A transmission electron microscope has a target body position on the electron optical axis of the microscope, and an electrically conductive body off the axis of the microscope. The microscope also has an electron source for producing an axial electron beam. In use, the beam impinges upon a target body located ...

The present invention provides an imaging probe which comprises a lipophilic cation, a hydrophobic moiety and a 0 PET nucleus. The present invention also provides a precursor molecule for the production of such an imaging probe and methods * for using the probe for analysing mitochondria1 membrane potential in a su...

The present invention relates to a nucleotide sequence for use in a prophylactic and/or therapeutic pharmaceutical composition having a sequence which is a modification of an isolated nucleotide sequence having : (i)   at least 95% nucleotide identity to the nucleotide sequence of SEQ ID No:1;or (ii)   a RNA seque...

Phosphate binding materials and compositions comprising them which are solid ligand-modif ied poly oxo-hydroxy metal ion materials are disclosed that are based on ferric iron oxo- hydroxides modified with carboxylic acid ligands, or ionised forms thereof. These materials are made and tested in the examples pro...

The invention relates to compounds having Formula (1): A L B or pharmaceutically acceptable salts thereof wherein: A is a dicarbonyl sequestering moiety comprising a substituted aryl group or a substituted heteroaryl group; L is an optional linker moiety; and B is a mitochondrial targeting moiety. The invention als...

The invention relates to a succinate dehydrogenase inhibitor or a prodrug and/or a pharmaceutically acceptable salt thereof for use in the treatment or prevention of reperfusion injury such as ischemia reperfusion injury by inhibiting the accumulation of succinate wherein the inhibitor or prodrug and/or pharmaceutic...

The present invention discloses cell penetrating peptides (CPP or membrane translocating peptide) and their conjugates with cargo molecules. The peptides are useful as drug delivery systems particularly as delivery vehicles for nucleotide based theraputics such as polynucleotides oligonucleotides and peptide nucleic...

A compound comprising a ligand which binds, directly or indirectly, specifically to an antigen of a pathogen, provided that said ligand is not the PRYSPRY domain of TRIM21; and a RING domain and/or an inducer of TRIM21 expression.

The invention provides an antibody or antigen binding fragment thereof capable of binding to the antigen binding pocket of the AP33 antibody, wherein said antibody or antigen binding fragment thereof comprises VL CDR1 (L1), VL CDR2 (L2), and VL CDR3 (L3) consisting of the amino acid sequences of SEQ ID NO:1, SEQ ID ...

The present invention concerns nanoparticle formulations suitable for the delivery of one or more therapeutic agents the formulations comprising: a cationic cholesterol derivative; a neutral phospholipid; cholesterol or a neutral cholesterol derivative; and a saturated fatty acid PEGylated neutral derivative of phos...

In one aspect provided herein is a method for detecting tuberculosis in a subject comprising (a) determining a level of one or more host immune system biomarkers in a sputum sample obtained from the subject; and (b) comparing the levels of the biomarkers in the sputum sample to one or more reference values; wherein ...

The invention relates to a complexing system comprising two polypeptide helices derived from a SNAP protein; one polypeptide helix derived from syntax in; one polypeptide helix derived from synaptobrevin or a homolog thereof; and one or more cargo moieties attached to the polypeptide helices, wherein the four polype...

The invention relates to a method for altering the conformational diversity of a first repertoire of polypeptide ligands  comprising a plurality of polypeptides comprising at least two reactive groups separated by a loop Sequence covalently linked to a molecular scaffold which forms covalent bonds with said reactive...

The invention relates to a method for incorporating an unnatural amino acid into a protein of interest in a eukaryotic cell said method comprising the steps of: i) providing a eukaryotic cell expressing an orthogonal tRNA synthetase  t RNA pair a nucleic acid sequence of interest encoding said protein of interest an...

The present invention relates to IL-25 antibody VH domains and target binding members (e.g., antibodies) that comprise such antibody VH domains and bind IL-25. The invention also relates to compositions comprising target binding members {e.g., antibodies) that bind IL-25, methods of producing such target binding mem...

The present invention relates to a compound of formula (I) or a tautomer and/or a pharmaceutically acceptable salt thereof wherein:R is alkyl Cl F or Br; R is H or F; R is selected from H and alkyl; R is selected from H and C(O)R; R is H; or R and R are linked to form a heterocyclic group which is optionally substit...

THE INVENTION RELATES TO A SWALLOWABLE CELL SAMPLING DEVICE COMPRISING AN ABRASIVE MATERIAL CAPABLE OF COLLECTING CELLS FROM THE SURFACE OF THE OESOPHAGUS, AND A MEANS FOR RETRIEVAL WHEREIN THE MEANS FOR RETRIEVAL COMPRISES A CORD, CHARACTERISED IN THAT THE CORD IS ATTACHED TO THE ABRASIVE MATERIAL BY MEANS OF A HIT...

THE INVENTION RELATES TO 16S RRNA COMPRISING A MUTATION AT A1196, AND TO 16S RRNA FURTHER COMPRISING A MUTATION AT C1195 AND/OR A1197, AND TO 16S RRNA WHICH COMPRISES (I) C1195A AND A1196G; OR (II) C1195T, A1196G AND A1197G; OR (III) A1196G AND A1197G. THE INVENTION ALSO RELATES TO RIBOSOMES COMPRISING SUCH 16S RRNA...

