Compositions And Methods For Treating Coronavirus Infection At

Compositions And Methods For Treating Coronavirus Infection At Different Level Of Disease Severity

Abstract: The present invention is in the technical field of a pharmaceutical composition comprising recombinant polypeptides; wherein the first recombinant polypeptide comprises a genetically modified ACE2 protein to increase binding to SARS-CoV and SARS-Cov2 viruses spike protein and neutralizing activity; and the second recombinant polypeptide comprises a Fc portion common to IgG and IgA; wherein the said composition is characterized in that the recombinant polypeptide are such that they exhibit a synergistic neutralizing activity, improved systemic and the mucosal circulation. Furthermore, invention deals with method of detecting a severe acute lung injury or failure in a subject comprising providing a pharmaceutical composition comprising ACE2 recombinant polypeptide to a subject with a severe acute lung injury or failure. In addition, invention deals with parenteral formulation for critical care and nasal formulation targeted for prophylactic and maintenance therapy.

Patent Information

Application #

Filing Date

24 February 2023

Publication Number

26/2023

Publication Type

INA

Invention Field

CHEMICAL

Status

Email

Parent Application

Applicants

MAZUMDAR SHAW MEDICAL FOUNDATION

A-Block, 8th Floor, Mazumdar Shaw Medical Centre, #258/A, Narayana Health City Bommasandra, Bangalore, Karnataka 560099

Inventors

1. DAS, Manjula

Mazumdar Shaw Medical Foundation, A-Block, 8th Floor, Mazumdar Shaw Medical Centre, #258/A, Narayana Health City Bommasandra, Bangalore, Karnataka 560099

2. KUMARAN, Smitha Pazhoor

Mazumdar Shaw Medical Foundation, A-Block, 8th Floor, Mazumdar Shaw Medical Centre, #258/A, Narayana Health City Bommasandra, Bangalore, Karnataka 560099

3. DHAR, Sujan K

Mazumdar Shaw Medical Foundation, A-Block, 8th Floor, Mazumdar Shaw Medical Centre, #258/A, Narayana Health City Bommasandra, Bangalore, Karnataka 560099

Specification

Documents

Application Documents

#	Name	Date
1	202347012687.pdf	2023-02-24
2	202347012687-Sequence Listing in PDF [24-02-2023(online)].pdf	2023-02-24
3	202347012687-RELEVANT DOCUMENTS [24-02-2023(online)].pdf	2023-02-24
4	202347012687-POWER OF AUTHORITY [24-02-2023(online)].pdf	2023-02-24
5	202347012687-POA [24-02-2023(online)].pdf	2023-02-24
6	202347012687-MARKED COPIES OF AMENDEMENTS [24-02-2023(online)].pdf	2023-02-24
7	202347012687-FORM 13 [24-02-2023(online)].pdf	2023-02-24
8	202347012687-FORM 1 [24-02-2023(online)].pdf	2023-02-24
9	202347012687-DRAWINGS [24-02-2023(online)].pdf	2023-02-24
10	202347012687-COMPLETE SPECIFICATION [24-02-2023(online)].pdf	2023-02-24
11	202347012687-AMMENDED DOCUMENTS [24-02-2023(online)].pdf	2023-02-24
12	202347012687-FORM 18 [12-04-2024(online)].pdf	2024-04-12
13	202347012687-FORM-5 [20-03-2025(online)].pdf	2025-03-20
14	202347012687-ENDORSEMENT BY INVENTORS [20-03-2025(online)].pdf	2025-03-20
15	202347012687-MARKED COPY [22-03-2025(online)].pdf	2025-03-22
16	202347012687-CORRECTED PAGES [22-03-2025(online)].pdf	2025-03-22