A contraceptive or non-contraceptive diaphragm having a rim (108) surrounding a thin membrane (110), the membrane having a cervical dome extending downwardly from a posterior portion of the membrane. The rim has a spring member (109) having non-uniform bending characteristics. The shape of the spring member can be con...

A packaged soft cling female condom (1, l', I"), comprising: a pouch (10, lo', 10") of resilient membranous material having an open end, a closed end, an outer surface and an inner surface; and at least one hydrophilic cling element (15, 15', 15") attached to said outer surface of said pouch (10, lo', lo"), said at le...

Malaria transmission-blocking vaccines with good preservation stability and immunostimulatory action are provided. According the present invention, combination use of a pharmaceutical composition comprising (4E,8E,12E,16E,20E)-N-{2-[{4-[(2-amino-4-{[(3S)-1-hydroxyhexan-3-yl]amino}-6-methylpyrimidin-5-yl)methyl]benzy...

Pre-erythrocytic malaria vaccines with good preservation stability and immunostimulatory action are provided. According the present invention, combination use of a pharmaceutical composition comprising (4E,8E,12E,16E,20E)-N-{2-[{4-[(2-amino-4-{[(3S)-1-hydroxyhexan-3-yl]amino}-6-methylpyrimidin-5-yl)methyl]benzyl}(me...