Novel Salt Forms Of A 4 H Pyran 4 One Structured Cyp11 A1 Inhibitor

Abstract: The present invention relates to novel salts, particularly crystalline salts, of 2-(isoindolin-2-ylmethyl)-5-((1-(methylsulfonyl)piperidin-4-yl)methoxy)-4H-pyran-4-one (I) which are particularly suitable for use in the manufacture of pharmaceutical 5 compositions. Furthermore, the invention relates to pharmaceutical compositions comprising such novel salts. Compound (I) is a selective inhibitor of CYP11A1 enzyme and is useful in the treatment of hormonally regulated cancers, such as prostate cancer and breast cancer.

Patent Information

Application #

Filing Date

30 August 2023

Publication Number

49/2023

Publication Type

INA

Invention Field

CHEMICAL

Status

Email

Parent Application

Applicants

ORION CORPORATION

Orionintie 1 FI-02200 Espoo

Inventors

1. KARJALAINEN, Oskari

c/o FERMION OY Koivu-Mankkaan tie 6 FI-02200 Espoo

2. MÄKELÄ, Mikko

c/o ORION CORPORATION P.O.Box 65 FI-02101 Espoo

3. POP, Mihaela

Le Tourmalet 14 1060NX AMSTERDAM

4. RUMMAKKO, Petteri

c/o ORION CORPORATION P.O.Box 65 FI-02101 Espoo

5. SHEVCHENKO, Anna

Agern Allé 3 2970 HORSHOLM

6. SINERVO, Kai

c/o ORION CORPORATION P.O.Box 65 FI-02101 Espoo

7. TIAINEN, Eija

Ruutikatu 3 A 17 FI-02650 ESPOO

Specification

Documents

Application Documents

#	Name	Date
1	202317058209-STATEMENT OF UNDERTAKING (FORM 3) [30-08-2023(online)].pdf	2023-08-30
2	202317058209-NOTIFICATION OF INT. APPLN. NO. & FILING DATE (PCT-RO-105-PCT Pamphlet) [30-08-2023(online)].pdf	2023-08-30
3	202317058209-FORM 1 [30-08-2023(online)].pdf	2023-08-30
4	202317058209-DRAWINGS [30-08-2023(online)].pdf	2023-08-30
5	202317058209-DECLARATION OF INVENTORSHIP (FORM 5) [30-08-2023(online)].pdf	2023-08-30
6	202317058209-COMPLETE SPECIFICATION [30-08-2023(online)].pdf	2023-08-30
7	202317058209-Proof of Right [17-10-2023(online)].pdf	2023-10-17
8	202317058209-FORM-26 [19-10-2023(online)].pdf	2023-10-19
9	202317058209-FORM 3 [27-02-2024(online)].pdf	2024-02-27
10	202317058209-FORM 18 [06-02-2025(online)].pdf	2025-02-06