An HPLC module utilizes a combination of compound-dedicated hardware providing line clearance between differing radiosyntheses and includes multiple compound-dedicated HPLC inject valves, each inject valve directing a fluid to a serially-connected HPLC column and UV flowcell so as to prevent cross-contamination betw...

Disposable components for a separation and purification system include a flow cell, an end cap for a chromatography column, and a chromatography column useful for medium-pressure liquid chromatography (MPLC).

The invention relates to a method of determination of PDH activity by 13C-MR detection using an imaging medium which comprises hyperpolarised 13C-pyruvate and to imaging media for use in said method.

The present invention relates to compounds having selective binding for MAO-B as compared with MAO-A. The invention also provides radioactive versions of these compounds, and precursor compounds for the synthesis of these radioactive 5 compounds. The radioactive compounds of the invention can find use for in vivo...

The invention relates to a process for preparation of radiopharmaceutical precursors and in particular protected amino acid derivatives which are used as precursors for production of radiolabelled amino acids for use in imaging procedures such as positron emission tomography (PET). Particularly the invention relates...

The present invention relates to a method for the production of tricyclic indole compounds comprising a cyclization step wherein this step is improved over known methods.

The invention relates to a process for preparation of radiopharmaceutical precursors and in particular protected amino acid derivatives which are used as precursors for production of radiolabelled amino acids for use in imaging procedures such as positron emission tomography (PET). Particularly the invention relates...

The present invention provides a method for the production of [18F]-FACBC which has advantages over know such methods. Also provided by the present invention is a system to carry out the method of the invention and a cassette suitable for carrying out the method of the invention on an automated radiosynthesis appara...

The present invention provides novel in vivo imaging agents useful for detecting the presence of mycobacteria using in vivo imaging methods. Also provided by the present invention is a precursor compound useful in the synthesis of the in vivo imaging agents of the invention and a method to obtain the in vivo imaging...

The present invention relates to imaging agents suitable for in vivo optical imaging, which comprise conjugates of benzopyrylium dyes with biological targeting moieties, such as peptides. Also disclosed are pharmaceutical compositions and kits, as well as in vivo imaging methods.

The present invention relates to radiopharmaceuticals and in particular to a radiopharmaceutical composition comprising a compound of Formula I: and polysorbate as an excipient. The radiopharmaceutical composition of the invention reduces problems encountered with prior art compositions comprising the same class of...

The present invention provides a pharmaceutical composition comprising [18F]FACBC having certain advantages over known compositions comprising [18F]FACBC. Also provided by the present invention is a method to obtain the composition of the invention.

The present invention relates to 99mTc maraciclatide radiopharmaceutical compositions which are stabilised with a radioprotectant. Also described are kits for the preparation of the radiopharmaceutical compositions as well as methods of preparing such compositions from the kit. The invention also includes methods of...

The present invention relates to imaging agent compositions comprising radiolabelled c Met binding peptides suitable for positron emission tomography (PET) imaging in vivo. The c Met binding peptides are labelled with the radioisotope F. Also disclosed are pharmaceutical compositions methods of preparation of the ag...

The present invention provides a novel method of labelling biological targeting molecules (BTMs) of interest with radio iodine. Also provided are novel radioiodinated BTMs prepared using the method, as well as radiopharmaceutical compositions comprising such radioiodinated BTMs. The invention also provides radio...

The present invention provides a simplified method for the preparation of F-labelled compounds that is particularly suitable for automation. The method of the invention is specifically applicable where the 1 8F-labelled compound is prepared from a labelling precursor that comprises protecting groups and wherein the ...

Novel radiotracer(s) for Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) imaging of disease states related to altered choline metabolism (e.g., tumor imaging of prostate, breast, brain, esophageal, ovarian, endometrial, lung and prostate cancer - primary tumor, nodal diseas...

Novel choline  derived radiotracer (s) having an isotopic carbon for Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) imaging of disease states related to altered choline metabolism (e.g. tumor imaging of prostate breast brain esophageal ovarian endometrial lung and prostate c...

The present invention relates to a composition comprising a tricyclic indole compound. The composition has a higher purity and better impurity profile than known compositions comprising said tricyclic indole compound and as a consequence has superior properties particularly when said compound is destined for use in ...

The present invention concerns in vivo imaging and in particular in vivo imaging of the peripheral benzodiazepine receptor (PBR). A tetracyclic indole in vivo imaging agent is provided that binds with high affinity to PBR, has good uptake into the brain following administration, and which preferentially binds to tis...

Heterocyclic compounds of formula (I) useful as imaging probes of Tau pathology in Alzheimer s disease are described. Compositions and methods of making such compounds are also described.

