Derivatives Of Glp 1 Like Peptides And Uses Thereof

Abstract: The invention relates to derivatives of GLP 1 like peptides which are C terminally extended analogues of native GLP 1. The derivatives comprise two side chains one at a position corresponding to position 42 and one at a position corresponding to position 18 23 27 31 36 or 38 wherein both positions are when compared to GLP 1(7 37). The side chains comprise a C19 C20 or C22 diacid protracting moiety and optionally a linker. The invention also relates to intermediate products in the form of novel GLP 1 analogues incorporated in the derivatives of the invention as well as pharmaceutical compositions and medical uses of the derivatives. The derivatives have very long half lives while maintaining a satisfactory potency which makes them potentially suitable for once monthly administration.

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