An improved process for the manufacture of 2,3:4,5-bis-O-(l-methylethylidene)-β-D-fructopyranose sulfamate, viz. Topiramate is reported. It consists of subjecting an intermediate of the formula 2,3:4,5-bis-0-(l-methylethylidene)-β-D-fructopyranose to a sulfamoylation reaction with sulfamoyl halide in a suitable solv...

Disclosed herein an improved processes for preparing an amorphous and crystalline forms  of  4-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,7β,10β-trihydroxy-9-oxo-11-taxen-13α-yl(2r,3s)-3-tert-butoxycarbonylamino-3-phenyl-2-hydroxypropionate

The present invention relates to an improved process for the manufacture of 1-[[[(1R)-1-[3-[(1E)-2-(7-chloro-2-quinolinyl) ethenyl] phenyl]-3-[2-(1-hydroxy-1-methylethyl) phenyl] propyl] thio] methyl] cyclopropane acetic acid, sodium salt I, which is known as Montelukast.

The invention relates to an improved process for the manufacture of Methyl-2-(3-(2-(7-chloro-2-quinolinyl)-ethenyl)phenyl)-3-oxopropyl)benzoate II, which is an intermediate in the manufacture of Montelukast sodium of formula I.

The invention describes an improved process for the manufacture of a Flecainide intermediate viz N-(pyridin-2-ylmethyl)-2,5-bis(2,2,2-trifluoroethoxy) benzamide (II). It consists of reacting 2,5-bis (2,2,2-trifluoroethoxy) benzoic acid with an acid chloride in a solvent mixture in presence of a base at -10 t...

An improved process for the manufacture of 1-[[[(1R)-1-[3-[(1E)-2-(7-chloro-2-quinoliny)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl) phenyl] propyl] thio] methyl] cyclopropane acetic acid, sodium salt [ montelukast sodium(I)]. It consists of converting a vital intermediate 1-(mercaptomethyl)-cyclopropane acetic ac...