The present invention relates to an improved [18F] labelled synthon composition, wherein the non-radio active impurities in said composition have been found to be more straightforward to remove than with known compositions comprising said [18F] labelled synthon. The resultant purified [18F] label led synthon the...

The present invention provides a method to prepare an F labelled tricyclic indole compound comprising a solid phase extraction (SPE) purification step. This method is particularly suitable for carrying out the radiofluorination method on an automated synthesiser. In addition to the radiofluorination method the prese...

The present invention relates to the field of radiopharmaceuticals for in vivo imaging, in particular to a method of labelling a biological targeting molecule with a radioisotope. The method of the invention is particularly suitable for use with an automated synthesizer apparatus. Also provided are precursors in ste...

Various embodiments of the invention relate to a system 100 and method 200 for image analysis. In particular, various embodiments of the invention relate to a system 100 and method 200 for extracting low-intensity features from an image data set comprising data corresponding to a sequence of original image frames 50...

The present invention relates to improved radiotracer imaging agent compositions which comprises F labelled biological targeting moieties wherein impurities which affect imaging are identified and suppressed. Also provided are radiopharmaceuticals comprising said improved compositions together with radiofluorinated ...

The present invention provides a novel method for the preparation of F fluoride (F) for use in radiofluorination reactions. The method of the invention finds use especially in the preparation of F labelled positron emission tomography (PET) tracers. The method of the invention is particularly advantageous where bulk...

A method of radiostabilizing an oxime ligation or imine formation reaction using aniline is described.

Imaging agents comprising an isolated polypeptide conjugated with a radionucleide and a chelator; wherein the isolated polypeptide binds specifically to HER2 or a variant thereof; and methods for preparing and using these imaging agents.

Imaging agents comprising an isolated polypeptide conjugated with a radionucleide and a chelator; wherein the isolated polypeptide binds specifically to HER2 or a variant thereof; and methods for preparing and using these imaging agents.

The present invention relates to an improved synthesis of N-monofluoroalkyl tropanes using fluoroalkyl iodides or fluoroalkyl sulfonate esters. The invention also provides the use of such method to prepare the non-radioactive tropane intermediate FP-CIT, and its subsequent conversion to the "23~-labelledra diopha...

Components and systems for a PET radiopharmacy include a transport shield for a radioisotope cartridge a cassette for dispensing from a transport shield a cassette synthesis platform for a cassette and a synthesizer shield.

A multi vial dispensing cassette provides serial dispensement into a plurality of dispense vials. Needle holders may be provided for one or more vials in the cassette and at clip may be incorporated into the needle holder.

The invention relates to methods for processing [18F]-fluoride target water using a solid-support bound Cryptand of formula (I) and to apparatus for performing such methods. The resultant [18F]-fluoride is useful for preparation of radiopharmaceuticals by nucleophilicfluorination, specifically for use in Positron E...

The present invention relates to technetium imaging agents comprising radiolabeled c-Met binding peptides suitable for SPECT or PET imaging in vivo. The c-Met binding peptides are labelled via chelator conjugates. Also disclosed are pharmaceutical compositions, methods of preparation of the agents and compositions,...

The present invention provides a method for the purification of cyclic indole compounds that provides advantages over previously-known methods. Using the method of the present invention allows for the facile preparation of a good quality solid form of these compounds.

The present invention relates to reagents and methods for [18F]-fluorination of biomolecules, particularly of peptides. The resultant 18F-labelled compounds are useful as radiopharmaceuticals, specifically for use in Positron Emission Tomography (PET).

The present invention provides a composition comprising anti 1 amino 3 F fluorocyclobutyl 1 carboxylic acid (F FACBC) having an improved impurity profile compared with previous such compositions. Also provided is a method to obtain said composition.

An indole-based in vivo imaging agent is provided by the present invention that binds with high affinity to PBR, has good uptake into the brain following administration, and which has good selective binding to PBR. The invention also includes a precursor compound useful in the synthesis of the in vivo imaging agent ...

The present invention provides novel compounds useful in the treatment and diagnosis of mycobacterial infections. Compounds of the present invention have enhanced biological properties as compared to the related known compounds. The present invention also provides a precursor compound useful in the synthesis of ce...

The present invention provides a method for the preparation of a radiolabeiied guanidine derivative, in particular wherein the radiolabeiied guanidine derivative is a positron emission tomography (PET) tracer. Certain intermediates useful in said method are also provided, as well as means for carrying out said metho...

