DESCRIPTION:

The present process involves the conversion of iodoindole to the N-sustituted derivatives with protecting groups such as acetyl, benzoyl or benzyl. Further the N-protected derivative was reacted with (R)-benzyl 2-(chlorocarbonyl)pyrrolidine-l-carboxylate in presence of ethylmagensium bromide to render the N-substituted benzyl (2R)-2-[(5-iodo- lH-indol-3-yl)carbonyl]pyrrolidine-l-carboxylate derivative. It was subjected to reduction with Vitride to afford 5-iodo-3-(((R)-l-methylpyrrolidin-2-yl)methyl)-1H- indole derivative followed by heck coupling with phenyl vinyl sulphone in presence of palladium catalyst to render a product of formula III.

CLAIMS;

We claim
1. heck coupling of indole derivative of formula I

with with phenyl vinyl sulphone formula II

to render the corresponding product of formula III

Where R1 is H or [(2R)-l-Methyl-2-pyrrolidinyl]methyl and R2 is benzyl, acetyl or benzoyl.

2. The process of claim 1, wherein the heck coupling is catalyzed by palladium catalyst.

3. The process of claim 1, wherein the heck coupling is carried out in the absence of any phosphene based ligand.

4. The process of claim 2, wherein the palladium catalyst is recycled.