Method For Secretory Production Of Protein

Abstract: A method for the efficient secretory production of a heterologous protein by a coryneform bacterium utilizing the TorA signal peptide is provided through the development of a novel technique for reducing missed cleavages of the TorA signal peptide. The secretory production of a heterologous protein is carried out by culturing a coryneform bacterium that has been modified to exhibit the ability to produce and secrete the heterologous protein utilizing the TorA signal peptide and to exhibit an increased LepB protein activity.

Patent Information

Application #

Filing Date

18 May 2021

Publication Number

24/2021

Publication Type

INA

Invention Field

BIOTECHNOLOGY

Status

Email

patent@depenning.com

Parent Application

Applicants

AJINOMOTO CO., INC.

15-1, Kyobashi 1-chome, Chuo-ku, Tokyo 1048315

Inventors

1. MATSUDA, Yoshihiko

c/o AJINOMOTO CO., INC., 1-1, Suzuki-cho, Kawasaki-ku, Kawasaki-shi, Kanagawa 2108681

Specification

Documents

Application Documents

#	Name	Date
1	202147022227-STATEMENT OF UNDERTAKING (FORM 3) [18-05-2021(online)].pdf	2021-05-18
2	202147022227-SEQUENCE LISTING(PDF) [18-05-2021(online)].pdf	2021-05-18
3	202147022227-SEQUENCE LISTING [18-05-2021(online)].txt	2021-05-18
4	202147022227-PROOF OF RIGHT [18-05-2021(online)].pdf	2021-05-18
5	202147022227-PRIORITY DOCUMENTS [18-05-2021(online)].pdf	2021-05-18
6	202147022227-POWER OF AUTHORITY [18-05-2021(online)].pdf	2021-05-18
7	202147022227-FORM 1 [18-05-2021(online)].pdf	2021-05-18
8	202147022227-DRAWINGS [18-05-2021(online)].pdf	2021-05-18
9	202147022227-DECLARATION OF INVENTORSHIP (FORM 5) [18-05-2021(online)].pdf	2021-05-18
10	202147022227-COMPLETE SPECIFICATION [18-05-2021(online)].pdf	2021-05-18
11	202147022227.pdf	2021-10-18
12	202147022227-FORM 3 [22-10-2021(online)].pdf	2021-10-22
13	202147022227-Correspondence_Form-1_15-03-2022.pdf	2022-03-15
14	202147022227-FORM 18 [15-09-2022(online)].pdf	2022-09-15