Malaria Transmission Blocking Vaccines

Abstract: Malaria transmission-blocking vaccines with good preservation stability and immunostimulatory action are provided. According the present invention, combination use of a pharmaceutical composition comprising (4E,8E,12E,16E,20E)-N-{2-[{4-[(2-amino-4-{[(3S)-1-hydroxyhexan-3-yl]amino}-6-methylpyrimidin-5-yl)methyl]benzyl}(methyl)amino]ethyl}-4,8,12,17,21,25-hexamethylhexacosa-4,8,12,16,20,24-hexaeneamide, or a pharmaceutically acceptable salt thereof, as a vaccine adjuvant with enhanced specific immune response against antigens and good preservation stability and a malaria vaccine with non-glycosylation, homogeneity, and biological activity allow for the provision of malaria transmission-blocking vaccines with good preservation stability and immunostimulatory action.

Patent Information

Application #

Filing Date

25 October 2022

Publication Number

44/2022

Publication Type

INA

Invention Field

BIOTECHNOLOGY

Status

Email

patent@depenning.com

Parent Application

Inventors

1. KING, C. Richter

1840 Park Road NW, Washington, District of Columbia 20010

2. WU, Yimin

18133 Coachmans Road, Germantown, Maryland 20874

3. PLIESKATT, Jordan Lee

624 N Columbus Street Alexandria, Virginia 22314

4. LEE, Shwu-Maan

17054 Catalpa Court Rockville, Maryland 20855

5. WU, Chia-Kuei

6 Elmwood Ct. Rockville, Maryland 20850

6. TSUBOI, Takafumi

c/o PROTEO-SCIENCE CENTER, NATIONAL UNIVERSITY CORPORATION EHIME UNIVERSITY, 3, Bunkyo-cho, Matsuyama-shi, Ehime 7908577

7. FUKUSHIMA, Akihisa

c/o Sumitomo Pharma Co., Ltd., 1-98, Kasugadenaka 3-chome, Konohana-ku, Osaka-shi, Osaka 5540022

Specification

Documents

Application Documents

#	Name	Date
1	202247060722.pdf	2022-10-25
2	202247060722-STATEMENT OF UNDERTAKING (FORM 3) [25-10-2022(online)].pdf	2022-10-25
3	202247060722-Sequence Listing in txt [25-10-2022(online)].txt	2022-10-25
4	202247060722-Sequence Listing in PDF [25-10-2022(online)].pdf	2022-10-25
5	202247060722-PRIORITY DOCUMENTS [25-10-2022(online)].pdf	2022-10-25
6	202247060722-FORM 1 [25-10-2022(online)].pdf	2022-10-25
7	202247060722-DRAWINGS [25-10-2022(online)].pdf	2022-10-25
8	202247060722-DECLARATION OF INVENTORSHIP (FORM 5) [25-10-2022(online)].pdf	2022-10-25
9	202247060722-COMPLETE SPECIFICATION [25-10-2022(online)].pdf	2022-10-25
10	202247060722-FORM-26 [15-11-2022(online)].pdf	2022-11-15
11	202247060722-Proof of Right [17-01-2023(online)].pdf	2023-01-17
12	202247060722-FORM-26 [17-01-2023(online)].pdf	2023-01-17
13	202247060722-Correspondence_Proof of Right (Form 1), POA_30-01-2023.pdf	2023-01-30
14	202247060722-Correspondence And POA_06-02-2023.pdf	2023-02-06
15	202247060722-Proof of Right [16-02-2023(online)].pdf	2023-02-16
16	202247060722-Correspondence_Assignment_27-02-2023.pdf	2023-02-27
17	202247060722-FORM 3 [10-04-2023(online)].pdf	2023-04-10
18	202247060722-FORM 3 [03-01-2024(online)].pdf	2024-01-03
19	202247060722-FORM 18 [21-03-2024(online)].pdf	2024-03-21