The present invention provides tetra-amine chelator conjugates with biological targeting moieties, linked via a linker group and technetium complexes thereof as radiopharmaceuticals. The linker group is such that the chelator is mono-funcdonalised at the bridgehead position and provides both flexibility and a lack o...

The invention provides a method for the synthesis of an 18F-labelled product comprising deprotected of a protected 18F-]abelled compound using a deprotection agent comprising a weak acid and wherein neutralisation and buffering of the depro-tected product are carried out by the addition of a neutralisation agent. T...

The present invention provides an automated method for the preparation of 99mTc radiopharmaceutical compositions, together with disposable cassettes for use in the method. The use of an automated synthesizer apparatus in the preparation of 99mTc radiopharmaceuticals is also described. Also described is the use of k...

The invention relates to an improved process for the fluoridation of sugar derivatives in which a controlled amount of water is present in the solvent.

The present invention relates to stabilised 99mTc radiopharmaceutical compositions of the ligand tetrofosmin, which include an ascorbic acid or ascorbate radioprotectant, in the absence of an antimicrobial preservative. The invention also provides lyophilised kits suitable for the bulk preparation of multiple uni...

The present invention relates to stabilised technetium and rhenium metal complex compositions comprising a radio-priieclant and a radiometal complex of a Iropane-telradentale chelating agent conjugate, wherein the radiornetal complex is neutral. Radiopharmaceuticals comprising the stabilised metal complex compositi...

The present invention relates to a method of producing radiolabelled gallium complexes that could be used as diagnostic agents, e.g. for positron emission tomography (PET) imaging.

The present invention relates to a synergistic composition for the treatment of diabetes in a subject in need thereof, said composition-comprising Trigonelline of concentration ranging between 20 to 30%, amino acids of concentration ranging between 20 to 60%, and soluble fiber of concentration ranging between 10 to ...

The invention provides a method for radiofluorination of biological vectors such as peptides comprising reaction of a compound of formula (II): or a salt thereof with a source of [18F]-fluoride, to give a compound of formula (I): or a salt thereof. The method may be effected under mild reaction conditions and offe...

The present invention provides an automated method for the preparation of I-labelled radiopharmaceutical compositions, together with disposable cassettes for use in the method. The use of an automated synthesizer apparatus in the preparation of 123I-labelled radiopharmaceuticals is also described. Also described ...

The invention relates to a process for preparation of a compound of formula (I): R1 is selected from C1-6alkyl, C2-6alkenyl, and C2.6alkynyl; which comprises: (i) reaction with fluoride, suitably [18F]fluoride, of a corresponding compound of formula (II): wherein R2 is selected from hydrogen, C1-10alkyl, Ci...

radioactive technetium and rhenium complexes comprising tripodal ligands are provided by the present invention. In particular, Tc(l) complexes are provided by the present invention. Novel ligands suitable for the formation of the technetium and rhenium complexes of the invention are also provided, as well as radioph...

The invention describes a method for stripping alumina which is particularly suitable for removal of fluoride from alumina and comprises washing said alumina with an aqueous acid or alkali at elevated temperature. The method may be used for removal of unreacted radiofluoride such as [18F]fluoride from alu...

The present invention provides a dispenser cassette (110) which provides at least one product dispense vial (122) to be filled. The cassette provides a filtrate conduit (128) extending between the dispense vial and a filter unit (116) so that flowpath (120) of the filtrate conduit and the dispense vial is provided a...

The present invention provides a novel imaging agent suitable for the non-invasive visualization of fibrosis. A precursor for the preparation of the imaging agent is also provided by the invention, as well as a pharmaceutical composition comprising the imaging agent and a kit for the preparation of the pharmaceutica...

The present invention relates to improved radiopharmaceutical compositions in sealed containers, where the container closure has an ETFE (ethylene-tetrafluoroethylene copolymer) coating. Also disclosed are kits for radiopharmaceutical preparation using the sealed containers, as well as methods of preparation of radi...

The present invention discloses that imaging agents which comprise a specific type of matrix metalloproteinase inhibitors (MMPi's) of the hydroxamate class labelled with an imaging moiety, are useful diagnostic imaging agents for in vivo imaging and diagnosis of the mammalian body.

A feature of the dissolution equipment for a DNP polarizer, namely a nozzle as part of the dissolution device. This nozzle provides for more efficient dissolution of the solid polarized sample, thereby enabling a rapid and complete dissolution.

Chemical Structures of Compounds 1 to 6. The present invention relates to improved chelator conjugates of formula (II) with biological targeting molecules, suitable for forming metal complexes with radiometals. The radiometal complexes, especially with the radiometal99l"Tc, are useful as radiopharmaceuticals. ...

