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Oligonucleotide Compositions And Methods Thereof
Abstract: Among other things, the present disclosure provides designed oligonucleotides and compositions thereof. In some embodiments, oligonucleotides and compositions of the present disclosure can provide high levels of adenosine editing. In some embodiments, oligonucleotides and compositions of the present disclosure are useful for treating various conditions, disorders or diseases, e.g., alpha- 1 antitrypsin deficiency. In some embodiments, the present disclosure provides methods for treating various conditions, disorders or diseases that can benefit from adenosine editing.
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Notices, Deadlines & Correspondence
Notices, Deadlines & Correspondence
Patent Information
Application #
Filing Date
24 April 2024
Publication Number
48/2024
Publication Type
INA
Invention Field
BIOTECHNOLOGY
Status
Email
Parent Application
Applicants
WAVE LIFE SCIENCES LTD.
7 Straits View #12-00
Marina One East Tower
Singapore 018936
Inventors
1. MONIAN, Prashant
c/o WAVE LIFE SCIENCES LTD.
733 Concord Avenue
Cambridge, Massachusetts 02138
2. SHIVALILA, Chikdu Shakti
c/o WAVE LIFE SCIENCES LTD.
733 Concord Avenue
Cambridge, Massachusetts 02138
3. LU, Genliang
c/o WAVE LIFE SCIENCES LTD.
733 Concord Avenue
Cambridge, Massachusetts 02138
4. VARGEESE, Chandra
c/o WAVE LIFE SCIENCES LTD.
733 Concord Avenue
Cambridge, Massachusetts 02138
5. GIANGRANDE, Paloma Hoban
c/o WAVE LIFE SCIENCES LTD.
733 Concord Avenue
Cambridge, Massachusetts 02138
6. KANDASAMY, Pachamuthu
c/o WAVE LIFE SCIENCES LTD.
733 Concord Avenue
Cambridge, Massachusetts 02138
7. IWAMOTO, Naoki
c/o WAVE LIFE SCIENCES LTD.
733 Concord Avenue
Cambridge, Massachusetts 02138
8. SHIMIZU, Mamoru
c/o WAVE LIFE SCIENCES LTD.
733 Concord Avenue
Cambridge, Massachusetts 02138
9. YU, Hui
c/o WAVE LIFE SCIENCES LTD.
733 Concord Avenue
Cambridge, Massachusetts 02138
10. YANG, Hailin
c/o WAVE LIFE SCIENCES LTD.
733 Concord Avenue
Cambridge, Massachusetts 02138
11. LAMORE, Sarah Diane
c/o WAVE LIFE SCIENCES LTD.
733 Concord Avenue
Cambridge, Massachusetts 02138
12. ZHANG, Fengjiao
c/o WAVE LIFE SCIENCES LTD.
733 Concord Avenue
Cambridge, Massachusetts 02138
13. NARAYANAN, Padmakumar
c/o WAVE LIFE SCIENCES LTD.
733 Concord Avenue
Cambridge, Massachusetts 02138
Specification
Documents
Application Documents
| # | Name | Date |
|---|---|---|
| 1 | 202417032570-STATEMENT OF UNDERTAKING (FORM 3) [24-04-2024(online)].pdf | 2024-04-24 |
| 3 | 202417032570-Sequence Listing in PDF [24-04-2024(online)].pdf | 2024-04-24 |
| 4 | 202417032570-REQUEST FOR EXAMINATION (FORM-18) [24-04-2024(online)].pdf | 2024-04-24 |
| 5 | 202417032570-POWER OF AUTHORITY [24-04-2024(online)].pdf | 2024-04-24 |
| 6 | 202417032570-NOTIFICATION OF INT. APPLN. NO. & FILING DATE (PCT-RO-105-PCT Pamphlet) [24-04-2024(online)].pdf | 2024-04-24 |
| 7 | 202417032570-FORM 18 [24-04-2024(online)].pdf | 2024-04-24 |
| 8 | 202417032570-FORM 1 [24-04-2024(online)].pdf | 2024-04-24 |
| 9 | 202417032570-DRAWINGS [24-04-2024(online)].pdf | 2024-04-24 |
| 10 | 202417032570-DECLARATION OF INVENTORSHIP (FORM 5) [24-04-2024(online)].pdf | 2024-04-24 |
| 11 | 202417032570-COMPLETE SPECIFICATION [24-04-2024(online)].pdf | 2024-04-24 |
| 12 | 202417032570-Proof of Right [02-05-2024(online)].pdf | 2024-05-02 |
| 13 | 202417032570-FORM 3 [23-10-2024(online)].pdf | 2024-10-23 |