The invention relates to a method for modifying one or more peptide ligands, comprising polypeptides covalently linked to a molecular scaffold at two or more amino acid residues, comprising the steps of providing one or more peptide ligands, wherein the polypeptide comprises two or more amino acids subtended between...

The present invention concerns a method and a system of preparing a flexographic printing form. It also concerns a preparation table (1) used in the method and system. Printing plates (5) are placed in a plate magazine (2) and the printing plates (5) are delivered in a predetermined order from the plate magazine (2)...

The invention provides functional mutants of activation-induced cytidine deaminase (AID) protein that have increased activity as compared to a wild-type AID protein. The invention also provides nucleic acids encoding the functional AID mutants, and vectors and cells comprising the nucleic acids. The invention furthe...

The invention relates to a caged lysine wherein the caged lysine is according to Formula (I): or salts thereof. The invention further relates to polypeptides comprising a caged lysine and to methods of making same. The invention further relates to tRNA synthetases capable of charging tRNA with caged lysine. ...

The invention provides the antibody D9.2 and antibody molecules based on D9.2 which bind interleukin-17 receptor B. These may be useful in therapy, e.g. the treatment of asthma, ulcerative colitis or Crohn's disease.

The invention relates to a method for alleviating the inhibition of neurite outgrowth from a neurone, wherein said neurone comprises a Nogo receptor, said method comprising contacting said neurone with a composition capable of causing phosphorylation of a Nogo receptor, wherein said composition comprises protein kin...

The Invention relates to kits and methods for aiding I he diagnosis of Barrett's oesophagus or Barrett's associated dysplasia. Preferred is a method comprising assaying cells from the surface of a subject's oesophagus for a non-squamous cellular marker, wherein detection of such a marker indicates increased likelih...

Ligand-modified poly oxo-hydroxy metal ion materials and their uses are disclosed, in particular for nutritional, medical, cosmetic or biologically related applications for example for the treatment of a deficiency related to a component of the material or for the removal of an endogenous substance capable of bindi...

The present invention relates to novel gag nucleotide and amino acid sequences. It also relates to pharmaceutical compositions containing these sequences.

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The invention provides the antibody 2C3 and target binding members based on 2C3 which binds interleukin-25. These are useful in therapy, e.g. the treatment of asthma.

The present invention relates to DNA polymerases. In particular the invention relates to a method for the generation of DNA polymerases exhibiting a relaxed substrate specificity. Uses of mutant polymerases produced using the methods of the invention are also described.

Oxygen sensors and their uses are disclosed and more particularly to oxygen sensors for use in product packaging for storing an article in a packaging envelope under modified atmosphere conditions wherein the oxygen sensors comprise solid oxo hydroxy metal ion materials optionally modified with one or more ligands a...

Processes for recovering colloids of carboxylate ligand modified ferric iron hydroxide materials such as IHAT (Iron Hydroxide Adipate Tartrate) are described based on the use of water miscible non aqueous solvents such as ethanol methanol and acetone. The processes produce materials with advantageous properties such...

1a3a5aaaThe present invention relates to inhibitors of PPP1 R15A and PPP1 R15B and their use in therapy particularly in the treatment of a disease state alleviated by the inhibition of PPP1 R15A and PPP1 R15B for example a disorder associated with accumulation of misfolded proteins or proteostatsis disorder. Compoun...

Stabilised and aquated polymeric silicate compositions are described in which the compositions are poorly condensed compositions in which the silicates are resorbable and are capable of undergoing efficient dissolution to provide bioavailable soluble silicic acid. In particular stabilised and aquated polymeric silic...

The invention relates to a polypeptide comprising an amino acid having a cyclopropene group wherein said cyclopropene group is joined to the amino acid via a carbamate group. Suitably the cyclopropene group is a 1 3 disubstituted cyclopropene such as a 1 3 di methylcyclopropene. Suitably the cyclopropene group is pr...

Stabilised silicate compositions and methods of making them are disclosed and more particularly to compositions comprising polysilicic acids optionally stabilised by a growth retardant and their uses as antiperspirant compositions.

The invention relates to a polypeptide comprising an amino acid having a bicyclo[6.1.0]non 4- yn -9- ylmethanol (BCN) group, particularly when said BCN group is present as: a residue of a lysine amino acid. The invention also relates to a method of producing a polypeptide comprising a BCN group , said method compris...

Amorphous magnesium substituted calcium phosphate compositions and their medical uses are described in particular for use in delivering cargo materials such as cargo molecules or cargo nanoparticles contained in pores of the amorphous magnesium substituted calcium phosphate to cells of the immune system fo exam...

The invention relates to a method for the diagnosis of TB in a subject, the method comprising (a) providing a sample from said subject, said sample being selected from the group consisting of: blood, serum and plasma; (b) determining the concentration in said sample of the following biomarkers: IL-1ra, IL6, IL-7, IL...

The present invention discloses a method to discover selective inhibitors of phosphatases. Thus the invention provides a method for screening a test compound to determine whether the compound binds a holophosphatase selectively or non selectively comprising: i) providing a first holophosphatase wherein said holophos...