The present invention relates to a method useful in facilitating the identification of fibrogenesis in a subject. The method of the invention is particularly useful when applied as part of a method to diagnose fibrogenesis of the liver. The invention also provides a compound for use in a method for identification of...

The present invention relates to radiodiagnostic methods and methods of use thereof as imaging agents for preferably a HA serotonin 5-HT1A receptor for use in PET or SPECT, preferably PET. Compositions comprising an imaging-effective amount of radiolabeled compounds are also disclosed.

The invention relates to a process for preparation of radiopharmaceutical precursors, and in particular protected amino acid derivatives which are used as precursors for production of radiolabelled amino acids for use in in vivo imaging procedures such as positron emission tomography (PET). Particularly, the inventi...

Novel radiotracer(s) for Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) imaging of disease states related to altered choline metabolism (e.g. tumor imaging of prostate breast brain esophageal ovarian endometrial lung and prostate cancer  primary tumor nodal disease or metast...

The invention relates to a process for preparation of radiopharmaceutical precursors and in particular protected amino acid derivatives which are used as precursors for production of radiolabeled amino acids for use in imaging procedures such as positron emission tomography (PET). Particularly the invention relates ...

The present invention relates to radiopharmaceutical imaging of apoptosis and other forms of cell death. The invention provides PET imaging agents which target apoptotic cells selective binding to the aminophospholipid phosphatidylethanolamine (PE) which is exposed on the surface of apoptotic cells. Also provided ar...

Novel radiotracers) for Positron Emission Tomography (PET) imaging are described. Novel radiotracers) for Positron Emission Tomography (PET) imaging of neuorendocrine tumors are described. Specifically the present invention describes novel [18F]Fluoroethyltriazol-[Tyr3]Octreotate analogs; in particular those that ...

The present invention discloses that imaging agents which comprise a specific type of matrix metalloproteinase inhibitors (MMPi's) of the sulphonamide hydroxamate class labelled with an imaging moiety, arc useful diagnostic imaging agents tor in vivo imaging and diagnosis of ihe mammaJian body. ...

The present invention relates to a novel composition comprising 1 amino 3 [F] fluorocyclobutanecarboxylic acid ([F] FACBC) wherein said composition has certain superior properties in comparison with known compositions comprising [F] FACBC. Also provided by the invention is a method to obtain said composition. ...

The present invention relates to radiopharmaceutical imaging of apoptosis. The invention provides imaging agents which target apoptotic cells selective binding to the aminophospholipid phosphatidylethanolamine (PE) which is exposed on the surface of apoptotic cells. The radiopharmaceuticals comprise radiometal compl...

As attached in PDF doThe present invention relates to compounds having selective binding for MAO-B as compared with MAO-A. The invention also provides radioactive versions of these compounds, and precursor compounds for the synthesis of these radioactive 5 compounds. The radioactive compounds of the invention can...

Provided by the present invention is a novel method for obtaining an 18F-labelled compound wherein said compound comprises an 18F- labelled pyridyl ring. The method of the invention is advantageous over the prior art methods as it provides these compounds in higher radiochemical yields than have been possible with p...

The present invention relates to a method of obtaining from a 68Ge/68Ga generator and a method of producing 68Ga-radiolabelled complexes using the obtained 68Ga. The invention further relates to a kit, which could be used to obtain 68Ga and a kit, which could be used for the production of 68Ga-radiolabelled complexe...

The present invention relates to diagnostic imaging agents for in vivo imaging. The imaging agents comprise a synthetic caspase-3 inhibitor labelled with an imaging moiety suitable for diagnostic imaging in vivo. The invention also provides pharmaceutical and radiopharmaceutical compositions comprising the imaging a...

The invention relates to a process for preparation of radiopharmaceutical precursors and in particular protected amino acid derivatives which are used as precursors for production of radiolabelled amino acids for use in imaging procedures such as positron emission tomography (PET). Particularly the invention relates...

The present invention provides a method for the synthesis of 18F labelled biomolecules which is amenable to automation. The present invention also provides a cassette for automating the method of the invention. The method of the present invention provides numerous advantages over the prior art methods. One less puri...

The present invention provides a method for the synthesis of F labelled biomolecules which is amenable to automation. The present invention also provides a cassette for automating the method of the invention. The method of the present invention provides numerous advantages over the prior art methods. One less purifi...

The present invention provides novel synthesis's for obtaining a protecting group aminoxy PEG-6 linker from cost effective, and readily available starting materials and chemicals or modified polyethylene glycols. More specifically, a novel synthesis of obtaining a modified Boc-protected aminoxy PEG-6 linker was achi...

