[4 [5 (Methylsulfonyl) Phenyl]Piperazin 1 Yl] (Phenyl)methanone Derivatives And Similar Compounds With Gfr Alpha 1 Ret Activity As Neuroprotective Agents For The Treatment Of Neurological Disorders

Abstract: The present invention relates to a compound of general formula (I). The invention further relates to the compounds of the invention as neuroprotective and/or neurorestorative agents, in particular for use in the treatment of neurological disorders, such as e.g. central nervous system (CNS) diseases, Alzheimer's disease (AD), Parkinson's disease (RD), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), dementia, stroke, head trauma, brain tumor, pain and epilepsy. The compounds of the invention show GFR alpha 1-RET activity in a luciferase assay.

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