Multifunctional Natural Killer (Nk) Cell Engagers Binding To Nkp46 And

Multifunctional Natural Killer (Nk) Cell Engagers Binding To Nkp46 And Cd123

Abstract: The present disclosure relates to multifunctional binding proteins comprising a first and a second antigen binding domains (ABDs) and all or part of an immunoglobulin Fc region or variant thereof, wherein the first ABD binds specifically to human CD123 and the second ABD binds specifically to human NKp46 and wherein all or part of the immunoglobulin Fc region or variant thereof to a human Fc-? receptor. The disclosure also relates to methods for making said binding proteins, compositions thereof, and their uses, including the treatment or prevention of proliferative disorders, including Acute Myeloid Leukemia (AML) and myelodysplastic syndromes (MDS).

Patent Information

Application #

Filing Date

26 July 2023

Publication Number

49/2023

Publication Type

INA

Invention Field

BIOTECHNOLOGY

Status

Email

Parent Application

Applicants

SANOFI

46 avenue de la Grande Armée 75017 Paris

INNATE PHARMA

117 avenue de Luminy F13009 Marseille

Inventors

1. GAUTHIER, Laurent

c/o Innate Pharma 117 avenue de Luminy F13009 Marseille

2. THIELENS, Ariane

c/o Innate Pharma 117 avenue de Luminy F13009 Marseille