The purpose of the present invention is to provide a novel hydrolase which can be used for efficiently producing a (1S 2S) 1 alkoxycarbonyl 2 vinylcyclopropanecarboxylic acid which is a compound useful as an intermediate for the synthesis of a therapeutic agent for hepatitis C through the hydrolysis of a dialkyl 2 v...

The present invention addresses the issue of providing a method whereby hydroxy -L- lysine can be efficiently produced. The present invention provides a production method for hydroxy- L- lysine, characterized by: causing a 2- oxoglutarate dependent L- lysine hydroxylase , cells including same, a preparation of said ...

The present invention addresses the problem of providing: a method for purifying high- purity cis- 5- hydroxy -2- piperidinecarboxylic acid; and a method for producing a derivative of the compound. Provided are: a method for producing a cis- 5- hydroxy- 2- piperidinecarboxylic acid derivative , characterized by invo...

[Problem] To provide an aqueous antibacterial dispersion comprising a metal pyrithione salt and a cationic polymer the antibacterial dispersion being capable of maintaining a stable dispersed state. [Solution] An antibacterial dispersion characterized by comprising at least one cationic polymer at least one metal py...

Provided is a novel developer capable of achieving a heat sensitive recording material having extremely high color development sensitivity providing good image density even when printing at a low applied energy (in other words high build up sensitivity) and having excellent heat resistance and plasticizer resistance...

33 A method for producing (2S 5S)/(2R 5R) 5 hydroxypiperidine 2 carboxylic acid indicated by formula (10) the method being characterized in including a step for removing protection from hydroxyl groups in a compound represented by formula (7) and synthesizing a compound represented by formula (8). (In the formula ...

The purpose of the present invention is to provide a novel process whereby rosuvastatin calcium and an intermediate thereof which each have a high purity can be efficiently produced at low cost. This process efficiently produces high purity rosuvastatin calcium and an intermediate thereof on an industrial scale with...

It is an object of the present invention to provide a novel method for producing (lR,2S)/(lS,2R)-l-amino-l-alkoxycarbonyl-2-vinylcyclopropane which is useful as a synthetic intermediate of therapeutic agents for hepatitis C and a synthetic intermediate thereof. According to the present invention, when a trans-2-bute...

The present invention provides a practically suitable industrial method for producing an optically active a substituted proline from a chain ketone compound by a short process under mild conditions. The present invention relates to a method for producing an optically active a substituted proline (4) and/or an optica...

ABSTRACT An object of the present invention is to provide a industrially appropriate method for producing the P-anomers of ribofuranose derivatives in a highly selective manner at a high yield. The present invention provides a method for producuigderivatives wherein (3-anomers is precipitated from among the generat...

Provided is a novel production method for an angiotensin II receptor antagonist which is related to a deprotection method for a tetrazole compound performed under conditions that are economical and suitable for industrial production said tetrazole compound being useful as an intermediate for the angiotensin II recep...

It is an object of the present invention to provide a process for producing l,2,3-tri-O-acetyl-5-deoxy-ribofuranose in an industrially appropriate manner. The present invention provides a process for producing a l,2,3-tri-O-acetyl-5-deoxy-ribofuranose which comprises hydrogenating a compound represented by the formu...

A method for producing (2S,5S)/(2R,5R)-5-hydroxypiperidine-2-carboxylic acid indicated by formula (10), the method being characterized in including a step for removing protection from hydroxyl groups in a compound represented by formula (7) and synthesizing a compound represented by formula (8). (In the formula, P i...

A method for producing (2S,5S)/(2R,5R)-5-hydroxypiperidine-2-carboxylic acid indicated by formula (10), the method being characterized in including a step for removing protection from hydroxyl groups in a compound represented by formula (7) and synthesizing a compound represented by formula (8). (In the formula, P i...

A method for manufacturing cis 5 hydroxy L pipecolic acid characterized in that cis 5 hydroxy L pipecolic acid is produced by causing 2 oxoglutarate dependent L pipecolic acid hydroxylase to act on L pipecolic acid the 2 oxoglutarate dependent L pipecolic acid hydroxylase including a polypeptide indicated by (A) (B)...

The present invention provides an industrially excellent production method by which N-benzyl-2-bromo-3-methoxypropionamide can be safely produced in high yield at lower cost. The production method of the present application comprises, in the following order, an amidation step in which diacrylic anhydride is reacted ...

An object of the present invention is to provide a novel method capable of producing rosuvastatin calcium and intermediates therefor efficiently, inexpensively and with high purity. The present invention provides a method of efficiently producing rosuvastatin calcium and intermediates therefor having a high pur...

The present invention provides: high purity 2-naphthylacetonitrile which contains few impurities and is useful as a raw material or intermediate for synthesizing a variety of medicinal products, agrochemicals and chemical products; and a method for producing same. The high purity 2-naphthylacetonitrile has a HPLC pu...

The present invention provides a carbonyl reductase that has an activity of reducing a carbonyl group-containing compound and thus converting the compound into an optically active compound, and a method for producing an optically active compound with the use of this enzyme. More specifically, provided are a carbonyl...

The present invention provides a method for manufacturing a high-purity aromatic nitrile compound and aromatic carboxylic acid compound safely, inexpensively, and with high efficiency. A compound (2) is subjected to the Willgerodt reaction in the presence of an additive as needed, and the resultant amide compound (3...

A method for producing (2S,5S)/(2R,5R)-5-hydroxypiperidine-2-carboxylic acid indicated by formula (10), the method being characterized in including a step for removing protection from hydroxyl groups in a compound represented by formula (7) and synthesizing a compound represented by formula (8). (In the formula, P i...

The present invention addresses the problem of providing a method for more easily and highly efficiently industrially producing high-purity L-cyclic amino acids from cyclic amino acids that have a double bond at the 1 position. According to the present invention, an L-cyclic amino acid is produced by making a specif...

According to the present method, salicylic acid is produced with high productivity by causing a 2-halogenated benzoic acid to react at 155-300°C in an aqueous solvent in the presence of a copper source and a ligand. Preferably, a refinement step A for putting the obtained salicylic acid in contact with a styrene-bas...

A method for producing a salicylic acid ester represented by general formula (2), characterized in that salicylic acid and an alcohol represented by general formula (1) are brought into contact with a solid acid catalyst at a reaction temperature of 50-200°C. Formula (1): X-R-OH (In formula (1), R represents a C1-6 ...

According to the present invention, 2-(halogenated methyl)naphthalene and 2-naphthyl acetonitrile are safely produced with high selectivity and high yield at low cost. According to the present invention, 2-(halogenated methyl)naphthalene is produced by causing 2-methylnaphthalene to react with a halogenation agent i...