Glp 1 Derivatives And Uses Thereof

Abstract: The invention relates to a derivative of a GLP 1 analogue optionally C terminally extended which derivative comprises a first and a second protracting moiety in the form of a C20 or C22 diacid radical a bis amino branched linker and a first and a second further linker each comprising an OEG like linker element; wherein these elements are interconnected via amide bonds and attached to a Lys residue of the GLP 1 analogue. The invention also relates to intermediate products in the form of novel GLP 1 analogues incorporated in the derivatives of the invention as well as pharmaceutical compositions and medical uses of the derivatives. The derivatives have very long half lives while maintaining a satisfactory potency which makes them potentially suitable for once monthly administration.

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