The present invention provides a PET tracer that has improved properties for imaging the peripheral benzodiazepine receptor (PBR) as compared with known such PET tracers. The present invention also provides a precursor compound useful in the preparation of the PET tracer of the invention and methods for the preparat...

A method for removing or controlling or quantifying the presence of aldehydes in particular acetaldehyde is described. Such a method is useful in prolonging the shelf life of a pharmaceutical product.

The present invention provides a system for evaporating a radioactive fluid a method for the synthesis of a radiolabelled compound including this system and a cassette for the synthesis of a radiolabelled compound comprising this system. The present invention provides advantages over known methods for evaporation of...

The present invention provides a method of purifying 68Ge/ 68Ga generator produced 68Ga from Fe (III). The invention further relates to an automated system within an existing Gallea Synthia prototype that provides purification 68Ga from various cations and preconcentrations of 68Ga. In general, the present invent...

The present invention relates to in vivo imaging and radiotherapeutic methods and agents which target the enzyme aldehyde dehydrogenase (ALDH ) and that are suitable for the in vivo imaging of tumours and treatment of cancer.

The present invention provides a method to obtain radiofluorinated compounds useful for in vivo imaging GABAA receptors. The method of the invention is high-yielding and may conveniently be carried out on an automated synthesizer such as Fastlab™. A further aspect of the invention is a cassette suitable for carrying...

A multi-stream optical interrogation flow cell for a radiopharmaceutical includes a multiple flow cell body defining a first elongate fluid flowpath therethrough for individually conducting a radiopharmaceutical therethrough in fluid isolation from other of the flow cell bodies. Each flow cell body further defines a...

The present invention relates to an automated radiosynthesis device adapted for enhanced automatic disconnection of a disposable kit once a radiosynthesis has been carried out. The automated radiosynthesis device of the invention therefore reduces the time to remove the disposable kit from the radiosynthesis device ...

The present invention relates to an automated radiosynthesis device adapted for the addition of multiple additional components. The automated radiosynthesis device of the invention enables a wider range of radiochemical synthetic processes to be carried out in an automated fashion.

A medical system useful in the determination of future disease progression in a subject. More specifically the present invention applies machine learning techniques to aid prediction of disease pathology and clinical outcomes in subjects presenting with symptoms of cognitive decline and to expedite clinical developm...

The present invention provides a radiopharmaceutical composition comprising the following four components: (i) a radio-labelled compound; (ii) ethanol; (iii) a stabilizer of the radio-labelled compound; and (iv) a cyclodextrin. The present invention also provides a radiopharmaceutical composition comprising: (i) a r...

The present invention relatesto radiopharmaceutical imaging of the brain, in particular to dopamine transporter imaging of the striatum (or a portion thereof). A method of imaging to permit calculation of left : right striatum uptake ratios is provided, and the degree of asymmetry used to assist in the diagnosis of ...

The invention provides a new chemical process a new cassette configuration and new software. The invention allows one synthesizer in one hot cell to produce sequentially two batches of [18F] labelled PET tracer in the same day.

The present invention relates to the field of radiopharmaceuticals for in vivo imaging, in particular to automated methods for the preparation and purification of 1 F-labelled tau imaging radiotracers. Also provided are interchangeable cassettes useful in the methods, and the use of automated synthesizers and cass...

The present invention provides a system for the production of a radiopharmaceutical including a radiosynthesis apparatus and a disposable cassette. The system of the invention includes a device that enables a position on the cassette to be freed for inclusion of an additional reagent vial. With the system of the inv...

The present invention provides a pharmaceutical composition comprising [ 18F] FACBC having certain advantages over known compositions comprising [18F] FACBC. Also provided by the present invention is a method to obtain the composition of the invention.

The present invention concerns a HPLC separation method useful in the synthesis of [18F]-labelled compounds, including positron emission tomography (PET) tracers. The method of the invention addresses constraints of previous methods imposed by the needs of free 5 [18F]fluoride. The present invention provides a simpl...

The invention relates to a method of preparing an [18F]radio-labelled compound, wherein the water content is controlled. Controlling the water content and the origin of the water within the reaction process has a significant effect on both the yield and the purity of the product of the radio-labelling process. ...

The present invention provides a radiopharmaceutical composition comprising the following four components: (i) a radio-labelled compound; (ii) ethanol; (iii) a stabilizer of the radio-labelled compound; and (iv) a cyclodextrin. The present invention also provides a radiopharmaceutical composition comprising: (i) ...