The present invention relates generally to the field of dispensing system. More particularly, the invention relates to a device for dispensing medicament. It may be used for delivering drugs in liquid form at predetermined rates. The main advantage associated with this invention is that the device is powerhl and ...

The present invention relates to polymorphic forms of salt of Pralatrexate, process for the preparation thereof, and pharmaceutical compositions thereof.

The present invention relates to Amorphous Form of 4 - acetoxy - 2a - benzoyloxy -Sß - 20 - epoxy - 1 - hydoxy - 7ß, 10ß - dimethoxy - 9 - oxotan - 11 - en - 13α - yl {2R,3S) -3 - tert - butoxycarbonylamino - 2 - hydoxy - 3 - phenylpropionate, i.e Cabazitaxel, methods for its preparation and pharmaceutical compositi...

The present invention relates to a process of preparing a stable pharmaceutical composition of compounds which are susceptible to hydrolysis comprising a. Addition of required quantity of pharmaceutically acceptable lyophilization excipients optionally in Water for Injection in a formulation vessel; b. Addition o...

Novel intermediates, process for their preparation and their use in the preparation of therapeutically effective antineoplastic agents, in particular Temsirolimus of formula (I).

The present invention relates to a tablet comprising Afatinib or a pharmaceutically acceptable salt thereof wherein the tablet is obtained by direct compression. The present invention further relates to a process for manufacturing a tablet of the invention as well as the use of the tablet of the invention. ...

The present invention relates to a stable ready to use pharmaceutical composition comprising the proteasome inhibitor carfilzomib or pharmaceutically acceptable salt thereof.

An improved process, which is simple, convenient, economical and industrially viable, for the preparation of stable, free flowing, non-hygroscopic crystalline alpha form of Imatinib mesylate, free from the beta form. The process comprises a) providing a clear solution of imatinib base in organic solvent; b) optional...

Abstract The present invention relates to crystalline forms of Afatinib and its dimaleate salt. The present invention also relates to processes for the preparation of crystalline forms of Afatinib and its dimaleate salt. The present invention further relates to pharmaceutical compositions of such crystalline form...

A stable pharmaceutical compositions of Rapamycin Esters, in particular Rapamycin 42-ester with 3-hydroxy-2-(hydroxymethyl)-2-methylpropionic acid that is free of antioxidants and a process of preparing the same.

A pharmaceutical composition of Pemetrexed represented by formula I, which is a liquid ready to use solution formulation or a lyophilized pharmaceutical composition for parenteral administration comprising a pharmaceutically acceptable organic amine, an inert gas and optionally containing at least one or more ph...

The present invention relates to an improved process for the preparation of xylene linked cyclam compounds. More particularly the invention provides a process for preparation of high purity plerixafor which does not involve the use of expensive chemicals, hazardous reagents or tedious purification techniques. Invent...

An improved process for the preparation of Pralatrexate which is less hazardous. The invention further relates to novel intermediates and process thereof useful for the preparation of Pralatrexate. The present invention also relates to a substantially pure Pralatrexate and a process for obtaining the same in hi...

The present invention relates to an improved process for the Preparation of Pyrazole substituted aminoheteroaryl compounds. More particularly, the present invention provides a highly pure 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine and its Intermediates. ...

The present invention relates to an improved process for the synthesis of bendamustine, in particular , bendamustine hydrochloride of the formula (VI) and its intermediate l-Methyl-5-[bis(2-chloroethyl)amino]-1H-benzimidazol-2-yl]lithium butanoate of formula(V), both having a purity of >99%, which is simple, conveni...

An improved process for the preparation of Pemetrexed of Formula I or its salt, the process comprisesReacting 4-(2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]-pyrimidin-5-yl)-ethyl) benzoic acid with L-glutamic acid or its ester, or its acid salt, in the presence of acid activating reagent having carbodiimide group...

The present invention relates to ready to use, non aqueous pharmaceutical compositions comprising 5-aza-2"deoxycitidine and at least one aprotic solvent. The pharmaceutical compositions may further comprise at least one protic solvent. The present invention also relates to processes for preparating the pharmaceut...

The present invention relates to an improved process for the preparation of Cabazitaxel and its Intermediates, which avoids the use of hazardous reagents, like Pyridine for silylation and 3HF.Et3N for deprotection of silyl group.

The present invention provides a pharmaceutical composition comprising 4-(3"-chloro-4"-fluoroanilino)-7-methoxy-6-(3-morpholinopropoxy) quinazoline (Gefitinib) or a pharmaceutically acceptable salt thereof and a film coating comprising a vinyl polymer.

The present invention relates to stable parenteral pharmaceutical compositions comprising Bortezomib or its pharmaceutically acceptable salts or solvates thereof and stabilizing agent selected from water soluble polymer and amino acids. Said compositions further comprise suitable co-solvents and optionally pharma...

The present invention relates to novel intermediates and its use in the preparation of Lapatinib and its pharmaceutically acceptable salts thereof. The present invention also relates to a novel process for the synthesis of Lapatinib and its pharmaceutically acceptable salts thereof. In particular, the present invent...

