Disclosed herein a method of preparing Bromfenac Sodium Sesquihydrate (Formula-III), comprising obtaining Sodium 2-(2-amino-3-(4-bromobenzoyl) phenyl) acetate (Formula-II) as a crude yellow solid prepared without using an inert atmosphere, dissolving the crude solid in Methanol, stirring and filtering the same at 25...

Abstract of the Invention Disclosed herein a method for producing 2,4-diamino-6-piperidinopyrimidine 3-oxide having formula (3) from 2,4-diamino-6-chloropyrimidine-3-oxide having formula (2) using piperidine having moisture content of 6-80%, wherein, a catalyst tetra butyl ammonium bromide (TBAB) is used in the re...