Glycosylation Of Immunoglobulin Single Variable Domains

Abstract: The present invention relates to glycosylation of immunoglobulin single variable domains (ISVDs). The present invention particularly relates to specific positions within the amino acid sequence of an ISVD for use as glycosylation acceptor sites. The present invention also relates to ISVDs modified with specific glycans at the specified glycosylation acceptor sites and to conjugates thereof. The present invention also relates to polypeptides comprising at least one ISVD of the present technology, at least one ISVD with specific glycans or at least one conjugate thereof. The invention furthermore relates to a nucleotide sequence or nucleic acid encoding such ISVD and/or polypeptide, a method of making such ISVDs and/or polypeptides, a composition comprising such ISVDs, conjugates and/or polypeptides, and the use of the polypeptide, nucleic sequence or nucleic acid, conjugate or composition according to the present technology in a medicament.

Patent Information

Application #

Filing Date

04 December 2025

Publication Number

52/2025

Publication Type

INA

Invention Field

BIOTECHNOLOGY

Status

Email

Parent Application

Applicants

SANOFI

46 avenue de la Grande Armée 75017 Paris

Inventors

1. COST, Robert

c/o Sanofi, Patent Department 450 Water Street Cambridge, MA, Massachusetts 02141

2. NIEBEL, Björn

c/o Ablynx N.V. Patent Department Technologiepark 21 9052 Ghent-Zwijnaarde

3. PARK, Sunghae

c/o Sanofi, Patent Department 450 Water Street Cambridge, MA, Massachusetts 02141

4. ZHOU, Qun

c/o Sanofi, Patent Department 450 Water Street Cambridge, MA, Massachusetts 02141

5. ZHOU, Yanfeng

c/o Sanofi, Patent Department 450 Water Street Cambridge, MA, Massachusetts 02141

Specification

Documents

Application Documents

#	Name	Date
1	202517121890-TRANSLATIOIN OF PRIOIRTY DOCUMENTS ETC. [04-12-2025(online)].pdf	2025-12-04
2	202517121890-STATEMENT OF UNDERTAKING (FORM 3) [04-12-2025(online)].pdf	2025-12-04
4	202517121890-Sequence Listing in PDF [04-12-2025(online)].pdf	2025-12-04
5	202517121890-REQUEST FOR EXAMINATION (FORM-18) [04-12-2025(online)].pdf	2025-12-04
6	202517121890-FORM 18 [04-12-2025(online)].pdf	2025-12-04
7	202517121890-FORM 1 [04-12-2025(online)].pdf	2025-12-04
8	202517121890-DRAWINGS [04-12-2025(online)].pdf	2025-12-04
9	202517121890-DECLARATION OF INVENTORSHIP (FORM 5) [04-12-2025(online)].pdf	2025-12-04
10	202517121890-COMPLETE SPECIFICATION [04-12-2025(online)].pdf	2025-12-04