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Methods For Freezing And Freeze Drying Lipid Nanoparticles (Ln Ps) And Ln Ps Obtained With The Same
Abstract: The present invention relates to a method for freezing or freeze-drying lipid nanoparticles (LNPs) comprising at least a nucleic acid and, at least, as lipid components, a cationic ionizable lipid, a neutral lipid, and a steroid alcohol, or an ester thereof. The method comprises the steps of providing a liquid composition comprising said LNPs, spraying the composition of step a) in conditions suitable for obtaining liquid droplets, and freezing the liquid droplets obtained at step b) to obtain frozen LNPs. The method may also comprise a step of drying the frozen LNPs obtained to obtain freeze-dried LNPs. The invention also relates to frozen and freeze-dried LNPs.
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Notices, Deadlines & Correspondence
Notices, Deadlines & Correspondence
Patent Information
Application #
Filing Date
30 April 2024
Publication Number
48/2024
Publication Type
INA
Invention Field
CHEMICAL
Status
Email
Parent Application
Applicants
SANOFI
46 avenue de la Grande Armée
75017 PARIS
Inventors
1. PERAL, Florent
c/o SANOFI, Patent Department
54 rue la Boétie
75008 PARIS
2. WOINET, Bertrand
c/o SANOFI, Patent Department
54 rue la Boétie
75008 PARIS
3. BOUTRY, Etienne
c/o SANOFI, Patent Department
54 rue la Boétie
75008 PARIS
Specification
Documents
Application Documents
| # | Name | Date |
|---|---|---|
| 1 | 202417034336-TRANSLATIOIN OF PRIOIRTY DOCUMENTS ETC. [30-04-2024(online)].pdf | 2024-04-30 |
| 2 | 202417034336-STATEMENT OF UNDERTAKING (FORM 3) [30-04-2024(online)].pdf | 2024-04-30 |
| 3 | 202417034336-REQUEST FOR EXAMINATION (FORM-18) [30-04-2024(online)].pdf | 2024-04-30 |
| 4 | 202417034336-FORM 18 [30-04-2024(online)].pdf | 2024-04-30 |
| 5 | 202417034336-FORM 1 [30-04-2024(online)].pdf | 2024-04-30 |
| 6 | 202417034336-DECLARATION OF INVENTORSHIP (FORM 5) [30-04-2024(online)].pdf | 2024-04-30 |
| 7 | 202417034336-COMPLETE SPECIFICATION [30-04-2024(online)].pdf | 2024-04-30 |
| 8 | 202417034336-FORM-26 [27-07-2024(online)].pdf | 2024-07-27 |
| 9 | 202417034336-FORM 3 [22-10-2024(online)].pdf | 2024-10-22 |
| 10 | 202417034336-Proof of Right [30-10-2024(online)].pdf | 2024-10-30 |
| 11 | 202417034336-PA [27-09-2025(online)].pdf | 2025-09-27 |
| 12 | 202417034336-ASSIGNMENT DOCUMENTS [27-09-2025(online)].pdf | 2025-09-27 |
| 13 | 202417034336-8(i)-Substitution-Change Of Applicant - Form 6 [27-09-2025(online)].pdf | 2025-09-27 |