IB-304 8326IN01.pdf | 2013-10-18 |
| 4 | Form-5 8326IN01.pdf | 2013-10-18 |
| 5 | Form-3 8326IN01.pdf | 2013-10-18 |
| 6 | Form-2 8326IN01.pdf | 2013-10-18 |
| 7 | 8404-CHENP-2013.pdf | 2013-10-18 |
| 8 | Form-18(Online).pdf | 2014-01-03 |
| 9 | 8404-CHENP-2013 FORM-3 15-04-2014.pdf | 2014-04-15 |
| 10 | 8404-CHENP-2013 FORM-1 15-04-2014.pdf | 2014-04-15 |
| 11 | 8404-CHENP-2013 CORRESPONDENCE OTHERS 15-04-2014.pdf | 2014-04-15 |
| 12 | 8404-CHENP-2013-Form 3-141015.pdf | 2016-03-15 |
| 13 | 8404-CHENP-2013-Correspondence-141015.pdf | 2016-03-15 |
| 14 | 8404-CHENP-2013-Power of Attorney-310316.pdf | 2016-06-10 |
| 15 | 8404-CHENP-2013-Form 3-310316.pdf | 2016-06-10 |
| 16 | 8404-CHENP-2013-Correspondence-Form 3-PA-310316.pdf | 2016-06-10 |
| 17 | Form 3 [10-11-2016(online)].pdf | 2016-11-10 |
| 18 | Form 26 [30-01-2017(online)].pdf | 2017-01-30 |
| 19 | Form 3 [12-04-2017(online)].pdf | 2017-04-12 |
| 20 | 8404-CHENP-2013-FORM 3 [13-10-2017(online)].pdf | 2017-10-13 |
| 21 | 8404-CHENP-2013-FORM 3 [11-04-2018(online)].pdf | 2018-04-11 |
| 22 | 8404-CHENP-2013-FER.pdf | 2018-04-26 |
| 23 | 8404-CHENP-2013-Information under section 8(2) (MANDATORY) [09-10-2018(online)].pdf | 2018-10-09 |
| 24 | 8404-CHENP-2013-FORM 3 [09-10-2018(online)].pdf | 2018-10-09 |
| 25 | 8404-CHENP-2013-FORM 4(ii) [22-10-2018(online)].pdf | 2018-10-22 |
| 26 | 8404-CHENP-2013-OTHERS [24-01-2019(online)].pdf | 2019-01-24 |
| 27 | 8404-CHENP-2013-FER_SER_REPLY [24-01-2019(online)].pdf | 2019-01-24 |
| 28 | 8404-CHENP-2013-CLAIMS [24-01-2019(online)].pdf | 2019-01-24 |
| 29 | 8404-CHENP-2013-Information under section 8(2) (MANDATORY) [03-04-2019(online)].pdf | 2019-04-03 |
| 30 | 8404-CHENP-2013-FORM 3 [03-04-2019(online)].pdf | 2019-04-03 |
| 31 | 8404-CHENP-2013-HearingNoticeLetter.pdf | 2019-05-02 |
| 32 | 8404-CHENP-2013-Correspondence to notify the Controller (Mandatory) [22-05-2019(online)].pdf | 2019-05-22 |
| 33 | 8404-CHENP-2013-Information under section 8(2) (MANDATORY) [06-06-2019(online)].pdf | 2019-06-06 |
| 34 | 8404-CHENP-2013-FORM 3 [06-06-2019(online)].pdf | 2019-06-06 |
| 35 | 8404-CHENP-2013-Written submissions and relevant documents (MANDATORY) [14-06-2019(online)].pdf | 2019-06-14 |
| 36 | 8404-CHENP-2013-Annexure (Optional) [14-06-2019(online)].pdf | 2019-06-14 |
| 37 | Marked up Claims_Granted 316243_17-07-2019.pdf | 2019-07-17 |
| 38 | Description_Granted 316243_17-07-2019.pdf | 2019-07-17 |
| 39 | Claims_Granted 316243_17-07-2019.pdf | 2019-07-17 |
| 40 | Abstract_Granted 316243_17-07-2019.pdf | 2019-07-17 |
| 41 | 8404-CHENP-2013-PatentCertificate17-07-2019.pdf | 2019-07-17 |
| 42 | 8404-CHENP-2013-IntimationOfGrant17-07-2019.pdf | 2019-07-17 |
| 43 | 8404-CHENP-2013-FORM-26 [20-01-2020(online)].pdf | 2020-01-20 |
| 44 | 8404-CHENP-2013-RELEVANT DOCUMENTS [18-03-2020(online)].pdf | 2020-03-18 |
Search Strategy
| 1 | search_19-04-2018.pdf |