Natural Killer (Nk) Cell Engagers Binding To Nkp46 And Bcma Variants

Natural Killer (Nk) Cell Engagers Binding To Nkp46 And Bcma Variants With Fc Engineering

Abstract: The present disclosure relates to multifunctional binding proteins comprising a first and a second antigen binding domains (ABDs) and all or part of an immunoglobulin Fc region or variant thereof, wherein the first ABD binds specifically to human BCMA and the second ABD binds specifically to human NKp46 and wherein all or part of the immunoglobulin Fc region or variant thereof bind to a human Fc-? receptor. The disclosure also relates to methods for making said binding proteins, compositions thereof, and their uses, including the treatment or prevention of proliferative disorders, including multiple myeloma (MM).

Patent Information

Application #

Filing Date

20 December 2024

Publication Number

08/2025

Publication Type

INA

Invention Field

BIOTECHNOLOGY

Status

Email

Parent Application

Applicants

SANOFI

46 avenue de la Grande Armée 75017 PARIS

INNATE PHARMA

117 avenue de Luminy 13009 MARSEILLE

Inventors

1. GOURDIN, Nicolas

c/o INNATE PHARMA 117 avenue de Luminy 13009 MARSEILLE

2. GAUTHIER, Laurent

c/o INNATE PHARMA 117 avenue de Luminy 13009 MARSEILLE

3. TANG, Alexandre

c/o SANOFI 46 avenue de la Grande Armée 75017 PARIS

4. CHIRON, Marielle

c/o SANOFI 46 avenue de la Grande Armée 75017 PARIS

5. VIRONE-ODDOS, Angela

c/o SANOFI 46 avenue de la Grande Armée 75017 PARIS

6. MASIERO, Alessandro

c/o SANOFI 46 avenue de la Grande Armée 75017 PARIS

7. BENINGA, Jochen

c/o Sanofi-Aventis Deutschland GmBH Patent Department Industriepark Höchst, K703 65926 Frankfurt am Main

8. FOCKEN, Ingo

c/o Sanofi-Aventis Deutschland GmBH Patent Department Industriepark Höchst, K703 65926 Frankfurt am Main

9. TILLMANN, Bodo

c/o Sanofi-Aventis Deutschland GmBH Patent Department Industriepark Höchst, K703 65926 Frankfurt am Main

10. LANGE, Christian

c/o Sanofi-Aventis Deutschland GmBH Patent Department Industriepark Höchst, K703 65926 Frankfurt am Main

11. RAO, Sambasiva

c/o Sanofi Patent Department 450 Water Street Cambridge, Massachusetts 02141

12. ZHOU, Yanfeng

c/o Sanofi Patent Department 450 Water Street Cambridge, Massachusetts 02141

13. SEVIGNY, Leila

c/o Sanofi Patent Department 450 Water Street Cambridge, Massachusetts 02141

Specification

Documents

Application Documents

#	Name	Date
1	202417101485-TRANSLATIOIN OF PRIOIRTY DOCUMENTS ETC. [20-12-2024(online)].pdf	2024-12-20
2	202417101485-STATEMENT OF UNDERTAKING (FORM 3) [20-12-2024(online)].pdf	2024-12-20
3	202417101485-REQUEST FOR EXAMINATION (FORM-18) [20-12-2024(online)].pdf	2024-12-20
4	202417101485-NOTIFICATION OF INT. APPLN. NO. & FILING DATE (PCT-RO-105-PCT Pamphlet) [20-12-2024(online)].pdf	2024-12-20
5	202417101485-FORM 18 [20-12-2024(online)].pdf	2024-12-20
6	202417101485-FORM 1 [20-12-2024(online)].pdf	2024-12-20
7	202417101485-DRAWINGS [20-12-2024(online)].pdf	2024-12-20
8	202417101485-DECLARATION OF INVENTORSHIP (FORM 5) [20-12-2024(online)].pdf	2024-12-20
9	202417101485-COMPLETE SPECIFICATION [20-12-2024(online)].pdf	2024-12-20
10	202417101485-Proof of Right [05-02-2025(online)].pdf	2025-02-05
11	202417101485-FORM-26 [05-02-2025(online)].pdf	2025-02-05
12	202417101485-FORM 3 [11-04-2025(online)].pdf	2025-04-11