The present invention relates to the Crystalline Forms of 4-acetoxy-2a-benzoyloxy-5ß-20-epoxy-1 -hydoxy-7ß, 10ß-dimethoxy-9-oxotan-11 -en-13α-yl(2R,3S)-3-tert-butoxycarbonylamino-2-hydoxy-3-phenylpropiona'te, i.e Cabazitaxel, methods for its preparation and Pharmaceutical composition thereof.

The present invention relates to a stable ready to use pharmaceutical composition comprising the known compound Pemetrexed that is free of any antioxidants or amino acids or chelating agents; which liquid composition is stable and pharmaceutically elegant.

ABSTRACT The present invention relates to a process for the purification of Carfilzomib of Formula I that reduces the level of an acetamide impurity of Formula II preferably below 0.10 wt%.

The present invention discloses a process for preparing a highly pure Meiphalan of Formula (I) or its pharmaceutically acceptable salt. comprising the steps of; a) reductively alkylating a compound of Formula (II), wherein R is C1-C6 Alkyl and P is a suitable protecting group in the presence of a triflate and a b...

The present invention relates to an improved process for the preparation of a compound of formula I, Formula I wherein PG1 may be independently selected from tert-butyloxycarbonyl (Boc), phthaloyl, 9-fluorenylmethyloxycarbonyl (Fmoc), triphenylmethyl (Trityl), carboxybenzyl (Cbz), trifluoroacetyl, benzyl (Bn), ben...

ABSTRACT The present invention relates to a process for the preparation of ribociclib or its salts. The invention also provides novel crystalline forms of ribociclib succinate and ribociclib trifluoroacetate.

The present invention relates to a process for the purification of compound of formula II, Formula II wherein X may be independently selected from trifluoroacetic acid, hydrochloric acid, hydrobromic acid, p-toluene sulfonic acid or phosphoric acid; its isolation as solid and use for the preparation of carfilz...

The present invention relates to the polymorphic forms of Belinostat. The invention also relates to the process for the preparation of the polymorphic forms of Belinostat. This invention further relates to pharmaceutical composition of said polymorphic forms of Belinostat and use thereof in the treatment of a patien...

The present invention relates to a process for the preparation of Treosulfan using sodium borohydride and iodine as reducing agent, which is less hazardous and convenient as compared to the reagents used in the prior art. The invention also relates to a novel intermediate to obtain Treosulfan in high yield and high ...

The present invention relates to a stable liquid pharmaceutical composition of pemetrexed for parenteral administration. The invention provides composition comprising pemetrexed diacid, an organic amine and cyclodextrin. The composition may further comprise an inert gas. The composition can be ready to use infusion...

The present invention relates to an improved process for the preparation of compound of formula I, Particularly, it relates to preparation of compound of formula Ia,from compound of formula Ila and Ilia wherein, X is imidazole or triazole The present invention also relates to preparation of an amorphous form of ...

The present invention relates to a process for preparing the Alectinib or a pharmaceutically acceptable salt thereof. The invention also relates to novel polymorphic forms of Alectinib and Alectinib hydrochloride.

The present invention relates to a process for the preparation of a compound of formula I or its salts, Formula I wherein R is C1-4 alkyl; and its use for the preparation of the compound of formula V, Formula V

The present invention provides an improved and industrially viable process for the preparation of Acalabrutinib and its intermediates in high yield and eliminating the use of time-consuming purification process. The present invention also relates to the purification of (S)-4-(8-Amino-3-(pyrrolidin-2-yl)imidazo[1,5-a...

The present invention relates to an improved process for the preparation of a compound of Formula 1, O O O NH O O O NH O O O NH O O O HN O OH HN O O 10 Formula 1 The invention also provides improved processes for the preparation of intermediates used in the synthesis of Formula 1. The compound ...

A pharmaceutical composition of Pemetrexed represented by formula I, which is a ready to use solution composition or a or a lyophilized pharmaceutical composition for parenteral administration comprising pharmaceutically acceptable organic amine or their mixtures thereof, an inert gas and optionally containing at ...

Process for the preparation of propofol The present provides a simple, convenient and time-efficient process for the preparation of propofol. Particularly, the present invention provides an improved process for the preparation of propofol using a heterocyclic base for the decarboxylation reaction. ...

ABSTRACT The present invention relates to an improved process for the preparation of a compound of formula V or a salt thereof, Formula V The present invention also provides a process for the preparation of a compound of formula I, used in the synthesis of the compound of formula V, Formula I w...

The present invention relates to an improved process for the preparation of a a tetrapeptide of formula I, Formula I wherein R1 and R2 are independently selected from an amine protecting group and R3 is t-Bu or Bn. The present invention further, relates to a process for the preparation Liraglutide or its...

ABSTRACT The present invention relates to an improved process for the preparation of CDK inhibiting pyrrolopyrimidine compounds. More particularly the invention provides a process for preparation of high purity 2'-{[5-(4-methylpiperazin-1-yl)pyridin-2-yl]amino}-7',8'¬ dihydro-6'H-spiro[cyclohexane-1,9'-pyrazino[1',...