Cd28/Ox40 Bispecific Antibodies

Abstract: Provided herein are multispecific binding proteins comprising (a) a first antigen binding domain (ABD) comprising an immunoglobulin single variable domain (ISVD) (e.g., VHH) with binding specificity to CD28; and (b) a second ABD comprising an immunoglobulin heavy chain variable domain (VH) and an immunoglobulin light chain variable domain (VL) with binding specificity to OX40. Also provided are methods of treating autoimmune diseases with said multispecific binding proteins.

Patent Information

Application #

Filing Date

15 July 2025

Publication Number

38/2025

Publication Type

INA

Invention Field

BIOTECHNOLOGY

Status

Email

Parent Application

Applicants

SANOFI

46 avenue de la Grande Armée 75017 Paris

Inventors

1. BESTE, Gerald

C/O ABLYNX N.V. PATENT DEPARTMENT TECHNOLOGIEPARK-ZWIJNAARDE 21 9052 Gent

2. DESRUMEAUX, Klervi

C/O SANOFI PATENT DEPARTMENT 46 AVENUE DE LA GRANDE ARMÉE 75017 Paris

3. KUEHN, Jennifer

C/O SANOFI-AVENTIS DEUTSCHLAND GMBH PATENT DEPARTMENT INDUSTRIEPARK HÖCHST, K703 65926 Frankfurt am Main

4. LAHOUTE, Charlotte

C/O SANOFI PATENT DEPARTMENT 46 AVENUE DE LA GRANDE ARMÉE 75017 Paris

5. LISSILAA, Rami

C/O SANOFI PATENT DEPARTMENT 46 AVENUE DE LA GRANDE ARMÉE 75017 Paris

6. OEZGUER BRUEDERLE, Sevim

C/O SANOFI-AVENTIS DEUTSCHLAND GMBH PATENT DEPARTMENT INDUSTRIEPARK HÖCHST, K703 65926 Frankfurt am Main

7. SURATT, Benjamin

C/O SANOFI PATENT DEPARTMENT 450 WATER STREET Cambridge, Massachusetts 02141

8. VIGNE, Emmanuelle

C/O SANOFI 46 AVENUE DE LA GRANDE ARMÉE Patent Department 75017 Paris

9. VOSS, Jessica

C/O SANOFI PATENT DEPARTMENT 450 WATER STREET Cambridge, Massachusetts 02141

10. BRUYNOOGHE, Yanik

c/o Ablynx N.V. Patent Department Technologiepark Zwijnaarde 21 9052 Gent

11. MASIERO, Alessandro

c/o Sanofi Patent Department 46 avenue de la Grande Armée 75017 Paris

Specification

Documents

Application Documents

#	Name	Date
1	202517067527-TRANSLATIOIN OF PRIOIRTY DOCUMENTS ETC. [15-07-2025(online)].pdf	2025-07-15
2	202517067527-STATEMENT OF UNDERTAKING (FORM 3) [15-07-2025(online)].pdf	2025-07-15
4	202517067527-Sequence Listing in PDF [15-07-2025(online)].pdf	2025-07-15
5	202517067527-REQUEST FOR EXAMINATION (FORM-18) [15-07-2025(online)].pdf	2025-07-15
6	202517067527-FORM 18 [15-07-2025(online)].pdf	2025-07-15
7	202517067527-FORM 1 [15-07-2025(online)].pdf	2025-07-15
8	202517067527-DRAWINGS [15-07-2025(online)].pdf	2025-07-15
9	202517067527-DECLARATION OF INVENTORSHIP (FORM 5) [15-07-2025(online)].pdf	2025-07-15
10	202517067527-COMPLETE SPECIFICATION [15-07-2025(online)].pdf	2025-07-15
11	202517067527-FORM-26 [22-08-2025(online)].pdf	2025-08-22
12	202517067527-Proof of Right [22-11-2025(online)].pdf	2025-11-22
13	202517067527-FORM 3 [22-11-2025(online)].pdf	2025-11-22