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Double Stranded Oligonucleotide Compositions For Rna Interference And Methods Relating Thereto
Abstract: The present disclosure provides double stranded oligonucleotides, compositions, and methods relating thereto. The present disclosure encompasses the recognition that structural elements of double stranded oligonucleotides, such as base sequence, chemical modifications (e.g., modifications of sugar, base, and/or intemucleotidic linkages) or patterns thereof, and/or stereochemistry (e.g., stereochemistry of backbone chiral centers (chiral intemucleotidic linkages), and/or patterns thereof, can have significant impact on oligonucleotide properties and activities, e.g., RNA interference (RNAi) activity, Ago2 loading, thermal stability, in vivo stability, delivery to tissues and into cells, etc. The present disclosure also provides methods for treatment of diseases, e.g., hepatic diseases, central nervous system (CNS) diseases, etc., using provided double stranded oligonucleotide compositions, for example, in RNA interference.
Notices, Deadlines & Correspondence
Patent Information
Applicants
WAVE LIFE SCIENCES LTD.
Inventors
1. VARGEESE, Chandra
2. IWAMOTO, Naoki
3. LIU, Wei
4. LUU, Khoa, Ngoc Dang
5. KANDASAMY, Pachamuthu
6. MARAPPAN, Subramanian
7. KUMARASAMY, Jayakanthan
8. SHAH, Himali, Kavin
9. CHATTERJEE, Arindom
10. ZHANG, Fengjiao
11. LAMATTINA, Anthony
12. LIU, Fangjun
13. CHOI, Jeonghoon
14. KOTHARI, Nayantara
15. SINGH, Kuldeep
Specification
Documents
Application Documents
| # | Name | Date |
|---|---|---|
| 1 | 202517089669-STATEMENT OF UNDERTAKING (FORM 3) [19-09-2025(online)].pdf | 2025-09-19 |
| 3 | 202517089669-Sequence Listing in PDF [19-09-2025(online)].pdf | 2025-09-19 |
| 4 | 202517089669-REQUEST FOR EXAMINATION (FORM-18) [19-09-2025(online)].pdf | 2025-09-19 |
| 5 | 202517089669-POWER OF AUTHORITY [19-09-2025(online)].pdf | 2025-09-19 |
| 6 | 202517089669-NOTIFICATION OF INT. APPLN. NO. & FILING DATE (PCT-RO-105-PCT Pamphlet) [19-09-2025(online)].pdf | 2025-09-19 |
| 7 | 202517089669-FORM 18 [19-09-2025(online)].pdf | 2025-09-19 |
| 8 | 202517089669-FORM 1 [19-09-2025(online)].pdf | 2025-09-19 |
| 9 | 202517089669-DECLARATION OF INVENTORSHIP (FORM 5) [19-09-2025(online)].pdf | 2025-09-19 |
| 10 | 202517089669-COMPLETE SPECIFICATION [19-09-2025(online)].pdf | 2025-09-19 |
| 11 | 202517089669-Proof of Right [04-11-2025(online)].pdf | 2025-11-04 |
| 12 | 202517089669-MARKED COPIES OF AMENDEMENTS [12-11-2025(online)].pdf | 2025-11-12 |
| 13 | 202517089669-FORM 13 [12-11-2025(online)].pdf | 2025-11-12 |
| 14 | 202517089669-Annexure [12-11-2025(online)].pdf | 2025-11-12 |
| 15 | 202517089669-AMMENDED DOCUMENTS [12-11-2025(online)].pdf | 2025-11-12 |