The present invention is related to a process for the preparation of a substituted phenothiazine of the general formula V wherein R1 and R2 are each independently selected from the group consisting of but not limited to H, alkyl, aryl, hydroxyl, methoxy, acetoxy, halide, by the condensation reaction of substitu...

ABSTRACT A process is provided for the preparation of N-debocdocetaxel (I), a common. . intermediate for the preparation paclitaxel and docetaxel. The process comprises the following steps: .  a) coupling of 7,10-di-O-chloroacetyl-10-deacetylbaccatin  III  (III)  with (4R,5S)-5-thoxyoxycarbonyl-2-(4-methoxyphenyl...

The present invention relates to an improved process for the preparation of diphenoxylate hydrochloride of the formula (I) by condensing 4-Bromo-2,2-diphenylbutanenitrile ( II) and Ethyl 4-phenylpiperidine-4-carboxylate (III) in aqueous medium under basic conditions in the presence of a catalyst. This invention also...

The present invention relates to the synthesis of 2-chloromalonaldhyde, a key intermediate in the synthesis of etoricoxib, which is a pharmaceutically active ingredient inhibiting cyclooxygenase-2 and used as a non-steroidal anti-inflammatory drug. In particular, the application concerns a single-step process of syn...

A process for the preparation of Bis-(l(2)H-tetrazol-5-yl)-amine monohydrate. This preparation process is carried out by the reaction between sodium dicynamide and sodium azide in presence of a dilute solution of an inorganic acid solution in aqueous medium.

The present invention is related to a process for the preparation of flurbiprofen of the general formula I in high purity from 2,4-difluoro nitrobenzene (II) and diethylmethyl malonate (III).

The present invention relates to the synthesis of phenylephrine hydrochloride from 3-hydroxyacetophenone, and is generally used as a decongestant. In particular, the process is a high yield process, easy to perform, industrially viable apart from the usage of commercially available raw materials. Also, the chiral pu...

The present invention relates to the synthesis of levo free (+)-3-methoxymorphinan hydrochloride, an intermediate for anti-tussive agent. In particular, the process involves the use of commercially available agents HCl, methanol, and acetone, to obtain the levo free (+)-3-methoxymorphinan hydrochloride from a racemi...